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The map label for this gene is gyaR [H]

Identifier: 187927994

GI number: 187927994

Start: 952386

End: 953387

Strand: Direct

Name: gyaR [H]

Synonym: Rpic_0899

Alternate gene names: 187927994

Gene position: 952386-953387 (Clockwise)

Preceding gene: 187927993

Following gene: 187927995

Centisome position: 24.16

GC content: 65.47

Gene sequence:

>1002_bases
ATGAAACCCGGAATCCTTGTCACCCGCGCGATGTTTCCCGAAGTGCTTGAGCGCTTGCGCGAGACCTTCGACGTGATCGA
CAACCAAGCGGACTTCGACTATCCGCCCGAAGCGCTGGCGGAGCGTCTGCAAGGTCGCGTGGGCCTGCTGTCGAACGCTG
CCGACACCATCAACGCCGAGCTGATCAGCCGCGTGCCCACGCTGCGAGCGGTGTGCAACATGGCCGTCGGCTATAACAAC
TTTGATCTCGCGGCGATGACGCGTGCGGGCATCCTGGCCACTAACACGCCCGACATCCTGACCGAGACCACCGCCGATTT
CGGCTGGGCCTTGCTGATGGCCGCTGCACGCCGCGTGTCCGAATCCGAACGCTGGCTGCGTTCCGGGCAATGGAAGCGCT
GGACCTACGATACGTTCCTCGGCGCAGAGGTGTATGGCAGCACGCTGGGCATTCTCGGCATGGGCCGCATCGGCCAGGCG
CTGGCGCGGCGTGCGAGCGGTTTCTCCATGCGCGTGATCTATCACAACCGCAGCCGGCTTTCGCCCGAAGTCGAGCGCGA
CACGCGCGCCACTTACGTCAGCAAGGACGACTTGCTGAAGCAGGCTGATCACCTCGTGCTGGTGCTGCCGTATTCCAAGG
AAAGCCACCACGCCATCGGTGCAGCTGAGCTGGCACAGATGAAGCCGACCGCCACGCTGGTCAATCTCGCGCGCGGCGGC
ATCGTGGATGACGCAGCGTTGGCGCAGGCGCTGGCGGACAAGCGCATCTTTGCCGCCGGCCTGGACGTCTACGAGGGTGA
GCCGAAGGTACATCCGGCGCTGCTGGAGGCCGAGCACGTTGCGCTCACTCCGCACATTGCCAGTGCCACTTTCGGCACGC
GCCTGGGCATGGCCAACCTGGCAGCCGACAACCTGATCGCTGCGCTGGGCTTTGGCCCCCGCGCGGGGCAGCCGCCCAAC
TTGTTGAACCCGGATGCGCTGGCGCAGCGCGCGTCCTCCTGA

Upstream 100 bases:

>100_bases
AGCTTCTTTGGCTACATGCTGTGGTCCGTGTGCATTCTCTTGCCGATTTTCGTTCTGATGACCTTCGTCTTCTTCCGCTA
ACCGAACGTGTGCTGAACGT

Downstream 100 bases:

>100_bases
TCGAACGCAAATATGGACTGGTTGGCTTTATTGACGTTGCTGGGCGTGGCCGTGGTGGCCGTGCTGTGTGTGCTGATCTG
GCGTGGTGTGTCTCGCCCGG

Product: NAD-binding D-isomer specific 2-hydroxyacid dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 333; Mature: 333

Protein sequence:

>333_residues
MKPGILVTRAMFPEVLERLRETFDVIDNQADFDYPPEALAERLQGRVGLLSNAADTINAELISRVPTLRAVCNMAVGYNN
FDLAAMTRAGILATNTPDILTETTADFGWALLMAAARRVSESERWLRSGQWKRWTYDTFLGAEVYGSTLGILGMGRIGQA
LARRASGFSMRVIYHNRSRLSPEVERDTRATYVSKDDLLKQADHLVLVLPYSKESHHAIGAAELAQMKPTATLVNLARGG
IVDDAALAQALADKRIFAAGLDVYEGEPKVHPALLEAEHVALTPHIASATFGTRLGMANLAADNLIAALGFGPRAGQPPN
LLNPDALAQRASS

Sequences:

>Translated_333_residues
MKPGILVTRAMFPEVLERLRETFDVIDNQADFDYPPEALAERLQGRVGLLSNAADTINAELISRVPTLRAVCNMAVGYNN
FDLAAMTRAGILATNTPDILTETTADFGWALLMAAARRVSESERWLRSGQWKRWTYDTFLGAEVYGSTLGILGMGRIGQA
LARRASGFSMRVIYHNRSRLSPEVERDTRATYVSKDDLLKQADHLVLVLPYSKESHHAIGAAELAQMKPTATLVNLARGG
IVDDAALAQALADKRIFAAGLDVYEGEPKVHPALLEAEHVALTPHIASATFGTRLGMANLAADNLIAALGFGPRAGQPPN
LLNPDALAQRASS
>Mature_333_residues
MKPGILVTRAMFPEVLERLRETFDVIDNQADFDYPPEALAERLQGRVGLLSNAADTINAELISRVPTLRAVCNMAVGYNN
FDLAAMTRAGILATNTPDILTETTADFGWALLMAAARRVSESERWLRSGQWKRWTYDTFLGAEVYGSTLGILGMGRIGQA
LARRASGFSMRVIYHNRSRLSPEVERDTRATYVSKDDLLKQADHLVLVLPYSKESHHAIGAAELAQMKPTATLVNLARGG
IVDDAALAQALADKRIFAAGLDVYEGEPKVHPALLEAEHVALTPHIASATFGTRLGMANLAADNLIAALGFGPRAGQPPN
LLNPDALAQRASS

Specific function: Unknown

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=310, Percent_Identity=34.8387096774194, Blast_Score=162, Evalue=6e-40,
Organism=Homo sapiens, GI23308577, Length=287, Percent_Identity=31.3588850174216, Blast_Score=146, Evalue=2e-35,
Organism=Homo sapiens, GI145580578, Length=270, Percent_Identity=34.8148148148148, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI4557499, Length=270, Percent_Identity=34.8148148148148, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI4557497, Length=248, Percent_Identity=36.2903225806452, Blast_Score=126, Evalue=3e-29,
Organism=Homo sapiens, GI61743967, Length=248, Percent_Identity=36.2903225806452, Blast_Score=126, Evalue=3e-29,
Organism=Homo sapiens, GI145580575, Length=270, Percent_Identity=34.8148148148148, Blast_Score=124, Evalue=9e-29,
Organism=Escherichia coli, GI87082289, Length=326, Percent_Identity=41.7177914110429, Blast_Score=227, Evalue=1e-60,
Organism=Escherichia coli, GI1789279, Length=239, Percent_Identity=31.3807531380753, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI1787645, Length=197, Percent_Identity=30.4568527918782, Blast_Score=99, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17532191, Length=259, Percent_Identity=30.8880308880309, Blast_Score=134, Evalue=5e-32,
Organism=Caenorhabditis elegans, GI25147481, Length=246, Percent_Identity=26.8292682926829, Blast_Score=85, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6324055, Length=259, Percent_Identity=33.976833976834, Blast_Score=150, Evalue=3e-37,
Organism=Saccharomyces cerevisiae, GI6320925, Length=296, Percent_Identity=26.3513513513513, Blast_Score=103, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6322116, Length=269, Percent_Identity=25.6505576208178, Blast_Score=99, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6321253, Length=259, Percent_Identity=25.0965250965251, Blast_Score=74, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6325144, Length=144, Percent_Identity=32.6388888888889, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI28574286, Length=318, Percent_Identity=37.1069182389937, Blast_Score=189, Evalue=2e-48,
Organism=Drosophila melanogaster, GI28574284, Length=324, Percent_Identity=35.1851851851852, Blast_Score=182, Evalue=3e-46,
Organism=Drosophila melanogaster, GI45551003, Length=324, Percent_Identity=35.1851851851852, Blast_Score=182, Evalue=3e-46,
Organism=Drosophila melanogaster, GI24585514, Length=324, Percent_Identity=35.1851851851852, Blast_Score=182, Evalue=4e-46,
Organism=Drosophila melanogaster, GI28574282, Length=324, Percent_Identity=35.1851851851852, Blast_Score=182, Evalue=4e-46,
Organism=Drosophila melanogaster, GI45552429, Length=324, Percent_Identity=35.1851851851852, Blast_Score=181, Evalue=4e-46,
Organism=Drosophila melanogaster, GI28571528, Length=311, Percent_Identity=35.3697749196142, Blast_Score=166, Evalue=2e-41,
Organism=Drosophila melanogaster, GI24585516, Length=248, Percent_Identity=32.6612903225806, Blast_Score=139, Evalue=2e-33,
Organism=Drosophila melanogaster, GI24646446, Length=251, Percent_Identity=34.6613545816733, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24646448, Length=251, Percent_Identity=34.6613545816733, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24646452, Length=251, Percent_Identity=34.6613545816733, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24646450, Length=251, Percent_Identity=34.6613545816733, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI62472511, Length=255, Percent_Identity=34.5098039215686, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI19921140, Length=332, Percent_Identity=27.710843373494, Blast_Score=122, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.26 [H]

Molecular weight: Translated: 36089; Mature: 36089

Theoretical pI: Translated: 6.64; Mature: 6.64

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPGILVTRAMFPEVLERLRETFDVIDNQADFDYPPEALAERLQGRVGLLSNAADTINAE
CCCCEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCHHHHHCCHHHHHHH
LISRVPTLRAVCNMAVGYNNFDLAAMTRAGILATNTPDILTETTADFGWALLMAAARRVS
HHHHHHHHHHHHHHHCCCCCCCHHHHHHCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHH
ESERWLRSGQWKRWTYDTFLGAEVYGSTLGILGMGRIGQALARRASGFSMRVIYHNRSRL
HHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCEEEEEEECCCCC
SPEVERDTRATYVSKDDLLKQADHLVLVLPYSKESHHAIGAAELAQMKPTATLVNLARGG
CCCHHHCCHHHCCCHHHHHHHCCCEEEEEECCCCCCCCCCHHHHHHCCCHHHHHHHHCCC
IVDDAALAQALADKRIFAAGLDVYEGEPKVHPALLEAEHVALTPHIASATFGTRLGMANL
CCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHCCCCEEECCCHHHHHHHHHHCHHHH
AADNLIAALGFGPRAGQPPNLLNPDALAQRASS
HHHHHHHHHCCCCCCCCCCCCCCHHHHHHHCCC
>Mature Secondary Structure
MKPGILVTRAMFPEVLERLRETFDVIDNQADFDYPPEALAERLQGRVGLLSNAADTINAE
CCCCEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCHHHHHCCHHHHHHH
LISRVPTLRAVCNMAVGYNNFDLAAMTRAGILATNTPDILTETTADFGWALLMAAARRVS
HHHHHHHHHHHHHHHCCCCCCCHHHHHHCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHH
ESERWLRSGQWKRWTYDTFLGAEVYGSTLGILGMGRIGQALARRASGFSMRVIYHNRSRL
HHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCEEEEEEECCCCC
SPEVERDTRATYVSKDDLLKQADHLVLVLPYSKESHHAIGAAELAQMKPTATLVNLARGG
CCCHHHCCHHHCCCHHHHHHHCCCEEEEEECCCCCCCCCCHHHHHHCCCHHHHHHHHCCC
IVDDAALAQALADKRIFAAGLDVYEGEPKVHPALLEAEHVALTPHIASATFGTRLGMANL
CCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHCCCCEEECCCHHHHHHHHHHCHHHH
AADNLIAALGFGPRAGQPPNLLNPDALAQRASS
HHHHHHHHHCCCCCCCCCCCCCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA