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The map label for this gene is pgk [H]

Identifier: 187927591

GI number: 187927591

Start: 522800

End: 524011

Strand: Direct

Name: pgk [H]

Synonym: Rpic_0491

Alternate gene names: 187927591

Gene position: 522800-524011 (Clockwise)

Preceding gene: 187927590

Following gene: 187927592

Centisome position: 13.26

GC content: 64.6

Gene sequence:

>1212_bases
ATGCCTCACGTCCTGCGTCTGTCCGATCTCATCTCCGAAGGAAAGCTTGCCGGTAAGCGCGTGTTCATCCGCGCCGACCT
CAACGTGCCGCAAGACGATGCTGGCAACATCACCGAAGACACGCGCATCCGCGCTTCCGTGCCGGCCGTCAAAGCCGCGC
TGGACGCCGGTGCCGCCGTCATGGTGACCTCACACCTGGGCCGTCCGACCGAGGGCGAATTCAAGCCGGAAGATTCGCTG
GCGCCGGTTGCCAAGCGTCTGTCCGAACTGCTTGGCCGTGACGTCAAACTCGTCCAGAACTGGGTTGACGGCGTGGAGGT
CGCACCCGGCCAGGTCGTCCTGCTGGAAAACTGCCGCGTGAACAAGGGCGAGAAGAAGAACAGCGACGAGTTGGCCCAGA
AAATGGCCAAGCTGTGCGACGTCTACGTCAACGACGCCTTCGGCACCGCCCACCGCGCGGAAGCCACCACACACGGCATC
GCCAAGTTCGCACCCATCGCCTGCGCCGGCCCGCTGCTGGCCGCCGAGCTGGATGCGCTGGGCAAGGCGCTGGGCCAGCC
GGCACGTCCGCTGGTGGCCATCGTGGCCGGCTCGAAGGTTTCGACCAAGCTGACCATCCTGAAATCGCTGGCCGACAAGG
TGGACAACCTGATCGTCGGCGGCGGAATTGCCAACACCTTCATGCTGGCTGCCGGTCTGAAGATCGGCAAATCGCTGGCG
GAAGCTGATCTAGTGGGCGATGCCAAGGCCATCATCGAGATGCTGGCGGCACGCGGCGCGTCGGTGCCCATCCCCGTCGA
CGTGGTGTGCGCCAAGGAATTCAGTGCCACCGCGGCCGCCACCGTCAAGGACGTGGCCGATGTGGCCGACGACGACATGA
TCCTCGACATCGGCCCGAAGACGGCTGCGCAACTGGCCGAACAACTGAAGACCGCCGGCACCATCGTCTGGAACGGCCCG
GTCGGCGTGTTCGAATTCGACCAGTTCGGCAATGGCACCAAGGTGCTGGCCGAGGCGATTGCTGCCTCGTCGGGTTTCTC
GATTGCGGGCGGCGGCGACACACTGGCTGCCATCGCCAAGTACAACATCGCCGACAAGGTGGGCTATATCTCCACCGGCG
GCGGTGCGTTCCTCGAATTCCTGGAAGGCAAGACACTGCCGGCTGTCGAAATCCTGGAGCAACGCGCGCAGAATCAGGCC
GCTGGGGCCTGA

Upstream 100 bases:

>100_bases
GCAAGACGGCCGAGGCCGGAGGACTCCGCCGAGAAACGCACGTTTTGACCAGGCGCATCGGGTAAAATCGTCGTTTTCCG
CGATTTCTTCCGAAGCTGCC

Downstream 100 bases:

>100_bases
CCGCCAGCGCCGCCAACATCCCCACCACAACAACGAGACACCGCCGCCCATGACCCGCGCTACCAAGATCGTCGCAACGC
TCGGCCCCGCGTCCAGCACG

Product: phosphoglycerate kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 403; Mature: 402

Protein sequence:

>403_residues
MPHVLRLSDLISEGKLAGKRVFIRADLNVPQDDAGNITEDTRIRASVPAVKAALDAGAAVMVTSHLGRPTEGEFKPEDSL
APVAKRLSELLGRDVKLVQNWVDGVEVAPGQVVLLENCRVNKGEKKNSDELAQKMAKLCDVYVNDAFGTAHRAEATTHGI
AKFAPIACAGPLLAAELDALGKALGQPARPLVAIVAGSKVSTKLTILKSLADKVDNLIVGGGIANTFMLAAGLKIGKSLA
EADLVGDAKAIIEMLAARGASVPIPVDVVCAKEFSATAAATVKDVADVADDDMILDIGPKTAAQLAEQLKTAGTIVWNGP
VGVFEFDQFGNGTKVLAEAIAASSGFSIAGGGDTLAAIAKYNIADKVGYISTGGGAFLEFLEGKTLPAVEILEQRAQNQA
AGA

Sequences:

>Translated_403_residues
MPHVLRLSDLISEGKLAGKRVFIRADLNVPQDDAGNITEDTRIRASVPAVKAALDAGAAVMVTSHLGRPTEGEFKPEDSL
APVAKRLSELLGRDVKLVQNWVDGVEVAPGQVVLLENCRVNKGEKKNSDELAQKMAKLCDVYVNDAFGTAHRAEATTHGI
AKFAPIACAGPLLAAELDALGKALGQPARPLVAIVAGSKVSTKLTILKSLADKVDNLIVGGGIANTFMLAAGLKIGKSLA
EADLVGDAKAIIEMLAARGASVPIPVDVVCAKEFSATAAATVKDVADVADDDMILDIGPKTAAQLAEQLKTAGTIVWNGP
VGVFEFDQFGNGTKVLAEAIAASSGFSIAGGGDTLAAIAKYNIADKVGYISTGGGAFLEFLEGKTLPAVEILEQRAQNQA
AGA
>Mature_402_residues
PHVLRLSDLISEGKLAGKRVFIRADLNVPQDDAGNITEDTRIRASVPAVKAALDAGAAVMVTSHLGRPTEGEFKPEDSLA
PVAKRLSELLGRDVKLVQNWVDGVEVAPGQVVLLENCRVNKGEKKNSDELAQKMAKLCDVYVNDAFGTAHRAEATTHGIA
KFAPIACAGPLLAAELDALGKALGQPARPLVAIVAGSKVSTKLTILKSLADKVDNLIVGGGIANTFMLAAGLKIGKSLAE
ADLVGDAKAIIEMLAARGASVPIPVDVVCAKEFSATAAATVKDVADVADDDMILDIGPKTAAQLAEQLKTAGTIVWNGPV
GVFEFDQFGNGTKVLAEAIAASSGFSIAGGGDTLAAIAKYNIADKVGYISTGGGAFLEFLEGKTLPAVEILEQRAQNQAA
GA

Specific function: Second phase of glycolysis; second step. [C]

COG id: COG0126

COG function: function code G; 3-phosphoglycerate kinase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphoglycerate kinase family [H]

Homologues:

Organism=Homo sapiens, GI31543397, Length=405, Percent_Identity=42.962962962963, Blast_Score=276, Evalue=3e-74,
Organism=Homo sapiens, GI4505763, Length=420, Percent_Identity=40.7142857142857, Blast_Score=267, Evalue=1e-71,
Organism=Escherichia coli, GI1789294, Length=394, Percent_Identity=63.4517766497462, Blast_Score=482, Evalue=1e-137,
Organism=Caenorhabditis elegans, GI17508823, Length=410, Percent_Identity=44.6341463414634, Blast_Score=296, Evalue=2e-80,
Organism=Saccharomyces cerevisiae, GI6319857, Length=406, Percent_Identity=42.3645320197044, Blast_Score=272, Evalue=7e-74,
Organism=Drosophila melanogaster, GI17136394, Length=405, Percent_Identity=43.2098765432099, Blast_Score=265, Evalue=6e-71,
Organism=Drosophila melanogaster, GI24581203, Length=408, Percent_Identity=37.7450980392157, Blast_Score=231, Evalue=6e-61,

Paralogues:

None

Copy number: 2990 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1460 Molecules/Cell In: Stationary-Phase, Rich-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001576
- InterPro:   IPR015901
- InterPro:   IPR015911
- InterPro:   IPR015824 [H]

Pfam domain/function: PF00162 PGK [H]

EC number: =2.7.2.3 [H]

Molecular weight: Translated: 41594; Mature: 41463

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: PS00111 PGLYCERATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPHVLRLSDLISEGKLAGKRVFIRADLNVPQDDAGNITEDTRIRASVPAVKAALDAGAAV
CCCHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCCCCCEEEHHCHHHHHHHHCCCEE
MVTSHLGRPTEGEFKPEDSLAPVAKRLSELLGRDVKLVQNWVDGVEVAPGQVVLLENCRV
EEEHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHCCCEECCCCEEEEECCCC
NKGEKKNSDELAQKMAKLCDVYVNDAFGTAHRAEATTHGIAKFAPIACAGPLLAAELDAL
CCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCHHHCCHHHHHHHHHH
GKALGQPARPLVAIVAGSKVSTKLTILKSLADKVDNLIVGGGIANTFMLAAGLKIGKSLA
HHHHCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHCEEECCCHHHHHHHHHHHHHHHHHH
EADLVGDAKAIIEMLAARGASVPIPVDVVCAKEFSATAAATVKDVADVADDDMILDIGPK
HHHHCCCHHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHCCCCEEEECCCH
TAAQLAEQLKTAGTIVWNGPVGVFEFDQFGNGTKVLAEAIAASSGFSIAGGGDTLAAIAK
HHHHHHHHHHHCCEEEECCCCCEEEHHCCCCHHHHHHHHHHHCCCCEEECCCHHHHHHHH
YNIADKVGYISTGGGAFLEFLEGKTLPAVEILEQRAQNQAAGA
HHHHHHCCEEECCHHHHHHHHCCCCCHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
PHVLRLSDLISEGKLAGKRVFIRADLNVPQDDAGNITEDTRIRASVPAVKAALDAGAAV
CCHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCCCCCEEEHHCHHHHHHHHCCCEE
MVTSHLGRPTEGEFKPEDSLAPVAKRLSELLGRDVKLVQNWVDGVEVAPGQVVLLENCRV
EEEHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHCCCEECCCCEEEEECCCC
NKGEKKNSDELAQKMAKLCDVYVNDAFGTAHRAEATTHGIAKFAPIACAGPLLAAELDAL
CCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCHHHCCHHHHHHHHHH
GKALGQPARPLVAIVAGSKVSTKLTILKSLADKVDNLIVGGGIANTFMLAAGLKIGKSLA
HHHHCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHCEEECCCHHHHHHHHHHHHHHHHHH
EADLVGDAKAIIEMLAARGASVPIPVDVVCAKEFSATAAATVKDVADVADDDMILDIGPK
HHHHCCCHHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHCCCCEEEECCCH
TAAQLAEQLKTAGTIVWNGPVGVFEFDQFGNGTKVLAEAIAASSGFSIAGGGDTLAAIAK
HHHHHHHHHHHCCEEEECCCCCEEEHHCCCCHHHHHHHHHHHCCCCEEECCCHHHHHHHH
YNIADKVGYISTGGGAFLEFLEGKTLPAVEILEQRAQNQAAGA
HHHHHHCCEEECCHHHHHHHHCCCCCHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]