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The map label for this gene is yrkA [H]

Identifier: 187735062

GI number: 187735062

Start: 654455

End: 655786

Strand: Reverse

Name: yrkA [H]

Synonym: Amuc_0555

Alternate gene names: 187735062

Gene position: 655786-654455 (Counterclockwise)

Preceding gene: 187735063

Following gene: 187735061

Centisome position: 24.62

GC content: 54.58

Gene sequence:

>1332_bases
ATGATGCTGGCAGTTGCCGGCTTTATCCTTTTTTTGTTGTTGAATGCGTTTTTTGCGGCAGGCGAGTTCGCCTTGATGAA
GGTTCGTGAAAGCCAGCTGCACGCCGGGGAAGGTGTTCCGGCCCGAACTCGGAAAAAACTGGCCCGGGCGCGGAAGGCTG
CCAAGCATCCTGATCTTTATTTGGCCGCCTGCCAGGCGGGCATTACGCTTTCTTCCCTGGCGTTGGGATTCCTGGGAACG
TTTTTTGTATCGGAACTGACAGCTCCCTTTCTGGTTTCCCTGGGATTGGGAGGCATGGTTTCCGTTTACGGAATCGCTCT
GGCCGTTACATTTATTTTCTTTGCCTGCTGCCAGGTGGTATTTGGGGAGTTTATCCCCAAGGCTATGGCGATGCGCCAGC
CGGACAAGGCCGCCCTGGCGACGGTTCCCCTGCTGTATTTCTTTTATACGGTGTTCAGATATACGGGTATTCTTGGCCTG
ACGGGCGGAATGGCGCGGTTTGTGCTGAAATACCTGCTGGGCATAGACCCCCGTTCCACGGCGTGCACGGTGCACAGCAC
GGATGAATTGATGTATCTGGTGGAAGAAAGCGAACGTTCCCGCGAGCTGACGAAGCAGGAGGCTGAAATTTCCAAAAATG
CCCTTGAACTGAACGATATGTGCGTCAAGGACGTAATGACCCCGCGCTCTGAAGTGGATGTGATGGATTTGACGGCTCCC
TTTGAGGAAAACTGGGAGCTTGCCCGGAAATCCCGCCACACCCGGTTTCCGCTGGTGGAGGGAGACCACCTGGATGAAGT
GAAAGGCTGGGTGCATGTCAAAGATCTGCTCAAACTGGTAGGACGGGAAAATCCGGATCTGAGGAGCGTGCGGCGTGAAT
TGCGCGTGGTGCCGGATACGATGCCCCTGGACAGCCTTCTCACGTTCTTTCTGAAAGAACATGCCCACTTTGCCCTGGTA
GTGGATGAATTCGGTGATTCTATCGGCCTGGTATTCCTGGATGATGTGCTGGAACAGATTGTGGGGGATGACATTCAGGA
CGAGTTTGACCAGGAGGAAATGCGGGAGTTTGTGAAAACCGGCAAGGATACATATGCCGTCAATGGGGCTATTACCCTGT
TTGACCTGGCAGATTACCTGCCTGAAATGGATTTGGATTGTCCGGGCGTTACTACGCTGGGCGGTTACGTAATCAGCCGG
ATGGGTTATATTCCGGAAGAAGGGGAGGAATTGCGGATTGGCCGCTACCGGGCTGTGGTGACGGGGTCTGACGGCAGGAG
AATCACGCAGATTCTGCTGGCCCGCCTTCCGGAGGAACAGGAGGAGGAATAG

Upstream 100 bases:

>100_bases
ATATATTATTTGAATCAGAATGAATGATCCGGATCCTCTGAGTATTCTTGCGGCCTTCGGGGCCGCTGAAGCGCCCGGTG
CAGGCCCGGCGCTGGGTGGG

Downstream 100 bases:

>100_bases
CGCCATGAAGGAAAAACCGCATCCGGATATGAGTTTTGAGATGGAGGCCCGGGCCTCCGGTTTTCTTTGCGTGGCTGGAG
TGGATGAGGCCGGGCGCGGG

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 443; Mature: 443

Protein sequence:

>443_residues
MMLAVAGFILFLLLNAFFAAGEFALMKVRESQLHAGEGVPARTRKKLARARKAAKHPDLYLAACQAGITLSSLALGFLGT
FFVSELTAPFLVSLGLGGMVSVYGIALAVTFIFFACCQVVFGEFIPKAMAMRQPDKAALATVPLLYFFYTVFRYTGILGL
TGGMARFVLKYLLGIDPRSTACTVHSTDELMYLVEESERSRELTKQEAEISKNALELNDMCVKDVMTPRSEVDVMDLTAP
FEENWELARKSRHTRFPLVEGDHLDEVKGWVHVKDLLKLVGRENPDLRSVRRELRVVPDTMPLDSLLTFFLKEHAHFALV
VDEFGDSIGLVFLDDVLEQIVGDDIQDEFDQEEMREFVKTGKDTYAVNGAITLFDLADYLPEMDLDCPGVTTLGGYVISR
MGYIPEEGEELRIGRYRAVVTGSDGRRITQILLARLPEEQEEE

Sequences:

>Translated_443_residues
MMLAVAGFILFLLLNAFFAAGEFALMKVRESQLHAGEGVPARTRKKLARARKAAKHPDLYLAACQAGITLSSLALGFLGT
FFVSELTAPFLVSLGLGGMVSVYGIALAVTFIFFACCQVVFGEFIPKAMAMRQPDKAALATVPLLYFFYTVFRYTGILGL
TGGMARFVLKYLLGIDPRSTACTVHSTDELMYLVEESERSRELTKQEAEISKNALELNDMCVKDVMTPRSEVDVMDLTAP
FEENWELARKSRHTRFPLVEGDHLDEVKGWVHVKDLLKLVGRENPDLRSVRRELRVVPDTMPLDSLLTFFLKEHAHFALV
VDEFGDSIGLVFLDDVLEQIVGDDIQDEFDQEEMREFVKTGKDTYAVNGAITLFDLADYLPEMDLDCPGVTTLGGYVISR
MGYIPEEGEELRIGRYRAVVTGSDGRRITQILLARLPEEQEEE
>Mature_443_residues
MMLAVAGFILFLLLNAFFAAGEFALMKVRESQLHAGEGVPARTRKKLARARKAAKHPDLYLAACQAGITLSSLALGFLGT
FFVSELTAPFLVSLGLGGMVSVYGIALAVTFIFFACCQVVFGEFIPKAMAMRQPDKAALATVPLLYFFYTVFRYTGILGL
TGGMARFVLKYLLGIDPRSTACTVHSTDELMYLVEESERSRELTKQEAEISKNALELNDMCVKDVMTPRSEVDVMDLTAP
FEENWELARKSRHTRFPLVEGDHLDEVKGWVHVKDLLKLVGRENPDLRSVRRELRVVPDTMPLDSLLTFFLKEHAHFALV
VDEFGDSIGLVFLDDVLEQIVGDDIQDEFDQEEMREFVKTGKDTYAVNGAITLFDLADYLPEMDLDCPGVTTLGGYVISR
MGYIPEEGEELRIGRYRAVVTGSDGRRITQILLARLPEEQEEE

Specific function: Unknown

COG id: COG1253

COG function: function code R; Hemolysins and related proteins containing CBS domains

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI310128564, Length=387, Percent_Identity=31.266149870801, Blast_Score=204, Evalue=2e-52,
Organism=Homo sapiens, GI40068055, Length=361, Percent_Identity=25.207756232687, Blast_Score=76, Evalue=6e-14,
Organism=Homo sapiens, GI40068053, Length=361, Percent_Identity=25.207756232687, Blast_Score=76, Evalue=6e-14,
Organism=Homo sapiens, GI94681046, Length=350, Percent_Identity=25.1428571428571, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI87082033, Length=240, Percent_Identity=33.3333333333333, Blast_Score=126, Evalue=3e-30,
Organism=Escherichia coli, GI1790664, Length=449, Percent_Identity=23.6080178173719, Blast_Score=109, Evalue=3e-25,
Organism=Escherichia coli, GI145693175, Length=409, Percent_Identity=25.4278728606357, Blast_Score=106, Evalue=4e-24,
Organism=Escherichia coli, GI1786879, Length=257, Percent_Identity=30.7392996108949, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1788119, Length=349, Percent_Identity=27.7936962750716, Blast_Score=81, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016169
- InterPro:   IPR000644
- InterPro:   IPR002550
- InterPro:   IPR005170 [H]

Pfam domain/function: PF00571 CBS; PF03471 CorC_HlyC; PF01595 DUF21 [H]

EC number: NA

Molecular weight: Translated: 49513; Mature: 49513

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMLAVAGFILFLLLNAFFAAGEFALMKVRESQLHAGEGVPARTRKKLARARKAAKHPDLY
CHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCHH
LAACQAGITLSSLALGFLGTFFVSELTAPFLVSLGLGGMVSVYGIALAVTFIFFACCQVV
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
FGEFIPKAMAMRQPDKAALATVPLLYFFYTVFRYTGILGLTGGMARFVLKYLLGIDPRST
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCC
ACTVHSTDELMYLVEESERSRELTKQEAEISKNALELNDMCVKDVMTPRSEVDVMDLTAP
EEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCC
FEENWELARKSRHTRFPLVEGDHLDEVKGWVHVKDLLKLVGRENPDLRSVRRELRVVPDT
CCCCHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCC
MPLDSLLTFFLKEHAHFALVVDEFGDSIGLVFLDDVLEQIVGDDIQDEFDQEEMREFVKT
CCHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCHHHHCCHHHHHHHHHC
GKDTYAVNGAITLFDLADYLPEMDLDCPGVTTLGGYVISRMGYIPEEGEELRIGRYRAVV
CCCCEEECCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCEEECEEEEEE
TGSDGRRITQILLARLPEEQEEE
ECCCCHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MMLAVAGFILFLLLNAFFAAGEFALMKVRESQLHAGEGVPARTRKKLARARKAAKHPDLY
CHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCHH
LAACQAGITLSSLALGFLGTFFVSELTAPFLVSLGLGGMVSVYGIALAVTFIFFACCQVV
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
FGEFIPKAMAMRQPDKAALATVPLLYFFYTVFRYTGILGLTGGMARFVLKYLLGIDPRST
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCC
ACTVHSTDELMYLVEESERSRELTKQEAEISKNALELNDMCVKDVMTPRSEVDVMDLTAP
EEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCC
FEENWELARKSRHTRFPLVEGDHLDEVKGWVHVKDLLKLVGRENPDLRSVRRELRVVPDT
CCCCHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCC
MPLDSLLTFFLKEHAHFALVVDEFGDSIGLVFLDDVLEQIVGDDIQDEFDQEEMREFVKT
CCHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCHHHHCCHHHHHHHHHC
GKDTYAVNGAITLFDLADYLPEMDLDCPGVTTLGGYVISRMGYIPEEGEELRIGRYRAVV
CCCCEEECCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCEEECEEEEEE
TGSDGRRITQILLARLPEEQEEE
ECCCCHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9308178; 9384377; 8969508; 7608059 [H]