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The map label for this gene is pth

Identifier: 187736599

GI number: 187736599

Start: 2583586

End: 2584158

Strand: Direct

Name: pth

Synonym: Amuc_2121

Alternate gene names: 187736599

Gene position: 2583586-2584158 (Clockwise)

Preceding gene: 187736598

Following gene: 187736600

Centisome position: 96.98

GC content: 61.26

Gene sequence:

>573_bases
GTGGATGCACCCGTTAAAATGATCGTGGGCCTGGGCAACCCGGGCAGAACCTATGAAGACACCCGCCATAACGCGGGGTT
CATGGTGCTTGACCGCCTGGCCGCCCGGTGGGGGGCCGTATTCAAGGCGGACAGGCAGCGCAAGTGCGAGGTGGCCGCCG
GCCCCGGCGTCCTGCTGGTGAAACCCTCCACGTTCATGAATGAATCCGGTCTGTGCGTGGGCCCCATGATGCGGTTTTTC
AAACTGGATCCCCGCAGCGTGTTCGTCATTCATGATGAAGTGGATTTCCCCCTGGGCGTGATCAAGCTGCGGGAAAAAGG
CTCCGCAGGCGGCCACAACGGCATTAAATCCCTCATCGCCCACATGGGCACCCAGGAATTCCCGCGCCTCCGTTTCGGCA
TCGGCCAGCCCCGTGGCAAAGGGGAAATGATAGGGCACGTGCTGGGCAAATTCCGCCCGGAGGAACGCGAGCTTCTGGAC
GTGACGCTTGGCAAGGCGGAGGACGCCGTGCTGTACACCATGGAACACGGCATTACCAGGGCAGGCAATATTTTCAACGC
TGTTCCAGGCTGA

Upstream 100 bases:

>100_bases
GGAACGGTTGATTGCTCCGCGGAACGGATGCAGGATGCACCCAGACGCTCCCCGGATTGCAGGAAGCGTCTGTTTTTCAT
CTCTTTCCCTTTTTTCCATT

Downstream 100 bases:

>100_bases
CAGCCGCATGAAAGGCCGCCCCATTTGCGCCATGACGTATCCCTGGACGGGCCGGAGAGCGTTTTTTCCTGAAGCCGGAG
CAGCCCGGGCCGCAGGATGA

Product: Aminoacyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH

Number of amino acids: Translated: 190; Mature: 190

Protein sequence:

>190_residues
MDAPVKMIVGLGNPGRTYEDTRHNAGFMVLDRLAARWGAVFKADRQRKCEVAAGPGVLLVKPSTFMNESGLCVGPMMRFF
KLDPRSVFVIHDEVDFPLGVIKLREKGSAGGHNGIKSLIAHMGTQEFPRLRFGIGQPRGKGEMIGHVLGKFRPEERELLD
VTLGKAEDAVLYTMEHGITRAGNIFNAVPG

Sequences:

>Translated_190_residues
MDAPVKMIVGLGNPGRTYEDTRHNAGFMVLDRLAARWGAVFKADRQRKCEVAAGPGVLLVKPSTFMNESGLCVGPMMRFF
KLDPRSVFVIHDEVDFPLGVIKLREKGSAGGHNGIKSLIAHMGTQEFPRLRFGIGQPRGKGEMIGHVLGKFRPEERELLD
VTLGKAEDAVLYTMEHGITRAGNIFNAVPG
>Mature_190_residues
MDAPVKMIVGLGNPGRTYEDTRHNAGFMVLDRLAARWGAVFKADRQRKCEVAAGPGVLLVKPSTFMNESGLCVGPMMRFF
KLDPRSVFVIHDEVDFPLGVIKLREKGSAGGHNGIKSLIAHMGTQEFPRLRFGIGQPRGKGEMIGHVLGKFRPEERELLD
VTLGKAEDAVLYTMEHGITRAGNIFNAVPG

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis

COG id: COG0193

COG function: function code J; Peptidyl-tRNA hydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH family

Homologues:

Organism=Homo sapiens, GI50897284, Length=171, Percent_Identity=40.9356725146199, Blast_Score=123, Evalue=1e-28,
Organism=Escherichia coli, GI1787455, Length=188, Percent_Identity=40.4255319148936, Blast_Score=118, Evalue=3e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PTH_AKKM8 (B2UPQ2)

Other databases:

- EMBL:   CP001071
- RefSeq:   YP_001878711.1
- GeneID:   6273731
- GenomeReviews:   CP001071_GR
- KEGG:   amu:Amuc_2121
- HOGENOM:   HBG610927
- OMA:   AMHRLHS
- GO:   GO:0005737
- GO:   GO:0006412
- HAMAP:   MF_00083
- InterPro:   IPR001328
- InterPro:   IPR018171
- Gene3D:   G3DSA:3.40.50.1470
- PANTHER:   PTHR17224
- TIGRFAMs:   TIGR00447

Pfam domain/function: PF01195 Pept_tRNA_hydro; SSF53178 Pept_tRNA_hydro

EC number: =3.1.1.29

Molecular weight: Translated: 20815; Mature: 20815

Theoretical pI: Translated: 9.92; Mature: 9.92

Prosite motif: PS01195 PEPT_TRNA_HYDROL_1; PS01196 PEPT_TRNA_HYDROL_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDAPVKMIVGLGNPGRTYEDTRHNAGFMVLDRLAARWGAVFKADRQRKCEVAAGPGVLLV
CCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEECCCCEEEE
KPSTFMNESGLCVGPMMRFFKLDPRSVFVIHDEVDFPLGVIKLREKGSAGGHNGIKSLIA
CCHHHCCCCCCCHHHHHHHHCCCCCEEEEEECCCCCCEEEEEEECCCCCCCHHHHHHHHH
HMGTQEFPRLRFGIGQPRGKGEMIGHVLGKFRPEERELLDVTLGKAEDAVLYTMEHGITR
HCCCCCCCCEEECCCCCCCCHHHHHHHHHCCCCCCHHEEEEECCCCCCEEEEEECCCCCC
AGNIFNAVPG
CCCCCCCCCC
>Mature Secondary Structure
MDAPVKMIVGLGNPGRTYEDTRHNAGFMVLDRLAARWGAVFKADRQRKCEVAAGPGVLLV
CCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEECCCCEEEE
KPSTFMNESGLCVGPMMRFFKLDPRSVFVIHDEVDFPLGVIKLREKGSAGGHNGIKSLIA
CCHHHCCCCCCCHHHHHHHHCCCCCEEEEEECCCCCCEEEEEEECCCCCCCHHHHHHHHH
HMGTQEFPRLRFGIGQPRGKGEMIGHVLGKFRPEERELLDVTLGKAEDAVLYTMEHGITR
HCCCCCCCCEEECCCCCCCCHHHHHHHHHCCCCCCHHEEEEECCCCCCEEEEEECCCCCC
AGNIFNAVPG
CCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA