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The map label for this gene is 187927885

Identifier: 187927885

GI number: 187927885

Start: 835373

End: 836296

Strand: Direct

Name: 187927885

Synonym: Rpic_0789

Alternate gene names: NA

Gene position: 835373-836296 (Clockwise)

Preceding gene: 187927883

Following gene: 187927886

Centisome position: 21.19

GC content: 65.04

Gene sequence:

>924_bases
ATGGCGACCGGCCTCTATACGCATCCCGAATTCCTCCGGCACGAGATGGGACCGCACCATCCCGAATGTCCGGATCGCCT
GCGCGCGATCGAAGACCAGCTCATCGCCAGCCGCATCGACGACCTGCTCGTTCCCTGCGAGGCGCCGCCCGCCACCGAGG
CGCAGCTGTGCCGCGTCCATCGCGCCGAATACGTGCGCGAACTGGTGGCCAGTGTGCCGATCGCCGGCTATATGCCGATT
GATCCCGACACCTCGATGAACCCGCACACCTATATGGCTGCGGTGCTGGCCGCAGGTGCCGCGGTGGACGCCACCGACAA
GGTCATCGCCGGCGAGCTGGAGAACGCCTTCTGCAGCGTGCGCCCACCGGGCCATCATGCGGAGCCGGGCCGTGCGATGG
GCTTCTGCTTCTTCAACAACGTGGCCGTGGCCGCACGTCATGCGCTTGATCATCACGGCCTGCAGCGCGTGGCGATCGTC
GACTTTGATGTGCACCATGGCAACGGCACCGAAGCGGCCTTCCGCGATGAGCCCCGCGTGCTGATGTGCAGCATCTTCCA
GCACCCGTTCTATCCGTATTCCGGCACCGAGCCGGTGGCGGCCAACATGGTGAACATCCCGTTACCGGCGTACACCAATG
GCCTGACCGTGCGGGAGGTGGTGGAAACCATCTGGCTGCCACGCCTGGAGGCGTTCCAGCCCGAGATGCTGTTCATCTCT
GCGGGCTTCGATGCGCACCGCGAAGATGATCTGGGCCAGATGGGCTTGGTCGAGGCAGACTACACCTGGATCACGCAGCA
GCTCATGCAAGTGGCGCGCACGCACGCCAAGGGCCGCATCGTCAGTTGTCTTGAGGGCGGCTACAACCTCAGTGCGCTTG
GCCGCAGCGTGGTGGCGCACGTCAAGGCGCTTGCCGAGCTTTAG

Upstream 100 bases:

>100_bases
AGCGGATGCGTCTGTTGGATCGTCCAGGGCACGCGGCGTTGTCGCACAGCCGTGCTAACGTAGCGGCTGGAGACACTGAA
GCACACCGGATCACAACAAC

Downstream 100 bases:

>100_bases
GCTATCAACGATGACGATTCATTGATGTCATTCGAAAAAGTAATAAAGACATCGTTAAAGAATCGTTCCTCGCATGTGGG
GCCTGCCTTACACTAGCGCC

Product: histone deacetylase superfamily protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 307; Mature: 306

Protein sequence:

>307_residues
MATGLYTHPEFLRHEMGPHHPECPDRLRAIEDQLIASRIDDLLVPCEAPPATEAQLCRVHRAEYVRELVASVPIAGYMPI
DPDTSMNPHTYMAAVLAAGAAVDATDKVIAGELENAFCSVRPPGHHAEPGRAMGFCFFNNVAVAARHALDHHGLQRVAIV
DFDVHHGNGTEAAFRDEPRVLMCSIFQHPFYPYSGTEPVAANMVNIPLPAYTNGLTVREVVETIWLPRLEAFQPEMLFIS
AGFDAHREDDLGQMGLVEADYTWITQQLMQVARTHAKGRIVSCLEGGYNLSALGRSVVAHVKALAEL

Sequences:

>Translated_307_residues
MATGLYTHPEFLRHEMGPHHPECPDRLRAIEDQLIASRIDDLLVPCEAPPATEAQLCRVHRAEYVRELVASVPIAGYMPI
DPDTSMNPHTYMAAVLAAGAAVDATDKVIAGELENAFCSVRPPGHHAEPGRAMGFCFFNNVAVAARHALDHHGLQRVAIV
DFDVHHGNGTEAAFRDEPRVLMCSIFQHPFYPYSGTEPVAANMVNIPLPAYTNGLTVREVVETIWLPRLEAFQPEMLFIS
AGFDAHREDDLGQMGLVEADYTWITQQLMQVARTHAKGRIVSCLEGGYNLSALGRSVVAHVKALAEL
>Mature_306_residues
ATGLYTHPEFLRHEMGPHHPECPDRLRAIEDQLIASRIDDLLVPCEAPPATEAQLCRVHRAEYVRELVASVPIAGYMPID
PDTSMNPHTYMAAVLAAGAAVDATDKVIAGELENAFCSVRPPGHHAEPGRAMGFCFFNNVAVAARHALDHHGLQRVAIVD
FDVHHGNGTEAAFRDEPRVLMCSIFQHPFYPYSGTEPVAANMVNIPLPAYTNGLTVREVVETIWLPRLEAFQPEMLFISA
GFDAHREDDLGQMGLVEADYTWITQQLMQVARTHAKGRIVSCLEGGYNLSALGRSVVAHVKALAEL

Specific function: Putative deacetylase [H]

COG id: COG0123

COG function: function code BQ; Deacetylases, including yeast histone deacetylase and acetoin utilization protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histone deacetylase family [H]

Homologues:

Organism=Homo sapiens, GI13128864, Length=323, Percent_Identity=37.4613003095975, Blast_Score=169, Evalue=4e-42,
Organism=Homo sapiens, GI20070354, Length=326, Percent_Identity=35.8895705521472, Blast_Score=165, Evalue=6e-41,
Organism=Homo sapiens, GI17158039, Length=353, Percent_Identity=34.2776203966006, Blast_Score=154, Evalue=7e-38,
Organism=Homo sapiens, GI30795204, Length=353, Percent_Identity=34.2776203966006, Blast_Score=154, Evalue=1e-37,
Organism=Homo sapiens, GI30795202, Length=353, Percent_Identity=34.2776203966006, Blast_Score=154, Evalue=1e-37,
Organism=Homo sapiens, GI153085395, Length=248, Percent_Identity=39.9193548387097, Blast_Score=148, Evalue=7e-36,
Organism=Homo sapiens, GI62750349, Length=258, Percent_Identity=37.2093023255814, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI62750347, Length=258, Percent_Identity=37.2093023255814, Blast_Score=143, Evalue=2e-34,
Organism=Homo sapiens, GI169234807, Length=248, Percent_Identity=38.3064516129032, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI148539870, Length=248, Percent_Identity=38.3064516129032, Blast_Score=139, Evalue=2e-33,
Organism=Homo sapiens, GI226529806, Length=323, Percent_Identity=33.4365325077399, Blast_Score=139, Evalue=3e-33,
Organism=Homo sapiens, GI13128860, Length=258, Percent_Identity=24.8062015503876, Blast_Score=76, Evalue=4e-14,
Organism=Homo sapiens, GI293336691, Length=258, Percent_Identity=25.1937984496124, Blast_Score=76, Evalue=5e-14,
Organism=Homo sapiens, GI13128862, Length=271, Percent_Identity=22.5092250922509, Blast_Score=75, Evalue=7e-14,
Organism=Homo sapiens, GI217272877, Length=266, Percent_Identity=26.3157894736842, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI193209491, Length=343, Percent_Identity=32.9446064139942, Blast_Score=151, Evalue=4e-37,
Organism=Caenorhabditis elegans, GI25154020, Length=299, Percent_Identity=33.1103678929766, Blast_Score=150, Evalue=6e-37,
Organism=Caenorhabditis elegans, GI17540334, Length=309, Percent_Identity=34.3042071197411, Blast_Score=146, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI193206283, Length=309, Percent_Identity=34.3042071197411, Blast_Score=145, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI25154022, Length=299, Percent_Identity=32.7759197324415, Blast_Score=145, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI17540332, Length=309, Percent_Identity=34.3042071197411, Blast_Score=145, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI17537347, Length=304, Percent_Identity=33.2236842105263, Blast_Score=134, Evalue=7e-32,
Organism=Caenorhabditis elegans, GI17534739, Length=268, Percent_Identity=27.2388059701493, Blast_Score=94, Evalue=9e-20,
Organism=Caenorhabditis elegans, GI17508561, Length=267, Percent_Identity=26.9662921348315, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17561978, Length=223, Percent_Identity=26.457399103139, Blast_Score=75, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6324307, Length=317, Percent_Identity=32.4921135646688, Blast_Score=150, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6323999, Length=257, Percent_Identity=28.0155642023346, Blast_Score=93, Evalue=6e-20,
Organism=Saccharomyces cerevisiae, GI6325141, Length=334, Percent_Identity=25.4491017964072, Blast_Score=88, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6321244, Length=266, Percent_Identity=27.4436090225564, Blast_Score=83, Evalue=7e-17,
Organism=Saccharomyces cerevisiae, GI6325325, Length=264, Percent_Identity=25.3787878787879, Blast_Score=79, Evalue=9e-16,
Organism=Drosophila melanogaster, GI281360899, Length=302, Percent_Identity=34.4370860927152, Blast_Score=162, Evalue=2e-40,
Organism=Drosophila melanogaster, GI24642146, Length=302, Percent_Identity=34.4370860927152, Blast_Score=162, Evalue=2e-40,
Organism=Drosophila melanogaster, GI24642142, Length=302, Percent_Identity=34.4370860927152, Blast_Score=162, Evalue=2e-40,
Organism=Drosophila melanogaster, GI24642144, Length=302, Percent_Identity=34.4370860927152, Blast_Score=162, Evalue=3e-40,
Organism=Drosophila melanogaster, GI24641720, Length=346, Percent_Identity=34.6820809248555, Blast_Score=152, Evalue=3e-37,
Organism=Drosophila melanogaster, GI281360799, Length=346, Percent_Identity=34.6820809248555, Blast_Score=152, Evalue=3e-37,
Organism=Drosophila melanogaster, GI281360801, Length=346, Percent_Identity=34.6820809248555, Blast_Score=152, Evalue=4e-37,
Organism=Drosophila melanogaster, GI24657891, Length=272, Percent_Identity=27.9411764705882, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24644244, Length=261, Percent_Identity=23.3716475095785, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24649807, Length=227, Percent_Identity=25.9911894273128, Blast_Score=68, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000286 [H]

Pfam domain/function: PF00850 Hist_deacetyl [H]

EC number: NA

Molecular weight: Translated: 33734; Mature: 33603

Theoretical pI: Translated: 5.61; Mature: 5.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATGLYTHPEFLRHEMGPHHPECPDRLRAIEDQLIASRIDDLLVPCEAPPATEAQLCRVH
CCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHEECCCCCCCCHHHHHHHH
RAEYVRELVASVPIAGYMPIDPDTSMNPHTYMAAVLAAGAAVDATDKVIAGELENAFCSV
HHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHCEEEC
RPPGHHAEPGRAMGFCFFNNVAVAARHALDHHGLQRVAIVDFDVHHGNGTEAAFRDEPRV
CCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHCCCCEEEEEEEEEECCCCCCCCCCCCCCE
LMCSIFQHPFYPYSGTEPVAANMVNIPLPAYTNGLTVREVVETIWLPRLEAFQPEMLFIS
EHHHHHHCCCCCCCCCCCHHHCEEECCCCCCCCCCCHHHHHHHHHCCCHHHCCCCEEEEE
AGFDAHREDDLGQMGLVEADYTWITQQLMQVARTHAKGRIVSCLEGGYNLSALGRSVVAH
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEHHHHCCCCHHHHHHHHHHH
VKALAEL
HHHHHCC
>Mature Secondary Structure 
ATGLYTHPEFLRHEMGPHHPECPDRLRAIEDQLIASRIDDLLVPCEAPPATEAQLCRVH
CCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHEECCCCCCCCHHHHHHHH
RAEYVRELVASVPIAGYMPIDPDTSMNPHTYMAAVLAAGAAVDATDKVIAGELENAFCSV
HHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHCEEEC
RPPGHHAEPGRAMGFCFFNNVAVAARHALDHHGLQRVAIVDFDVHHGNGTEAAFRDEPRV
CCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHCCCCEEEEEEEEEECCCCCCCCCCCCCCE
LMCSIFQHPFYPYSGTEPVAANMVNIPLPAYTNGLTVREVVETIWLPRLEAFQPEMLFIS
EHHHHHHCCCCCCCCCCCHHHCEEECCCCCCCCCCCHHHHHHHHHCCCHHHCCCCEEEEE
AGFDAHREDDLGQMGLVEADYTWITQQLMQVARTHAKGRIVSCLEGGYNLSALGRSVVAH
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEHHHHCCCCHHHHHHHHHHH
VKALAEL
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]