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The map label for this gene is clpP [H]

Identifier: 187918699

GI number: 187918699

Start: 811987

End: 812577

Strand: Direct

Name: clpP [H]

Synonym: BH0757

Alternate gene names: 187918699

Gene position: 811987-812577 (Clockwise)

Preceding gene: 187918605

Following gene: 187918612

Centisome position: 88.04

GC content: 33.16

Gene sequence:

>591_bases
ATGGATTTTAAAGATATGAAGATGCAGACGGAAATACAGCAATCATTAGAGTTTGCATTAAAGAGTAGATCAATAGTTAT
TACAGGAGAGATTAATAAAGATACTTCTAAGTTATTTCAGGAAAAAATATTATTTTTAGAAGCATCGGATTGCGATAAGC
CGATATTTGTTTACATTGACTCAGAAGGTGGTGATATTGATGCTGGGTTTGCTATTTTTAATATGATACGCTTTGTAAAG
CCTAAGGTTTTTACAATTGGAGTTGGACTTGTGGCAAGTGCTGGTGCTTTAATTTTTTTAGCGGCAGATTCAAATAGTAG
GTTTTCTTTGCCTCATGCGAGATATTTATTGCATCAACCCTTAAGTGGTTTTAAAGGAGTTGCTACAGATATTGAGATTT
ACACAAATGAACTTAATAAAGTTAAGAGTGAACTTAATGATATTGTTGCAAAGGAGACGGGGCAGGAACTTAATAAGGTT
GAAAAGGATACTGATAGGGATTTTTGGTTGGATAGTGAATCTGCAATGCAATATGGTCTTGTCTTTAAGATTGTTACAAC
TAGACTTGAGCTTGAAAAATTTATTTCTTAG

Upstream 100 bases:

>100_bases
TTTTTAGTAGTATGTCTGTCTTATTTTATGTAAACATTTAAAAACCTTTTGTTTTTAATTATAATATGTATCAAATTATA
ATTGTTGAAAAGGTAAGTTT

Downstream 100 bases:

>100_bases
TTTTTTAATGTTATCTTGTAGCTTATCTAAGAGGGATTTTAGCATTTTGGAATTTGGTGTTACTAGTTTTCCAAAAAATT
TTATTTCTTTAAATACATTA

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp 2 [H]

Number of amino acids: Translated: 196; Mature: 196

Protein sequence:

>196_residues
MDFKDMKMQTEIQQSLEFALKSRSIVITGEINKDTSKLFQEKILFLEASDCDKPIFVYIDSEGGDIDAGFAIFNMIRFVK
PKVFTIGVGLVASAGALIFLAADSNSRFSLPHARYLLHQPLSGFKGVATDIEIYTNELNKVKSELNDIVAKETGQELNKV
EKDTDRDFWLDSESAMQYGLVFKIVTTRLELEKFIS

Sequences:

>Translated_196_residues
MDFKDMKMQTEIQQSLEFALKSRSIVITGEINKDTSKLFQEKILFLEASDCDKPIFVYIDSEGGDIDAGFAIFNMIRFVK
PKVFTIGVGLVASAGALIFLAADSNSRFSLPHARYLLHQPLSGFKGVATDIEIYTNELNKVKSELNDIVAKETGQELNKV
EKDTDRDFWLDSESAMQYGLVFKIVTTRLELEKFIS
>Mature_196_residues
MDFKDMKMQTEIQQSLEFALKSRSIVITGEINKDTSKLFQEKILFLEASDCDKPIFVYIDSEGGDIDAGFAIFNMIRFVK
PKVFTIGVGLVASAGALIFLAADSNSRFSLPHARYLLHQPLSGFKGVATDIEIYTNELNKVKSELNDIVAKETGQELNKV
EKDTDRDFWLDSESAMQYGLVFKIVTTRLELEKFIS

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins [H]

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family [H]

Homologues:

Organism=Homo sapiens, GI5174419, Length=166, Percent_Identity=35.5421686746988, Blast_Score=125, Evalue=3e-29,
Organism=Escherichia coli, GI1786641, Length=169, Percent_Identity=44.9704142011834, Blast_Score=164, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI17538017, Length=167, Percent_Identity=32.9341317365269, Blast_Score=118, Evalue=2e-27,
Organism=Drosophila melanogaster, GI20129427, Length=162, Percent_Identity=37.037037037037, Blast_Score=126, Evalue=9e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001907
- InterPro:   IPR018215 [H]

Pfam domain/function: PF00574 CLP_protease [H]

EC number: =3.4.21.92 [H]

Molecular weight: Translated: 22094; Mature: 22094

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: PS00382 CLP_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFKDMKMQTEIQQSLEFALKSRSIVITGEINKDTSKLFQEKILFLEASDCDKPIFVYID
CCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHEEEECCCCCCCEEEEEE
SEGGDIDAGFAIFNMIRFVKPKVFTIGVGLVASAGALIFLAADSNSRFSLPHARYLLHQP
CCCCCCCHHHHHHHHHHHHCCEEEEEEHHHHHCCCEEEEEEECCCCCCCCCHHHHHHHCC
LSGFKGVATDIEIYTNELNKVKSELNDIVAKETGQELNKVEKDTDRDFWLDSESAMQYGL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCHHHHHHHH
VFKIVTTRLELEKFIS
HHHHHHHHHHHHHHCC
>Mature Secondary Structure
MDFKDMKMQTEIQQSLEFALKSRSIVITGEINKDTSKLFQEKILFLEASDCDKPIFVYID
CCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHEEEECCCCCCCEEEEEE
SEGGDIDAGFAIFNMIRFVKPKVFTIGVGLVASAGALIFLAADSNSRFSLPHARYLLHQP
CCCCCCCHHHHHHHHHHHHCCEEEEEEHHHHHCCCEEEEEEECCCCCCCCCHHHHHHHCC
LSGFKGVATDIEIYTNELNKVKSELNDIVAKETGQELNKVEKDTDRDFWLDSESAMQYGL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCHHHHHHHH
VFKIVTTRLELEKFIS
HHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9403685 [H]