Click here to switch to the map view.

The map label for this gene is tpiA [H]

Identifier: 187735068

GI number: 187735068

Start: 661692

End: 662456

Strand: Direct

Name: tpiA [H]

Synonym: Amuc_0562

Alternate gene names: 187735068

Gene position: 661692-662456 (Clockwise)

Preceding gene: 187735067

Following gene: 187735069

Centisome position: 24.84

GC content: 57.25

Gene sequence:

>765_bases
ATGTCCCGCAAACCCATCATTGCCGCCAACTGGAAGATGAACATCGGCCCCGCCGAAGGCACCCAGTTCATCGAAAGCTT
CAAAAACCTCATTAAGGGGAAAGACGTCGCGTGTGACGTGGTCATCATCCCTCCCTTCACCACCATTCCCTCCGTGCAGA
ACGCTCTGGGCGGTTGCTCCTGCATCGCCGCCGGAGCCCAGAACGTCTCCCAGTACGACAACGGAGCTTATACCGGTGAA
ATCTCCACCAGCATGCTGAATGAACTGAACCTCAAGTATGTGGTGCTCGGCCACAGCGAACGCCGCCAATATTTCGGAGA
AACGGATGCCATTATCAACTCCAAAATCAAGAAGGCCATCGCCGCAGGCATCACCCCCATTTTCTGCATCGGAGAAACGA
AGGACGAACGCCTGGGGGGCATTTTGGAACCCGTGCTGGAAATCCAGCTCAAGGGCGGCCTCAAGGATCTCACCCCGGAG
GAGGTATCCAACCTGGTCATCGCCTATGAACCCGTCTGGGCCATTGGCACCGGCCTGACCGCAACTTCCAAGGAAGCCCA
AGAAGCCCATTCCTTTATCCGCAAGGTTATTTCCGACGTCTTCGGAGCAGACGCCGCCGCCAAGGTGCGCATCCAGTACG
GCGGCTCCGTAAAACCGGAAAACGTGGAGGAACTCATGGCCCAGCCGGACATTGACGGGGCTCTGGTTGGCGGCGCTTCC
CTGAAGCCGGAATCCTTCGCTGCTCTGGTAACTTCCGCCAAATAA

Upstream 100 bases:

>100_bases
GAGGAAAAATCGGACGGCGCGTATGCGGCCCTTTTGATCTGTGCTTGACCTCAGCTTCAATTTGTCAACAATGCGTGTTC
CTGATTAATATCATTCCATT

Downstream 100 bases:

>100_bases
GCGGAATCCGGCGCCACCCCTTCTACAGGCCGGTCCTTCACGGGACCGGCCTTTTTCATCTCCGGAGCACCGGCCTCGCT
CTTTTCACCCAAGAGCGCAG

Product: Triose-phosphate isomerase

Products: NA

Alternate protein names: TIM; Triose-phosphate isomerase [H]

Number of amino acids: Translated: 254; Mature: 253

Protein sequence:

>254_residues
MSRKPIIAANWKMNIGPAEGTQFIESFKNLIKGKDVACDVVIIPPFTTIPSVQNALGGCSCIAAGAQNVSQYDNGAYTGE
ISTSMLNELNLKYVVLGHSERRQYFGETDAIINSKIKKAIAAGITPIFCIGETKDERLGGILEPVLEIQLKGGLKDLTPE
EVSNLVIAYEPVWAIGTGLTATSKEAQEAHSFIRKVISDVFGADAAAKVRIQYGGSVKPENVEELMAQPDIDGALVGGAS
LKPESFAALVTSAK

Sequences:

>Translated_254_residues
MSRKPIIAANWKMNIGPAEGTQFIESFKNLIKGKDVACDVVIIPPFTTIPSVQNALGGCSCIAAGAQNVSQYDNGAYTGE
ISTSMLNELNLKYVVLGHSERRQYFGETDAIINSKIKKAIAAGITPIFCIGETKDERLGGILEPVLEIQLKGGLKDLTPE
EVSNLVIAYEPVWAIGTGLTATSKEAQEAHSFIRKVISDVFGADAAAKVRIQYGGSVKPENVEELMAQPDIDGALVGGAS
LKPESFAALVTSAK
>Mature_253_residues
SRKPIIAANWKMNIGPAEGTQFIESFKNLIKGKDVACDVVIIPPFTTIPSVQNALGGCSCIAAGAQNVSQYDNGAYTGEI
STSMLNELNLKYVVLGHSERRQYFGETDAIINSKIKKAIAAGITPIFCIGETKDERLGGILEPVLEIQLKGGLKDLTPEE
VSNLVIAYEPVWAIGTGLTATSKEAQEAHSFIRKVISDVFGADAAAKVRIQYGGSVKPENVEELMAQPDIDGALVGGASL
KPESFAALVTSAK

Specific function: Plays an important role in several metabolic pathways. [C]

COG id: COG0149

COG function: function code G; Triosephosphate isomerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the triosephosphate isomerase family [H]

Homologues:

Organism=Homo sapiens, GI226529917, Length=246, Percent_Identity=44.7154471544715, Blast_Score=180, Evalue=1e-45,
Organism=Homo sapiens, GI4507645, Length=246, Percent_Identity=44.7154471544715, Blast_Score=179, Evalue=2e-45,
Organism=Escherichia coli, GI1790353, Length=252, Percent_Identity=44.4444444444444, Blast_Score=198, Evalue=3e-52,
Organism=Caenorhabditis elegans, GI17536593, Length=244, Percent_Identity=45.0819672131148, Blast_Score=191, Evalue=3e-49,
Organism=Saccharomyces cerevisiae, GI6320255, Length=252, Percent_Identity=40.4761904761905, Blast_Score=173, Evalue=3e-44,
Organism=Drosophila melanogaster, GI28572008, Length=245, Percent_Identity=46.1224489795918, Blast_Score=192, Evalue=1e-49,
Organism=Drosophila melanogaster, GI28572006, Length=245, Percent_Identity=46.1224489795918, Blast_Score=192, Evalue=1e-49,
Organism=Drosophila melanogaster, GI28572004, Length=245, Percent_Identity=46.1224489795918, Blast_Score=192, Evalue=2e-49,

Paralogues:

None

Copy number: 1120 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR022896
- InterPro:   IPR000652
- InterPro:   IPR020861 [H]

Pfam domain/function: PF00121 TIM [H]

EC number: =5.3.1.1 [H]

Molecular weight: Translated: 26985; Mature: 26854

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: PS00171 TIM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRKPIIAANWKMNIGPAEGTQFIESFKNLIKGKDVACDVVIIPPFTTIPSVQNALGGCS
CCCCCEEEECCEEECCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCHHHHHCCHH
CIAAGAQNVSQYDNGAYTGEISTSMLNELNLKYVVLGHSERRQYFGETDAIINSKIKKAI
HHHHHHHHHHHCCCCCEECCHHHHHHHHCCEEEEEECCHHHHHHCCCHHHHHHHHHHHHH
AAGITPIFCIGETKDERLGGILEPVLEIQLKGGLKDLTPEEVSNLVIAYEPVWAIGTGLT
HHCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCEEEEECCHHHHCCCCC
ATSKEAQEAHSFIRKVISDVFGADAAAKVRIQYGGSVKPENVEELMAQPDIDGALVGGAS
CCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCHHHHHHCCCCCCEEECCCC
LKPESFAALVTSAK
CCCHHHHHHHCCCC
>Mature Secondary Structure 
SRKPIIAANWKMNIGPAEGTQFIESFKNLIKGKDVACDVVIIPPFTTIPSVQNALGGCS
CCCCEEEECCEEECCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCHHHHHCCHH
CIAAGAQNVSQYDNGAYTGEISTSMLNELNLKYVVLGHSERRQYFGETDAIINSKIKKAI
HHHHHHHHHHHCCCCCEECCHHHHHHHHCCEEEEEECCHHHHHHCCCHHHHHHHHHHHHH
AAGITPIFCIGETKDERLGGILEPVLEIQLKGGLKDLTPEEVSNLVIAYEPVWAIGTGLT
HHCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCEEEEECCHHHHCCCCC
ATSKEAQEAHSFIRKVISDVFGADAAAKVRIQYGGSVKPENVEELMAQPDIDGALVGGAS
CCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCHHHHHHCCCCCCEEECCCC
LKPESFAALVTSAK
CCCHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA