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The map label for this gene is caiD [C]

Identifier: 187928223

GI number: 187928223

Start: 1209039

End: 1210283

Strand: Direct

Name: caiD [C]

Synonym: Rpic_1131

Alternate gene names: 187928223

Gene position: 1209039-1210283 (Clockwise)

Preceding gene: 187928221

Following gene: 187928224

Centisome position: 30.67

GC content: 64.18

Gene sequence:

>1245_bases
ATGTGTGTCGTCTCCAACTGGCAGGTATACGCCCAACACCCGCGCTGCGAAAGGGGGCAGGCTAGAGCCCTTCCTCGCTT
CAATACGCTGTCGTGTACAGTGCGAGCCGTTATTACCCACAACAACATTCGAGACATGCAATCCACCGCTTCCCCCGCGC
CCCAGGCTGAAGTTCAACCCAACGTGATCGCCGAAGTACGCGGCGGCATCGGCTGGCTGACGCTGAACCGGCCGCAGGCG
CTCAACGCGCTGTCGCTGGAGATGATTCGCGCCATGTCGCATGCGCTGCTGGCGTGGCAGCACGATCCGGAAGTCCACGC
TGTCATCCTGCGTGGCGAGGGCGGCAAAGCCCTGTGCGCGGGCGGCGATATCCGTTTCTTCTACCGCGCGGCCACGGCAG
GCGACCCGCAGCTCATCACCTTTTTCACCGAGGAGTACCGCCTCAACCACCTCATCTTCAGCTATGCCAAGCCCTACATC
GCGCTGATGGACGGCGTCGTCATGGGCGGTGGCATGGGCATCTCGCAAGGCGCATCGCTGCGCGTGGTGACCGAACGCAC
GAAGATGGCCATGCCCGAAACCAACATCGGCCTGTTTCCGGACGTGGGCGGCGGGTGGTTCCTGGCGCGCGTGCCGGGTC
ATGTGGGCGAATACCTGGGCGTGACCGGCCAGATGATCGAAGCGGCGGATGCGTTGTCGATCGGCCTTGCCGATTGCCAT
GTCACCACCGCGGCGCTGGCGTCCATCTTCCAGCGCCTGCGCGACGGCAACTGGGGCAGCGCCGAGCAGATCACCGCCTG
CTTTACCGAAGCCGCATCGGCGCCCGATGATGCCAAGGCCATCATCGCCCTTCACCGCGAGACCATTGATGCCTGCTTCA
GCCAAAGCAGCGTGCAAGGCATCTTCGCGGATCTGGCCGGCAGCACGGATACCGAATGGGCCGCTCAGACCGCCGCGCAC
ATGGCCAAGCGCTCGCCGTTGATGATCGCGGTGACGCTTGAGTTGATCCGCCGCGGCCGCCACACCACGTTGGCCGATGA
GCTGCGCCGCGAACTGGACATGATGACGCACGTGTTTGCCGAAGGCGATGGCATCGAAGGCATTCGGGCCCTCGCGGTCG
ACAAGGATCATGCGCCCAAGTGGAAGCACGCCAGCATTGACGCCGTGCGTGACGACGAAGTGGCCGCCTTCTTTGTTTCG
CCTTGGCGCCATGAGCAGCATCCGCTGCTGGGGCTGTCGGACTAG

Upstream 100 bases:

>100_bases
TGGTCAGCAGGAAGACCGGCGCGAAGGCCAGAAGGATCAGGCCGGGGTCGAAACTCGACGCGCCCGGGGCGGCGTTGGCA
GGGGTCATTGGATTGTTGTG

Downstream 100 bases:

>100_bases
AACCGGTAAATTGCGCGCCTGGATTTTGAACCGTTGACTTGCTGTGACTGGTGAACGCCCCTCGCCGAACCCCCGCCGCT
TGTCGCTTGCGCCCATGAGG

Product: 3-hydroxyisobutyryl-CoA hydrolase

Products: NA

Alternate protein names: 3-hydroxypropionyl-CoA dehydratase [H]

Number of amino acids: Translated: 414; Mature: 414

Protein sequence:

>414_residues
MCVVSNWQVYAQHPRCERGQARALPRFNTLSCTVRAVITHNNIRDMQSTASPAPQAEVQPNVIAEVRGGIGWLTLNRPQA
LNALSLEMIRAMSHALLAWQHDPEVHAVILRGEGGKALCAGGDIRFFYRAATAGDPQLITFFTEEYRLNHLIFSYAKPYI
ALMDGVVMGGGMGISQGASLRVVTERTKMAMPETNIGLFPDVGGGWFLARVPGHVGEYLGVTGQMIEAADALSIGLADCH
VTTAALASIFQRLRDGNWGSAEQITACFTEAASAPDDAKAIIALHRETIDACFSQSSVQGIFADLAGSTDTEWAAQTAAH
MAKRSPLMIAVTLELIRRGRHTTLADELRRELDMMTHVFAEGDGIEGIRALAVDKDHAPKWKHASIDAVRDDEVAAFFVS
PWRHEQHPLLGLSD

Sequences:

>Translated_414_residues
MCVVSNWQVYAQHPRCERGQARALPRFNTLSCTVRAVITHNNIRDMQSTASPAPQAEVQPNVIAEVRGGIGWLTLNRPQA
LNALSLEMIRAMSHALLAWQHDPEVHAVILRGEGGKALCAGGDIRFFYRAATAGDPQLITFFTEEYRLNHLIFSYAKPYI
ALMDGVVMGGGMGISQGASLRVVTERTKMAMPETNIGLFPDVGGGWFLARVPGHVGEYLGVTGQMIEAADALSIGLADCH
VTTAALASIFQRLRDGNWGSAEQITACFTEAASAPDDAKAIIALHRETIDACFSQSSVQGIFADLAGSTDTEWAAQTAAH
MAKRSPLMIAVTLELIRRGRHTTLADELRRELDMMTHVFAEGDGIEGIRALAVDKDHAPKWKHASIDAVRDDEVAAFFVS
PWRHEQHPLLGLSD
>Mature_414_residues
MCVVSNWQVYAQHPRCERGQARALPRFNTLSCTVRAVITHNNIRDMQSTASPAPQAEVQPNVIAEVRGGIGWLTLNRPQA
LNALSLEMIRAMSHALLAWQHDPEVHAVILRGEGGKALCAGGDIRFFYRAATAGDPQLITFFTEEYRLNHLIFSYAKPYI
ALMDGVVMGGGMGISQGASLRVVTERTKMAMPETNIGLFPDVGGGWFLARVPGHVGEYLGVTGQMIEAADALSIGLADCH
VTTAALASIFQRLRDGNWGSAEQITACFTEAASAPDDAKAIIALHRETIDACFSQSSVQGIFADLAGSTDTEWAAQTAAH
MAKRSPLMIAVTLELIRRGRHTTLADELRRELDMMTHVFAEGDGIEGIRALAVDKDHAPKWKHASIDAVRDDEVAAFFVS
PWRHEQHPLLGLSD

Specific function: Plays a role in autotrophic carbon fixation via the 3- hydroxypropionate/4-hydroxybutyrate cycle. Catalyzes the reversible dehydration of 3-hydroxypropionyl-CoA to form acryloyl- CoA, and the reversible dehydration of (S)-3-hydroxybutyryl-CoA to form crot

COG id: COG1024

COG function: function code I; Enoyl-CoA hydratase/carnithine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI37594471, Length=387, Percent_Identity=35.6589147286822, Blast_Score=239, Evalue=3e-63,
Organism=Homo sapiens, GI37594469, Length=338, Percent_Identity=36.094674556213, Blast_Score=209, Evalue=3e-54,
Organism=Homo sapiens, GI194097323, Length=250, Percent_Identity=30.4, Blast_Score=93, Evalue=4e-19,
Organism=Escherichia coli, GI221142681, Length=181, Percent_Identity=31.4917127071823, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1787660, Length=269, Percent_Identity=26.3940520446097, Blast_Score=65, Evalue=6e-12,
Organism=Escherichia coli, GI1788597, Length=190, Percent_Identity=27.3684210526316, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI25144157, Length=381, Percent_Identity=37.5328083989501, Blast_Score=235, Evalue=4e-62,
Organism=Caenorhabditis elegans, GI25144160, Length=361, Percent_Identity=38.5041551246537, Blast_Score=234, Evalue=5e-62,
Organism=Caenorhabditis elegans, GI17540714, Length=181, Percent_Identity=29.8342541436464, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17554946, Length=215, Percent_Identity=28.3720930232558, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI25145438, Length=168, Percent_Identity=32.1428571428571, Blast_Score=72, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6320241, Length=361, Percent_Identity=29.6398891966759, Blast_Score=151, Evalue=2e-37,
Organism=Drosophila melanogaster, GI28571729, Length=377, Percent_Identity=34.7480106100796, Blast_Score=222, Evalue=3e-58,
Organism=Drosophila melanogaster, GI28571730, Length=377, Percent_Identity=34.7480106100796, Blast_Score=222, Evalue=3e-58,
Organism=Drosophila melanogaster, GI20129971, Length=212, Percent_Identity=29.7169811320755, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24653477, Length=212, Percent_Identity=29.7169811320755, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24653139, Length=202, Percent_Identity=29.7029702970297, Blast_Score=75, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014748
- InterPro:   IPR001753
- InterPro:   IPR018376 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.2.1.116 [H]

Molecular weight: Translated: 45047; Mature: 45047

Theoretical pI: Translated: 6.30; Mature: 6.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCVVSNWQVYAQHPRCERGQARALPRFNTLSCTVRAVITHNNIRDMQSTASPAPQAEVQP
CEEECCCEEEECCCCCCCCCCCCCCCCCCCEEEEEEEEECCCHHHHHHHCCCCCCCCCCC
NVIAEVRGGIGWLTLNRPQALNALSLEMIRAMSHALLAWQHDPEVHAVILRGEGGKALCA
CHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHEECCCCCEEEEEEECCCCCEEEE
GGDIRFFYRAATAGDPQLITFFTEEYRLNHLIFSYAKPYIALMDGVVMGGGMGISQGASL
CCCEEEEEEECCCCCCEEEEEEEHHHHHHHHHHHHHCCHHHHHCCHHCCCCCCCCCCCEE
RVVTERTKMAMPETNIGLFPDVGGGWFLARVPGHVGEYLGVTGQMIEAADALSIGLADCH
EEEECHHHHCCCCCCCCCCCCCCCCEEEEECCCHHHHHHCCCHHHHHHHHHHHCCHHHHH
VTTAALASIFQRLRDGNWGSAEQITACFTEAASAPDDAKAIIALHRETIDACFSQSSVQG
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCHHHHH
IFADLAGSTDTEWAAQTAAHMAKRSPLMIAVTLELIRRGRHTTLADELRRELDMMTHVFA
HHHHHCCCCCCHHHHHHHHHHHHCCCEEEEEEHHHHHCCCCCHHHHHHHHHHHHHHHHHH
EGDGIEGIRALAVDKDHAPKWKHASIDAVRDDEVAAFFVSPWRHEQHPLLGLSD
CCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCC
>Mature Secondary Structure
MCVVSNWQVYAQHPRCERGQARALPRFNTLSCTVRAVITHNNIRDMQSTASPAPQAEVQP
CEEECCCEEEECCCCCCCCCCCCCCCCCCCEEEEEEEEECCCHHHHHHHCCCCCCCCCCC
NVIAEVRGGIGWLTLNRPQALNALSLEMIRAMSHALLAWQHDPEVHAVILRGEGGKALCA
CHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHEECCCCCEEEEEEECCCCCEEEE
GGDIRFFYRAATAGDPQLITFFTEEYRLNHLIFSYAKPYIALMDGVVMGGGMGISQGASL
CCCEEEEEEECCCCCCEEEEEEEHHHHHHHHHHHHHCCHHHHHCCHHCCCCCCCCCCCEE
RVVTERTKMAMPETNIGLFPDVGGGWFLARVPGHVGEYLGVTGQMIEAADALSIGLADCH
EEEECHHHHCCCCCCCCCCCCCCCCEEEEECCCHHHHHHCCCHHHHHHHHHHHCCHHHHH
VTTAALASIFQRLRDGNWGSAEQITACFTEAASAPDDAKAIIALHRETIDACFSQSSVQG
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCHHHHH
IFADLAGSTDTEWAAQTAAHMAKRSPLMIAVTLELIRRGRHTTLADELRRELDMMTHVFA
HHHHHCCCCCCHHHHHHHHHHHHCCCEEEEEEHHHHHCCCCCHHHHHHHHHHHHHHHHHH
EGDGIEGIRALAVDKDHAPKWKHASIDAVRDDEVAAFFVSPWRHEQHPLLGLSD
CCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA