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The map label for this gene is fabI [H]

Identifier: 187928106

GI number: 187928106

Start: 1071184

End: 1071978

Strand: Reverse

Name: fabI [H]

Synonym: Rpic_1013

Alternate gene names: 187928106

Gene position: 1071978-1071184 (Counterclockwise)

Preceding gene: 187928114

Following gene: 187928100

Centisome position: 27.19

GC content: 63.14

Gene sequence:

>795_bases
ATGGGATTCCTCGCTGGCAAGCGCATTCTGATTACCGGCCTTCTGTCCAATCGCTCGATCGCCTACGGCATCGCCAACGC
CTGCAAGCGCGAAGGCGCGGAACTGGCGTTCACCTACGTCGGCGAACGCTTCAAAGACCGCATTACTGAATTCGCCACCG
AGTTCGACAGCAAGCTGGTGTTTGATTGCGACGTCGGCAGCGATGAACAGATCGCCAAGGTGTTCGAAGATCTTGGCCAG
CACTGGGGCCACTTCGATGGCCTGGTGCACTCGATCGGCTTTGCGCCGCGCGAAGCGATTGCCGGCAACTTCATCGAAGG
CCTGTCGCGCGAGTCGTTCCGCATCGCGCACGACATCTCGGCATATAGCTTCCCGGCGCTGGCGAAGGCCGCGCTGCCGA
TGCTCTCGCCCACTGCTTCGCTGCTCGCCCTGACGTACCTGGGTGCTGAGCGCATCGTCCCGAACTACAACACGATGGGC
CTGGCCAAGGCGTCGTTGGAAGCCGGCGTGCGCTACCTGGCCGGCGCGCTGGGGCCGAAGGGCATTCGTGCCAACGGCAT
CTCGGCTGGCCCGATCAAGACGCTGGCTGCTTCCGGCATCAAGGATTTCGGCAAGCTGCTGAAGTACATGGAAGATGTCG
CCCCGCTGCGCCGTAACGTCACGATCGAGGAAGTCGGCAACGTGGCCGCGTTCCTGCTGTCGGACCTGGCAAGCGGCGTG
ACCGGTGAGATCACCTACGTCGACTGCGGCTTCAACGTGACCGCAGGCGTGCCGGAGAGCGTCGGCCAAGGCTGA

Upstream 100 bases:

>100_bases
ATTGCCTCGTGCCCCGGATACCGCCGCTGCGCAACCGCAGCGACGAGTGACCACAGCAACATACGGGCGCGACGTTGCCC
CACATTTGTACGGAGAAACT

Downstream 100 bases:

>100_bases
TGCATTGATTGATGGGTGCAAGCGGCGCCATCTTCGGATGGCGCTTGCAAGTCAGGGCGCGACGCGTACAAGACCCCAGC
AGACAAAGAAAAAGCCCGCA

Product: enoyl-(acyl carrier protein) reductase

Products: NA

Alternate protein names: NADH-dependent enoyl-ACP reductase [H]

Number of amino acids: Translated: 264; Mature: 263

Protein sequence:

>264_residues
MGFLAGKRILITGLLSNRSIAYGIANACKREGAELAFTYVGERFKDRITEFATEFDSKLVFDCDVGSDEQIAKVFEDLGQ
HWGHFDGLVHSIGFAPREAIAGNFIEGLSRESFRIAHDISAYSFPALAKAALPMLSPTASLLALTYLGAERIVPNYNTMG
LAKASLEAGVRYLAGALGPKGIRANGISAGPIKTLAASGIKDFGKLLKYMEDVAPLRRNVTIEEVGNVAAFLLSDLASGV
TGEITYVDCGFNVTAGVPESVGQG

Sequences:

>Translated_264_residues
MGFLAGKRILITGLLSNRSIAYGIANACKREGAELAFTYVGERFKDRITEFATEFDSKLVFDCDVGSDEQIAKVFEDLGQ
HWGHFDGLVHSIGFAPREAIAGNFIEGLSRESFRIAHDISAYSFPALAKAALPMLSPTASLLALTYLGAERIVPNYNTMG
LAKASLEAGVRYLAGALGPKGIRANGISAGPIKTLAASGIKDFGKLLKYMEDVAPLRRNVTIEEVGNVAAFLLSDLASGV
TGEITYVDCGFNVTAGVPESVGQG
>Mature_263_residues
GFLAGKRILITGLLSNRSIAYGIANACKREGAELAFTYVGERFKDRITEFATEFDSKLVFDCDVGSDEQIAKVFEDLGQH
WGHFDGLVHSIGFAPREAIAGNFIEGLSRESFRIAHDISAYSFPALAKAALPMLSPTASLLALTYLGAERIVPNYNTMGL
AKASLEAGVRYLAGALGPKGIRANGISAGPIKTLAASGIKDFGKLLKYMEDVAPLRRNVTIEEVGNVAAFLLSDLASGVT
GEITYVDCGFNVTAGVPESVGQG

Specific function: Fatty acid biosynthesis pathway; second reduction step. [C]

COG id: COG0623

COG function: function code I; Enoyl-[acyl-carrier-protein] reductase (NADH)

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily [H]

Homologues:

Organism=Homo sapiens, GI4503301, Length=204, Percent_Identity=32.3529411764706, Blast_Score=67, Evalue=1e-11,
Organism=Escherichia coli, GI1787545, Length=255, Percent_Identity=60.7843137254902, Blast_Score=329, Evalue=1e-91,
Organism=Escherichia coli, GI87082100, Length=273, Percent_Identity=27.4725274725275, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1789378, Length=253, Percent_Identity=28.0632411067194, Blast_Score=65, Evalue=3e-12,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR014358
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.3.1.9 [H]

Molecular weight: Translated: 28030; Mature: 27899

Theoretical pI: Translated: 5.73; Mature: 5.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGFLAGKRILITGLLSNRSIAYGIANACKREGAELAFTYVGERFKDRITEFATEFDSKLV
CCCCCCCCEEEEEHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCEE
FDCDVGSDEQIAKVFEDLGQHWGHFDGLVHSIGFAPREAIAGNFIEGLSRESFRIAHDIS
EECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHCC
AYSFPALAKAALPMLSPTASLLALTYLGAERIVPNYNTMGLAKASLEAGVRYLAGALGPK
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCC
GIRANGISAGPIKTLAASGIKDFGKLLKYMEDVAPLRRNVTIEEVGNVAAFLLSDLASGV
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCC
TGEITYVDCGFNVTAGVPESVGQG
CCEEEEEECCCCCCCCCCCCCCCC
>Mature Secondary Structure 
GFLAGKRILITGLLSNRSIAYGIANACKREGAELAFTYVGERFKDRITEFATEFDSKLV
CCCCCCCEEEEEHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCEE
FDCDVGSDEQIAKVFEDLGQHWGHFDGLVHSIGFAPREAIAGNFIEGLSRESFRIAHDIS
EECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHCC
AYSFPALAKAALPMLSPTASLLALTYLGAERIVPNYNTMGLAKASLEAGVRYLAGALGPK
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCC
GIRANGISAGPIKTLAASGIKDFGKLLKYMEDVAPLRRNVTIEEVGNVAAFLLSDLASGV
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCC
TGEITYVDCGFNVTAGVPESVGQG
CCEEEEEECCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 10710307 [H]