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The map label for this gene is dnaX [H]

Identifier: 187928128

GI number: 187928128

Start: 1100943

End: 1103138

Strand: Direct

Name: dnaX [H]

Synonym: Rpic_1035

Alternate gene names: 187928128

Gene position: 1100943-1103138 (Clockwise)

Preceding gene: 187928127

Following gene: 187928129

Centisome position: 27.92

GC content: 68.21

Gene sequence:

>2196_bases
ATGAGTTATCAAGTGCTCGCCCGCAAGTGGCGCCCTCGCGATTTCACCACGCTGGTCGGTCAGGAACACGTGGTGAAAGC
GCTCACGCATGCGCTCGAACAGCAGCGCCTGCACCACGCATACCTGTTCACGGGTACGCGCGGTGTCGGCAAGACGACGC
TGTCGCGCATCCTTGCCAAATCGCTCAATTGCGTCGGCGCGGACGGGCAGGGCGGCATCACTGCGCAGCCGTGCGGCGTG
TGCCGCGCCTGCACTGAAATCGATGCCGGGCGCTTTGTCGATTACATCGAGATGGATGCCGCCTCCAACCGCGGCGTCGA
CGAGATGGCCCAGTTGCTGGACCGCGCGGTCTATGCACCCACAAGCGGCCGCTTCAAGGTCTACATGATCGACGAAGTGC
ACATGCTGACCAACCACGCCTTCAATGCGATGCTGAAGACGCTGGAAGAGCCGCCCGAGCACGTCAAGTTCATCCTCGCG
ACCACCGATCCGCAGAAGATTCCGGTGACGGTGCTGTCGCGCTGCCTGCAGTTCAACCTCAAGCAGATGCCGCCGGGGCA
CATCGTGTCTCACCTCGATCGCATCCTTGGCGAAGAGGGCATCGCCCACGAGCCGAACGCGCTGCGTCTGCTGGCCGCCG
CCGCCCAGGGTTCGATGCGTGATGCGCTGTCGCTCACCGACCAGGCCATCGCGTACAGCGCCGGCGACGTGAGCGAAGCC
GCCGTGCGCGGCATGCTCGGCGCGATTGATCAGAGCTACCTCGTGCGCCTGCTCGATGCACTGGCCGATGAGAACGGCGC
CGCGCTTGTCGAGATTGCCGACGAAATGGCCGGGCGCAGTCTGAGCTTCTCGGGCGCGCTGCAGGATCTTGCATCCCTGC
TGCAGAAGATTGCGCTGGCGCAGGTCGTGCCCGCCGCTGTGCAGGACGATTGGCCAGAGGCTGATGATGTACGCCGCCTT
GCCGAGCGGTTCGATGCGCAGTCCGTGCAACTGTTCTACCAGTTTGCCAACCTGGGCCGCAACGAATTGGCGCTCGCGCC
GGATGAGTACGCCGGCTTCACGATGACGCTGCTGCGCATGCTTGCGTTCCAGCCCGGGCAGTCGGGTGGGGACACGGCGC
CGCCTTCTGGCGGTGGCGGCGGGAAGCGCGCGATGCCGTTGGCTGCAACGCCAGCCGCATCGACGCGTCCGGCGGTTACG
GCGACTGCGCCTGTGGCGGCGCCGGTTGCTCAGGTGGCGCCGGTGGCGGTGCGTCCGGAGCCGGTGGTCGAGGCGCCGCG
TGCGACTTATCAGGCAACACCGCCGGCGCCTGCGCCCGTTGCTGCGGTTGCGCACACGCCGGCTGCAGCGCCAGCGCGTC
GCTCGCCGGCGATGGAAGCCTTGGCCGCAGCCCGCCAGGCTTCGAACCGTGGCCGTGGCGGTGCTTCCGCACCTGTCGCC
TCGCCGGTAGCCGCGCCTGCGCCTGCCGCACGTCCAGCTGCGCCCGCTGTGGGTCCACGTCCGAATCCTGCTGCTGCTGC
GCCGGCATCCGCGCCGCCGCGCCGCGAACAGCCGGCTGGCGCTGCCGCTGCGTCCGATGACGGGCCGCCGCCCTGGGATG
AAATGCCAGGCGAATTTGCTTCGCCGCCGCTTGACGAGATGGACGCCGCGTTTGCCGGCTGGGATTCCGCGTCGAGCATG
CGCCCCGGTGCGCCTGAACCGGCAGCACGTCCAGCGCAGATCGAGGCGCCGTCAGCCGCGCTTGTGCCGGTCACGACGAT
CGCCCCGGAGCCGTTCGCCGCTGCTACGCCGCCTGATCTGAGCGCCAGCAGTCTTACAACGTTCGACGGCAGTTGGCCGG
CGCTGGCGGCCAGCCTGCCGATCCGCGGCCTGGCTCAACAGCTGGCTTACCAGAGCGAGTTGGTGGCCGTGGAAGGCGCC
ACGATGCGCCTGCGTGTTCCGTTGCCCCCGCTGACCGACGCCAATGTCGTCGAGCGTCTGGAGGCAGCACTCACGGAACA
CTTCAGCACGCCCGTTCGCGTGGCGTGTGATATCGGACCGGCGCGCGCCACCGCGGCGGCGGTGGACGCCGAGCAGCGCG
CCGAGCGCCAACGTAGTGCCGAAGACGCCATCGCCGCCAACCCGTTTGTTCAGGCTCTGGTCCGGGACTTTGCTGCGCAG
GTCGTCCCCGGATCGATCCAACCGCACGCGCACTGA

Upstream 100 bases:

>100_bases
GTCCCCACTTGAATATCCTTGCAATTCGCTCGGCGCGCATGGAGGTTGACGCCTCCAAAACCGCGTCGGAAATCCACCTC
GCTTTGCTACAATCCGCCGC

Downstream 100 bases:

>100_bases
ACGGAATTTCAGGACTGAACATTGAACCCCGGCGTGCCCCGCTGAGCGGCACGCCTTGCACGACCCATTCCAAGGAGCAA
TGACCATGATGAAAGGCCAG

Product: DNA polymerase III subunits gamma and tau

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 731; Mature: 730

Protein sequence:

>731_residues
MSYQVLARKWRPRDFTTLVGQEHVVKALTHALEQQRLHHAYLFTGTRGVGKTTLSRILAKSLNCVGADGQGGITAQPCGV
CRACTEIDAGRFVDYIEMDAASNRGVDEMAQLLDRAVYAPTSGRFKVYMIDEVHMLTNHAFNAMLKTLEEPPEHVKFILA
TTDPQKIPVTVLSRCLQFNLKQMPPGHIVSHLDRILGEEGIAHEPNALRLLAAAAQGSMRDALSLTDQAIAYSAGDVSEA
AVRGMLGAIDQSYLVRLLDALADENGAALVEIADEMAGRSLSFSGALQDLASLLQKIALAQVVPAAVQDDWPEADDVRRL
AERFDAQSVQLFYQFANLGRNELALAPDEYAGFTMTLLRMLAFQPGQSGGDTAPPSGGGGGKRAMPLAATPAASTRPAVT
ATAPVAAPVAQVAPVAVRPEPVVEAPRATYQATPPAPAPVAAVAHTPAAAPARRSPAMEALAAARQASNRGRGGASAPVA
SPVAAPAPAARPAAPAVGPRPNPAAAAPASAPPRREQPAGAAAASDDGPPPWDEMPGEFASPPLDEMDAAFAGWDSASSM
RPGAPEPAARPAQIEAPSAALVPVTTIAPEPFAAATPPDLSASSLTTFDGSWPALAASLPIRGLAQQLAYQSELVAVEGA
TMRLRVPLPPLTDANVVERLEAALTEHFSTPVRVACDIGPARATAAAVDAEQRAERQRSAEDAIAANPFVQALVRDFAAQ
VVPGSIQPHAH

Sequences:

>Translated_731_residues
MSYQVLARKWRPRDFTTLVGQEHVVKALTHALEQQRLHHAYLFTGTRGVGKTTLSRILAKSLNCVGADGQGGITAQPCGV
CRACTEIDAGRFVDYIEMDAASNRGVDEMAQLLDRAVYAPTSGRFKVYMIDEVHMLTNHAFNAMLKTLEEPPEHVKFILA
TTDPQKIPVTVLSRCLQFNLKQMPPGHIVSHLDRILGEEGIAHEPNALRLLAAAAQGSMRDALSLTDQAIAYSAGDVSEA
AVRGMLGAIDQSYLVRLLDALADENGAALVEIADEMAGRSLSFSGALQDLASLLQKIALAQVVPAAVQDDWPEADDVRRL
AERFDAQSVQLFYQFANLGRNELALAPDEYAGFTMTLLRMLAFQPGQSGGDTAPPSGGGGGKRAMPLAATPAASTRPAVT
ATAPVAAPVAQVAPVAVRPEPVVEAPRATYQATPPAPAPVAAVAHTPAAAPARRSPAMEALAAARQASNRGRGGASAPVA
SPVAAPAPAARPAAPAVGPRPNPAAAAPASAPPRREQPAGAAAASDDGPPPWDEMPGEFASPPLDEMDAAFAGWDSASSM
RPGAPEPAARPAQIEAPSAALVPVTTIAPEPFAAATPPDLSASSLTTFDGSWPALAASLPIRGLAQQLAYQSELVAVEGA
TMRLRVPLPPLTDANVVERLEAALTEHFSTPVRVACDIGPARATAAAVDAEQRAERQRSAEDAIAANPFVQALVRDFAAQ
VVPGSIQPHAH
>Mature_730_residues
SYQVLARKWRPRDFTTLVGQEHVVKALTHALEQQRLHHAYLFTGTRGVGKTTLSRILAKSLNCVGADGQGGITAQPCGVC
RACTEIDAGRFVDYIEMDAASNRGVDEMAQLLDRAVYAPTSGRFKVYMIDEVHMLTNHAFNAMLKTLEEPPEHVKFILAT
TDPQKIPVTVLSRCLQFNLKQMPPGHIVSHLDRILGEEGIAHEPNALRLLAAAAQGSMRDALSLTDQAIAYSAGDVSEAA
VRGMLGAIDQSYLVRLLDALADENGAALVEIADEMAGRSLSFSGALQDLASLLQKIALAQVVPAAVQDDWPEADDVRRLA
ERFDAQSVQLFYQFANLGRNELALAPDEYAGFTMTLLRMLAFQPGQSGGDTAPPSGGGGGKRAMPLAATPAASTRPAVTA
TAPVAAPVAQVAPVAVRPEPVVEAPRATYQATPPAPAPVAAVAHTPAAAPARRSPAMEALAAARQASNRGRGGASAPVAS
PVAAPAPAARPAAPAVGPRPNPAAAAPASAPPRREQPAGAAAASDDGPPPWDEMPGEFASPPLDEMDAAFAGWDSASSMR
PGAPEPAARPAQIEAPSAALVPVTTIAPEPFAAATPPDLSASSLTTFDGSWPALAASLPIRGLAQQLAYQSELVAVEGAT
MRLRVPLPPLTDANVVERLEAALTEHFSTPVRVACDIGPARATAAAVDAEQRAERQRSAEDAIAANPFVQALVRDFAAQV
VPGSIQPHAH

Specific function: The gamma chain seems to interact with the delta subunit to transfer the beta subunit on the DNA [H]

COG id: COG2812

COG function: function code L; DNA polymerase III, gamma/tau subunits

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1786676, Length=366, Percent_Identity=56.2841530054645, Blast_Score=418, Evalue=1e-118,
Organism=Escherichia coli, GI1787341, Length=289, Percent_Identity=29.4117647058824, Blast_Score=68, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71986063, Length=252, Percent_Identity=26.1904761904762, Blast_Score=72, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6324039, Length=222, Percent_Identity=25.6756756756757, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI18859927, Length=299, Percent_Identity=24.4147157190635, Blast_Score=74, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR001270
- InterPro:   IPR008921
- InterPro:   IPR022001
- InterPro:   IPR022754
- InterPro:   IPR012763
- InterPro:   IPR021029 [H]

Pfam domain/function: PF00004 AAA; PF12169 DNA_pol3_gamma3; PF12168 DNA_pol3_tau_4; PF12170 DNA_pol3_tau_5 [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 76268; Mature: 76137

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYQVLARKWRPRDFTTLVGQEHVVKALTHALEQQRLHHAYLFTGTRGVGKTTLSRILAK
CCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCHHHHHHHHHH
SLNCVGADGQGGITAQPCGVCRACTEIDAGRFVDYIEMDAASNRGVDEMAQLLDRAVYAP
HCCEECCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHCCC
TSGRFKVYMIDEVHMLTNHAFNAMLKTLEEPPEHVKFILATTDPQKIPVTVLSRCLQFNL
CCCCEEEEEECHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCHHHHHHHHHHCH
KQMPPGHIVSHLDRILGEEGIAHEPNALRLLAAAAQGSMRDALSLTDQAIAYSAGDVSEA
HCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCHHHH
AVRGMLGAIDQSYLVRLLDALADENGAALVEIADEMAGRSLSFSGALQDLASLLQKIALA
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEHHHHCCCCCCHHHHHHHHHHHHHHHHHH
QVVPAAVQDDWPEADDVRRLAERFDAQSVQLFYQFANLGRNELALAPDEYAGFTMTLLRM
HHHHHHHHCCCCCHHHHHHHHHHHCHHHHHHHHHHHHCCCCCEEECCHHHCHHHHHHHHH
LAFQPGQSGGDTAPPSGGGGGKRAMPLAATPAASTRPAVTATAPVAAPVAQVAPVAVRPE
HHCCCCCCCCCCCCCCCCCCCCCCCCEECCCCCCCCCCEEECCCHHHHHHHHCCCCCCCC
PVVEAPRATYQATPPAPAPVAAVAHTPAAAPARRSPAMEALAAARQASNRGRGGASAPVA
CCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCC
SPVAAPAPAARPAAPAVGPRPNPAAAAPASAPPRREQPAGAAAASDDGPPPWDEMPGEFA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCC
SPPLDEMDAAFAGWDSASSMRPGAPEPAARPAQIEAPSAALVPVTTIAPEPFAAATPPDL
CCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCC
SASSLTTFDGSWPALAASLPIRGLAQQLAYQSELVAVEGATMRLRVPLPPLTDANVVERL
CCCCEEECCCCCCHHHHHCCHHHHHHHHHHHHHEEEECCCEEEEEECCCCCCCHHHHHHH
EAALTEHFSTPVRVACDIGPARATAAAVDAEQRAERQRSAEDAIAANPFVQALVRDFAAQ
HHHHHHHCCCCEEEEECCCCHHHHHHHHCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
VVPGSIQPHAH
HCCCCCCCCCC
>Mature Secondary Structure 
SYQVLARKWRPRDFTTLVGQEHVVKALTHALEQQRLHHAYLFTGTRGVGKTTLSRILAK
CHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCHHHHHHHHHH
SLNCVGADGQGGITAQPCGVCRACTEIDAGRFVDYIEMDAASNRGVDEMAQLLDRAVYAP
HCCEECCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHCCC
TSGRFKVYMIDEVHMLTNHAFNAMLKTLEEPPEHVKFILATTDPQKIPVTVLSRCLQFNL
CCCCEEEEEECHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCHHHHHHHHHHCH
KQMPPGHIVSHLDRILGEEGIAHEPNALRLLAAAAQGSMRDALSLTDQAIAYSAGDVSEA
HCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCHHHH
AVRGMLGAIDQSYLVRLLDALADENGAALVEIADEMAGRSLSFSGALQDLASLLQKIALA
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEHHHHCCCCCCHHHHHHHHHHHHHHHHHH
QVVPAAVQDDWPEADDVRRLAERFDAQSVQLFYQFANLGRNELALAPDEYAGFTMTLLRM
HHHHHHHHCCCCCHHHHHHHHHHHCHHHHHHHHHHHHCCCCCEEECCHHHCHHHHHHHHH
LAFQPGQSGGDTAPPSGGGGGKRAMPLAATPAASTRPAVTATAPVAAPVAQVAPVAVRPE
HHCCCCCCCCCCCCCCCCCCCCCCCCEECCCCCCCCCCEEECCCHHHHHHHHCCCCCCCC
PVVEAPRATYQATPPAPAPVAAVAHTPAAAPARRSPAMEALAAARQASNRGRGGASAPVA
CCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCC
SPVAAPAPAARPAAPAVGPRPNPAAAAPASAPPRREQPAGAAAASDDGPPPWDEMPGEFA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCC
SPPLDEMDAAFAGWDSASSMRPGAPEPAARPAQIEAPSAALVPVTTIAPEPFAAATPPDL
CCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCC
SASSLTTFDGSWPALAASLPIRGLAQQLAYQSELVAVEGATMRLRVPLPPLTDANVVERL
CCCCEEECCCCCCHHHHHCCHHHHHHHHHHHHHEEEECCCEEEEEECCCCCCCHHHHHHH
EAALTEHFSTPVRVACDIGPARATAAAVDAEQRAERQRSAEDAIAANPFVQALVRDFAAQ
HHHHHHHCCCCEEEEECCCCHHHHHHHHCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
VVPGSIQPHAH
HCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3534795; 3018672; 9278503; 2186364; 2187190; 2181440; 1575709 [H]