Click here to switch to the map view.

The map label for this gene is atsA [H]

Identifier: 187734958

GI number: 187734958

Start: 536416

End: 538575

Strand: Reverse

Name: atsA [H]

Synonym: Amuc_0451

Alternate gene names: 187734958

Gene position: 538575-536416 (Counterclockwise)

Preceding gene: 187734959

Following gene: 187734957

Centisome position: 20.22

GC content: 56.44

Gene sequence:

>2160_bases
ATGAAGCTGGTATCTTTACTATCCGTTCTTCTGACTTCCCTGGTTCCGTGCATGGGCGCTTCCGGGCAGGCAGCGAAGCC
GGCTGCCCGGTCTGTCAAAACTTCAAAACCCAATGTTATTTTCATTCTGGTGGACGACATGGGCTGGGGTGATCTGGATT
CCAACTGGAGCCAGCAGAAGCTGAATGGCCGGACGGTGGAGAGAAAGAACGAGTTCAAGACTCCTGCCCTGTCCGCTCTG
GCCCGGGAGGGGATTCAGCTGCGCCGTCATTATTCCGCCGCTCCGGTTTGCGCTCCGGCGCGCGCCTCCCTGCTGCTGGG
GGTGCACCAGGGGAATTCCCGCGTGGTGAGAAACAACCGTTTCGACCAGCCTATTGAAGATTCCCATACGCTGGGTACCG
TGATGCGTGATGCCGGGTATGATACTGCCGCCATTGGCAAATGGGGTGTAGGCGGCGGAGGCCAGAGCCATGTGCCCATG
ACCGCCGGCCCCCATCAGCGGGGATTCAATTATTTTTATGGTATCCTGGACCATTTGGCAGGGCATTTCCATTATCCTTC
CGAATCCCGTGACGTTTTCGAGTACAACGGTTACGCTTCCAATCCCGAGTGGAAAAATATCAAGGACCAGGTGCCCCAGA
CGGCTTATTCCACGGATTTATTTGCCGCCTGCGCCAAGCAGTGGATTGTGGACCAGCGCAAGTCCGCCCGCAAGACCGGA
AAGCCGTTTTTCCTGTACCTGGCTTTTCCGGCGCCCCACGGCAATCTGGTGGTTCCGGGGGTCCCCTATCCTTCCGGCGG
CGGGTTGAAAGGAGGCCTGCAATGGGTAAAGAAGGAAGGCACAGAATCCGTGAATACGGCTTTTGACGCCAGGGCGGAAA
AGAATAAGGATACCTATATTCATCCGGACAATTCCCGTTTCCCGAATGATGTGGCCAAACGTCATTCCACCATGATCCGC
CGCGTGGACGACGCCGTAGCTGATTTGATCCGTCTGCTGAAAGATTTGAAGATTGACGATAATACGATGATCGTCTTCAC
GTCCGACAATGGCCCCCACAATGAGGGCGGTTCCGACTCCAGGCACTGGCACGGAGCGCAAAATCCGCAGTTTTTCAAGA
GTTATGGCATGATGGACGGCATTAAGCGCGATTGCTGGGAAGGTGGCATGCGCGTGCCTACGCTGGTACGCTGGCCCGCC
CGTATTCCCAAAGGGCAGGTCAGCCTGCATCTTGGACAGTTCCATGACTGGCTGGCTACGCTGGCGGATGTCGCCGGGGT
GCCGGTTCCTGCCCGCAGTGACGGCGTTTCCCTGCTGCCGACGCTGACCGGTCATGCGGACCAGCAGAAGCCCGGCATTG
TTTATGCCGAATATAATTTCGCCGGCAAAACGCCGGAGTATAAGGATTTCCTGGGCGAACACAAGGGAGCGCAGCGAGGC
CAGCAGCAGATTGTCTTTGTGGATGGATTGAAGGGCCTGCGCATGGGGGTGAAGGATGCGGACAAGGATTTCATGATTTT
TGATACTTTGAATGATCCGCAGGAAAGCAAAGATCTCGCATCCTCCAAGCCGGAACTTCAGGCCCGCATGAAAGCCGCCG
CTTTGTCCAATCGCCGGGCTTCCCTTCCTTCCAAAACAGTGTTTGATTCTGCGCTGGTGCCTGCCGTGGATGTGAAGGGA
ACCGTTTCTCCCGGGTTGCAATGGGCCTTGTATGAGGGGGATTTTCCCTGGGTACCGGATTTTCGCCAGTGGAAGAAGCC
TGCTTCCGCCCATGGCGTGACGCCTTCCCCATCCGTGAAAATGAACGGTCCGGCCAAGCGCGGTGTGGAGCTGACGGGAT
ATGTGAAGATTCCTGAGGACGGAGCATATACGTTTTATCTGACCACGGATGAAAATAAGGGCAGCAAGGCTTTTGTCCGT
CTGCACGGCATGGAACTGATTGACGCGGACAAAACTTATGAGCCGGGGGCCGAGGTCTCCTCCGATTTGGGGGACCGGAA
GAATCCCGTTTATTTGAAAGCCGGACTTCATCCCATCCGCATCGGCTATGTGGGGAACTCCGGTACTGCCTCCAAACTGG
TTTTGAAGTGGGAAGGCCCCGGTTTGTCCAAGCAGGAGATTCCCGCCTCCGCCTTCAGTCACGGGAAGGAATCCAGGTAA

Upstream 100 bases:

>100_bases
CTCTGTGCCCTTTCCTCGTAATTTTCTTGAGGGATGAGAAAATTCATGTAAGATGACGCCTTATTTTAACGTCTTTTTTA
TAGTCTATTTTCTTTGAATC

Downstream 100 bases:

>100_bases
GCGTCCCTATGAGCGATCTGTACGAGTACCAGGCAATTGACGGTTCTTCCAAAGGCCCGGTTGACCTGGTGCTCTTGTTG
CGGGCCCGTAACCTCGGCCG

Product: sulfatase

Products: NA

Alternate protein names: AS; Aryl-sulfate sulphohydrolase [H]

Number of amino acids: Translated: 719; Mature: 719

Protein sequence:

>719_residues
MKLVSLLSVLLTSLVPCMGASGQAAKPAARSVKTSKPNVIFILVDDMGWGDLDSNWSQQKLNGRTVERKNEFKTPALSAL
AREGIQLRRHYSAAPVCAPARASLLLGVHQGNSRVVRNNRFDQPIEDSHTLGTVMRDAGYDTAAIGKWGVGGGGQSHVPM
TAGPHQRGFNYFYGILDHLAGHFHYPSESRDVFEYNGYASNPEWKNIKDQVPQTAYSTDLFAACAKQWIVDQRKSARKTG
KPFFLYLAFPAPHGNLVVPGVPYPSGGGLKGGLQWVKKEGTESVNTAFDARAEKNKDTYIHPDNSRFPNDVAKRHSTMIR
RVDDAVADLIRLLKDLKIDDNTMIVFTSDNGPHNEGGSDSRHWHGAQNPQFFKSYGMMDGIKRDCWEGGMRVPTLVRWPA
RIPKGQVSLHLGQFHDWLATLADVAGVPVPARSDGVSLLPTLTGHADQQKPGIVYAEYNFAGKTPEYKDFLGEHKGAQRG
QQQIVFVDGLKGLRMGVKDADKDFMIFDTLNDPQESKDLASSKPELQARMKAAALSNRRASLPSKTVFDSALVPAVDVKG
TVSPGLQWALYEGDFPWVPDFRQWKKPASAHGVTPSPSVKMNGPAKRGVELTGYVKIPEDGAYTFYLTTDENKGSKAFVR
LHGMELIDADKTYEPGAEVSSDLGDRKNPVYLKAGLHPIRIGYVGNSGTASKLVLKWEGPGLSKQEIPASAFSHGKESR

Sequences:

>Translated_719_residues
MKLVSLLSVLLTSLVPCMGASGQAAKPAARSVKTSKPNVIFILVDDMGWGDLDSNWSQQKLNGRTVERKNEFKTPALSAL
AREGIQLRRHYSAAPVCAPARASLLLGVHQGNSRVVRNNRFDQPIEDSHTLGTVMRDAGYDTAAIGKWGVGGGGQSHVPM
TAGPHQRGFNYFYGILDHLAGHFHYPSESRDVFEYNGYASNPEWKNIKDQVPQTAYSTDLFAACAKQWIVDQRKSARKTG
KPFFLYLAFPAPHGNLVVPGVPYPSGGGLKGGLQWVKKEGTESVNTAFDARAEKNKDTYIHPDNSRFPNDVAKRHSTMIR
RVDDAVADLIRLLKDLKIDDNTMIVFTSDNGPHNEGGSDSRHWHGAQNPQFFKSYGMMDGIKRDCWEGGMRVPTLVRWPA
RIPKGQVSLHLGQFHDWLATLADVAGVPVPARSDGVSLLPTLTGHADQQKPGIVYAEYNFAGKTPEYKDFLGEHKGAQRG
QQQIVFVDGLKGLRMGVKDADKDFMIFDTLNDPQESKDLASSKPELQARMKAAALSNRRASLPSKTVFDSALVPAVDVKG
TVSPGLQWALYEGDFPWVPDFRQWKKPASAHGVTPSPSVKMNGPAKRGVELTGYVKIPEDGAYTFYLTTDENKGSKAFVR
LHGMELIDADKTYEPGAEVSSDLGDRKNPVYLKAGLHPIRIGYVGNSGTASKLVLKWEGPGLSKQEIPASAFSHGKESR
>Mature_719_residues
MKLVSLLSVLLTSLVPCMGASGQAAKPAARSVKTSKPNVIFILVDDMGWGDLDSNWSQQKLNGRTVERKNEFKTPALSAL
AREGIQLRRHYSAAPVCAPARASLLLGVHQGNSRVVRNNRFDQPIEDSHTLGTVMRDAGYDTAAIGKWGVGGGGQSHVPM
TAGPHQRGFNYFYGILDHLAGHFHYPSESRDVFEYNGYASNPEWKNIKDQVPQTAYSTDLFAACAKQWIVDQRKSARKTG
KPFFLYLAFPAPHGNLVVPGVPYPSGGGLKGGLQWVKKEGTESVNTAFDARAEKNKDTYIHPDNSRFPNDVAKRHSTMIR
RVDDAVADLIRLLKDLKIDDNTMIVFTSDNGPHNEGGSDSRHWHGAQNPQFFKSYGMMDGIKRDCWEGGMRVPTLVRWPA
RIPKGQVSLHLGQFHDWLATLADVAGVPVPARSDGVSLLPTLTGHADQQKPGIVYAEYNFAGKTPEYKDFLGEHKGAQRG
QQQIVFVDGLKGLRMGVKDADKDFMIFDTLNDPQESKDLASSKPELQARMKAAALSNRRASLPSKTVFDSALVPAVDVKG
TVSPGLQWALYEGDFPWVPDFRQWKKPASAHGVTPSPSVKMNGPAKRGVELTGYVKIPEDGAYTFYLTTDENKGSKAFVR
LHGMELIDADKTYEPGAEVSSDLGDRKNPVYLKAGLHPIRIGYVGNSGTASKLVLKWEGPGLSKQEIPASAFSHGKESR

Specific function: Plays an important role in the mineralization of sulfates [H]

COG id: COG3119

COG function: function code P; Arylsulfatase A and related enzymes

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sulfatase family [H]

Homologues:

Organism=Homo sapiens, GI45430057, Length=453, Percent_Identity=28.0353200883002, Blast_Score=130, Evalue=3e-30,
Organism=Homo sapiens, GI109389362, Length=410, Percent_Identity=26.0975609756098, Blast_Score=122, Evalue=2e-27,
Organism=Homo sapiens, GI31742482, Length=476, Percent_Identity=24.7899159663866, Blast_Score=117, Evalue=5e-26,
Organism=Homo sapiens, GI4503899, Length=574, Percent_Identity=25.9581881533101, Blast_Score=112, Evalue=1e-24,
Organism=Homo sapiens, GI38569405, Length=580, Percent_Identity=23.2758620689655, Blast_Score=108, Evalue=2e-23,
Organism=Homo sapiens, GI38569407, Length=410, Percent_Identity=25.3658536585366, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI59797060, Length=538, Percent_Identity=24.3494423791822, Blast_Score=100, Evalue=8e-21,
Organism=Homo sapiens, GI53831991, Length=156, Percent_Identity=33.3333333333333, Blast_Score=86, Evalue=9e-17,
Organism=Homo sapiens, GI71852586, Length=155, Percent_Identity=31.6129032258064, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI71852584, Length=155, Percent_Identity=31.6129032258064, Blast_Score=85, Evalue=3e-16,
Organism=Homo sapiens, GI157266309, Length=185, Percent_Identity=28.6486486486486, Blast_Score=84, Evalue=7e-16,
Organism=Homo sapiens, GI58743319, Length=153, Percent_Identity=28.7581699346405, Blast_Score=79, Evalue=2e-14,
Organism=Escherichia coli, GI1790233, Length=555, Percent_Identity=27.027027027027, Blast_Score=104, Evalue=2e-23,
Organism=Escherichia coli, GI87081924, Length=453, Percent_Identity=26.9315673289183, Blast_Score=102, Evalue=7e-23,
Organism=Escherichia coli, GI1790112, Length=519, Percent_Identity=22.7360308285164, Blast_Score=75, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI115533416, Length=534, Percent_Identity=27.3408239700375, Blast_Score=132, Evalue=4e-31,
Organism=Caenorhabditis elegans, GI115533418, Length=510, Percent_Identity=26.4705882352941, Blast_Score=117, Evalue=3e-26,
Organism=Drosophila melanogaster, GI24666175, Length=462, Percent_Identity=27.0562770562771, Blast_Score=123, Evalue=5e-28,
Organism=Drosophila melanogaster, GI281366397, Length=442, Percent_Identity=26.9230769230769, Blast_Score=115, Evalue=8e-26,
Organism=Drosophila melanogaster, GI281366395, Length=442, Percent_Identity=26.9230769230769, Blast_Score=115, Evalue=8e-26,
Organism=Drosophila melanogaster, GI24666163, Length=442, Percent_Identity=26.9230769230769, Blast_Score=115, Evalue=8e-26,
Organism=Drosophila melanogaster, GI281363223, Length=426, Percent_Identity=26.5258215962441, Blast_Score=114, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24666109, Length=554, Percent_Identity=25.4512635379061, Blast_Score=110, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24653364, Length=448, Percent_Identity=24.1071428571429, Blast_Score=83, Evalue=7e-16,
Organism=Drosophila melanogaster, GI19922168, Length=448, Percent_Identity=23.4375, Blast_Score=81, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017849
- InterPro:   IPR017850
- InterPro:   IPR000917 [H]

Pfam domain/function: PF00884 Sulfatase [H]

EC number: =3.1.6.1 [H]

Molecular weight: Translated: 78833; Mature: 78833

Theoretical pI: Translated: 9.60; Mature: 9.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLVSLLSVLLTSLVPCMGASGQAAKPAARSVKTSKPNVIFILVDDMGWGDLDSNWSQQK
CHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCCCCCCEEEEEECCCCCCCCCCCCCHHH
LNGRTVERKNEFKTPALSALAREGIQLRRHYSAAPVCAPARASLLLGVHQGNSRVVRNNR
CCCCCCCHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEECCCCEEEECCC
FDQPIEDSHTLGTVMRDAGYDTAAIGKWGVGGGGQSHVPMTAGPHQRGFNYFYGILDHLA
CCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
GHFHYPSESRDVFEYNGYASNPEWKNIKDQVPQTAYSTDLFAACAKQWIVDQRKSARKTG
HCCCCCCCCCCEEEECCCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
KPFFLYLAFPAPHGNLVVPGVPYPSGGGLKGGLQWVKKEGTESVNTAFDARAEKNKDTYI
CCEEEEEEECCCCCCEEECCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHCCCCCCEE
HPDNSRFPNDVAKRHSTMIRRVDDAVADLIRLLKDLKIDDNTMIVFTSDNGPHNEGGSDS
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCC
RHWHGAQNPQFFKSYGMMDGIKRDCWEGGMRVPTLVRWPARIPKGQVSLHLGQFHDWLAT
CCCCCCCCCHHHHHHCHHHHHHHHHHHCCCCCCCEEECCCCCCCCCEEEEHHHHHHHHHH
LADVAGVPVPARSDGVSLLPTLTGHADQQKPGIVYAEYNFAGKTPEYKDFLGEHKGAQRG
HHHHHCCCCCCCCCCCEEEEECCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHCCHHCC
QQQIVFVDGLKGLRMGVKDADKDFMIFDTLNDPQESKDLASSKPELQARMKAAALSNRRA
CCEEEEEECCCHHHCCCCCCCCCEEEEECCCCCHHHHHHHCCCHHHHHHHHHHHHHCCCC
SLPSKTVFDSALVPAVDVKGTVSPGLQWALYEGDFPWVPDFRQWKKPASAHGVTPSPSVK
CCCCHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCCCCCHHHHCCCCCCCCCCCCCCEE
MNGPAKRGVELTGYVKIPEDGAYTFYLTTDENKGSKAFVRLHGMELIDADKTYEPGAEVS
ECCCHHCCCEEEEEEECCCCCCEEEEEEECCCCCCEEEEEEECCEEECCCCCCCCCCHHH
SDLGDRKNPVYLKAGLHPIRIGYVGNSGTASKLVLKWEGPGLSKQEIPASAFSHGKESR
HHCCCCCCCEEEEECCCEEEEEEECCCCCCEEEEEEECCCCCCHHHCCHHHHCCCCCCC
>Mature Secondary Structure
MKLVSLLSVLLTSLVPCMGASGQAAKPAARSVKTSKPNVIFILVDDMGWGDLDSNWSQQK
CHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCCCCCCEEEEEECCCCCCCCCCCCCHHH
LNGRTVERKNEFKTPALSALAREGIQLRRHYSAAPVCAPARASLLLGVHQGNSRVVRNNR
CCCCCCCHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEECCCCEEEECCC
FDQPIEDSHTLGTVMRDAGYDTAAIGKWGVGGGGQSHVPMTAGPHQRGFNYFYGILDHLA
CCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
GHFHYPSESRDVFEYNGYASNPEWKNIKDQVPQTAYSTDLFAACAKQWIVDQRKSARKTG
HCCCCCCCCCCEEEECCCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
KPFFLYLAFPAPHGNLVVPGVPYPSGGGLKGGLQWVKKEGTESVNTAFDARAEKNKDTYI
CCEEEEEEECCCCCCEEECCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHCCCCCCEE
HPDNSRFPNDVAKRHSTMIRRVDDAVADLIRLLKDLKIDDNTMIVFTSDNGPHNEGGSDS
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCC
RHWHGAQNPQFFKSYGMMDGIKRDCWEGGMRVPTLVRWPARIPKGQVSLHLGQFHDWLAT
CCCCCCCCCHHHHHHCHHHHHHHHHHHCCCCCCCEEECCCCCCCCCEEEEHHHHHHHHHH
LADVAGVPVPARSDGVSLLPTLTGHADQQKPGIVYAEYNFAGKTPEYKDFLGEHKGAQRG
HHHHHCCCCCCCCCCCEEEEECCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHCCHHCC
QQQIVFVDGLKGLRMGVKDADKDFMIFDTLNDPQESKDLASSKPELQARMKAAALSNRRA
CCEEEEEECCCHHHCCCCCCCCCEEEEECCCCCHHHHHHHCCCHHHHHHHHHHHHHCCCC
SLPSKTVFDSALVPAVDVKGTVSPGLQWALYEGDFPWVPDFRQWKKPASAHGVTPSPSVK
CCCCHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCCCCCHHHHCCCCCCCCCCCCCCEE
MNGPAKRGVELTGYVKIPEDGAYTFYLTTDENKGSKAFVRLHGMELIDADKTYEPGAEVS
ECCCHHCCCEEEEEEECCCCCCEEEEEEECCCCCCEEEEEEECCEEECCCCCCCCCCHHH
SDLGDRKNPVYLKAGLHPIRIGYVGNSGTASKLVLKWEGPGLSKQEIPASAFSHGKESR
HHCCCCCCCEEEEECCCEEEEEEECCCCCCEEEEEEECCCCCCHHHCCHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10336424 [H]