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The map label for this gene is pth

Identifier: 187918639

GI number: 187918639

Start: 835410

End: 835976

Strand: Direct

Name: pth

Synonym: BH0787

Alternate gene names: 187918639

Gene position: 835410-835976 (Clockwise)

Preceding gene: 187918701

Following gene: 187918640

Centisome position: 90.58

GC content: 30.34

Gene sequence:

>567_bases
ATGGATTTGTTAATAGTTGGCCTGGGTAATCCCGGGTCTAATTTTTTTCATACTAGACATAATGTTGGTTTTGAACTTGT
AGATAACTTGGTTATAAAGAATGGTCTTTCTTTGAAAAAGGTAAAAAATTATGAATATTCTGATTTTAATTTTGAAAATA
AACGGATAGTTTTAATTAAACCTTTAACTTATATGAATTTGAGTGGCAATATTTTTCCTTCTGTTTTTGCTAAGTTTTAT
ATGAAAATAGCTAATCTGTTAGTTGTGGTTGATAATGTTGATTTGCCTTTGGGAAAGTGTAAACTTAGAAAGGTAGGGGG
TACTTCTACTCATAATGGACTTCGTTCTATTTCTTTAAGCCTTGGAAGTACGAATTATGGTAGGCTTTATATTGGAGTTG
GCAGTAACAATGAATCTAGTCTTAGAGAGTTTGTTCTTGCAAAATTTAGAGGTAGTGAGCTTGAGCGTATTAAAAGTGTA
TTTGAGTTTTTAAGTGAAGAGATATTAGGCATTGATGAGTCTAATTTTGAACATAAAGTTGCAACTATTAATTCTAGTAG
TTTTTGA

Upstream 100 bases:

>100_bases
GGGAGATCAAGTAACTTTTAAGGATATTGTACTTCCTGATAATGTTAAACTTTCTGAAGAGAATGAGAATTCAGTTGTTT
TGCTTGTAAAATAGAGAGTT

Downstream 100 bases:

>100_bases
TGTTTTGGAATGATATAGTAACAAAAATAGAAAGTTTTTACTTTAAAAATTCTCTGCCCAAAGGAAAATCAATTGTTGCT
TTTTCTGGAGGTGCAGATTC

Product: peptidyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH

Number of amino acids: Translated: 188; Mature: 188

Protein sequence:

>188_residues
MDLLIVGLGNPGSNFFHTRHNVGFELVDNLVIKNGLSLKKVKNYEYSDFNFENKRIVLIKPLTYMNLSGNIFPSVFAKFY
MKIANLLVVVDNVDLPLGKCKLRKVGGTSTHNGLRSISLSLGSTNYGRLYIGVGSNNESSLREFVLAKFRGSELERIKSV
FEFLSEEILGIDESNFEHKVATINSSSF

Sequences:

>Translated_188_residues
MDLLIVGLGNPGSNFFHTRHNVGFELVDNLVIKNGLSLKKVKNYEYSDFNFENKRIVLIKPLTYMNLSGNIFPSVFAKFY
MKIANLLVVVDNVDLPLGKCKLRKVGGTSTHNGLRSISLSLGSTNYGRLYIGVGSNNESSLREFVLAKFRGSELERIKSV
FEFLSEEILGIDESNFEHKVATINSSSF
>Mature_188_residues
MDLLIVGLGNPGSNFFHTRHNVGFELVDNLVIKNGLSLKKVKNYEYSDFNFENKRIVLIKPLTYMNLSGNIFPSVFAKFY
MKIANLLVVVDNVDLPLGKCKLRKVGGTSTHNGLRSISLSLGSTNYGRLYIGVGSNNESSLREFVLAKFRGSELERIKSV
FEFLSEEILGIDESNFEHKVATINSSSF

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis

COG id: COG0193

COG function: function code J; Peptidyl-tRNA hydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH family

Homologues:

Organism=Escherichia coli, GI1787455, Length=163, Percent_Identity=36.1963190184049, Blast_Score=71, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6321983, Length=179, Percent_Identity=29.0502793296089, Blast_Score=69, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PTH_BORHD (B2S1C9)

Other databases:

- EMBL:   CP000048
- RefSeq:   YP_001884205.1
- EnsemblBacteria:   EBBORT00000006605
- GeneID:   6276521
- GenomeReviews:   CP000048_GR
- KEGG:   bhr:BH0787
- GeneTree:   EBGT00050000006854
- HOGENOM:   HBG610927
- OMA:   NESGRQV
- ProtClustDB:   PRK05426
- BioCyc:   BHER314723:BH0787-MONOMER
- GO:   GO:0005737
- GO:   GO:0006412
- HAMAP:   MF_00083
- InterPro:   IPR001328
- InterPro:   IPR018171
- Gene3D:   G3DSA:3.40.50.1470
- PANTHER:   PTHR17224
- TIGRFAMs:   TIGR00447

Pfam domain/function: PF01195 Pept_tRNA_hydro; SSF53178 Pept_tRNA_hydro

EC number: =3.1.1.29

Molecular weight: Translated: 21035; Mature: 21035

Theoretical pI: Translated: 9.57; Mature: 9.57

Prosite motif: PS01195 PEPT_TRNA_HYDROL_1; PS01196 PEPT_TRNA_HYDROL_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLLIVGLGNPGSNFFHTRHNVGFELVDNLVIKNGLSLKKVKNYEYSDFNFENKRIVLIK
CCEEEEECCCCCCCCEEECCCCCHHHHHHHHHHCCCCHHHHCCCCCCCCCCCCCEEEEEC
PLTYMNLSGNIFPSVFAKFYMKIANLLVVVDNVDLPLGKCKLRKVGGTSTHNGLRSISLS
CEEEEECCCCCCHHHHHHHHHHHHHHEEEEECCCCCCCCEEEEECCCCCCCCCCEEEEEE
LGSTNYGRLYIGVGSNNESSLREFVLAKFRGSELERIKSVFEFLSEEILGIDESNFEHKV
CCCCCCCEEEEEECCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEE
ATINSSSF
EEECCCCC
>Mature Secondary Structure
MDLLIVGLGNPGSNFFHTRHNVGFELVDNLVIKNGLSLKKVKNYEYSDFNFENKRIVLIK
CCEEEEECCCCCCCCEEECCCCCHHHHHHHHHHCCCCHHHHCCCCCCCCCCCCCEEEEEC
PLTYMNLSGNIFPSVFAKFYMKIANLLVVVDNVDLPLGKCKLRKVGGTSTHNGLRSISLS
CEEEEECCCCCCHHHHHHHHHHHHHHEEEEECCCCCCCCEEEEECCCCCCCCCCEEEEEE
LGSTNYGRLYIGVGSNNESSLREFVLAKFRGSELERIKSVFEFLSEEILGIDESNFEHKV
CCCCCCCEEEEEECCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEE
ATINSSSF
EEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA