Click here to switch to the map view.

The map label for this gene is lpxK [H]

Identifier: 187735081

GI number: 187735081

Start: 672995

End: 674200

Strand: Direct

Name: lpxK [H]

Synonym: Amuc_0575

Alternate gene names: 187735081

Gene position: 672995-674200 (Clockwise)

Preceding gene: 187735080

Following gene: 187735082

Centisome position: 25.26

GC content: 59.2

Gene sequence:

>1206_bases
ATGAAATCCAGATCGGAAGAATTTGAAGAGTGGGGGACGGAAGTCATCTTCGGCCGTGCCAAGGGATTCCGCGCTGCCAT
GATGCGCATGATCCTGCGCGGCGCCTCCTGGCTGTTCAGGCTGGTGGTTCTGGCACGGCTGTATCTGTTTCATTCCAGCA
TCGCCAGGCAGGCCAGGCTGGGAATGCTGGTGGTCAGCGTGGGCAACATCACCGTGGGAGGAACCGGAAAAACCCCGGTG
GTGGAACTGCTGGCCCGCACCCTTACCCGGCGCGGGCGCAAAGTAGCCATCCTGACACGCGGCTACAAGAGCGCAGAGCT
GGATAAACCTCAGGAATGGAGGGACAAGGACGGCAGGCTGCCGGAGAATCTTCCCAAAATCGCCAGCGACGGGAAAACGC
GCTACCTGGGCCCCCTGCATTCCGGAGATGAACCTTTCATGCTCGCCAAAAATCTGGACGGCGTGGCGGTGCTGGTGGAT
AAAAACCGCATCAAGTCCGGCATCTTCGCCATTGAGCACCTGGGGTGCGACACCCTGTTGCTGGACGACGGCATGCAATA
TTTGAAACTGGCGCATGAACTGGATATCGTGCTGGTGGATTGCGGCGCGCCCTTTGGCACCGGAGCCATGCTCCCGCGCG
GCACCCTGCGGGAACCCAGGAGCAGTCTGGCGCGCGCCAGTTACATCATTCTGACCAAATGCGGCGGAAAGCCACAGGAT
GAGCTGATCTCCGCCATCAGGAAGTACAATCCCGTGGCGGACATCATCGTGAGCGACCACGGCCCCCGGTATCTGGAAAA
TGTGTTCACGGGGGAACGCCTTCCTCTGGAGGCCCTCCGGGGGAAATGGGTGGCGTGCCTCAGCGGCATCGCACGTCCGG
AAAGTTTTGAAAACTCCCTGCGCTCCCTGGGCGCCCACGTGGAAATCTGCCGCAGGTTTCCGGACCACCACTGGTTTGAA
CAAACGGAATTGCAGGAATTTTACGACCGCTGCGCAGACCGGGCCATGGACATGATCGTAACTACGGAGAAGGATGCCGT
GCGGCTGGAAAAACCGGAGGAAAAACCGGAGGTCCCTATCTATTTCCTGCGCATTGAGGTGGAAATTTACCAGGGCCGGG
AGGCATGGGAACGTTGTGTAGACCGCATCTGCGGAATTTCAGAACCGCGCCCACGGGATGAATGGATGCCTTCTTCATCC
CTTTGA

Upstream 100 bases:

>100_bases
GCCCGCATGAAAGTGCTGGGCGGCCACGAGACCGTTTACTGCGACAGCTGCCACCGCATCCTCCACTGAAGGAGTTTCCA
GGAACGCCGCCGGGCTTGCC

Downstream 100 bases:

>100_bases
CATGGTTCACGTTTCCTGAGGTTTTCCGGAAATTCACCTCTTTTATGCAGAGAAGGCCGCTTGACTTGCCCGGAAAATCG
TGTGAAACAAAAAGGCAGTA

Product: tetraacyldisaccharide 4'-kinase

Products: NA

Alternate protein names: Lipid A 4'-kinase [H]

Number of amino acids: Translated: 401; Mature: 401

Protein sequence:

>401_residues
MKSRSEEFEEWGTEVIFGRAKGFRAAMMRMILRGASWLFRLVVLARLYLFHSSIARQARLGMLVVSVGNITVGGTGKTPV
VELLARTLTRRGRKVAILTRGYKSAELDKPQEWRDKDGRLPENLPKIASDGKTRYLGPLHSGDEPFMLAKNLDGVAVLVD
KNRIKSGIFAIEHLGCDTLLLDDGMQYLKLAHELDIVLVDCGAPFGTGAMLPRGTLREPRSSLARASYIILTKCGGKPQD
ELISAIRKYNPVADIIVSDHGPRYLENVFTGERLPLEALRGKWVACLSGIARPESFENSLRSLGAHVEICRRFPDHHWFE
QTELQEFYDRCADRAMDMIVTTEKDAVRLEKPEEKPEVPIYFLRIEVEIYQGREAWERCVDRICGISEPRPRDEWMPSSS
L

Sequences:

>Translated_401_residues
MKSRSEEFEEWGTEVIFGRAKGFRAAMMRMILRGASWLFRLVVLARLYLFHSSIARQARLGMLVVSVGNITVGGTGKTPV
VELLARTLTRRGRKVAILTRGYKSAELDKPQEWRDKDGRLPENLPKIASDGKTRYLGPLHSGDEPFMLAKNLDGVAVLVD
KNRIKSGIFAIEHLGCDTLLLDDGMQYLKLAHELDIVLVDCGAPFGTGAMLPRGTLREPRSSLARASYIILTKCGGKPQD
ELISAIRKYNPVADIIVSDHGPRYLENVFTGERLPLEALRGKWVACLSGIARPESFENSLRSLGAHVEICRRFPDHHWFE
QTELQEFYDRCADRAMDMIVTTEKDAVRLEKPEEKPEVPIYFLRIEVEIYQGREAWERCVDRICGISEPRPRDEWMPSSS
L
>Mature_401_residues
MKSRSEEFEEWGTEVIFGRAKGFRAAMMRMILRGASWLFRLVVLARLYLFHSSIARQARLGMLVVSVGNITVGGTGKTPV
VELLARTLTRRGRKVAILTRGYKSAELDKPQEWRDKDGRLPENLPKIASDGKTRYLGPLHSGDEPFMLAKNLDGVAVLVD
KNRIKSGIFAIEHLGCDTLLLDDGMQYLKLAHELDIVLVDCGAPFGTGAMLPRGTLREPRSSLARASYIILTKCGGKPQD
ELISAIRKYNPVADIIVSDHGPRYLENVFTGERLPLEALRGKWVACLSGIARPESFENSLRSLGAHVEICRRFPDHHWFE
QTELQEFYDRCADRAMDMIVTTEKDAVRLEKPEEKPEVPIYFLRIEVEIYQGREAWERCVDRICGISEPRPRDEWMPSSS
L

Specific function: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) [H]

COG id: COG1663

COG function: function code M; Tetraacyldisaccharide-1-P 4'-kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxK family [H]

Homologues:

Organism=Escherichia coli, GI1787144, Length=314, Percent_Identity=30.2547770700637, Blast_Score=112, Evalue=6e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003758 [H]

Pfam domain/function: PF02606 LpxK [H]

EC number: =2.7.1.130 [H]

Molecular weight: Translated: 45372; Mature: 45372

Theoretical pI: Translated: 8.21; Mature: 8.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSRSEEFEEWGTEVIFGRAKGFRAAMMRMILRGASWLFRLVVLARLYLFHSSIARQARL
CCCCHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GMLVVSVGNITVGGTGKTPVVELLARTLTRRGRKVAILTRGYKSAELDKPQEWRDKDGRL
CEEEEEECCEEECCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCHHHHCCCCCC
PENLPKIASDGKTRYLGPLHSGDEPFMLAKNLDGVAVLVDKNRIKSGIFAIEHLGCDTLL
CHHHHHHHCCCCCEEECCCCCCCCCEEEEECCCCEEEEEECHHHHHHHHHHHHCCCCEEE
LDDGMQYLKLAHELDIVLVDCGAPFGTGAMLPRGTLREPRSSLARASYIILTKCGGKPQD
HHCCHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHEEEEEECCCCCCHH
ELISAIRKYNPVADIIVSDHGPRYLENVFTGERLPLEALRGKWVACLSGIARPESFENSL
HHHHHHHHCCCCEEEEECCCCHHHHHHHHCCCCCCHHHHHCHHHHHHHHCCCCHHHHHHH
RSLGAHVEICRRFPDHHWFEQTELQEFYDRCADRAMDMIVTTEKDAVRLEKPEEKPEVPI
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHEEECCCCCEECCCCCCCCCCCE
YFLRIEVEIYQGREAWERCVDRICGISEPRPRDEWMPSSSL
EEEEEEEEEECCHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKSRSEEFEEWGTEVIFGRAKGFRAAMMRMILRGASWLFRLVVLARLYLFHSSIARQARL
CCCCHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GMLVVSVGNITVGGTGKTPVVELLARTLTRRGRKVAILTRGYKSAELDKPQEWRDKDGRL
CEEEEEECCEEECCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCHHHHCCCCCC
PENLPKIASDGKTRYLGPLHSGDEPFMLAKNLDGVAVLVDKNRIKSGIFAIEHLGCDTLL
CHHHHHHHCCCCCEEECCCCCCCCCEEEEECCCCEEEEEECHHHHHHHHHHHHCCCCEEE
LDDGMQYLKLAHELDIVLVDCGAPFGTGAMLPRGTLREPRSSLARASYIILTKCGGKPQD
HHCCHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHEEEEEECCCCCCHH
ELISAIRKYNPVADIIVSDHGPRYLENVFTGERLPLEALRGKWVACLSGIARPESFENSL
HHHHHHHHCCCCEEEEECCCCHHHHHHHHCCCCCCHHHHHCHHHHHHHHCCCCHHHHHHH
RSLGAHVEICRRFPDHHWFEQTELQEFYDRCADRAMDMIVTTEKDAVRLEKPEEKPEVPI
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHEEECCCCCEECCCCCCCCCCCE
YFLRIEVEIYQGREAWERCVDRICGISEPRPRDEWMPSSSL
EEEEEEEEEECCHHHHHHHHHHHHCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA