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The map label for this gene is maeB [H]

Identifier: 187736584

GI number: 187736584

Start: 2562143

End: 2563453

Strand: Reverse

Name: maeB [H]

Synonym: Amuc_2106

Alternate gene names: 187736584

Gene position: 2563453-2562143 (Counterclockwise)

Preceding gene: 187736587

Following gene: 187736554

Centisome position: 96.22

GC content: 58.28

Gene sequence:

>1311_bases
ATGAGTTCCGATATTAGATTAGATGCCTTGCAGTACCATTCCCAGCCCCGCCCCGGCAAGGTGGAAACGCTGCCCTGCAA
GCCCTGCTTTTCACAACGGGATCTGACTCTTGCCTATTCCCCGGGCGTGGCCGAGCCCTGCCTCCGCATTAAAGAGGATC
CTTCTCAAAGCGCCCTGTACACTGGTCGCTCCAATCTGGTGGGCGTAATCACCAACGGCACCGCCGTTCTGGGACTGGGC
AATATCGGTCCGGATGCCTCCAAGCCGGTGATGGAGGGCAAGGGCGTTCTGTTCAAGGTGTTCGCGGATATTGACGTTTT
TGACATTGAGCTGAACGTGAAGGAACCGGAAAAGCTGATTGAGACGATCAAGACCATGGAACCCACTTTCGGCGCCATCA
ATCTGGAGGACATCAAGGCTCCGGAATGCTTCATGGTGGAAGAACGCCTGCGGGAGGAGATGAATATTCCCGTGTTTCAT
GACGACCAGCATGGCACGGCCGTGATTTCCGGCGCCGCCCTGCTGAACGCCGCGGAGTTGACGGGCCGCAAGCTGGAGGA
TATGAAGGTTGTCGTCGTGGGGGCCGGCGCTGCCGGCATTTCCTGCGCCAAGTTCTACATGACGTTAGGGGTGCGTCGCG
AACATATCTACATGTTTGATTCCAAGGGGCTGATTCATACCGGACGCATTGATCTTCATGCCACGAAAGCGCAGTTCTCC
CAGTCGGAAGACTGCTCCCTGGAGGAGGCCCTTACCGGAGCGGACGTGTTCCTGGGGCTGTCCACCAAGGGACTGCTCAC
GCAGGACATGGTGAAGCTCATGGCTCCTTCCCCCATCATTTTCGCCTGTGCGAATCCGGACCCGGAAATTACGTATCAGG
ATGCTAAAAAAGCGCGGCCTGACTGCATTATGGGGTCCGGCCGTTCCGACTGGCCCAACCAGGTGAACAATGTTTCCTGT
TTCCCCTTTATTTTCCGTGCCGCCCTGGATGTGCGCGCTTCCGTCATCAATGAACAGATGAAGATTGCCGCCGCCCGCGC
CCTGGCCGATCTGGCGAAGGAGCCCGTCCCCCAGGAAGTGATTGACCTTTACGGGGGAGCCCCGCTCAGCTTCGGCATCG
ACTACGTGATTCCCAAGCCCATTGATCCCCGCATTATTGAATGGGAGTGCCCGGCGGTAGCCCAGGCGGCCATGATTTCC
GGGGTGGCCCAGTCCCCCATCCGGGATATGGAAGCCTACACGCTGGAATTGCGCAAGCGCATTGCCGCGGCTCGTGAACG
CGTCTCCGGCGTGGTGCGCAGCTATCTTTAA

Upstream 100 bases:

>100_bases
TTTTCCGGAGCGTGTGACGCAATTAATTGATTATTTACTTGAATGCATGTCTGTTCTGTGGTGCAAGCAAGGCTCGATTT
TCTGTTTTTTCATTACAATC

Downstream 100 bases:

>100_bases
CTGGTTTCCGGCGGAAGGCCGGCAACCTCATGCCGTGCAGGAACGTATTTAATGGCAAGGGGGGGAGACTGCGTCAAATG
CCTCTGGAGGCGGAAAAAAG

Product: Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+))

Products: NA

Alternate protein names: NADP-ME [H]

Number of amino acids: Translated: 436; Mature: 435

Protein sequence:

>436_residues
MSSDIRLDALQYHSQPRPGKVETLPCKPCFSQRDLTLAYSPGVAEPCLRIKEDPSQSALYTGRSNLVGVITNGTAVLGLG
NIGPDASKPVMEGKGVLFKVFADIDVFDIELNVKEPEKLIETIKTMEPTFGAINLEDIKAPECFMVEERLREEMNIPVFH
DDQHGTAVISGAALLNAAELTGRKLEDMKVVVVGAGAAGISCAKFYMTLGVRREHIYMFDSKGLIHTGRIDLHATKAQFS
QSEDCSLEEALTGADVFLGLSTKGLLTQDMVKLMAPSPIIFACANPDPEITYQDAKKARPDCIMGSGRSDWPNQVNNVSC
FPFIFRAALDVRASVINEQMKIAAARALADLAKEPVPQEVIDLYGGAPLSFGIDYVIPKPIDPRIIEWECPAVAQAAMIS
GVAQSPIRDMEAYTLELRKRIAAARERVSGVVRSYL

Sequences:

>Translated_436_residues
MSSDIRLDALQYHSQPRPGKVETLPCKPCFSQRDLTLAYSPGVAEPCLRIKEDPSQSALYTGRSNLVGVITNGTAVLGLG
NIGPDASKPVMEGKGVLFKVFADIDVFDIELNVKEPEKLIETIKTMEPTFGAINLEDIKAPECFMVEERLREEMNIPVFH
DDQHGTAVISGAALLNAAELTGRKLEDMKVVVVGAGAAGISCAKFYMTLGVRREHIYMFDSKGLIHTGRIDLHATKAQFS
QSEDCSLEEALTGADVFLGLSTKGLLTQDMVKLMAPSPIIFACANPDPEITYQDAKKARPDCIMGSGRSDWPNQVNNVSC
FPFIFRAALDVRASVINEQMKIAAARALADLAKEPVPQEVIDLYGGAPLSFGIDYVIPKPIDPRIIEWECPAVAQAAMIS
GVAQSPIRDMEAYTLELRKRIAAARERVSGVVRSYL
>Mature_435_residues
SSDIRLDALQYHSQPRPGKVETLPCKPCFSQRDLTLAYSPGVAEPCLRIKEDPSQSALYTGRSNLVGVITNGTAVLGLGN
IGPDASKPVMEGKGVLFKVFADIDVFDIELNVKEPEKLIETIKTMEPTFGAINLEDIKAPECFMVEERLREEMNIPVFHD
DQHGTAVISGAALLNAAELTGRKLEDMKVVVVGAGAAGISCAKFYMTLGVRREHIYMFDSKGLIHTGRIDLHATKAQFSQ
SEDCSLEEALTGADVFLGLSTKGLLTQDMVKLMAPSPIIFACANPDPEITYQDAKKARPDCIMGSGRSDWPNQVNNVSCF
PFIFRAALDVRASVINEQMKIAAARALADLAKEPVPQEVIDLYGGAPLSFGIDYVIPKPIDPRIIEWECPAVAQAAMISG
VAQSPIRDMEAYTLELRKRIAAARERVSGVVRSYL

Specific function: Unknown

COG id: COG0281

COG function: function code C; Malic enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4505145, Length=353, Percent_Identity=25.7790368271955, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1788806, Length=420, Percent_Identity=56.6666666666667, Blast_Score=478, Evalue=1e-136,
Organism=Escherichia coli, GI87081919, Length=399, Percent_Identity=23.8095238095238, Blast_Score=69, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17537199, Length=347, Percent_Identity=29.1066282420749, Blast_Score=73, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6322823, Length=268, Percent_Identity=30.2238805970149, Blast_Score=85, Evalue=2e-17,
Organism=Drosophila melanogaster, GI78707242, Length=341, Percent_Identity=26.6862170087977, Blast_Score=80, Evalue=4e-15,
Organism=Drosophila melanogaster, GI78707238, Length=341, Percent_Identity=26.6862170087977, Blast_Score=80, Evalue=4e-15,
Organism=Drosophila melanogaster, GI78707240, Length=341, Percent_Identity=26.6862170087977, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24646388, Length=348, Percent_Identity=27.2988505747126, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24646386, Length=348, Percent_Identity=27.2988505747126, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI281362674, Length=362, Percent_Identity=25.6906077348066, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI281362672, Length=362, Percent_Identity=25.6906077348066, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI21356279, Length=362, Percent_Identity=25.6906077348066, Blast_Score=70, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015884
- InterPro:   IPR012301
- InterPro:   IPR012302
- InterPro:   IPR012188
- InterPro:   IPR016040
- InterPro:   IPR002505 [H]

Pfam domain/function: PF00390 malic; PF03949 Malic_M; PF01515 PTA_PTB [H]

EC number: =1.1.1.40 [H]

Molecular weight: Translated: 47517; Mature: 47386

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSDIRLDALQYHSQPRPGKVETLPCKPCFSQRDLTLAYSPGVAEPCLRIKEDPSQSALY
CCCCCEEHHHHHCCCCCCCCEEEECCCCCCCCCCEEEEECCCCCCHHHHCCCCCCCCEEE
TGRSNLVGVITNGTAVLGLGNIGPDASKPVMEGKGVLFKVFADIDVFDIELNVKEPEKLI
ECCCCEEEEEECCEEEEEECCCCCCCCCCCCCCCCEEEEEEECCEEEEEEECCCCHHHHH
ETIKTMEPTFGAINLEDIKAPECFMVEERLREEMNIPVFHDDQHGTAVISGAALLNAAEL
HHHHHCCCCCCEEEHHHCCCCCHHHHHHHHHHHCCCCEEECCCCCCEEEEHHHHHHHHHH
TGRKLEDMKVVVVGAGAAGISCAKFYMTLGVRREHIYMFDSKGLIHTGRIDLHATKAQFS
CCCCCCCEEEEEEECCCCHHHHHHHHHHHCCCEEEEEEEECCCEEEECEEEEEECHHHCC
QSEDCSLEEALTGADVFLGLSTKGLLTQDMVKLMAPSPIIFACANPDPEITYQDAKKARP
CCCCCCHHHHHCCCEEEEECCCCCHHHHHHHHHHCCCCEEEEECCCCCCEEECCHHCCCC
DCIMGSGRSDWPNQVNNVSCFPFIFRAALDVRASVINEQMKIAAARALADLAKEPVPQEV
CEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
IDLYGGAPLSFGIDYVIPKPIDPRIIEWECPAVAQAAMISGVAQSPIRDMEAYTLELRKR
HHHHCCCCHHCCCEEECCCCCCCCEEEECCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
IAAARERVSGVVRSYL
HHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SSDIRLDALQYHSQPRPGKVETLPCKPCFSQRDLTLAYSPGVAEPCLRIKEDPSQSALY
CCCCEEHHHHHCCCCCCCCEEEECCCCCCCCCCEEEEECCCCCCHHHHCCCCCCCCEEE
TGRSNLVGVITNGTAVLGLGNIGPDASKPVMEGKGVLFKVFADIDVFDIELNVKEPEKLI
ECCCCEEEEEECCEEEEEECCCCCCCCCCCCCCCCEEEEEEECCEEEEEEECCCCHHHHH
ETIKTMEPTFGAINLEDIKAPECFMVEERLREEMNIPVFHDDQHGTAVISGAALLNAAEL
HHHHHCCCCCCEEEHHHCCCCCHHHHHHHHHHHCCCCEEECCCCCCEEEEHHHHHHHHHH
TGRKLEDMKVVVVGAGAAGISCAKFYMTLGVRREHIYMFDSKGLIHTGRIDLHATKAQFS
CCCCCCCEEEEEEECCCCHHHHHHHHHHHCCCEEEEEEEECCCEEEECEEEEEECHHHCC
QSEDCSLEEALTGADVFLGLSTKGLLTQDMVKLMAPSPIIFACANPDPEITYQDAKKARP
CCCCCCHHHHHCCCEEEEECCCCCHHHHHHHHHHCCCCEEEEECCCCCCEEECCHHCCCC
DCIMGSGRSDWPNQVNNVSCFPFIFRAALDVRASVINEQMKIAAARALADLAKEPVPQEV
CEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
IDLYGGAPLSFGIDYVIPKPIDPRIIEWECPAVAQAAMISGVAQSPIRDMEAYTLELRKR
HHHHCCCCHHCCCEEECCCCCCCCEEEECCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
IAAARERVSGVVRSYL
HHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503; 36376 [H]