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The map label for this gene is uvrB [H]

Identifier: 187927971

GI number: 187927971

Start: 927703

End: 929793

Strand: Direct

Name: uvrB [H]

Synonym: Rpic_0876

Alternate gene names: 187927971

Gene position: 927703-929793 (Clockwise)

Preceding gene: 187927968

Following gene: 187927972

Centisome position: 23.53

GC content: 62.75

Gene sequence:

>2091_bases
ATGACCGATCTGAGCCAAGTCCCCAGCCCGCACGACGAGTCGAAGTTCGTGACTTTCGAGGGCTCGCCGTTCCAGTTGTA
CCAGCCGTATCCGCCGGCCGGCGACCAGCCGGAGGCCATCCGCCAGCTCGTCGAGAACATTGGCGACGGCCTGTCGTACC
AGACCCTCCTGGGTGTGACGGGCTCGGGCAAGACATTCACCATGGCCAATGTGATCGCGCAGGTGGGTCGGCCGGCCATC
GTCTTTGCGCCCAACAAGACGCTGGCGGCGCAGCTGTATTCCGAGTTCCGGGAGTTCTTCCCGCGCAATGCGGTCGAATA
CTTCGTCTCGTACTACGACTACTACCAGCCTGAGGCCTACGTGCCGCAGCGCGACCTCTTCATCGAGAAGGATTCGTCGA
TCAACGAGCACATCGAGCAGATGCGGCTCTCCGCCACCAAGAGCCTGCTGGAGCGCCGCGATGTGGTGATCGTGGCCACC
GTCTCGGCCATCTACGGTATCGGCAATCCGAGCGAATACCACCAGATGATCTTGACGCTGCGCGCGGGGGACAAGGTCAG
CCAGCGCGACGTGATCGCGCGCCTGATCGCCATGCAATACACACGCAACGAGACGGATTTCCAGCGCGGCACCTTCCGCG
TGCGCGGCGACACGGTCGACATCTTCCCCGCCGAGCATGCGGAAATGGCGGTGCGCCTGGAGCTGTTCGACGACGAGGTC
GAATCGCTGCAGCTGTTCGATCCGCTGACCGGCCGTGTGCGGCAGAAGATTCCGCGCTTTACGGTGTACCCGTCGAGCCA
CTACGTGACGCCGCGCGAAACCGTGCTGCGCGCCATCGAGACCATCAAGGCTGAACTGCGCGAGCGGCTCGATTTCTTCT
ACAAGGAAAACAAGCTGGTGGAAGCGCAGCGGTTGGAGCAGCGCACGCGCTTCGATCTGGAGATGCTGCAGGAGCTGGGC
TTCTGCAAGGGCATCGAAAATTATTCGCGGCACCTTTCTGGCTCCGCGCCCGGCGAACCGCCGCCGACGCTGGTCGACTA
TCTGCCGCCCGATGCGCTGATGTTCCTTGATGAATCGCACGTGCTGATCGGCCAGCTCAACGGCATGTACAACGGTGACC
GCGCGCGCAAGGAAACGCTGGCCGAATACGGCTTCCGGCTGCCTTCTGCGCTCGACAACCGGCCGCTCAAGTTCGCCGAA
TTCGAGACCAAGATGCGGCAGGTTACCTTCGTGTCTGCCACGCCGGGGGATTACGAAAAGAAGACCGCGGGCACGGAAGT
CGTCGAGCAGGTCGTTCGACCCACGGGCCTCGTCGACCCGATCATCGAGGTGCGCCCCGCCACGACGCAGGTCGACGATC
TGCTGTCCGAGATCCATGTGCGTGTCGAGGCCGGCGAGCGCGTGCTGGTGACCACGCTCACCAAGCGCATGGCCGAGCAA
CTGACCGAGTTCCTGTCGGAGAACGGCGTCAAGGTCCGCTACCTGCATTCGGACATCGATACCGTGGAGCGCGTGGAGAT
CATCCGTGACCTGCGCCTGGGCACGTTCGACGTGCTGGTTGGCATCAACCTGTTGCGCGAGGGTCTGGATATTCCCGAAG
TGTCGCTCGTGGCGATCCTGGATGCGGACAAGGAAGGTTTCCTCCGTGCCGAGCGCTCGCTCATCCAGACCATTGGCCGC
GCGGCGCGGAACGTGAACGGCACCGCCATCCTGTATGCCGATCGCATGACCGATTCGATGAAGAAGGCGATTGGCGAGAC
CGAACGCCGCCGCGCCAAGCAGATCGCCCACAACGAGGCGCATGGCATCACGCCGCGCGGCGTTGTCAAACGCATCAAGG
ACATCATCGACGGCGTGTACAACGTCGACGATGCGCGCGCGGAACTGAAGGCCGCGCAAGAGGCCGCCAAGTACGAGGAC
ATGAGCGAGAAGCAGGCGTCCAAGGAAATCAAACGCCTGGAAAAACAGATGCTCGACCACGCCAAGAACCTCGAATTCGA
AAAGGCGGCGGCGGTGCGCGATCAGCTTGCCAAGCTCAAGTCGCAGCTCTTTGGAGCGAGCGGCGAAGATCACATCGTTC
CGGCCGCCTGA

Upstream 100 bases:

>100_bases
TACACTACACGATTGGTTGCAATTGCCGCTGCCGCCCTCATTTGCTGAGGACGTGCGAGTCACTTTGTCGACTTCCCGCG
CTGCCATCCCACCCGCCGCC

Downstream 100 bases:

>100_bases
ACTGCGCGGCCATCTGCGTTGTCGGTGTCCCGCTGCCTTGCCCGAGGCGGGCGGCGGGTGAGTGTCGACACCATTTCAAA
TCAGGCTCAGGCTCAGGCGC

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B [H]

Number of amino acids: Translated: 696; Mature: 695

Protein sequence:

>696_residues
MTDLSQVPSPHDESKFVTFEGSPFQLYQPYPPAGDQPEAIRQLVENIGDGLSYQTLLGVTGSGKTFTMANVIAQVGRPAI
VFAPNKTLAAQLYSEFREFFPRNAVEYFVSYYDYYQPEAYVPQRDLFIEKDSSINEHIEQMRLSATKSLLERRDVVIVAT
VSAIYGIGNPSEYHQMILTLRAGDKVSQRDVIARLIAMQYTRNETDFQRGTFRVRGDTVDIFPAEHAEMAVRLELFDDEV
ESLQLFDPLTGRVRQKIPRFTVYPSSHYVTPRETVLRAIETIKAELRERLDFFYKENKLVEAQRLEQRTRFDLEMLQELG
FCKGIENYSRHLSGSAPGEPPPTLVDYLPPDALMFLDESHVLIGQLNGMYNGDRARKETLAEYGFRLPSALDNRPLKFAE
FETKMRQVTFVSATPGDYEKKTAGTEVVEQVVRPTGLVDPIIEVRPATTQVDDLLSEIHVRVEAGERVLVTTLTKRMAEQ
LTEFLSENGVKVRYLHSDIDTVERVEIIRDLRLGTFDVLVGINLLREGLDIPEVSLVAILDADKEGFLRAERSLIQTIGR
AARNVNGTAILYADRMTDSMKKAIGETERRRAKQIAHNEAHGITPRGVVKRIKDIIDGVYNVDDARAELKAAQEAAKYED
MSEKQASKEIKRLEKQMLDHAKNLEFEKAAAVRDQLAKLKSQLFGASGEDHIVPAA

Sequences:

>Translated_696_residues
MTDLSQVPSPHDESKFVTFEGSPFQLYQPYPPAGDQPEAIRQLVENIGDGLSYQTLLGVTGSGKTFTMANVIAQVGRPAI
VFAPNKTLAAQLYSEFREFFPRNAVEYFVSYYDYYQPEAYVPQRDLFIEKDSSINEHIEQMRLSATKSLLERRDVVIVAT
VSAIYGIGNPSEYHQMILTLRAGDKVSQRDVIARLIAMQYTRNETDFQRGTFRVRGDTVDIFPAEHAEMAVRLELFDDEV
ESLQLFDPLTGRVRQKIPRFTVYPSSHYVTPRETVLRAIETIKAELRERLDFFYKENKLVEAQRLEQRTRFDLEMLQELG
FCKGIENYSRHLSGSAPGEPPPTLVDYLPPDALMFLDESHVLIGQLNGMYNGDRARKETLAEYGFRLPSALDNRPLKFAE
FETKMRQVTFVSATPGDYEKKTAGTEVVEQVVRPTGLVDPIIEVRPATTQVDDLLSEIHVRVEAGERVLVTTLTKRMAEQ
LTEFLSENGVKVRYLHSDIDTVERVEIIRDLRLGTFDVLVGINLLREGLDIPEVSLVAILDADKEGFLRAERSLIQTIGR
AARNVNGTAILYADRMTDSMKKAIGETERRRAKQIAHNEAHGITPRGVVKRIKDIIDGVYNVDDARAELKAAQEAAKYED
MSEKQASKEIKRLEKQMLDHAKNLEFEKAAAVRDQLAKLKSQLFGASGEDHIVPAA
>Mature_695_residues
TDLSQVPSPHDESKFVTFEGSPFQLYQPYPPAGDQPEAIRQLVENIGDGLSYQTLLGVTGSGKTFTMANVIAQVGRPAIV
FAPNKTLAAQLYSEFREFFPRNAVEYFVSYYDYYQPEAYVPQRDLFIEKDSSINEHIEQMRLSATKSLLERRDVVIVATV
SAIYGIGNPSEYHQMILTLRAGDKVSQRDVIARLIAMQYTRNETDFQRGTFRVRGDTVDIFPAEHAEMAVRLELFDDEVE
SLQLFDPLTGRVRQKIPRFTVYPSSHYVTPRETVLRAIETIKAELRERLDFFYKENKLVEAQRLEQRTRFDLEMLQELGF
CKGIENYSRHLSGSAPGEPPPTLVDYLPPDALMFLDESHVLIGQLNGMYNGDRARKETLAEYGFRLPSALDNRPLKFAEF
ETKMRQVTFVSATPGDYEKKTAGTEVVEQVVRPTGLVDPIIEVRPATTQVDDLLSEIHVRVEAGERVLVTTLTKRMAEQL
TEFLSENGVKVRYLHSDIDTVERVEIIRDLRLGTFDVLVGINLLREGLDIPEVSLVAILDADKEGFLRAERSLIQTIGRA
ARNVNGTAILYADRMTDSMKKAIGETERRRAKQIAHNEAHGITPRGVVKRIKDIIDGVYNVDDARAELKAAQEAAKYEDM
SEKQASKEIKRLEKQMLDHAKNLEFEKAAAVRDQLAKLKSQLFGASGEDHIVPAA

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI1786996, Length=670, Percent_Identity=67.0149253731343, Blast_Score=897, Evalue=0.0,
Organism=Escherichia coli, GI1787357, Length=306, Percent_Identity=24.5098039215686, Blast_Score=70, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055 [H]

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR [H]

EC number: NA

Molecular weight: Translated: 78733; Mature: 78601

Theoretical pI: Translated: 5.28; Mature: 5.28

Prosite motif: PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDLSQVPSPHDESKFVTFEGSPFQLYQPYPPAGDQPEAIRQLVENIGDGLSYQTLLGVT
CCCCCCCCCCCCCCCEEEECCCCEEEECCCCCCCCCHHHHHHHHHHHCCCCCCHHHEEEC
GSGKTFTMANVIAQVGRPAIVFAPNKTLAAQLYSEFREFFPRNAVEYFVSYYDYYQPEAY
CCCCCHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCC
VPQRDLFIEKDSSINEHIEQMRLSATKSLLERRDVVIVATVSAIYGIGNPSEYHQMILTL
CCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCEEEEEEHHHHHCCCCHHHHHHHHHEE
RAGDKVSQRDVIARLIAMQYTRNETDFQRGTFRVRGDTVDIFPAEHAEMAVRLELFDDEV
ECCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCEEEECCCCCCCCEEEEEHHHHHH
ESLQLFDPLTGRVRQKIPRFTVYPSSHYVTPRETVLRAIETIKAELRERLDFFYKENKLV
HHHHHHCHHHHHHHHHCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
EAQRLEQRTRFDLEMLQELGFCKGIENYSRHLSGSAPGEPPPTLVDYLPPDALMFLDESH
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCCHHHCCCCCCEEEECCCC
VLIGQLNGMYNGDRARKETLAEYGFRLPSALDNRPLKFAEFETKMRQVTFVSATPGDYEK
EEEEECCCCCCCCHHHHHHHHHHCCCCCHHHCCCCCCHHHHHHHHHEEEEEECCCCCCHH
KTAGTEVVEQVVRPTGLVDPIIEVRPATTQVDDLLSEIHVRVEAGERVLVTTLTKRMAEQ
HHHHHHHHHHHHCCCCCCCCHHHCCCCCHHHHHHHHHHEEEEECCCEEHHHHHHHHHHHH
LTEFLSENGVKVRYLHSDIDTVERVEIIRDLRLGTFDVLVGINLLREGLDIPEVSLVAIL
HHHHHHCCCCEEEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCEEEEEEE
DADKEGFLRAERSLIQTIGRAARNVNGTAILYADRMTDSMKKAIGETERRRAKQIAHNEA
ECCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHCHHHHHHHHHHHHCCC
HGITPRGVVKRIKDIIDGVYNVDDARAELKAAQEAAKYEDMSEKQASKEIKRLEKQMLDH
CCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AKNLEFEKAAAVRDQLAKLKSQLFGASGEDHIVPAA
HHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
TDLSQVPSPHDESKFVTFEGSPFQLYQPYPPAGDQPEAIRQLVENIGDGLSYQTLLGVT
CCCCCCCCCCCCCCEEEECCCCEEEECCCCCCCCCHHHHHHHHHHHCCCCCCHHHEEEC
GSGKTFTMANVIAQVGRPAIVFAPNKTLAAQLYSEFREFFPRNAVEYFVSYYDYYQPEAY
CCCCCHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCC
VPQRDLFIEKDSSINEHIEQMRLSATKSLLERRDVVIVATVSAIYGIGNPSEYHQMILTL
CCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCEEEEEEHHHHHCCCCHHHHHHHHHEE
RAGDKVSQRDVIARLIAMQYTRNETDFQRGTFRVRGDTVDIFPAEHAEMAVRLELFDDEV
ECCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCEEEECCCCCCCCEEEEEHHHHHH
ESLQLFDPLTGRVRQKIPRFTVYPSSHYVTPRETVLRAIETIKAELRERLDFFYKENKLV
HHHHHHCHHHHHHHHHCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
EAQRLEQRTRFDLEMLQELGFCKGIENYSRHLSGSAPGEPPPTLVDYLPPDALMFLDESH
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCCHHHCCCCCCEEEECCCC
VLIGQLNGMYNGDRARKETLAEYGFRLPSALDNRPLKFAEFETKMRQVTFVSATPGDYEK
EEEEECCCCCCCCHHHHHHHHHHCCCCCHHHCCCCCCHHHHHHHHHEEEEEECCCCCCHH
KTAGTEVVEQVVRPTGLVDPIIEVRPATTQVDDLLSEIHVRVEAGERVLVTTLTKRMAEQ
HHHHHHHHHHHHCCCCCCCCHHHCCCCCHHHHHHHHHHEEEEECCCEEHHHHHHHHHHHH
LTEFLSENGVKVRYLHSDIDTVERVEIIRDLRLGTFDVLVGINLLREGLDIPEVSLVAIL
HHHHHHCCCCEEEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCEEEEEEE
DADKEGFLRAERSLIQTIGRAARNVNGTAILYADRMTDSMKKAIGETERRRAKQIAHNEA
ECCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHCHHHHHHHHHHHHCCC
HGITPRGVVKRIKDIIDGVYNVDDARAELKAAQEAAKYEDMSEKQASKEIKRLEKQMLDH
CCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AKNLEFEKAAAVRDQLAKLKSQLFGASGEDHIVPAA
HHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]