Click here to switch to the map view.

The map label for this gene is coaBC [H]

Identifier: 187734978

GI number: 187734978

Start: 560000

End: 560683

Strand: Direct

Name: coaBC [H]

Synonym: Amuc_0471

Alternate gene names: 187734978

Gene position: 560000-560683 (Clockwise)

Preceding gene: 187734975

Following gene: 187734979

Centisome position: 21.02

GC content: 56.58

Gene sequence:

>684_bases
ATGCCTCTCATGCGTTTTCTTATCACGGCAGGCCCCACCAGGGAAGCTATTGACCCCGTCAGATACCTCACCAACCACTC
CTCCGGGAAAATGGGGTATTGCCTGGCGGAAGCGGCTGTTCACGAAGGCCACAGCGTCCTTCTCATCTCCGGCCCCACTT
CCCTGGACATTCCGCACGGCGTGGACTTCCTGCCGGTTGAATGTGCACAGGAAATGTATGATGCTGTCAAAAACCAGGCT
CCCTACGCCGACGCCGCCATCCTCAGCGCCGCCGTAGCGGATTATCGACCCGTCTCCGTTCCGGACCGCAAAATCAAGAA
AACGGGGGAACGCATGATTTTGGAGCTGGAACGTACTGCGGACATTTTGGGCTCCATGCGTGCGGAATTCGGCTTCAGCG
GCATTCTGGTAGGCTTTGCGGCGGAAACCCATGACGTGGAAAATTACGCGCGCGGCAAACTGGAACGCAAGCGGTGCGAT
ATGATTGTGGCCAACGACGTTTCCCGCAGTGACATTGGTTTTAACTCCTCTGAAAATGAAGTGCTGCTCGTTTACCCGGA
CCGGACGGAGTTCCTGGAAAAAGCGCCTAAAGCACAAATTGCCCTTCAAATCATTGAGCGCGCTTCCCGTCTCGCACAGG
GAAAAGCTCCGTCATGGCGCACGGCAGACCCGTTCCACGCTTGA

Upstream 100 bases:

>100_bases
CACGCCTTCATAACTCCCCCAATCGCGGGAAGGAGTCAAGCCGGAACATAATGCGCAGCTGCACAAGATCACTCTTCACT
TTTACCCGTGATTCCGCATA

Downstream 100 bases:

>100_bases
AGCGGCAGGGAGTTTGCCCCACGATCCAATGCTGGCATGTAAATGCCGGCCACCTTTCCCAGAACCACATTTTCACTTTT
CATGCCCGTCACTCTTCAGG

Product: Phosphopantothenate--cysteine ligase

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 227; Mature: 226

Protein sequence:

>227_residues
MPLMRFLITAGPTREAIDPVRYLTNHSSGKMGYCLAEAAVHEGHSVLLISGPTSLDIPHGVDFLPVECAQEMYDAVKNQA
PYADAAILSAAVADYRPVSVPDRKIKKTGERMILELERTADILGSMRAEFGFSGILVGFAAETHDVENYARGKLERKRCD
MIVANDVSRSDIGFNSSENEVLLVYPDRTEFLEKAPKAQIALQIIERASRLAQGKAPSWRTADPFHA

Sequences:

>Translated_227_residues
MPLMRFLITAGPTREAIDPVRYLTNHSSGKMGYCLAEAAVHEGHSVLLISGPTSLDIPHGVDFLPVECAQEMYDAVKNQA
PYADAAILSAAVADYRPVSVPDRKIKKTGERMILELERTADILGSMRAEFGFSGILVGFAAETHDVENYARGKLERKRCD
MIVANDVSRSDIGFNSSENEVLLVYPDRTEFLEKAPKAQIALQIIERASRLAQGKAPSWRTADPFHA
>Mature_226_residues
PLMRFLITAGPTREAIDPVRYLTNHSSGKMGYCLAEAAVHEGHSVLLISGPTSLDIPHGVDFLPVECAQEMYDAVKNQAP
YADAAILSAAVADYRPVSVPDRKIKKTGERMILELERTADILGSMRAEFGFSGILVGFAAETHDVENYARGKLERKRCDM
IVANDVSRSDIGFNSSENEVLLVYPDRTEFLEKAPKAQIALQIIERASRLAQGKAPSWRTADPFHA

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Escherichia coli, GI87082301, Length=192, Percent_Identity=45.3125, Blast_Score=143, Evalue=1e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 24976; Mature: 24845

Theoretical pI: Translated: 5.96; Mature: 5.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLMRFLITAGPTREAIDPVRYLTNHSSGKMGYCLAEAAVHEGHSVLLISGPTSLDIPHG
CCHHHHHHHCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCEEEEEECCCCCCCCCC
VDFLPVECAQEMYDAVKNQAPYADAAILSAAVADYRPVSVPDRKIKKTGERMILELERTA
CCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHH
DILGSMRAEFGFSGILVGFAAETHDVENYARGKLERKRCDMIVANDVSRSDIGFNSSENE
HHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCCCCCCCC
VLLVYPDRTEFLEKAPKAQIALQIIERASRLAQGKAPSWRTADPFHA
EEEEECCHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure 
PLMRFLITAGPTREAIDPVRYLTNHSSGKMGYCLAEAAVHEGHSVLLISGPTSLDIPHG
CHHHHHHHCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCEEEEEECCCCCCCCCC
VDFLPVECAQEMYDAVKNQAPYADAAILSAAVADYRPVSVPDRKIKKTGERMILELERTA
CCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHH
DILGSMRAEFGFSGILVGFAAETHDVENYARGKLERKRCDMIVANDVSRSDIGFNSSENE
HHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCCCCCCCC
VLLVYPDRTEFLEKAPKAQIALQIIERASRLAQGKAPSWRTADPFHA
EEEEECCHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12620739 [H]