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The map label for this gene is groEL [H]

Identifier: 187927675

GI number: 187927675

Start: 612375

End: 614018

Strand: Direct

Name: groEL [H]

Synonym: Rpic_0579

Alternate gene names: 187927675

Gene position: 612375-614018 (Clockwise)

Preceding gene: 187927674

Following gene: 187927676

Centisome position: 15.53

GC content: 62.96

Gene sequence:

>1644_bases
ATGGCAGCTAAAGACGTAGTGTTCGGCGACGCCGCACGTGCCAAGATGGTCGAAGGCGTGAACATTCTCGCCAACGCAGT
GAAGGTGACCCTGGGCCCGAAGGGCCGTAACGTGGTGCTGGAGCGCAGCTTCGGTGGCCCGACCGTGACCAAGGACGGTG
TGTCGGTCGCCAAGGAAATCGAGCTGAAGGACAAGCTGCAGAACATGGGCGCGCAAATGGTCAAGGAAGTGGCTTCCAAG
ACCAGCGACAACGCCGGTGACGGCACCACCACCGCAACGGTGCTGGCCCAGTCGATCGTGCGCGAAGGCATGAAGTACGT
TGCCGCCGGCATGAACCCGATGGACCTGAAGCGCGGCATCGACAAGGCTGTCGGCGCTGCCGTCGAAGAGCTGAAGAAGA
TCAGCAAGCCGACGACCACCAGCAAGGAAATCGCTCAGGTTGGCGCCATCTCGGCCAACAGCGACGAATCCATCGGCCAG
CGCATCGCTGAAGCCATGGACAAGGTCGGCAAGGAAGGCGTGATCACGGTGGAAGACGGCAAGTCCCTGGCCGACGAGCT
GGACGTCGTGGAAGGCATGCAGTTCGACCGCGGCTACCTGTCGCCGTACTTCATCAACAACCCGGAAAAGCAAGTTGTCC
AGCTGGACAACCCGTTCGTGCTGCTGTTCGACAAGAAGGTCAGCAACATCCGCGACCTGCTGCCGATCCTGGAGCAAGTG
GCCAAGGCTGGCCGTCCGCTGCTGATCATCGCTGAAGACGTCGAAGGCGAAGCCCTGGCAACGCTGGTGGTCAACAACAT
CCGCGGCATCCTGAAGACCGCCGCCGTCAAGGCTCCGGGCTTCGGCGACCGCCGCAAGGCCATGCTGGAAGACATCGCCA
TCCTGACGGGCGGCCAGGTCATCGCTGAAGAAGTCGGCCTGACGCTGGAAAAGGCAACCCTGAACGACCTGGGTCAAGCC
AAGCGCGTTGAAATCGGCAAGGAAAACACCACGATCATCGATGGCGCAGGCGATGCCCGCAACATCGAAGCCCGCGTGAA
GCAAGTGCGTGCCCAGATCGAAGAAGCGACCTCGGACTACGACCGTGAGAAGCTGCAAGAGCGCGTGGCCAAGCTGGCCG
GCGGTGTTGCCGTGATCAAGGTCGGCGCTGCCACCGAAGTCGAAATGAAGGAAAAGAAGGCCCGCGTGGAAGATGCGCTG
CATGCAACGCGCGCTGCCGTGGAAGAAGGCATCGTGGCTGGCGGCGGTGTTGCGCTGCTGCGCGCCCGTGCGCTGATCTC
CGGCCTGAAGGGTGCGAACGCTGACCAGGACGCCGGTATCAAGATCGTGCTGCGCGCCATGGAAGAGCCGCTGCGCCAGA
TCGTCACCAACGCTGGCGACGAGGCTTCGGTGGTGGTGGCCAACGTCATCGCCGGCCAGGGCAACTACGGCTACAACGCC
TCGACCGGCGAGTACGGTGACCTGGTGGAAATGGGCGTGTTGGACCCGACCAAGGTGACCCGCACCGCGCTGCAGAACGC
TGCTTCGGTCGCTTCGCTGATGCTGACGACGGACTGCGCCGTGGCAGAACTGCCGAAGGACGATGCTGCTCCGGCAATGC
CGGGCGGCATGGGTGGCATGGGCGGCATGGACGGCATGATGTAA

Upstream 100 bases:

>100_bases
GCGCTCAGTCGCATTGGCTTACCAGTAAACCATTCCTCATTGCCTGCCCCGCGGATTCCCCCGGCGCAGGCAACATCCAA
AGATTTCGGAGATTCTCAAG

Downstream 100 bases:

>100_bases
TTTGCCGTACCGGTCCTGGCCCGGCCATCCTTCGGGATGGCTGTTCCAAACAAAAAACCCCGTGGGTGCGAGCCTGCGGG
GTTTTTTGTTGGTCGCTTTG

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein; Protein Cpn60 [H]

Number of amino acids: Translated: 547; Mature: 546

Protein sequence:

>547_residues
MAAKDVVFGDAARAKMVEGVNILANAVKVTLGPKGRNVVLERSFGGPTVTKDGVSVAKEIELKDKLQNMGAQMVKEVASK
TSDNAGDGTTTATVLAQSIVREGMKYVAAGMNPMDLKRGIDKAVGAAVEELKKISKPTTTSKEIAQVGAISANSDESIGQ
RIAEAMDKVGKEGVITVEDGKSLADELDVVEGMQFDRGYLSPYFINNPEKQVVQLDNPFVLLFDKKVSNIRDLLPILEQV
AKAGRPLLIIAEDVEGEALATLVVNNIRGILKTAAVKAPGFGDRRKAMLEDIAILTGGQVIAEEVGLTLEKATLNDLGQA
KRVEIGKENTTIIDGAGDARNIEARVKQVRAQIEEATSDYDREKLQERVAKLAGGVAVIKVGAATEVEMKEKKARVEDAL
HATRAAVEEGIVAGGGVALLRARALISGLKGANADQDAGIKIVLRAMEEPLRQIVTNAGDEASVVVANVIAGQGNYGYNA
STGEYGDLVEMGVLDPTKVTRTALQNAASVASLMLTTDCAVAELPKDDAAPAMPGGMGGMGGMDGMM

Sequences:

>Translated_547_residues
MAAKDVVFGDAARAKMVEGVNILANAVKVTLGPKGRNVVLERSFGGPTVTKDGVSVAKEIELKDKLQNMGAQMVKEVASK
TSDNAGDGTTTATVLAQSIVREGMKYVAAGMNPMDLKRGIDKAVGAAVEELKKISKPTTTSKEIAQVGAISANSDESIGQ
RIAEAMDKVGKEGVITVEDGKSLADELDVVEGMQFDRGYLSPYFINNPEKQVVQLDNPFVLLFDKKVSNIRDLLPILEQV
AKAGRPLLIIAEDVEGEALATLVVNNIRGILKTAAVKAPGFGDRRKAMLEDIAILTGGQVIAEEVGLTLEKATLNDLGQA
KRVEIGKENTTIIDGAGDARNIEARVKQVRAQIEEATSDYDREKLQERVAKLAGGVAVIKVGAATEVEMKEKKARVEDAL
HATRAAVEEGIVAGGGVALLRARALISGLKGANADQDAGIKIVLRAMEEPLRQIVTNAGDEASVVVANVIAGQGNYGYNA
STGEYGDLVEMGVLDPTKVTRTALQNAASVASLMLTTDCAVAELPKDDAAPAMPGGMGGMGGMDGMM
>Mature_546_residues
AAKDVVFGDAARAKMVEGVNILANAVKVTLGPKGRNVVLERSFGGPTVTKDGVSVAKEIELKDKLQNMGAQMVKEVASKT
SDNAGDGTTTATVLAQSIVREGMKYVAAGMNPMDLKRGIDKAVGAAVEELKKISKPTTTSKEIAQVGAISANSDESIGQR
IAEAMDKVGKEGVITVEDGKSLADELDVVEGMQFDRGYLSPYFINNPEKQVVQLDNPFVLLFDKKVSNIRDLLPILEQVA
KAGRPLLIIAEDVEGEALATLVVNNIRGILKTAAVKAPGFGDRRKAMLEDIAILTGGQVIAEEVGLTLEKATLNDLGQAK
RVEIGKENTTIIDGAGDARNIEARVKQVRAQIEEATSDYDREKLQERVAKLAGGVAVIKVGAATEVEMKEKKARVEDALH
ATRAAVEEGIVAGGGVALLRARALISGLKGANADQDAGIKIVLRAMEEPLRQIVTNAGDEASVVVANVIAGQGNYGYNAS
TGEYGDLVEMGVLDPTKVTRTALQNAASVASLMLTTDCAVAELPKDDAAPAMPGGMGGMGGMDGMM

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions [H]

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family [H]

Homologues:

Organism=Homo sapiens, GI41399285, Length=530, Percent_Identity=53.0188679245283, Blast_Score=548, Evalue=1e-156,
Organism=Homo sapiens, GI31542947, Length=530, Percent_Identity=53.0188679245283, Blast_Score=548, Evalue=1e-156,
Organism=Homo sapiens, GI5453607, Length=533, Percent_Identity=22.7016885553471, Blast_Score=73, Evalue=6e-13,
Organism=Homo sapiens, GI24307939, Length=363, Percent_Identity=22.5895316804408, Blast_Score=66, Evalue=7e-11,
Organism=Escherichia coli, GI1790586, Length=530, Percent_Identity=76.6037735849057, Blast_Score=811, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17555558, Length=530, Percent_Identity=53.3962264150943, Blast_Score=551, Evalue=1e-157,
Organism=Caenorhabditis elegans, GI193210679, Length=212, Percent_Identity=52.8301886792453, Blast_Score=216, Evalue=2e-56,
Organism=Caenorhabditis elegans, GI25147750, Length=131, Percent_Identity=35.1145038167939, Blast_Score=67, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6323288, Length=526, Percent_Identity=52.0912547528517, Blast_Score=541, Evalue=1e-154,
Organism=Saccharomyces cerevisiae, GI6322350, Length=571, Percent_Identity=22.4168126094571, Blast_Score=72, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6322446, Length=556, Percent_Identity=22.1223021582734, Blast_Score=71, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6322524, Length=374, Percent_Identity=22.4598930481283, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24641193, Length=527, Percent_Identity=53.3206831119545, Blast_Score=560, Evalue=1e-160,
Organism=Drosophila melanogaster, GI24641191, Length=527, Percent_Identity=53.3206831119545, Blast_Score=560, Evalue=1e-160,
Organism=Drosophila melanogaster, GI45550936, Length=524, Percent_Identity=51.3358778625954, Blast_Score=539, Evalue=1e-153,
Organism=Drosophila melanogaster, GI45550132, Length=524, Percent_Identity=51.3358778625954, Blast_Score=539, Evalue=1e-153,
Organism=Drosophila melanogaster, GI45550935, Length=524, Percent_Identity=51.3358778625954, Blast_Score=539, Evalue=1e-153,
Organism=Drosophila melanogaster, GI17864606, Length=542, Percent_Identity=45.2029520295203, Blast_Score=473, Evalue=1e-133,
Organism=Drosophila melanogaster, GI24584129, Length=532, Percent_Identity=36.6541353383459, Blast_Score=339, Evalue=2e-93,
Organism=Drosophila melanogaster, GI19921262, Length=532, Percent_Identity=36.6541353383459, Blast_Score=339, Evalue=2e-93,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423 [H]

Pfam domain/function: PF00118 Cpn60_TCP1 [H]

EC number: NA

Molecular weight: Translated: 57404; Mature: 57272

Theoretical pI: Translated: 4.80; Mature: 4.80

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAKDVVFGDAARAKMVEGVNILANAVKVTLGPKGRNVVLERSFGGPTVTKDGVSVAKEI
CCCCCCEECCHHHHHHHHHHHHHHHHHEEEECCCCCEEEEEECCCCCCCCCCHHHHHHHH
ELKDKLQNMGAQMVKEVASKTSDNAGDGTTTATVLAQSIVREGMKYVAAGMNPMDLKRGI
HHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
DKAVGAAVEELKKISKPTTTSKEIAQVGAISANSDESIGQRIAEAMDKVGKEGVITVEDG
HHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCEEEECCC
KSLADELDVVEGMQFDRGYLSPYFINNPEKQVVQLDNPFVLLFDKKVSNIRDLLPILEQV
HHHHHHHHHHHCCCCCCCCCCCEEECCCHHHEEEECCCEEEEECCHHHHHHHHHHHHHHH
AKAGRPLLIIAEDVEGEALATLVVNNIRGILKTAAVKAPGFGDRRKAMLEDIAILTGGQV
HHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCHH
IAEEVGLTLEKATLNDLGQAKRVEIGKENTTIIDGAGDARNIEARVKQVRAQIEEATSDY
HHHHHCCEEEHHHHHHCCCHHHEECCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHH
DREKLQERVAKLAGGVAVIKVGAATEVEMKEKKARVEDALHATRAAVEEGIVAGGGVALL
HHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
RARALISGLKGANADQDAGIKIVLRAMEEPLRQIVTNAGDEASVVVANVIAGQGNYGYNA
HHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHEEEEEHHCCCCCCCCCC
STGEYGDLVEMGVLDPTKVTRTALQNAASVASLMLTTDCAVAELPKDDAAPAMPGGMGGM
CCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCCCCCCCCC
GGMDGMM
CCCCCCC
>Mature Secondary Structure 
AAKDVVFGDAARAKMVEGVNILANAVKVTLGPKGRNVVLERSFGGPTVTKDGVSVAKEI
CCCCCEECCHHHHHHHHHHHHHHHHHEEEECCCCCEEEEEECCCCCCCCCCHHHHHHHH
ELKDKLQNMGAQMVKEVASKTSDNAGDGTTTATVLAQSIVREGMKYVAAGMNPMDLKRGI
HHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
DKAVGAAVEELKKISKPTTTSKEIAQVGAISANSDESIGQRIAEAMDKVGKEGVITVEDG
HHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCEEEECCC
KSLADELDVVEGMQFDRGYLSPYFINNPEKQVVQLDNPFVLLFDKKVSNIRDLLPILEQV
HHHHHHHHHHHCCCCCCCCCCCEEECCCHHHEEEECCCEEEEECCHHHHHHHHHHHHHHH
AKAGRPLLIIAEDVEGEALATLVVNNIRGILKTAAVKAPGFGDRRKAMLEDIAILTGGQV
HHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCHH
IAEEVGLTLEKATLNDLGQAKRVEIGKENTTIIDGAGDARNIEARVKQVRAQIEEATSDY
HHHHHCCEEEHHHHHHCCCHHHEECCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHH
DREKLQERVAKLAGGVAVIKVGAATEVEMKEKKARVEDALHATRAAVEEGIVAGGGVALL
HHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
RARALISGLKGANADQDAGIKIVLRAMEEPLRQIVTNAGDEASVVVANVIAGQGNYGYNA
HHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHEEEEEHHCCCCCCCCCC
STGEYGDLVEMGVLDPTKVTRTALQNAASVASLMLTTDCAVAELPKDDAAPAMPGGMGGM
CCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCCCCCCCCC
GGMDGMM
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA