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The map label for this gene is purL [H]

Identifier: 187735041

GI number: 187735041

Start: 628360

End: 630762

Strand: Direct

Name: purL [H]

Synonym: Amuc_0534

Alternate gene names: 187735041

Gene position: 628360-630762 (Clockwise)

Preceding gene: 187735040

Following gene: 187735042

Centisome position: 23.59

GC content: 60.55

Gene sequence:

>2403_bases
ATGTCCGCCAAAACCTACCGAACCGTTCCCGTGAGGAACCTGAGCAGCGACGAACTGCTTGAGCTCAGCAAGAAACAGAA
GCTTTCCCTGTCCCGTGAAGACATGGAAGTCGTCCAGCAGATTTTCCGGGAAATCGACCGCGACCCCACTGACGTGGAAC
TGGAAGTAATCGCCCAGACGTGGTCGGAACACTGCAAACACCGCATCTTCTCCGCCTCCATCAGCCACAGCGTCAACGGC
GGCGCACCGGAGACGGTGAACAGCCTGTTCAAGACCTACATCAAGAAGCCTTCCGAAAAGATCATGGAACGCAAACCGGG
CTTCGTGCTCAGCGCGTTTGACGACAATGCCGGCTTCATCGCCCTGGACGACAACCTGGCCGTCTGCCTGAAGGCGGAAA
CGCACAACCACCCCTCCGCCATTGAACCGTACGCGGGGGCCAACACCGGGCTGGGCGGCGTTATCCGCGACATCCTGGGC
GCAGGCAAGGGTGCCAAGCCCATCGCCTCCCTGGATGTCTTCTGCTTCGGCGCTCCGGACACGAATCCGGCAGACATCAC
CGCCCCGGACGTCATCCACCCCCTGGGCATCATGCGCGGCGTGGTGCGCGGCGTGCGCGACTACGGCAACCGCATGGGCA
TTCCCACCGTCAACGGCGCCATCCAGTTTGACCCCACGTACATTTACAACCCCCTCGTCTTCTGCGGCACCGCCGGCGTG
ATTCCGCGCGGCGACATCCTGAAGGAAATGCGTCCCGGCCTCAAGGTCATCGTCATCGGCGGGCGCACGGGACGGGACGG
CCTCAAGGGAGCCACGTTCTCTTCCGCCGCTCTGGATGAAGCCTCCCATGAGGAAGACTTCACCGCCGTGCAAATCGGTA
ACCCGATTGAAGAGAAGAAAACGCTGGACTTCATTCTGGAAGCGCGCGAACGCGGCCTCATCGTCTTTATTACGGACTGC
GGCGCCGGCGGCTTCTCTTCCGCCGCCGGGGAAATGCTCTCCGTCACGGGCGGTGAAATTTTCCTGGACAACGCCCCTCT
CAAGGAACCGGGCCTCATCTCCTGGGAAATCTTCCTGTCGGAATCCCAGGAACGCATGGTTATGGCCGTGGAGGAAAAAG
ACCTTCCGGAACTCCGGAAGCTGGCAGACACCTTCCAGACGGAACTGACCGTCCTAGGCCATTCCGACGATACGGGAATC
CTGAAGGTCTGGCACAAGGGGGAACTCGTCTGCTGCCTGGACAACTCCAAGCTGCATGACGCCCCCATCAAGAAGCTGGA
ATCCGTATTCACTCCCGGCAAGGCGCTCACGGGCCAGCCCCTCCCGGACAAGGATCTGAATAAATCCCTGGAAACCGTGA
TGGGGGATTTCGCCATCGTTTCCCGGGAACCCATCATCCGCGAGTATGACCACGAGGTGCAGGGCAACACCATCCTGAAG
CCTCTGGCGGGCGCCCAGGCGGACGCTCCGCAGGACGGCTCCGTGGTGGATATCGACGGCTCGGACAAATGCATGGCCAT
GGCTTGCGCCATTCTTCCGGAATGGGGCAAAACGGATCCCTACGCCATGGGTACCGGCACCGTGGATGAATGTGTGCGCC
AGCTCATCCTGGTTGGCTCCAACCCGGACAAAATCGGCCTGCTGGACAACTTCTGCATGGGTAATCCGGAAGATCCGGCG
GAACTCGGCCGCCTGGTGGAATGCGTGAAAGCCATCGCCAAGGCGGCGGACGCGTACAATGCCCCCTTCATTTCCGGCAA
GGACTCCTTCTACAACTATTTTGAAACGGAAGACGGCCCTATCAACGTGCCCGTCACCTTCCTCTGCTCCGGCTTTGGTG
TGGTGGAAAACCCGGACCACGTCATCGGTTCTTCCCTGAGGCGGAGCAACAGCCTGCTGTACCTCATCGGCCATACGGAA
GATGAAATGGGCGGTTCCGTCTTCGCCCGCACCCACGGGGTGGAAGACGGCAAGGTTCCCCAGACGGACTGCGCCGCGAA
CATGGAACTGTACAAAGCCTACTACGGCGCCCTGACTTCCGGTCTGGTGCTCTCCGCCCATGACGTTTCCGAAGGCGGCC
TGGCCGTCACGGCGGCGGAAATGGCCTTTTCCGGCAAGGGAGGCGTTCGGCTGGATCTCACGAAAGTACCGACCGTCAAC
GGCTGGAAATCCCCCGCAGTGCCTCTGTTCAGTGAAAGCACGGGCCGCATCCTTGTGGAGGTGGATCCGGAATTCGCCGC
GGATTTTGAAACGGCTATGGACGGCTTCCCCTGCGCCTGCATCGGCGGTGTTACGGAGGAAAAGCGTCTCACGGCCACCT
GCTGCGGCGGAGAAAAGGTGCTGGATTGCGACATAGCCAACCTCAAAAAACTCTGGAAGGACGGACTTACCCCCTATTAT
TGA

Upstream 100 bases:

>100_bases
GGGAGACAAGGAAACCCTGGCGGCGCGCTTTGCCAAGGACGTCTGCAACCCCGCCATTCACAACTGGACCATCGCCTAAC
CCTTTTCCTTTCCCATCCAC

Downstream 100 bases:

>100_bases
CCTCCTGAAACCGGCATCTTATCAAACCATCGATTTATTTCTACCAATATGCCTCACGCACTTTTACTGAAATACCCCGG
CACCAACTGCGATGTGGAAA

Product: phosphoribosylformylglycinamidine synthase II

Products: NA

Alternate protein names: Phosphoribosylformylglycinamidine synthase II; FGAM synthase II [H]

Number of amino acids: Translated: 800; Mature: 799

Protein sequence:

>800_residues
MSAKTYRTVPVRNLSSDELLELSKKQKLSLSREDMEVVQQIFREIDRDPTDVELEVIAQTWSEHCKHRIFSASISHSVNG
GAPETVNSLFKTYIKKPSEKIMERKPGFVLSAFDDNAGFIALDDNLAVCLKAETHNHPSAIEPYAGANTGLGGVIRDILG
AGKGAKPIASLDVFCFGAPDTNPADITAPDVIHPLGIMRGVVRGVRDYGNRMGIPTVNGAIQFDPTYIYNPLVFCGTAGV
IPRGDILKEMRPGLKVIVIGGRTGRDGLKGATFSSAALDEASHEEDFTAVQIGNPIEEKKTLDFILEARERGLIVFITDC
GAGGFSSAAGEMLSVTGGEIFLDNAPLKEPGLISWEIFLSESQERMVMAVEEKDLPELRKLADTFQTELTVLGHSDDTGI
LKVWHKGELVCCLDNSKLHDAPIKKLESVFTPGKALTGQPLPDKDLNKSLETVMGDFAIVSREPIIREYDHEVQGNTILK
PLAGAQADAPQDGSVVDIDGSDKCMAMACAILPEWGKTDPYAMGTGTVDECVRQLILVGSNPDKIGLLDNFCMGNPEDPA
ELGRLVECVKAIAKAADAYNAPFISGKDSFYNYFETEDGPINVPVTFLCSGFGVVENPDHVIGSSLRRSNSLLYLIGHTE
DEMGGSVFARTHGVEDGKVPQTDCAANMELYKAYYGALTSGLVLSAHDVSEGGLAVTAAEMAFSGKGGVRLDLTKVPTVN
GWKSPAVPLFSESTGRILVEVDPEFAADFETAMDGFPCACIGGVTEEKRLTATCCGGEKVLDCDIANLKKLWKDGLTPYY

Sequences:

>Translated_800_residues
MSAKTYRTVPVRNLSSDELLELSKKQKLSLSREDMEVVQQIFREIDRDPTDVELEVIAQTWSEHCKHRIFSASISHSVNG
GAPETVNSLFKTYIKKPSEKIMERKPGFVLSAFDDNAGFIALDDNLAVCLKAETHNHPSAIEPYAGANTGLGGVIRDILG
AGKGAKPIASLDVFCFGAPDTNPADITAPDVIHPLGIMRGVVRGVRDYGNRMGIPTVNGAIQFDPTYIYNPLVFCGTAGV
IPRGDILKEMRPGLKVIVIGGRTGRDGLKGATFSSAALDEASHEEDFTAVQIGNPIEEKKTLDFILEARERGLIVFITDC
GAGGFSSAAGEMLSVTGGEIFLDNAPLKEPGLISWEIFLSESQERMVMAVEEKDLPELRKLADTFQTELTVLGHSDDTGI
LKVWHKGELVCCLDNSKLHDAPIKKLESVFTPGKALTGQPLPDKDLNKSLETVMGDFAIVSREPIIREYDHEVQGNTILK
PLAGAQADAPQDGSVVDIDGSDKCMAMACAILPEWGKTDPYAMGTGTVDECVRQLILVGSNPDKIGLLDNFCMGNPEDPA
ELGRLVECVKAIAKAADAYNAPFISGKDSFYNYFETEDGPINVPVTFLCSGFGVVENPDHVIGSSLRRSNSLLYLIGHTE
DEMGGSVFARTHGVEDGKVPQTDCAANMELYKAYYGALTSGLVLSAHDVSEGGLAVTAAEMAFSGKGGVRLDLTKVPTVN
GWKSPAVPLFSESTGRILVEVDPEFAADFETAMDGFPCACIGGVTEEKRLTATCCGGEKVLDCDIANLKKLWKDGLTPYY
>Mature_799_residues
SAKTYRTVPVRNLSSDELLELSKKQKLSLSREDMEVVQQIFREIDRDPTDVELEVIAQTWSEHCKHRIFSASISHSVNGG
APETVNSLFKTYIKKPSEKIMERKPGFVLSAFDDNAGFIALDDNLAVCLKAETHNHPSAIEPYAGANTGLGGVIRDILGA
GKGAKPIASLDVFCFGAPDTNPADITAPDVIHPLGIMRGVVRGVRDYGNRMGIPTVNGAIQFDPTYIYNPLVFCGTAGVI
PRGDILKEMRPGLKVIVIGGRTGRDGLKGATFSSAALDEASHEEDFTAVQIGNPIEEKKTLDFILEARERGLIVFITDCG
AGGFSSAAGEMLSVTGGEIFLDNAPLKEPGLISWEIFLSESQERMVMAVEEKDLPELRKLADTFQTELTVLGHSDDTGIL
KVWHKGELVCCLDNSKLHDAPIKKLESVFTPGKALTGQPLPDKDLNKSLETVMGDFAIVSREPIIREYDHEVQGNTILKP
LAGAQADAPQDGSVVDIDGSDKCMAMACAILPEWGKTDPYAMGTGTVDECVRQLILVGSNPDKIGLLDNFCMGNPEDPAE
LGRLVECVKAIAKAADAYNAPFISGKDSFYNYFETEDGPINVPVTFLCSGFGVVENPDHVIGSSLRRSNSLLYLIGHTED
EMGGSVFARTHGVEDGKVPQTDCAANMELYKAYYGALTSGLVLSAHDVSEGGLAVTAAEMAFSGKGGVRLDLTKVPTVNG
WKSPAVPLFSESTGRILVEVDPEFAADFETAMDGFPCACIGGVTEEKRLTATCCGGEKVLDCDIANLKKLWKDGLTPYY

Specific function: Unknown

COG id: COG0046

COG function: function code F; Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGAMS family [H]

Homologues:

Organism=Homo sapiens, GI31657129, Length=858, Percent_Identity=24.7086247086247, Blast_Score=173, Evalue=6e-43,
Organism=Escherichia coli, GI48994899, Length=773, Percent_Identity=27.2962483829237, Blast_Score=205, Evalue=1e-53,
Organism=Caenorhabditis elegans, GI17553022, Length=817, Percent_Identity=25.5813953488372, Blast_Score=161, Evalue=1e-39,
Organism=Saccharomyces cerevisiae, GI6321498, Length=796, Percent_Identity=25.8793969849246, Blast_Score=174, Evalue=4e-44,
Organism=Drosophila melanogaster, GI24582111, Length=884, Percent_Identity=25.2262443438914, Blast_Score=175, Evalue=1e-43,
Organism=Drosophila melanogaster, GI24582109, Length=884, Percent_Identity=25.2262443438914, Blast_Score=175, Evalue=1e-43,
Organism=Drosophila melanogaster, GI17137292, Length=884, Percent_Identity=25.2262443438914, Blast_Score=175, Evalue=1e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR010074
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.5.3 [H]

Molecular weight: Translated: 86148; Mature: 86017

Theoretical pI: Translated: 4.57; Mature: 4.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAKTYRTVPVRNLSSDELLELSKKQKLSLSREDMEVVQQIFREIDRDPTDVELEVIAQT
CCCCCEEECCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCEEHHHHHHH
WSEHCKHRIFSASISHSVNGGAPETVNSLFKTYIKKPSEKIMERKPGFVLSAFDDNAGFI
HHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCHHHHHHHCCCCEEEEEECCCCCEE
ALDDNLAVCLKAETHNHPSAIEPYAGANTGLGGVIRDILGAGKGAKPIASLDVFCFGAPD
EECCCEEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCEEEEEEEECCCC
TNPADITAPDVIHPLGIMRGVVRGVRDYGNRMGIPTVNGAIQFDPTYIYNPLVFCGTAGV
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCHHEECCCCC
IPRGDILKEMRPGLKVIVIGGRTGRDGLKGATFSSAALDEASHEEDFTAVQIGNPIEEKK
CCCHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCHHHHCCCCCCCCCEEEECCCCHHHHH
TLDFILEARERGLIVFITDCGAGGFSSAAGEMLSVTGGEIFLDNAPLKEPGLISWEIFLS
HHHHHHHHHHCCEEEEEEECCCCCCCHHCCCEEEECCCEEEECCCCCCCCCEEEEEEEEC
ESQERMVMAVEEKDLPELRKLADTFQTELTVLGHSDDTGILKVWHKGELVCCLDNSKLHD
CCCCEEEEEECCCCCHHHHHHHHHHHHEEEEEECCCCCCEEEEEECCCEEEEECCCCCCH
APIKKLESVFTPGKALTGQPLPDKDLNKSLETVMGDFAIVSREPIIREYDHEVQGNTILK
HHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHEECCCCHHHHHCCCCCCCEEEC
PLAGAQADAPQDGSVVDIDGSDKCMAMACAILPEWGKTDPYAMGTGTVDECVRQLILVGS
CCCCCCCCCCCCCCEEEECCCCHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHEEECC
NPDKIGLLDNFCMGNPEDPAELGRLVECVKAIAKAADAYNAPFISGKDSFYNYFETEDGP
CCCCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEECCCHHHHHHCCCCCCC
INVPVTFLCSGFGVVENPDHVIGSSLRRSNSLLYLIGHTEDEMGGSVFARTHGVEDGKVP
CCCCHHEEECCCCCCCCCHHHHHHHHHCCCCEEEEEECCCCCCCCEEEEEECCCCCCCCC
QTDCAANMELYKAYYGALTSGLVLSAHDVSEGGLAVTAAEMAFSGKGGVRLDLTKVPTVN
CHHHHCCHHHHHHHHHHHHCCEEEEECCCCCCCEEEEEEHHEECCCCCEEEEEEECCCCC
GWKSPAVPLFSESTGRILVEVDPEFAADFETAMDGFPCACIGGVTEEKRLTATCCGGEKV
CCCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHCCCCEEEECCCCCCCEEEEEECCCCEE
LDCDIANLKKLWKDGLTPYY
EECCHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SAKTYRTVPVRNLSSDELLELSKKQKLSLSREDMEVVQQIFREIDRDPTDVELEVIAQT
CCCCEEECCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCEEHHHHHHH
WSEHCKHRIFSASISHSVNGGAPETVNSLFKTYIKKPSEKIMERKPGFVLSAFDDNAGFI
HHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCHHHHHHHCCCCEEEEEECCCCCEE
ALDDNLAVCLKAETHNHPSAIEPYAGANTGLGGVIRDILGAGKGAKPIASLDVFCFGAPD
EECCCEEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCEEEEEEEECCCC
TNPADITAPDVIHPLGIMRGVVRGVRDYGNRMGIPTVNGAIQFDPTYIYNPLVFCGTAGV
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCHHEECCCCC
IPRGDILKEMRPGLKVIVIGGRTGRDGLKGATFSSAALDEASHEEDFTAVQIGNPIEEKK
CCCHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCHHHHCCCCCCCCCEEEECCCCHHHHH
TLDFILEARERGLIVFITDCGAGGFSSAAGEMLSVTGGEIFLDNAPLKEPGLISWEIFLS
HHHHHHHHHHCCEEEEEEECCCCCCCHHCCCEEEECCCEEEECCCCCCCCCEEEEEEEEC
ESQERMVMAVEEKDLPELRKLADTFQTELTVLGHSDDTGILKVWHKGELVCCLDNSKLHD
CCCCEEEEEECCCCCHHHHHHHHHHHHEEEEEECCCCCCEEEEEECCCEEEEECCCCCCH
APIKKLESVFTPGKALTGQPLPDKDLNKSLETVMGDFAIVSREPIIREYDHEVQGNTILK
HHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHEECCCCHHHHHCCCCCCCEEEC
PLAGAQADAPQDGSVVDIDGSDKCMAMACAILPEWGKTDPYAMGTGTVDECVRQLILVGS
CCCCCCCCCCCCCCEEEECCCCHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHEEECC
NPDKIGLLDNFCMGNPEDPAELGRLVECVKAIAKAADAYNAPFISGKDSFYNYFETEDGP
CCCCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEECCCHHHHHHCCCCCCC
INVPVTFLCSGFGVVENPDHVIGSSLRRSNSLLYLIGHTEDEMGGSVFARTHGVEDGKVP
CCCCHHEEECCCCCCCCCHHHHHHHHHCCCCEEEEEECCCCCCCCEEEEEECCCCCCCCC
QTDCAANMELYKAYYGALTSGLVLSAHDVSEGGLAVTAAEMAFSGKGGVRLDLTKVPTVN
CHHHHCCHHHHHHHHHHHHCCEEEEECCCCCCCEEEEEEHHEECCCCCEEEEEEECCCCC
GWKSPAVPLFSESTGRILVEVDPEFAADFETAMDGFPCACIGGVTEEKRLTATCCGGEKV
CCCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHCCCCEEEECCCCCCCEEEEEECCCCEE
LDCDIANLKKLWKDGLTPYY
EECCHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9389475 [H]