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The map label for this gene is ycbM [H]

Identifier: 187928036

GI number: 187928036

Start: 996299

End: 998632

Strand: Direct

Name: ycbM [H]

Synonym: Rpic_0941

Alternate gene names: 187928036

Gene position: 996299-998632 (Clockwise)

Preceding gene: 187928035

Following gene: 187928037

Centisome position: 25.27

GC content: 68.29

Gene sequence:

>2334_bases
ATGACTGAACCCGTACCCGCCCAATCGGCCGTGCGCAGCCTTGGGCGGCGCGCGCTGGTGGAGTGGGGGGTGCTGGTGGC
GCTGGCAGCGCTGTTGACATTCGGCGCGGTGCGCTGGAGCGTGGTCGCGCGGCTGGATGCGGCGCTATACGACACGGTCG
TCACGCTGCACGGGCATGCACCGCGCGACGACATCGTCGTCGTTGCCATTGATGACCAGAGTCTTGACGCAGTGGGACGC
TGGCCCTGGCCCCGCAGCCGCTTGGCCGACCTGATTACGCGGGTGGGACGGGCGCAGCCGCGCGCCATCGGCGTCGATAT
TCTGCTGATCGAACCCGATCTCGCGCAGCCCGAAGGCGATCGAGCATTGACTGCCGCCATCGAGCAGGCCGGACACGTCA
TCCTGCCGGCCTTGCCGGAGCGCACCGAGCAGGGGCGCGTGTATCACTATCCGTTCCTCGGTATCAACGCGTCCGTCGCG
CATATCAATGCCGCCCCCGATGCGGATAGCGTGGTGCGCGGCATGTATCTGGCAGAGGGGCCGCGAGCGCATGTGCTGGA
CCATCTTGCCGTGCAGCTTGCGCGGCACGCGCTGCGCCCGCCTTCATCCGTACCGGCGCTGCCTGATGCGGAGTCCGACG
CCGGCGGTTGGATGCGGCAGGCGCATATCCGCCTGAATTTTGCGGGGCCGGCCGGTACCTACCGGCATGTGCCGGCGCTG
GATGTGCTCAACGGCCACGTGCCGACCGAGGTGCTTGCCGGCAAGCTGGTGCTGATCGGGGCCACCGCATCGGGAGTGTC
CGACATCTTTGCGACGCCGCCCTCGCGCACGATGAGCGGCGTCGAAGTGCTTGCCAATGCCACGCAGACGGTACTCGACG
GCAGCGCCATCCTGCCGGCGCCACCGGGCGTGTTCTGGGCGATGACGCTGCTCCCCCTGCTGATGACCGCATTTGCCGTG
CGCTGGCTCACGCCGCGCATGGCGCTTGCCGTGGCGGTAACGGGTGCCGCCGTGTTGTTGCTGAGCGCAATCGGCGCGCT
GGTGGTCGGCAATCGCTGGCTGCCGCCGTTTGCGGCGCTGGTGGGCCCGCTGGTGTTGTATCCGCTGTGGAGCTGGCGCC
AGCAGGAAGCCGCGTTGCGCTTTCTGCGCGACGAGCTGCAGCGTCTGGCGCGCGAGCCCGGCCTGTTGGGCGATACCGCG
CCGCTGGCCCGCACCGGCCGCACGCTCGGCGCGCACATGGATGCCGTCGCCTCGCTGACGGACAAGCTGCGTGGGCTGCG
CCGCTTCCTGGCCGATGCGCTGGAGAGCCTGCCCGATGCGACCGTCATCTGCACGCACGACGGCACGATCCGCCTGGCGA
ATGGCCGAAGCGCAGACCTGGCCGGCCAGATGCAGACGCCGGGCCAGATCCGCGCGGCCGCGCTGCGCGACCTGTCGACG
CTGCTGGCGCGTGCGTTTCCCGACCCCACAGCGGGAGAGCACTACTGGGCACGCTGGCTCGCCGATCCCACCGGGCTCGA
ACCTGTCGAGCTACAGACGCACGACGGCCGCTCGATGTTGATGCATGCTGCCGCGTTGCGGGACGAAGCGGGCCGCCCTG
TCGACATCATCGTCAGCTTTGCCGACATCACCCCGGTGCGGCAGGCGGAACGCCATCGCGAAGAAGCACTGCAGTTCATC
TCGCACGATATGCGCTCGCCGCAGAGTGCCATCCTTGCCCTGATCGAACTGCAGCGCGATGCCTCGCGTGCGCTGGACCG
CGAGGTGCTGCTGTTTCGCATCGAGCAGCTTTCGTCGCGAACACTTGAGCTGGCCGATGCCTTTATCGACCTGGCGCGCG
CCGAATCGCAAACGCTCAAGCTGGTGGATGTGGATCTGGTGGGCCTTGTGCTCGATGCCGCCGACGAGGTCTGGCCGCTC
GCGAATCGCCACCAGGTGGAAGTGCGCGTGGTGGCCGACATCGAAGCAGCGGTGCGCGGCGAGCCGCGCTTGCTGGTGCG
CGCGCTGGTGAACCTGCTCAACAACGCCATCAAGTTCAGCGCAGCCGGCTCCATGGTGACGGTATCGGTGGAGCAGGACG
AGGCGATGTTCTCGGTGGCCGTGGCCGACCAGGGTGCTGGCATTGCCCTGGCTGATCAGCCGCGGCTGTTCCAGCCGTTC
CATCGCTTGCATGAGGGCGCGGCCAATGCGCCGTCCGGCAGTGGGCTGGGTCTCGTGTTCGTGAAGACCGTGGTTGACCG
GCACGGCGGCCGGATTGCTGTGCAGAGTGCACCGGGTCTGGGTTCCACCTTCACGCTGTGGCTGCCGCGCGCCAAGCATC
GCCACGACGCCTGA

Upstream 100 bases:

>100_bases
TCGGTGGTCTACGCCAAGCCGCAGCGCATTGACGTCGGTGCCTTCGTCGGCGATTCCGCGCGCAGCCCGGTGCAGAGCGG
CGGCGGCAATCTCCTCCTCA

Downstream 100 bases:

>100_bases
GGCCATCGCGGCCTCGTGTGGTCTTCGCCACATTTCCTTTTCAATCATTTGCATTTCGGCACTGCGGCGGCCCTACAGTT
CATTGGCCGACCCGCACAGC

Product: multi-sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 777; Mature: 776

Protein sequence:

>777_residues
MTEPVPAQSAVRSLGRRALVEWGVLVALAALLTFGAVRWSVVARLDAALYDTVVTLHGHAPRDDIVVVAIDDQSLDAVGR
WPWPRSRLADLITRVGRAQPRAIGVDILLIEPDLAQPEGDRALTAAIEQAGHVILPALPERTEQGRVYHYPFLGINASVA
HINAAPDADSVVRGMYLAEGPRAHVLDHLAVQLARHALRPPSSVPALPDAESDAGGWMRQAHIRLNFAGPAGTYRHVPAL
DVLNGHVPTEVLAGKLVLIGATASGVSDIFATPPSRTMSGVEVLANATQTVLDGSAILPAPPGVFWAMTLLPLLMTAFAV
RWLTPRMALAVAVTGAAVLLLSAIGALVVGNRWLPPFAALVGPLVLYPLWSWRQQEAALRFLRDELQRLAREPGLLGDTA
PLARTGRTLGAHMDAVASLTDKLRGLRRFLADALESLPDATVICTHDGTIRLANGRSADLAGQMQTPGQIRAAALRDLST
LLARAFPDPTAGEHYWARWLADPTGLEPVELQTHDGRSMLMHAAALRDEAGRPVDIIVSFADITPVRQAERHREEALQFI
SHDMRSPQSAILALIELQRDASRALDREVLLFRIEQLSSRTLELADAFIDLARAESQTLKLVDVDLVGLVLDAADEVWPL
ANRHQVEVRVVADIEAAVRGEPRLLVRALVNLLNNAIKFSAAGSMVTVSVEQDEAMFSVAVADQGAGIALADQPRLFQPF
HRLHEGAANAPSGSGLGLVFVKTVVDRHGGRIAVQSAPGLGSTFTLWLPRAKHRHDA

Sequences:

>Translated_777_residues
MTEPVPAQSAVRSLGRRALVEWGVLVALAALLTFGAVRWSVVARLDAALYDTVVTLHGHAPRDDIVVVAIDDQSLDAVGR
WPWPRSRLADLITRVGRAQPRAIGVDILLIEPDLAQPEGDRALTAAIEQAGHVILPALPERTEQGRVYHYPFLGINASVA
HINAAPDADSVVRGMYLAEGPRAHVLDHLAVQLARHALRPPSSVPALPDAESDAGGWMRQAHIRLNFAGPAGTYRHVPAL
DVLNGHVPTEVLAGKLVLIGATASGVSDIFATPPSRTMSGVEVLANATQTVLDGSAILPAPPGVFWAMTLLPLLMTAFAV
RWLTPRMALAVAVTGAAVLLLSAIGALVVGNRWLPPFAALVGPLVLYPLWSWRQQEAALRFLRDELQRLAREPGLLGDTA
PLARTGRTLGAHMDAVASLTDKLRGLRRFLADALESLPDATVICTHDGTIRLANGRSADLAGQMQTPGQIRAAALRDLST
LLARAFPDPTAGEHYWARWLADPTGLEPVELQTHDGRSMLMHAAALRDEAGRPVDIIVSFADITPVRQAERHREEALQFI
SHDMRSPQSAILALIELQRDASRALDREVLLFRIEQLSSRTLELADAFIDLARAESQTLKLVDVDLVGLVLDAADEVWPL
ANRHQVEVRVVADIEAAVRGEPRLLVRALVNLLNNAIKFSAAGSMVTVSVEQDEAMFSVAVADQGAGIALADQPRLFQPF
HRLHEGAANAPSGSGLGLVFVKTVVDRHGGRIAVQSAPGLGSTFTLWLPRAKHRHDA
>Mature_776_residues
TEPVPAQSAVRSLGRRALVEWGVLVALAALLTFGAVRWSVVARLDAALYDTVVTLHGHAPRDDIVVVAIDDQSLDAVGRW
PWPRSRLADLITRVGRAQPRAIGVDILLIEPDLAQPEGDRALTAAIEQAGHVILPALPERTEQGRVYHYPFLGINASVAH
INAAPDADSVVRGMYLAEGPRAHVLDHLAVQLARHALRPPSSVPALPDAESDAGGWMRQAHIRLNFAGPAGTYRHVPALD
VLNGHVPTEVLAGKLVLIGATASGVSDIFATPPSRTMSGVEVLANATQTVLDGSAILPAPPGVFWAMTLLPLLMTAFAVR
WLTPRMALAVAVTGAAVLLLSAIGALVVGNRWLPPFAALVGPLVLYPLWSWRQQEAALRFLRDELQRLAREPGLLGDTAP
LARTGRTLGAHMDAVASLTDKLRGLRRFLADALESLPDATVICTHDGTIRLANGRSADLAGQMQTPGQIRAAALRDLSTL
LARAFPDPTAGEHYWARWLADPTGLEPVELQTHDGRSMLMHAAALRDEAGRPVDIIVSFADITPVRQAERHREEALQFIS
HDMRSPQSAILALIELQRDASRALDREVLLFRIEQLSSRTLELADAFIDLARAESQTLKLVDVDLVGLVLDAADEVWPLA
NRHQVEVRVVADIEAAVRGEPRLLVRALVNLLNNAIKFSAAGSMVTVSVEQDEAMFSVAVADQGAGIALADQPRLFQPFH
RLHEGAANAPSGSGLGLVFVKTVVDRHGGRIAVQSAPGLGSTFTLWLPRAKHRHDA

Specific function: Member of the two-component regulatory system ycbM/ycbL. Probably activates ycbL by phosphorylation [H]

COG id: COG4252

COG function: function code T; Predicted transmembrane sensor domain

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI145693157, Length=228, Percent_Identity=30.2631578947368, Blast_Score=102, Evalue=1e-22,
Organism=Escherichia coli, GI1786600, Length=347, Percent_Identity=25.0720461095101, Blast_Score=99, Evalue=7e-22,
Organism=Escherichia coli, GI1786783, Length=217, Percent_Identity=32.7188940092166, Blast_Score=96, Evalue=6e-21,
Organism=Escherichia coli, GI1788713, Length=226, Percent_Identity=25.6637168141593, Blast_Score=89, Evalue=1e-18,
Organism=Escherichia coli, GI1790436, Length=226, Percent_Identity=31.4159292035398, Blast_Score=88, Evalue=2e-18,
Organism=Escherichia coli, GI1789149, Length=229, Percent_Identity=28.3842794759825, Blast_Score=88, Evalue=2e-18,
Organism=Escherichia coli, GI1788549, Length=260, Percent_Identity=24.2307692307692, Blast_Score=83, Evalue=5e-17,
Organism=Escherichia coli, GI1790861, Length=235, Percent_Identity=28.5106382978723, Blast_Score=76, Evalue=9e-15,
Organism=Escherichia coli, GI48994928, Length=243, Percent_Identity=27.5720164609054, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI1790346, Length=114, Percent_Identity=32.4561403508772, Blast_Score=74, Evalue=4e-14,
Organism=Escherichia coli, GI1789808, Length=226, Percent_Identity=28.3185840707965, Blast_Score=71, Evalue=3e-13,
Organism=Escherichia coli, GI1788393, Length=244, Percent_Identity=23.7704918032787, Blast_Score=70, Evalue=6e-13,
Organism=Escherichia coli, GI87081816, Length=120, Percent_Identity=33.3333333333333, Blast_Score=69, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 83556; Mature: 83425

Theoretical pI: Translated: 6.59; Mature: 6.59

Prosite motif: PS50113 PAC ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEPVPAQSAVRSLGRRALVEWGVLVALAALLTFGAVRWSVVARLDAALYDTVVTLHGHA
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCC
PRDDIVVVAIDDQSLDAVGRWPWPRSRLADLITRVGRAQPRAIGVDILLIEPDLAQPEGD
CCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCEECEEEEEECCCCCCCCCC
RALTAAIEQAGHVILPALPERTEQGRVYHYPFLGINASVAHINAAPDADSVVRGMYLAEG
HHHHHHHHHCCCEEECCCCCCCCCCEEEEEEEECCCCEEEEEECCCCHHHHHHHHHHCCC
PRAHVLDHLAVQLARHALRPPSSVPALPDAESDAGGWMRQAHIRLNFAGPAGTYRHVPAL
CHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEEEEEECCCCCCCCCCCHH
DVLNGHVPTEVLAGKLVLIGATASGVSDIFATPPSRTMSGVEVLANATQTVLDGSAILPA
HHHCCCCCHHHHCCCEEEEEECCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCC
PPGVFWAMTLLPLLMTAFAVRWLTPRMALAVAVTGAAVLLLSAIGALVVGNRWLPPFAAL
CCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
VGPLVLYPLWSWRQQEAALRFLRDELQRLAREPGLLGDTAPLARTGRTLGAHMDAVASLT
HHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCHHHHHHHHHHHHH
DKLRGLRRFLADALESLPDATVICTHDGTIRLANGRSADLAGQMQTPGQIRAAALRDLST
HHHHHHHHHHHHHHHHCCCCEEEEECCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHH
LLARAFPDPTAGEHYWARWLADPTGLEPVELQTHDGRSMLMHAAALRDEAGRPVDIIVSF
HHHHHCCCCCCCCHHHHHHHCCCCCCCCEEEECCCCHHHHHHHHHHHHCCCCCEEEEEEE
ADITPVRQAERHREEALQFISHDMRSPQSAILALIELQRDASRALDREVLLFRIEQLSSR
CCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TLELADAFIDLARAESQTLKLVDVDLVGLVLDAADEVWPLANRHQVEVRVVADIEAAVRG
HHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHCCHHHCCCCCCCEEEEEEEEEHHHHHCC
EPRLLVRALVNLLNNAIKFSAAGSMVTVSVEQDEAMFSVAVADQGAGIALADQPRLFQPF
CHHHHHHHHHHHHHHHHEEECCCCEEEEEEECCCCEEEEEEECCCCCEEECCCCHHHHHH
HRLHEGAANAPSGSGLGLVFVKTVVDRHGGRIAVQSAPGLGSTFTLWLPRAKHRHDA
HHHHCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCEEEEECCCCCCCCCC
>Mature Secondary Structure 
TEPVPAQSAVRSLGRRALVEWGVLVALAALLTFGAVRWSVVARLDAALYDTVVTLHGHA
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCC
PRDDIVVVAIDDQSLDAVGRWPWPRSRLADLITRVGRAQPRAIGVDILLIEPDLAQPEGD
CCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCEECEEEEEECCCCCCCCCC
RALTAAIEQAGHVILPALPERTEQGRVYHYPFLGINASVAHINAAPDADSVVRGMYLAEG
HHHHHHHHHCCCEEECCCCCCCCCCEEEEEEEECCCCEEEEEECCCCHHHHHHHHHHCCC
PRAHVLDHLAVQLARHALRPPSSVPALPDAESDAGGWMRQAHIRLNFAGPAGTYRHVPAL
CHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEEEEEECCCCCCCCCCCHH
DVLNGHVPTEVLAGKLVLIGATASGVSDIFATPPSRTMSGVEVLANATQTVLDGSAILPA
HHHCCCCCHHHHCCCEEEEEECCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCC
PPGVFWAMTLLPLLMTAFAVRWLTPRMALAVAVTGAAVLLLSAIGALVVGNRWLPPFAAL
CCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
VGPLVLYPLWSWRQQEAALRFLRDELQRLAREPGLLGDTAPLARTGRTLGAHMDAVASLT
HHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCHHHHHHHHHHHHH
DKLRGLRRFLADALESLPDATVICTHDGTIRLANGRSADLAGQMQTPGQIRAAALRDLST
HHHHHHHHHHHHHHHHCCCCEEEEECCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHH
LLARAFPDPTAGEHYWARWLADPTGLEPVELQTHDGRSMLMHAAALRDEAGRPVDIIVSF
HHHHHCCCCCCCCHHHHHHHCCCCCCCCEEEECCCCHHHHHHHHHHHHCCCCCEEEEEEE
ADITPVRQAERHREEALQFISHDMRSPQSAILALIELQRDASRALDREVLLFRIEQLSSR
CCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TLELADAFIDLARAESQTLKLVDVDLVGLVLDAADEVWPLANRHQVEVRVVADIEAAVRG
HHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHCCHHHCCCCCCCEEEEEEEEEHHHHHCC
EPRLLVRALVNLLNNAIKFSAAGSMVTVSVEQDEAMFSVAVADQGAGIALADQPRLFQPF
CHHHHHHHHHHHHHHHHEEECCCCEEEEEEECCCCEEEEEEECCCCCEEECCCCHHHHHH
HRLHEGAANAPSGSGLGLVFVKTVVDRHGGRIAVQSAPGLGSTFTLWLPRAKHRHDA
HHHHCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7704254; 9384377 [H]