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The map label for this gene is trpC [H]

Identifier: 187735059

GI number: 187735059

Start: 652489

End: 653274

Strand: Direct

Name: trpC [H]

Synonym: Amuc_0552

Alternate gene names: 187735059

Gene position: 652489-653274 (Clockwise)

Preceding gene: 187735058

Following gene: 187735065

Centisome position: 24.49

GC content: 58.4

Gene sequence:

>786_bases
ATGGATTATTTAAACAGTATTCTGGAGCGCAAACGCGCCGATTTGAAAAAACTTCTTCCCCTGGAAGGAAAATTACGGGC
CTCCGCCATCCAGCGGAACGACTACGCGGGATTCCGCACCGCGGCGGACCTTGGGGAAACCCGCCTCTCCGTAATTCCGG
AGATATCCAGGGTACATCCCGCCCTCCGCCTCCGGGAAGCAGCCCAGGATATCCGGCACATGTACGGCATGTTCCTCCAG
GGCGGAGCGCAGGGCATTTCCATCGCTGTGGAACCGGAAGTATACGGCGGGTCATGGGACATGGTTTCCACTGTTTCCAG
AATCAGTTCCATTCCCGTCATGGCGCGCGACGTGTTCATTCATCCCGCCATGATCTGCCAGGCCATCGTCTCGGGGGCGG
ATGCCGTCAATCTGGTGGCGGCCGCCCTGCCGGCAAAGGATTTGTCGGAGCTGTACCGCATGGCTTCCGGGCTGGGATTG
GACGTGATGATGGAGGTCCATACCCTGAAGGAGCTTGAAACCGTCATGGATCTGGAAGCGGAATTCATCTGCATCAACAA
TGCAGACCCGCACACTCTCCAGGCCAATCCTGCAGTCACGGAGAAACTCATTGAAGAAATACCCGCCTCCGTCACTGTCC
TGTCCGCAGGGGGCATCCGCACCGTGGAAGACGCGCGCCGCATGCTGGACGCAGGAGCCAATGGCGTCCTTCTCCAAGAC
GAACTTGCCCGCATGGATATTCCCCAGGATTTCATGGAGGCCATTCTGGCTCTCCGGACGGACTGA

Upstream 100 bases:

>100_bases
AAAGCGAAAGGTTTGGGAGGATATGCTGTGTGTCATGGAACAGGCAGGCCTGCCCATCTCCGAAAAACAACGTTCCTATT
TCCTGCCCAAAAAGTAATAT

Downstream 100 bases:

>100_bases
GTTTCCACTCCCTCTATATTATCATAGAAAAACATCTGCATCCGCATGGGGAAATGCGGGGCTGAAGAGATTGTCCCGTC
CACTGCGGCAGGGCTTCGCG

Product: Indole-3-glycerol-phosphate synthase

Products: NA

Alternate protein names: IGPS [H]

Number of amino acids: Translated: 261; Mature: 261

Protein sequence:

>261_residues
MDYLNSILERKRADLKKLLPLEGKLRASAIQRNDYAGFRTAADLGETRLSVIPEISRVHPALRLREAAQDIRHMYGMFLQ
GGAQGISIAVEPEVYGGSWDMVSTVSRISSIPVMARDVFIHPAMICQAIVSGADAVNLVAAALPAKDLSELYRMASGLGL
DVMMEVHTLKELETVMDLEAEFICINNADPHTLQANPAVTEKLIEEIPASVTVLSAGGIRTVEDARRMLDAGANGVLLQD
ELARMDIPQDFMEAILALRTD

Sequences:

>Translated_261_residues
MDYLNSILERKRADLKKLLPLEGKLRASAIQRNDYAGFRTAADLGETRLSVIPEISRVHPALRLREAAQDIRHMYGMFLQ
GGAQGISIAVEPEVYGGSWDMVSTVSRISSIPVMARDVFIHPAMICQAIVSGADAVNLVAAALPAKDLSELYRMASGLGL
DVMMEVHTLKELETVMDLEAEFICINNADPHTLQANPAVTEKLIEEIPASVTVLSAGGIRTVEDARRMLDAGANGVLLQD
ELARMDIPQDFMEAILALRTD
>Mature_261_residues
MDYLNSILERKRADLKKLLPLEGKLRASAIQRNDYAGFRTAADLGETRLSVIPEISRVHPALRLREAAQDIRHMYGMFLQ
GGAQGISIAVEPEVYGGSWDMVSTVSRISSIPVMARDVFIHPAMICQAIVSGADAVNLVAAALPAKDLSELYRMASGLGL
DVMMEVHTLKELETVMDLEAEFICINNADPHTLQANPAVTEKLIEEIPASVTVLSAGGIRTVEDARRMLDAGANGVLLQD
ELARMDIPQDFMEAILALRTD

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpC family [H]

Homologues:

Organism=Escherichia coli, GI87081863, Length=164, Percent_Identity=31.0975609756098, Blast_Score=69, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6322638, Length=274, Percent_Identity=26.2773722627737, Blast_Score=89, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00218 IGPS [H]

EC number: =4.1.1.48 [H]

Molecular weight: Translated: 28483; Mature: 28483

Theoretical pI: Translated: 4.64; Mature: 4.64

Prosite motif: PS00912 DHODEHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDYLNSILERKRADLKKLLPLEGKLRASAIQRNDYAGFRTAADLGETRLSVIPEISRVHP
CCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCHHHHHH
ALRLREAAQDIRHMYGMFLQGGAQGISIAVEPEVYGGSWDMVSTVSRISSIPVMARDVFI
HHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCEECCCHHHHHHHHHHHHCCHHHHHHHH
HPAMICQAIVSGADAVNLVAAALPAKDLSELYRMASGLGLDVMMEVHTLKELETVMDLEA
HHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCC
EFICINNADPHTLQANPAVTEKLIEEIPASVTVLSAGGIRTVEDARRMLDAGANGVLLQD
CEEEECCCCCCEEECCHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHCCCCCEEEHH
ELARMDIPQDFMEAILALRTD
HHHHCCCCHHHHHHHHHHCCC
>Mature Secondary Structure
MDYLNSILERKRADLKKLLPLEGKLRASAIQRNDYAGFRTAADLGETRLSVIPEISRVHP
CCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCHHHHHH
ALRLREAAQDIRHMYGMFLQGGAQGISIAVEPEVYGGSWDMVSTVSRISSIPVMARDVFI
HHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCEECCCHHHHHHHHHHHHCCHHHHHHHH
HPAMICQAIVSGADAVNLVAAALPAKDLSELYRMASGLGLDVMMEVHTLKELETVMDLEA
HHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCC
EFICINNADPHTLQANPAVTEKLIEEIPASVTVLSAGGIRTVEDARRMLDAGANGVLLQD
CEEEECCCCCCEEECCHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHCCCCCEEEHH
ELARMDIPQDFMEAILALRTD
HHHHCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA