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The map label for this gene is exuT [H]

Identifier: 187928042

GI number: 187928042

Start: 1002643

End: 1003935

Strand: Direct

Name: exuT [H]

Synonym: Rpic_0947

Alternate gene names: 187928042

Gene position: 1002643-1003935 (Clockwise)

Preceding gene: 187928041

Following gene: 187928043

Centisome position: 25.43

GC content: 64.19

Gene sequence:

>1293_bases
GTGAAGACCATCAAGGGCTTGCGCTGGTGGATCATCGTGCTGGTGTGCCTGGGCACGATCGTCAACTATCTGGCGCGTAA
CTCGCTGGGCGTGCTGGCGCCCACACTCAAGAACGAGCTGGGGATGAGCACCCAGCAGTATTCCTACGTGGTGGCGGCCT
TCCAAGTCGGCTACACGATCATGCAGCCGGTCTGCGGCTTTATCGTTGACCTGGTCGGCTTGCGTATCGGCTTTGCGCTG
TTTGGTGTGTTGTGGTCGTTTGCTGGCGTGCTGCACGCGGGCGCTACCGGCTGGCTGTCGCTGGCGGGCTTTCGCGCCCT
GATGGGCCTGACCGAAGCCGCTGCCATTCCGTCCGGTATGAAGGCCGTGGCCGAATGGTTCCCGGACAAGGAAAAATCCG
TCGCCGTCGGCTGGTTCAATTCGGGCACCTCGCTGGGTGCGATGTTGGCACCGCCGCTGGTGGTCTTCCTGCATCTGCGT
TACGGCTGGCAGTCGGCGTTTGTGGTGACTGGCGCCATCGGCTTCCTGTGGGCCGCGCTGTGGTTCGCGTTCTACCGTTC
GCCGAAAGACCACGCCGCGCTGTCCGACGCCGAGCGCGAAAAGATCATCGGCGGACAGCTCCGCCCCGTGAGCGCCGAGC
GCGGCAAGCGCCCGGTCAAGGACGTCGTGACGTCCCGCCGTTTCTGGGCGATTGCGCTGGCGCGCTTCTTCGCCGAGCCG
GCGTGGCAGACGTTCAGCTTCTGGATTCCGCTGTACTTCGTGAACGAACGCCATCTCGATCTGAAAGCGATCGCCATGTT
CGCGTGGCTGCCGTTCCTGGCGGCGGACCTGGGCGGCCTGGTGGGCGGTTACCTGTCGCCGTTCCTGATCAAGCGTTTCC
GCATTCCGCTGGTGTGGTCGCGTGTGTGCGGCGTCGTGCTGGGTGCGTTCATGATGATCGGTCCGGCGTGCGTCGGGCTC
GTGGCGTCTCCCTACACGGCGATTGCGTTGTTCTGCGTGGGCGGCTTTGCGCACCAGATGATCTCCGGCTTGGTCAACAC
GCTGTCGGCGGACGTCTTCGATCCGGAAGAGGTCGGCACCGCCAGCGGCTTTGCCGGCATGGCGGCGTGGATCGGCGGCC
TGGGCTTCTCGCTGTTGGTGGGCGCGCTGGCTGACAAGGTCGGTTATGGTCCGCTGTTCGGCCTGCTCGGCGCGTTCGAT
CTGATTGGCGCGGCGTTGCTGATTGTTCTGATTCGCGGTCAGTCGCATGAAGAACGTGCCGCGCGTCAGATGCGTCTCTC
TGCTTCAAACTGA

Upstream 100 bases:

>100_bases
CGTTGACTGTTGACTGCTACGGCGGAACCCGAGGCGGCGCACGTCGTAGCACGCCGCCTCGTAGATCGGTAACCAATAAA
AAAATATCGGAGACAACACC

Downstream 100 bases:

>100_bases
GTTGAAACCGATGTCCATGTTGAATCCCCCCCGATTCGAAGTCCAGGCGCAGGAAGGCAACCGGCTGCGGCTGGCCAGCA
GCGCCGGCGCTGCGATTGAA

Product: major facilitator superfamily protein

Products: galacturonate [Cytoplasm]; Proton [Cytoplasm]; glucuronate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 430; Mature: 430

Protein sequence:

>430_residues
MKTIKGLRWWIIVLVCLGTIVNYLARNSLGVLAPTLKNELGMSTQQYSYVVAAFQVGYTIMQPVCGFIVDLVGLRIGFAL
FGVLWSFAGVLHAGATGWLSLAGFRALMGLTEAAAIPSGMKAVAEWFPDKEKSVAVGWFNSGTSLGAMLAPPLVVFLHLR
YGWQSAFVVTGAIGFLWAALWFAFYRSPKDHAALSDAEREKIIGGQLRPVSAERGKRPVKDVVTSRRFWAIALARFFAEP
AWQTFSFWIPLYFVNERHLDLKAIAMFAWLPFLAADLGGLVGGYLSPFLIKRFRIPLVWSRVCGVVLGAFMMIGPACVGL
VASPYTAIALFCVGGFAHQMISGLVNTLSADVFDPEEVGTASGFAGMAAWIGGLGFSLLVGALADKVGYGPLFGLLGAFD
LIGAALLIVLIRGQSHEERAARQMRLSASN

Sequences:

>Translated_430_residues
MKTIKGLRWWIIVLVCLGTIVNYLARNSLGVLAPTLKNELGMSTQQYSYVVAAFQVGYTIMQPVCGFIVDLVGLRIGFAL
FGVLWSFAGVLHAGATGWLSLAGFRALMGLTEAAAIPSGMKAVAEWFPDKEKSVAVGWFNSGTSLGAMLAPPLVVFLHLR
YGWQSAFVVTGAIGFLWAALWFAFYRSPKDHAALSDAEREKIIGGQLRPVSAERGKRPVKDVVTSRRFWAIALARFFAEP
AWQTFSFWIPLYFVNERHLDLKAIAMFAWLPFLAADLGGLVGGYLSPFLIKRFRIPLVWSRVCGVVLGAFMMIGPACVGL
VASPYTAIALFCVGGFAHQMISGLVNTLSADVFDPEEVGTASGFAGMAAWIGGLGFSLLVGALADKVGYGPLFGLLGAFD
LIGAALLIVLIRGQSHEERAARQMRLSASN
>Mature_430_residues
MKTIKGLRWWIIVLVCLGTIVNYLARNSLGVLAPTLKNELGMSTQQYSYVVAAFQVGYTIMQPVCGFIVDLVGLRIGFAL
FGVLWSFAGVLHAGATGWLSLAGFRALMGLTEAAAIPSGMKAVAEWFPDKEKSVAVGWFNSGTSLGAMLAPPLVVFLHLR
YGWQSAFVVTGAIGFLWAALWFAFYRSPKDHAALSDAEREKIIGGQLRPVSAERGKRPVKDVVTSRRFWAIALARFFAEP
AWQTFSFWIPLYFVNERHLDLKAIAMFAWLPFLAADLGGLVGGYLSPFLIKRFRIPLVWSRVCGVVLGAFMMIGPACVGL
VASPYTAIALFCVGGFAHQMISGLVNTLSADVFDPEEVGTASGFAGMAAWIGGLGFSLLVGALADKVGYGPLFGLLGAFD
LIGAALLIVLIRGQSHEERAARQMRLSASN

Specific function: Aldohexuronate transport system [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Phthalate permease family [H]

Homologues:

Organism=Homo sapiens, GI148743791, Length=384, Percent_Identity=27.6041666666667, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI148728191, Length=335, Percent_Identity=28.955223880597, Blast_Score=100, Evalue=5e-21,
Organism=Homo sapiens, GI154800443, Length=418, Percent_Identity=23.2057416267943, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI6912666, Length=399, Percent_Identity=24.3107769423559, Blast_Score=79, Evalue=9e-15,
Organism=Homo sapiens, GI154350196, Length=415, Percent_Identity=23.855421686747, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI9966811, Length=192, Percent_Identity=30.2083333333333, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI5031955, Length=198, Percent_Identity=25.7575757575758, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI9945322, Length=314, Percent_Identity=25.796178343949, Blast_Score=70, Evalue=5e-12,
Organism=Homo sapiens, GI21322234, Length=308, Percent_Identity=24.6753246753247, Blast_Score=65, Evalue=8e-11,
Organism=Escherichia coli, GI2367193, Length=423, Percent_Identity=49.8817966903073, Blast_Score=423, Evalue=1e-120,
Organism=Escherichia coli, GI87082320, Length=414, Percent_Identity=29.4685990338164, Blast_Score=169, Evalue=4e-43,
Organism=Escherichia coli, GI2367379, Length=371, Percent_Identity=28.5714285714286, Blast_Score=147, Evalue=2e-36,
Organism=Escherichia coli, GI1789515, Length=322, Percent_Identity=28.8819875776398, Blast_Score=137, Evalue=2e-33,
Organism=Escherichia coli, GI1789152, Length=398, Percent_Identity=25.1256281407035, Blast_Score=115, Evalue=6e-27,
Organism=Escherichia coli, GI1788573, Length=437, Percent_Identity=22.4256292906178, Blast_Score=65, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17560030, Length=350, Percent_Identity=25.7142857142857, Blast_Score=91, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI32565914, Length=342, Percent_Identity=23.3918128654971, Blast_Score=75, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI17554148, Length=409, Percent_Identity=24.6943765281174, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI193205400, Length=202, Percent_Identity=26.7326732673267, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17554962, Length=366, Percent_Identity=22.1311475409836, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17552542, Length=269, Percent_Identity=25.6505576208178, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71997452, Length=443, Percent_Identity=24.3792325056433, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24639764, Length=320, Percent_Identity=24.0625, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24658658, Length=407, Percent_Identity=26.2899262899263, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI20129235, Length=355, Percent_Identity=27.0422535211268, Blast_Score=82, Evalue=6e-16,
Organism=Drosophila melanogaster, GI45550460, Length=319, Percent_Identity=26.9592476489028, Blast_Score=82, Evalue=6e-16,
Organism=Drosophila melanogaster, GI24641682, Length=388, Percent_Identity=25.2577319587629, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24648416, Length=291, Percent_Identity=25.4295532646048, Blast_Score=80, Evalue=4e-15,
Organism=Drosophila melanogaster, GI21356189, Length=291, Percent_Identity=25.4295532646048, Blast_Score=80, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24655255, Length=277, Percent_Identity=26.3537906137184, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI19922400, Length=295, Percent_Identity=25.0847457627119, Blast_Score=75, Evalue=6e-14,
Organism=Drosophila melanogaster, GI24654215, Length=295, Percent_Identity=25.0847457627119, Blast_Score=75, Evalue=7e-14,
Organism=Drosophila melanogaster, GI28573299, Length=308, Percent_Identity=25, Blast_Score=75, Evalue=8e-14,
Organism=Drosophila melanogaster, GI24653727, Length=392, Percent_Identity=24.234693877551, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24580790, Length=288, Percent_Identity=26.0416666666667, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI28573708, Length=404, Percent_Identity=24.2574257425743, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI28573707, Length=404, Percent_Identity=24.2574257425743, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24655271, Length=455, Percent_Identity=23.2967032967033, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI20130135, Length=320, Percent_Identity=25, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI45550364, Length=289, Percent_Identity=25.6055363321799, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24583789, Length=288, Percent_Identity=23.6111111111111, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24658674, Length=288, Percent_Identity=26.0416666666667, Blast_Score=69, Evalue=5e-12,
Organism=Drosophila melanogaster, GI45550495, Length=285, Percent_Identity=24.9122807017544, Blast_Score=69, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24658666, Length=291, Percent_Identity=24.7422680412371, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24584153, Length=290, Percent_Identity=22.7586206896552, Blast_Score=66, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004744
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 46429; Mature: 46429

Theoretical pI: Translated: 9.77; Mature: 9.77

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTIKGLRWWIIVLVCLGTIVNYLARNSLGVLAPTLKNELGMSTQQYSYVVAAFQVGYTI
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
MQPVCGFIVDLVGLRIGFALFGVLWSFAGVLHAGATGWLSLAGFRALMGLTEAAAIPSGM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHH
KAVAEWFPDKEKSVAVGWFNSGTSLGAMLAPPLVVFLHLRYGWQSAFVVTGAIGFLWAAL
HHHHHHCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
WFAFYRSPKDHAALSDAEREKIIGGQLRPVSAERGKRPVKDVVTSRRFWAIALARFFAEP
HHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHCC
AWQTFSFWIPLYFVNERHLDLKAIAMFAWLPFLAADLGGLVGGYLSPFLIKRFRIPLVWS
CHHHHHHHEEHEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
RVCGVVLGAFMMIGPACVGLVASPYTAIALFCVGGFAHQMISGLVNTLSADVFDPEEVGT
HHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCC
ASGFAGMAAWIGGLGFSLLVGALADKVGYGPLFGLLGAFDLIGAALLIVLIRGQSHEERA
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
ARQMRLSASN
HHHHHHCCCC
>Mature Secondary Structure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HHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: galacturonate [Periplasm]; Proton [Periplasm]; glucuronate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + galacturonate [Periplasm] = galacturonate [Cytoplasm] + Proton [Cytoplasm] Proton [Periplasm] + glucuronate [Periplasm] = Proton [Cytoplasm] + glucuronate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]