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The map label for this gene is dnaA

Identifier: 187927113

GI number: 187927113

Start: 328

End: 1917

Strand: Direct

Name: dnaA

Synonym: Rpic_0001

Alternate gene names: 187927113

Gene position: 328-1917 (Clockwise)

Preceding gene: NA

Following gene: 187927114

Centisome position: 0.01

GC content: 63.27

Gene sequence:

>1590_bases
ATGCAGGATTTCTGGCATGCGGCGTCCGCTCAACTCGAGAGTGAGCTGACGCCGCAACAATTCAAGACGTGGATCAAGCC
GCTGACGCCGCTGTCGTTTGACGAGCAGGCGTGCACGCTGCGGATTGCCGCGCCCAACCGTTTCAAGCTCGACTGGGTCA
AGAGCCAGTTCTCGGGCCGCATCCAGTCGCTCGCGTGCGACTACTGGGAGGCAACGGTCGACGTGCAGTTCGTGCTCGAC
CCGAGCGCCGGCCAGCGCCAGGCGGCGCTTCAGCCGGCGCTCGCGCCAGTGCCGATGCAACCCCTTGGGGCGCAAGCAGG
TCAACCGCGGCAGGCCATGCCGGCCGGCAACGGTGTCTCGCATGACGCCGCAACGTTGCGCCCCGCGCCGTCTGTGTATC
GCGAAACCGCGCTCGCAACGGCGAGCCATGCCGCCGCCGATATCGATGTGCCCGTGATGGACGCCGCCGAGGTCAGCGCC
CGGTCGTACCGCATGCCGCCGCAGGCGCCTGCCGTGGTCGCGACCCTGGCTGCGCCGCCGCAGGCGCACGTGGACGATTC
CGTGCATGAGCGCTCGCGGCTGAACCAGATCCTGACGTTCGACAACTTCGTCACCGGTAAGGCGAACCAGTTGGCGCGCG
CCGCGGCTATCCAGGTCGCCAACAACCCCGGCAAGTCGTACAACCCGCTGTACTTGTACGGCGGCGTGGGCCTGGGCAAG
ACGCACTTGATCCATGCCATCGGCAACTTCATGCTGATGGAGAACCCGCGCGCGCGCATCCGCTACATCCATGCGGAGCA
GTACGTGTCGGATGTGGTGAAGGCGTACCAGCGCAAGGCGTTTGATGATTTCAAACGCTACTACCACTCGCTCGATCTGC
TGCTGATCGATGACATCCAGTTCTTCTCGGGCAAGAACCGCACGCAGGAAGAATTCTTCTACGCGTTCGAGGCGCTGATC
GCCAATCGCGCGCAGGTCATCATCACCAGCGATACGTATCCGAAAGAGATCACGGGCATCGACGACCGCCTGATCTCGCG
CTTCGACTCCGGCCTGACCGTGGCCATTGAGCCGCCCGAGCTGGAGATGCGCGTTGCGATTCTGATGAAGAAGGCGCAGG
CAGAGAACGTGACCGTGCCGGAAGAGGTGGCCTTCTTCGTGGCCAAGCACCTGCGCTCGAACGTGCGTGAGCTGGAAGGC
GCGCTGCGCAAGATCCTGGCGTACTCCAACTTCCACGGCAAAGAGATCACGATCGAGGTCACGCGGGAGGCGCTCAAAGA
CCTGCTGACGGTGCAGAACCGCCAAATTTCGGTGGAAAACATCCAGAAGACCTGCGCGGATTTCTACAACATCAAGGTCG
CGGATATGTACTCCAAGAAGAGGCCGGCCAACATCGCGCGCCCGCGTCAGATCGCCATGTATCTGGCCAAGGAACTCACG
CAGAAGAGCCTGCCCGAGATTGGTGAGCTCTTCGGCGGACGCGACCACACCACGGTGCTGCACGCCGTGCGCAAGATCGC
CGACGAGCGCACCAAAGACGCCCAGCTCAACCACGAGTTGCACGTGCTGGAGCAAACGCTCAAGGGCTGA

Upstream 100 bases:

>100_bases
AAGCCACCCGGTTTCTGGCCACAGCCAGGAGCCCGGCGGCCGGCCCTCCCGGGGACGTCATCAGACGCGTGTGGCGCCGG
TCAAACACCTAACGATAACG

Downstream 100 bases:

>100_bases
CCGCGCGATGGTCAGCAGAGCGCATGGCAACGCCATTCGCCCTGAATCAAGCCTCGACAGACGCCCGCTCGAATGCGGGC
GTCTTTTCATGCACAATAGA

Product: chromosomal replication initiation protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 529; Mature: 529

Protein sequence:

>529_residues
MQDFWHAASAQLESELTPQQFKTWIKPLTPLSFDEQACTLRIAAPNRFKLDWVKSQFSGRIQSLACDYWEATVDVQFVLD
PSAGQRQAALQPALAPVPMQPLGAQAGQPRQAMPAGNGVSHDAATLRPAPSVYRETALATASHAAADIDVPVMDAAEVSA
RSYRMPPQAPAVVATLAAPPQAHVDDSVHERSRLNQILTFDNFVTGKANQLARAAAIQVANNPGKSYNPLYLYGGVGLGK
THLIHAIGNFMLMENPRARIRYIHAEQYVSDVVKAYQRKAFDDFKRYYHSLDLLLIDDIQFFSGKNRTQEEFFYAFEALI
ANRAQVIITSDTYPKEITGIDDRLISRFDSGLTVAIEPPELEMRVAILMKKAQAENVTVPEEVAFFVAKHLRSNVRELEG
ALRKILAYSNFHGKEITIEVTREALKDLLTVQNRQISVENIQKTCADFYNIKVADMYSKKRPANIARPRQIAMYLAKELT
QKSLPEIGELFGGRDHTTVLHAVRKIADERTKDAQLNHELHVLEQTLKG

Sequences:

>Translated_529_residues
MQDFWHAASAQLESELTPQQFKTWIKPLTPLSFDEQACTLRIAAPNRFKLDWVKSQFSGRIQSLACDYWEATVDVQFVLD
PSAGQRQAALQPALAPVPMQPLGAQAGQPRQAMPAGNGVSHDAATLRPAPSVYRETALATASHAAADIDVPVMDAAEVSA
RSYRMPPQAPAVVATLAAPPQAHVDDSVHERSRLNQILTFDNFVTGKANQLARAAAIQVANNPGKSYNPLYLYGGVGLGK
THLIHAIGNFMLMENPRARIRYIHAEQYVSDVVKAYQRKAFDDFKRYYHSLDLLLIDDIQFFSGKNRTQEEFFYAFEALI
ANRAQVIITSDTYPKEITGIDDRLISRFDSGLTVAIEPPELEMRVAILMKKAQAENVTVPEEVAFFVAKHLRSNVRELEG
ALRKILAYSNFHGKEITIEVTREALKDLLTVQNRQISVENIQKTCADFYNIKVADMYSKKRPANIARPRQIAMYLAKELT
QKSLPEIGELFGGRDHTTVLHAVRKIADERTKDAQLNHELHVLEQTLKG
>Mature_529_residues
MQDFWHAASAQLESELTPQQFKTWIKPLTPLSFDEQACTLRIAAPNRFKLDWVKSQFSGRIQSLACDYWEATVDVQFVLD
PSAGQRQAALQPALAPVPMQPLGAQAGQPRQAMPAGNGVSHDAATLRPAPSVYRETALATASHAAADIDVPVMDAAEVSA
RSYRMPPQAPAVVATLAAPPQAHVDDSVHERSRLNQILTFDNFVTGKANQLARAAAIQVANNPGKSYNPLYLYGGVGLGK
THLIHAIGNFMLMENPRARIRYIHAEQYVSDVVKAYQRKAFDDFKRYYHSLDLLLIDDIQFFSGKNRTQEEFFYAFEALI
ANRAQVIITSDTYPKEITGIDDRLISRFDSGLTVAIEPPELEMRVAILMKKAQAENVTVPEEVAFFVAKHLRSNVRELEG
ALRKILAYSNFHGKEITIEVTREALKDLLTVQNRQISVENIQKTCADFYNIKVADMYSKKRPANIARPRQIAMYLAKELT
QKSLPEIGELFGGRDHTTVLHAVRKIADERTKDAQLNHELHVLEQTLKG

Specific function: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box):5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phosph

COG id: COG0593

COG function: function code L; ATPase involved in DNA replication initiation

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dnaA family

Homologues:

Organism=Escherichia coli, GI2367267, Length=337, Percent_Identity=61.7210682492582, Blast_Score=441, Evalue=1e-125,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DNAA_RALPJ (B2UCF1)

Other databases:

- EMBL:   CP001068
- RefSeq:   YP_001897600.1
- GeneID:   6289854
- GenomeReviews:   CP001068_GR
- KEGG:   rpi:Rpic_0001
- HOGENOM:   HBG695666
- OMA:   WPLCLRR
- ProtClustDB:   PRK00149
- GO:   GO:0005737
- HAMAP:   MF_00377
- InterPro:   IPR003593
- InterPro:   IPR001957
- InterPro:   IPR020591
- InterPro:   IPR018312
- InterPro:   IPR013159
- InterPro:   IPR013317
- InterPro:   IPR010921
- Gene3D:   G3DSA:1.10.1750.10
- PRINTS:   PR00051
- SMART:   SM00382
- SMART:   SM00760
- TIGRFAMs:   TIGR00362

Pfam domain/function: PF00308 Bac_DnaA; PF08299 Bac_DnaA_C; SSF48295 Trp_repress_rep

EC number: NA

Molecular weight: Translated: 59132; Mature: 59132

Theoretical pI: Translated: 7.79; Mature: 7.79

Prosite motif: PS01008 DNAA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQDFWHAASAQLESELTPQQFKTWIKPLTPLSFDEQACTLRIAAPNRFKLDWVKSQFSGR
CCCHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCEEEEEECCCCEEHHHHHHHHCCH
IQSLACDYWEATVDVQFVLDPSAGQRQAALQPALAPVPMQPLGAQAGQPRQAMPAGNGVS
HHHHHHHHHEEEEEEEEEECCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
HDAATLRPAPSVYRETALATASHAAADIDVPVMDAAEVSARSYRMPPQAPAVVATLAAPP
CCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCCCCEEEEECCCC
QAHVDDSVHERSRLNQILTFDNFVTGKANQLARAAAIQVANNPGKSYNPLYLYGGVGLGK
CCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHEEECCCCCCCCCEEEECCCCCCH
THLIHAIGNFMLMENPRARIRYIHAEQYVSDVVKAYQRKAFDDFKRYYHSLDLLLIDDIQ
HHHHHHHHHHEEECCCCHHEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECHH
FFSGKNRTQEEFFYAFEALIANRAQVIITSDTYPKEITGIDDRLISRFDSGLTVAIEPPE
HHCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCHHCCCHHHHHHHHCCCCEEEECCCC
LEMRVAILMKKAQAENVTVPEEVAFFVAKHLRSNVRELEGALRKILAYSNFHGKEITIEV
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHH
TREALKDLLTVQNRQISVENIQKTCADFYNIKVADMYSKKRPANIARPRQIAMYLAKELT
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCEEHHHHCCCCCCCCCCHHHHHHHHHHHHH
QKSLPEIGELFGGRDHTTVLHAVRKIADERTKDAQLNHELHVLEQTLKG
HHCCHHHHHHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MQDFWHAASAQLESELTPQQFKTWIKPLTPLSFDEQACTLRIAAPNRFKLDWVKSQFSGR
CCCHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCEEEEEECCCCEEHHHHHHHHCCH
IQSLACDYWEATVDVQFVLDPSAGQRQAALQPALAPVPMQPLGAQAGQPRQAMPAGNGVS
HHHHHHHHHEEEEEEEEEECCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
HDAATLRPAPSVYRETALATASHAAADIDVPVMDAAEVSARSYRMPPQAPAVVATLAAPP
CCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCCCCEEEEECCCC
QAHVDDSVHERSRLNQILTFDNFVTGKANQLARAAAIQVANNPGKSYNPLYLYGGVGLGK
CCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHEEECCCCCCCCCEEEECCCCCCH
THLIHAIGNFMLMENPRARIRYIHAEQYVSDVVKAYQRKAFDDFKRYYHSLDLLLIDDIQ
HHHHHHHHHHEEECCCCHHEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECHH
FFSGKNRTQEEFFYAFEALIANRAQVIITSDTYPKEITGIDDRLISRFDSGLTVAIEPPE
HHCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCHHCCCHHHHHHHHCCCCEEEECCCC
LEMRVAILMKKAQAENVTVPEEVAFFVAKHLRSNVRELEGALRKILAYSNFHGKEITIEV
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHH
TREALKDLLTVQNRQISVENIQKTCADFYNIKVADMYSKKRPANIARPRQIAMYLAKELT
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCEEHHHHCCCCCCCCCCHHHHHHHHHHHHH
QKSLPEIGELFGGRDHTTVLHAVRKIADERTKDAQLNHELHVLEQTLKG
HHCCHHHHHHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA