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The map label for this gene is rnc [H]

Identifier: 187735104

GI number: 187735104

Start: 707473

End: 708168

Strand: Direct

Name: rnc [H]

Synonym: Amuc_0598

Alternate gene names: 187735104

Gene position: 707473-708168 (Clockwise)

Preceding gene: 187735102

Following gene: 187735105

Centisome position: 26.56

GC content: 59.63

Gene sequence:

>696_bases
ATGAACCACACCGCGCTGGAAGACAAGCTGGGTTACCGTTTCAACAATCCGGATCTGCTCGTTCAGGCCCTTACCCACCC
CAGCACGGACAGCAAGCCGGAAACGCGCCGGGCGTATGAACGGCTGGAATTCCTGGGAGACGCCATCCTGCAGCTGGCCG
TCACACAGTACCTTTACCACCACATGCCCCAATCCCCGGAAGGGGAACTAACCCAGCTGCGCGCCCGGACCGTCAGCCGC
GCCAATCTGGGCAAATACGGCTTTATCCTGGGGCTGGATAAACACATTGCCCTGGGAAAAGGGGAGGAACGGGCCGGCGG
ACGGGGCAAAAATTCCATCATCGCCAACACATTTGAATCCGTCTTCGGAGCCATGTCCCTGGATTCCGACTATGAAACGG
CCAAGGCTGTAGCCCTGCGCGTCCTCCATGAAGCTCTGGATTCCGCGGCCAGCCATCCCAAGGAAATCAACCCCAAGGGG
GAACTCCAGGCTATCCTTCAGGACATCCTGCCCGAAACTCCTTCCTATGAAACGGAAGAAAAAGGGCCGAGAGACGCCGA
AAACCGTTTTGAATCCCGCGTTTTCTGGCATGGTCACGCCATTGGAGCCGGTTCCGGGGCCAGCAAGAGGAAGGCGGAAG
TGGCCGCCGCCGCAGACGCCCTGGACGCCAGGGCATGGCTCCGCATGACCTTGTAA

Upstream 100 bases:

>100_bases
GAGAGGCCGGGATGACGCGGGAAAACAAATTCCGTCCCCGCCGGGAAGCTCCCTCCGTTTGGAGTTGCATTTCCGGAACG
GCGGCCCTAGCATTTCCGGG

Downstream 100 bases:

>100_bases
CCGCCAAAGGGGGACGGGTGGCTATTTTGTCACCCTTAAGCCTTGGACACTCCTGTGGCTGGTTTGATAGACAGAAGCCG
TCTCCGTGAGGAAGAACCTT

Product: Ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III [H]

Number of amino acids: Translated: 231; Mature: 231

Protein sequence:

>231_residues
MNHTALEDKLGYRFNNPDLLVQALTHPSTDSKPETRRAYERLEFLGDAILQLAVTQYLYHHMPQSPEGELTQLRARTVSR
ANLGKYGFILGLDKHIALGKGEERAGGRGKNSIIANTFESVFGAMSLDSDYETAKAVALRVLHEALDSAASHPKEINPKG
ELQAILQDILPETPSYETEEKGPRDAENRFESRVFWHGHAIGAGSGASKRKAEVAAAADALDARAWLRMTL

Sequences:

>Translated_231_residues
MNHTALEDKLGYRFNNPDLLVQALTHPSTDSKPETRRAYERLEFLGDAILQLAVTQYLYHHMPQSPEGELTQLRARTVSR
ANLGKYGFILGLDKHIALGKGEERAGGRGKNSIIANTFESVFGAMSLDSDYETAKAVALRVLHEALDSAASHPKEINPKG
ELQAILQDILPETPSYETEEKGPRDAENRFESRVFWHGHAIGAGSGASKRKAEVAAAADALDARAWLRMTL
>Mature_231_residues
MNHTALEDKLGYRFNNPDLLVQALTHPSTDSKPETRRAYERLEFLGDAILQLAVTQYLYHHMPQSPEGELTQLRARTVSR
ANLGKYGFILGLDKHIALGKGEERAGGRGKNSIIANTFESVFGAMSLDSDYETAKAVALRVLHEALDSAASHPKEINPKG
ELQAILQDILPETPSYETEEKGPRDAENRFESRVFWHGHAIGAGSGASKRKAEVAAAADALDARAWLRMTL

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs [H]

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain [H]

Homologues:

Organism=Homo sapiens, GI155030236, Length=233, Percent_Identity=30.4721030042918, Blast_Score=91, Evalue=8e-19,
Organism=Homo sapiens, GI155030234, Length=233, Percent_Identity=30.4721030042918, Blast_Score=91, Evalue=8e-19,
Organism=Escherichia coli, GI1788920, Length=208, Percent_Identity=36.5384615384615, Blast_Score=114, Evalue=6e-27,
Organism=Caenorhabditis elegans, GI17506883, Length=225, Percent_Identity=28.4444444444444, Blast_Score=69, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI193202651, Length=225, Percent_Identity=28.4444444444444, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17552834, Length=202, Percent_Identity=28.2178217821782, Blast_Score=68, Evalue=4e-12,
Organism=Drosophila melanogaster, GI17137682, Length=226, Percent_Identity=28.3185840707965, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI22026807, Length=84, Percent_Identity=40.4761904761905, Blast_Score=65, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907 [H]

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3 [H]

EC number: =3.1.26.3 [H]

Molecular weight: Translated: 25449; Mature: 25449

Theoretical pI: Translated: 6.61; Mature: 6.61

Prosite motif: PS50137 DS_RBD ; PS00517 RNASE_3_1 ; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNHTALEDKLGYRFNNPDLLVQALTHPSTDSKPETRRAYERLEFLGDAILQLAVTQYLYH
CCCCCCHHHCCCEECCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HMPQSPEGELTQLRARTVSRANLGKYGFILGLDKHIALGKGEERAGGRGKNSIIANTFES
HCCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCEECCCCCCCCCCCCCCHHHHHHHHH
VFGAMSLDSDYETAKAVALRVLHEALDSAASHPKEINPKGELQAILQDILPETPSYETEE
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCCCCCC
KGPRDAENRFESRVFWHGHAIGAGSGASKRKAEVAAAADALDARAWLRMTL
CCCCCHHHHHHHHHEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNHTALEDKLGYRFNNPDLLVQALTHPSTDSKPETRRAYERLEFLGDAILQLAVTQYLYH
CCCCCCHHHCCCEECCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HMPQSPEGELTQLRARTVSRANLGKYGFILGLDKHIALGKGEERAGGRGKNSIIANTFES
HCCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCEECCCCCCCCCCCCCCHHHHHHHHH
VFGAMSLDSDYETAKAVALRVLHEALDSAASHPKEINPKGELQAILQDILPETPSYETEE
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCCCCCC
KGPRDAENRFESRVFWHGHAIGAGSGASKRKAEVAAAADALDARAWLRMTL
CCCCCHHHHHHHHHEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA