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The map label for this gene is ghrB [H]

Identifier: 187927788

GI number: 187927788

Start: 730295

End: 731269

Strand: Direct

Name: ghrB [H]

Synonym: Rpic_0692

Alternate gene names: 187927788

Gene position: 730295-731269 (Clockwise)

Preceding gene: 187927787

Following gene: 187927789

Centisome position: 18.52

GC content: 63.49

Gene sequence:

>975_bases
ATGAAACCGCTTGTCGTTGCCTACAAGCCTTTGCCCGACGATGTCACGGCTCAGTTGCGCGAGCATGTCGAACTCGTGCA
GGTTGACGGTGCCGAGGCGTTGACCGAGGCGCTTACAAAGGCCGAGGGTGCGATCGGTGCGAGCCTGAAGATCACCTCCC
AGATGCTCGACCGCGCGCCCCGGCTCAAGGCGTGGTCCACGATCTCGGTCGGCTACGACAATTTCGACGTGCCCGATCTG
ACGCGTCGTGGCATTACGCTGGCGCACACACCTGATGTGTTGACGGAATCAACTGCCGATACCGTGTTTTCGCTGATCCT
CTCGTCTGCGCGGCGCGTTGTGGAACTGGCCGAGTGGGTCAGGGCCGGCAACTGGCAGCGCAGCATCGGACCCGAGCTTT
ACGGCACGGATGTTCAGGGCAAGACGATTGGCATCGTCGGCCTGGGGCGGATCGGTGCGGCATTGGCTCGCCGTGCAGCA
CTGGGTTTCCGGATGCGCGTCGTGTACACGAATCGGCATCCGCATCCCGAGGCCGAAGCGCAGTACGGCGCGCGCCGCGT
GACGCTCGACACGTTGCTGGCCGAAGCGGATTTTGTTTGCCTGCAGGTGCCGCTGACGCCGGAAACGCAGCACCTGATCG
GCGCGGCAGAACTGGCGAAGATGAAGCGCAGTGCGACTCTCATCAATGCATCGCGTGGGGCCGTCGTCGACGAAGCAGCG
CTCATCGATGCGTTGCGTAACGGGACGATACGCGGCGCGGGGCTCGATGTGTTCGAGCACGAACCGCTGCCGGCCAACTC
GCCACTGCTGGCGATGAACAACGTGGTTGCACTACCCCATATCGGCTCCGCGACGCACGAGACGCGACACGCAATGGCCC
GCTGCGCCGCTGACAACCTGATCAAGGCGCTGGTCGGTACGTTGCGTGAGAACCTAGTCAATCCACAGGTGCTGGAGCCC
ACCCGCGCCTCATGA

Upstream 100 bases:

>100_bases
AGCGCCGCGCTCCTCGCAGCCGTAGTGCTTACGCTTTGCGTCAAGCCGCAACCGCGTGATGCGTACACGCTCGCCCACCC
TGTGCCTGGAAAATGAACTG

Downstream 100 bases:

>100_bases
GCCGAGTGCCGGGATTGCGCTATGATCCTCGCACTCCGGCTTCGGCCCCTCGTGCCGACGGCCTGCTCTGAAGCGCAACG
TGACTGATTTCCCATCCTCT

Product: gluconate 2-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 324; Mature: 324

Protein sequence:

>324_residues
MKPLVVAYKPLPDDVTAQLREHVELVQVDGAEALTEALTKAEGAIGASLKITSQMLDRAPRLKAWSTISVGYDNFDVPDL
TRRGITLAHTPDVLTESTADTVFSLILSSARRVVELAEWVRAGNWQRSIGPELYGTDVQGKTIGIVGLGRIGAALARRAA
LGFRMRVVYTNRHPHPEAEAQYGARRVTLDTLLAEADFVCLQVPLTPETQHLIGAAELAKMKRSATLINASRGAVVDEAA
LIDALRNGTIRGAGLDVFEHEPLPANSPLLAMNNVVALPHIGSATHETRHAMARCAADNLIKALVGTLRENLVNPQVLEP
TRAS

Sequences:

>Translated_324_residues
MKPLVVAYKPLPDDVTAQLREHVELVQVDGAEALTEALTKAEGAIGASLKITSQMLDRAPRLKAWSTISVGYDNFDVPDL
TRRGITLAHTPDVLTESTADTVFSLILSSARRVVELAEWVRAGNWQRSIGPELYGTDVQGKTIGIVGLGRIGAALARRAA
LGFRMRVVYTNRHPHPEAEAQYGARRVTLDTLLAEADFVCLQVPLTPETQHLIGAAELAKMKRSATLINASRGAVVDEAA
LIDALRNGTIRGAGLDVFEHEPLPANSPLLAMNNVVALPHIGSATHETRHAMARCAADNLIKALVGTLRENLVNPQVLEP
TRAS
>Mature_324_residues
MKPLVVAYKPLPDDVTAQLREHVELVQVDGAEALTEALTKAEGAIGASLKITSQMLDRAPRLKAWSTISVGYDNFDVPDL
TRRGITLAHTPDVLTESTADTVFSLILSSARRVVELAEWVRAGNWQRSIGPELYGTDVQGKTIGIVGLGRIGAALARRAA
LGFRMRVVYTNRHPHPEAEAQYGARRVTLDTLLAEADFVCLQVPLTPETQHLIGAAELAKMKRSATLINASRGAVVDEAA
LIDALRNGTIRGAGLDVFEHEPLPANSPLLAMNNVVALPHIGSATHETRHAMARCAADNLIKALVGTLRENLVNPQVLEP
TRAS

Specific function: Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively [H]

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GhrB subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=257, Percent_Identity=44.7470817120623, Blast_Score=208, Evalue=7e-54,
Organism=Homo sapiens, GI23308577, Length=291, Percent_Identity=32.6460481099656, Blast_Score=162, Evalue=6e-40,
Organism=Homo sapiens, GI145580578, Length=291, Percent_Identity=33.6769759450172, Blast_Score=139, Evalue=2e-33,
Organism=Homo sapiens, GI4557499, Length=291, Percent_Identity=33.6769759450172, Blast_Score=139, Evalue=2e-33,
Organism=Homo sapiens, GI145580575, Length=282, Percent_Identity=34.0425531914894, Blast_Score=136, Evalue=3e-32,
Organism=Homo sapiens, GI61743967, Length=291, Percent_Identity=32.9896907216495, Blast_Score=133, Evalue=2e-31,
Organism=Homo sapiens, GI4557497, Length=291, Percent_Identity=32.9896907216495, Blast_Score=133, Evalue=2e-31,
Organism=Escherichia coli, GI87082289, Length=322, Percent_Identity=58.695652173913, Blast_Score=375, Evalue=1e-105,
Organism=Escherichia coli, GI1789279, Length=261, Percent_Identity=34.8659003831418, Blast_Score=120, Evalue=8e-29,
Organism=Escherichia coli, GI1787645, Length=192, Percent_Identity=34.375, Blast_Score=114, Evalue=8e-27,
Organism=Escherichia coli, GI87081824, Length=210, Percent_Identity=30.952380952381, Blast_Score=84, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17532191, Length=263, Percent_Identity=33.8403041825095, Blast_Score=148, Evalue=5e-36,
Organism=Caenorhabditis elegans, GI25147481, Length=276, Percent_Identity=28.9855072463768, Blast_Score=111, Evalue=6e-25,
Organism=Saccharomyces cerevisiae, GI6324055, Length=233, Percent_Identity=42.0600858369099, Blast_Score=177, Evalue=2e-45,
Organism=Saccharomyces cerevisiae, GI6320925, Length=289, Percent_Identity=34.9480968858132, Blast_Score=137, Evalue=3e-33,
Organism=Saccharomyces cerevisiae, GI6322116, Length=275, Percent_Identity=33.4545454545455, Blast_Score=131, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6325144, Length=177, Percent_Identity=33.3333333333333, Blast_Score=85, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6324964, Length=248, Percent_Identity=27.4193548387097, Blast_Score=85, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6321253, Length=282, Percent_Identity=26.9503546099291, Blast_Score=76, Evalue=7e-15,
Organism=Saccharomyces cerevisiae, GI6324980, Length=179, Percent_Identity=27.9329608938547, Blast_Score=70, Evalue=3e-13,
Organism=Drosophila melanogaster, GI45552429, Length=311, Percent_Identity=39.2282958199357, Blast_Score=208, Evalue=3e-54,
Organism=Drosophila melanogaster, GI24585514, Length=311, Percent_Identity=39.2282958199357, Blast_Score=208, Evalue=4e-54,
Organism=Drosophila melanogaster, GI28574282, Length=311, Percent_Identity=39.2282958199357, Blast_Score=208, Evalue=4e-54,
Organism=Drosophila melanogaster, GI28574284, Length=311, Percent_Identity=39.2282958199357, Blast_Score=208, Evalue=5e-54,
Organism=Drosophila melanogaster, GI45551003, Length=311, Percent_Identity=39.2282958199357, Blast_Score=208, Evalue=5e-54,
Organism=Drosophila melanogaster, GI28574286, Length=312, Percent_Identity=38.4615384615385, Blast_Score=202, Evalue=3e-52,
Organism=Drosophila melanogaster, GI28571528, Length=285, Percent_Identity=42.1052631578947, Blast_Score=197, Evalue=7e-51,
Organism=Drosophila melanogaster, GI24585516, Length=264, Percent_Identity=36.3636363636364, Blast_Score=170, Evalue=1e-42,
Organism=Drosophila melanogaster, GI19921140, Length=282, Percent_Identity=35.1063829787234, Blast_Score=137, Evalue=7e-33,
Organism=Drosophila melanogaster, GI24646446, Length=304, Percent_Identity=33.2236842105263, Blast_Score=128, Evalue=5e-30,
Organism=Drosophila melanogaster, GI24646448, Length=304, Percent_Identity=33.2236842105263, Blast_Score=128, Evalue=5e-30,
Organism=Drosophila melanogaster, GI24646452, Length=304, Percent_Identity=33.2236842105263, Blast_Score=128, Evalue=5e-30,
Organism=Drosophila melanogaster, GI24646450, Length=304, Percent_Identity=33.2236842105263, Blast_Score=128, Evalue=5e-30,
Organism=Drosophila melanogaster, GI62472511, Length=294, Percent_Identity=33.6734693877551, Blast_Score=127, Evalue=9e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.79; =1.1.1.81 [H]

Molecular weight: Translated: 34883; Mature: 34883

Theoretical pI: Translated: 7.03; Mature: 7.03

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPLVVAYKPLPDDVTAQLREHVELVQVDGAEALTEALTKAEGAIGASLKITSQMLDRAP
CCCEEEEECCCCHHHHHHHHHHHHHEEECCHHHHHHHHHHHCCCCCCHHHHHHHHHCCCC
RLKAWSTISVGYDNFDVPDLTRRGITLAHTPDVLTESTADTVFSLILSSARRVVELAEWV
CCCCCEEEEECCCCCCCCCHHHCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RAGNWQRSIGPELYGTDVQGKTIGIVGLGRIGAALARRAALGFRMRVVYTNRHPHPEAEA
HCCCCCHHCCCCCCCCCCCCCEEEEEECHHHHHHHHHHHHHCEEEEEEEECCCCCCCHHH
QYGARRVTLDTLLAEADFVCLQVPLTPETQHLIGAAELAKMKRSATLINASRGAVVDEAA
HHCCHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHEEECCCCCHHHHHH
LIDALRNGTIRGAGLDVFEHEPLPANSPLLAMNNVVALPHIGSATHETRHAMARCAADNL
HHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEECCEEECCCCCCCHHHHHHHHHHHHHHHH
IKALVGTLRENLVNPQVLEPTRAS
HHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure
MKPLVVAYKPLPDDVTAQLREHVELVQVDGAEALTEALTKAEGAIGASLKITSQMLDRAP
CCCEEEEECCCCHHHHHHHHHHHHHEEECCHHHHHHHHHHHCCCCCCHHHHHHHHHCCCC
RLKAWSTISVGYDNFDVPDLTRRGITLAHTPDVLTESTADTVFSLILSSARRVVELAEWV
CCCCCEEEEECCCCCCCCCHHHCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RAGNWQRSIGPELYGTDVQGKTIGIVGLGRIGAALARRAALGFRMRVVYTNRHPHPEAEA
HCCCCCHHCCCCCCCCCCCCCEEEEEECHHHHHHHHHHHHHCEEEEEEEECCCCCCCHHH
QYGARRVTLDTLLAEADFVCLQVPLTPETQHLIGAAELAKMKRSATLINASRGAVVDEAA
HHCCHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHEEECCCCCHHHHHH
LIDALRNGTIRGAGLDVFEHEPLPANSPLLAMNNVVALPHIGSATHETRHAMARCAADNL
HHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEECCEEECCCCCCCHHHHHHHHHHHHHHHH
IKALVGTLRENLVNPQVLEPTRAS
HHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA