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The map label for this gene is cysM [H]

Identifier: 187927883

GI number: 187927883

Start: 833147

End: 834049

Strand: Direct

Name: cysM [H]

Synonym: Rpic_0787

Alternate gene names: 187927883

Gene position: 833147-834049 (Clockwise)

Preceding gene: 187927882

Following gene: 187927885

Centisome position: 21.13

GC content: 63.46

Gene sequence:

>903_bases
ATGGCCTATCTCACGATCGAAGACACCATCGGCAACACGCCGCTGGTTCAGCTCCAGCGCATTCCCGGCGAAGGCAACGC
GCGCCGCGGTAATGTCATCCTCGGCAAACTCGAAGGCAACAACCCGGCCGGTTCGGTCAAGGATCGCCCTGCGCTGTCCA
TGATCAAGCACGCCGAAGCGCGCGGCCGCATCAAGCCGGGCGACACGCTGATCGAATCCACGTCGGGCAACACCGGCATT
GCCCTGGCCATGGCCGCTGCGGTGCGTGGTTACAAGATGGTGCTGATCATGCCGGAAGACCTGTCGGTGGAGCGCCGCCA
GAGCATGGCCGCTTACGGCGCTGAGATCATCCTCACCCCCGTCAAGGGCGGCATGGAATACGCGCGCGACCTGGCCGACG
CGATGGAAAAGGAAGGCAAGGGCGTCATCCTCGATCAGTTTGCCAACCCGGACAACCCGCTTGCGCATTACGAGACCACC
GGCCCCGAACTGTGGCGCGACACCGAAGGCCGCATCACGCATTTCGTTTCGGCGATGGGTACGACGGGCACGATTACCGG
TGTCTCGCGCTTTCTGAAAGAGAAGAACGCTGACATCCAGATCGTTGGCGCACAGCCGGAAGAAGGCTCGCGCATTCCGG
GTATCCGGAAGTGGCCCGAAGCGTACATGCCGAAGATCTACGATCCGAAGTACATCGACCGCACCGAGGCGGTCAGCCAG
TCCGACGCCGAGCACATGGCACGTCGAATGGCGCGTGAAGAGGGCATCTTCTGCGGGATCTCTGCCGCCGGTGCGTTGTG
CGTGGCGCTGCGTGTGGCCGAGGAGGTCGAGAACGCGACGATCGCTTTCGTGGTGTGCGACCGGGGCGATCGTTACCTGT
CGACGGGGGTCTTCCCCGCCTGA

Upstream 100 bases:

>100_bases
TGCTGCCGACAACGCCTCGCTCTGAGCGAGGCGTTTTGCCATGTGCGAGGGAGGGCTTTGGGCTGCATTACAATGGTCAA
ATTCCCGTCCCCCACGCATC

Downstream 100 bases:

>100_bases
CGGCTCGCCGCATCGCCATGAAAAAAGCGCAGCTTCGGCTGCGCTTTTTGTTTGTGTGGACGGCGGGTCAACCCTGCATC
GCCTGCCGCACGGCCTGGCC

Product: cysteine synthase B

Products: NA

Alternate protein names: CSase B; O-acetylserine (thiol)-lyase B; OAS-TL B; O-acetylserine sulfhydrylase B [H]

Number of amino acids: Translated: 300; Mature: 299

Protein sequence:

>300_residues
MAYLTIEDTIGNTPLVQLQRIPGEGNARRGNVILGKLEGNNPAGSVKDRPALSMIKHAEARGRIKPGDTLIESTSGNTGI
ALAMAAAVRGYKMVLIMPEDLSVERRQSMAAYGAEIILTPVKGGMEYARDLADAMEKEGKGVILDQFANPDNPLAHYETT
GPELWRDTEGRITHFVSAMGTTGTITGVSRFLKEKNADIQIVGAQPEEGSRIPGIRKWPEAYMPKIYDPKYIDRTEAVSQ
SDAEHMARRMAREEGIFCGISAAGALCVALRVAEEVENATIAFVVCDRGDRYLSTGVFPA

Sequences:

>Translated_300_residues
MAYLTIEDTIGNTPLVQLQRIPGEGNARRGNVILGKLEGNNPAGSVKDRPALSMIKHAEARGRIKPGDTLIESTSGNTGI
ALAMAAAVRGYKMVLIMPEDLSVERRQSMAAYGAEIILTPVKGGMEYARDLADAMEKEGKGVILDQFANPDNPLAHYETT
GPELWRDTEGRITHFVSAMGTTGTITGVSRFLKEKNADIQIVGAQPEEGSRIPGIRKWPEAYMPKIYDPKYIDRTEAVSQ
SDAEHMARRMAREEGIFCGISAAGALCVALRVAEEVENATIAFVVCDRGDRYLSTGVFPA
>Mature_299_residues
AYLTIEDTIGNTPLVQLQRIPGEGNARRGNVILGKLEGNNPAGSVKDRPALSMIKHAEARGRIKPGDTLIESTSGNTGIA
LAMAAAVRGYKMVLIMPEDLSVERRQSMAAYGAEIILTPVKGGMEYARDLADAMEKEGKGVILDQFANPDNPLAHYETTG
PELWRDTEGRITHFVSAMGTTGTITGVSRFLKEKNADIQIVGAQPEEGSRIPGIRKWPEAYMPKIYDPKYIDRTEAVSQS
DAEHMARRMAREEGIFCGISAAGALCVALRVAEEVENATIAFVVCDRGDRYLSTGVFPA

Specific function: Two Cysteine Synthase Enzymes Are Found. Both Catalyze The Same Reaction. Cysteine Synthase B Can Also Use Thiosulfate In Place Of Sulfide To Give Cysteine Thiosulfonate As A Product. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=292, Percent_Identity=38.3561643835616, Blast_Score=186, Evalue=2e-47,
Organism=Homo sapiens, GI295821200, Length=292, Percent_Identity=38.3561643835616, Blast_Score=186, Evalue=2e-47,
Organism=Homo sapiens, GI4557415, Length=292, Percent_Identity=38.3561643835616, Blast_Score=186, Evalue=2e-47,
Organism=Escherichia coli, GI2367138, Length=294, Percent_Identity=62.5850340136054, Blast_Score=374, Evalue=1e-105,
Organism=Escherichia coli, GI1788754, Length=309, Percent_Identity=42.3948220064725, Blast_Score=204, Evalue=5e-54,
Organism=Caenorhabditis elegans, GI17535051, Length=305, Percent_Identity=44.2622950819672, Blast_Score=229, Evalue=2e-60,
Organism=Caenorhabditis elegans, GI17562970, Length=302, Percent_Identity=42.3841059602649, Blast_Score=217, Evalue=6e-57,
Organism=Caenorhabditis elegans, GI32566674, Length=297, Percent_Identity=43.0976430976431, Blast_Score=215, Evalue=3e-56,
Organism=Caenorhabditis elegans, GI115535073, Length=300, Percent_Identity=40.6666666666667, Blast_Score=197, Evalue=8e-51,
Organism=Caenorhabditis elegans, GI17561720, Length=302, Percent_Identity=40.0662251655629, Blast_Score=187, Evalue=4e-48,
Organism=Caenorhabditis elegans, GI25147552, Length=284, Percent_Identity=39.4366197183099, Blast_Score=153, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17534315, Length=313, Percent_Identity=37.6996805111821, Blast_Score=151, Evalue=5e-37,
Organism=Caenorhabditis elegans, GI32566672, Length=212, Percent_Identity=37.2641509433962, Blast_Score=140, Evalue=7e-34,
Organism=Saccharomyces cerevisiae, GI6321594, Length=316, Percent_Identity=37.6582278481013, Blast_Score=177, Evalue=2e-45,
Organism=Saccharomyces cerevisiae, GI6321449, Length=333, Percent_Identity=33.6336336336336, Blast_Score=136, Evalue=4e-33,
Organism=Drosophila melanogaster, GI24643623, Length=310, Percent_Identity=36.7741935483871, Blast_Score=166, Evalue=1e-41,
Organism=Drosophila melanogaster, GI20129101, Length=310, Percent_Identity=36.7741935483871, Blast_Score=166, Evalue=1e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005858
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 32512; Mature: 32380

Theoretical pI: Translated: 5.49; Mature: 5.49

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAYLTIEDTIGNTPLVQLQRIPGEGNARRGNVILGKLEGNNPAGSVKDRPALSMIKHAEA
CEEEEEECCCCCCCEEEEEECCCCCCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHH
RGRIKPGDTLIESTSGNTGIALAMAAAVRGYKMVLIMPEDLSVERRQSMAAYGAEIILTP
CCCCCCCCCEEECCCCCCCHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHCCCEEEEEE
VKGGMEYARDLADAMEKEGKGVILDQFANPDNPLAHYETTGPELWRDTEGRITHFVSAMG
CCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCEEECCCHHHHCCCCCHHHHHHHHHC
TTGTITGVSRFLKEKNADIQIVGAQPEEGSRIPGIRKWPEAYMPKIYDPKYIDRTEAVSQ
CCCHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCHHHCCCCCCCCCCCHHHHHHH
SDAEHMARRMAREEGIFCGISAAGALCVALRVAEEVENATIAFVVCDRGDRYLSTGVFPA
CCHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCEECCCCCCC
>Mature Secondary Structure 
AYLTIEDTIGNTPLVQLQRIPGEGNARRGNVILGKLEGNNPAGSVKDRPALSMIKHAEA
EEEEEECCCCCCCEEEEEECCCCCCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHH
RGRIKPGDTLIESTSGNTGIALAMAAAVRGYKMVLIMPEDLSVERRQSMAAYGAEIILTP
CCCCCCCCCEEECCCCCCCHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHCCCEEEEEE
VKGGMEYARDLADAMEKEGKGVILDQFANPDNPLAHYETTGPELWRDTEGRITHFVSAMG
CCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCEEECCCHHHHCCCCCHHHHHHHHHC
TTGTITGVSRFLKEKNADIQIVGAQPEEGSRIPGIRKWPEAYMPKIYDPKYIDRTEAVSQ
CCCHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCHHHCCCCCCCCCCCHHHHHHH
SDAEHMARRMAREEGIFCGISAAGALCVALRVAEEVENATIAFVVCDRGDRYLSTGVFPA
CCHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]