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The map label for this gene is dxs [H]

Identifier: 187734826

GI number: 187734826

Start: 371543

End: 373429

Strand: Direct

Name: dxs [H]

Synonym: Amuc_0315

Alternate gene names: 187734826

Gene position: 371543-373429 (Clockwise)

Preceding gene: 187734825

Following gene: 187734827

Centisome position: 13.95

GC content: 57.71

Gene sequence:

>1887_bases
ATGAATTCTCCCTCACCTGAACTTCCGGAACTGCTGGCAAGCATCCGCAGTCACGCAGATCTGATGGAAATCCCTGAGTC
GGAACTGCCCAGGCTTGCGGAAGAAATCCGGAATACTCTCATTCACTCCCTTTCCCTCACCGGAGGCCACCTGGGCCCCA
ACCTGGGCGTGGTAGAGCTGAGCATTGCCCTTCACCGCGTCTTTGAAACGCCGCGGGATAAAATCATCTTTGATGTCTCC
CACCAGGCCTATGTCCATAAAATGCTGACTGGGCGCGCTCCCCTGATCCACACCATCCGCCAGCACGGGGGGCTTTCCGG
ATTTGCCAAAATGTCCGAATCCCCTCATGACTCCTACGGAGCGGGGCATGCGGGCACGGCGCTTTCCGCCGCCCTGGGCA
TGTGCGCGGCCAGGGACCTGAAAGGAGAAGACTACCATGTGGTGGCCGTAGCCGGGGATGCGGCATTCACCTGCGGCACC
ACTCTGGAGGCGCTGAACAATATCAGCCAGACCACCAAACGGTACATCACCATTCTGAATGACAACGAATGGGCCATCGA
CAAAAACGTAGGAGCGCTGGCAAAATACTTCAACTCCCTGCAAACATCGGAAACGTTTTCCTGGTTAAGGGATAAAACGG
CTTCCTTCATTGAAAAGCTGGGCGGCACGCAGGCCAGGGACTTTGCTTTCAAGCTGGAAGGCACCACCAAAAACCTTATC
TTCCCGTCCCTGCTGTTCAACAAATTCGGGCTGCGCTATTTCGGCCCCCTGGACGGACACGACATTCCCACCCTGATACG
CACCCTTGCCTACATCAAGGATCTCAACGAACCCGTTATTCTGCATGTGGTCACTCAGAAGGGTAAGGGCTACCAGCCCG
CTCTGGACAACCCCACCAAATTCCACGGCCTGGGCTCCTATTGCGTGAGGGACGGGGAAACGCAGGCCGCCCCCACCCCC
ACATTCTCCCATATCTTCGGCTCCACGCTGGTGGAAATGGCGCGCGAGGATGAATCCATCACAGCCATCACGGCCGCCAT
GGCCAGCGGCACCAAGCTGGACTTATTCAAGGAAGCCTTCCCCAAACGCTATTTCGACGTAGGGATCGCGGAAGAGCACG
GCGCCCTCTTCGCCTGCGGGCTGGCGGCGGAGGGCATGAAACCCTACATCGCCATTTACTCCACTTTCATGCAGCGCTGT
ATTGACATGATTCAACATGACGCCGCGCTGCAAAAACTGCCCGTGCGTTTCTGCATGGACCGCGCCGGGCTTTCCCCGGA
CGACGGCCCCACACACCACGGGCTGTTTGACATTGCCATGATTCGCAGTATCCCGAACATTGTCTTCATGCAGCCCAAGG
ATGAAGCCGAATTCGTCCACATGCTCCGAACCATGAACCATTACCAGAACGGCCCCACCGTTATCCGCTATCCCAGAGGA
TGCGGCGCCGGAACCCCCGTCCCCGCCAAGGCGGAAATCCTCCCCATCGGCAAGGCGGAAGTACTTCAGGCGGGACAGGA
TGTAACCCTCGTTTCCCTGGGCACCATGATCGGCATCGCCCGGGAAACCGCCTCGCTGCTGGAAGTCCGCGGCTACACCG
TCACCCTGATCAATGCCCGTTTCATCAAACCTCTGGATGATGAATGCATCCGCCGTCACGCAGCACGCAGCCGGGTGGTC
TGCACCTTCGAAGACCACTCCATCAGCGGCGGCTTCAACTCAGCCGTTCTCGAATCCCTGGAAACCGGAGATGTCAAGAC
GCCCGTGGAAGCCATCGCTTGGCCGGACCAATTTATTGAGCATGGTTCGGAATCCATCCTCAGAAAAAAATATGGACTCA
CGGCGGAAGCCGCGCTACAAAAAATCATTCCCCACCTGAACTCCTGA

Upstream 100 bases:

>100_bases
CACTGCCGCAGCATCCTGCATGATGCGGAACTGCGCATTCAAACTCTCAGCAACCCGGAAACCGTTCAGGATAAAACGGA
TACTGATGAACCAGACAGCA

Downstream 100 bases:

>100_bases
TCTGTTTATGAAAACACGCACCTTCCTGCTGGCAGCCCTTGCGCTTGCCCTTCTTCCCGTCTCCGCGCGGCAATCCCTGC
CGGCCTCCCCTTCCCCTGCC

Product: deoxyxylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS [H]

Number of amino acids: Translated: 628; Mature: 628

Protein sequence:

>628_residues
MNSPSPELPELLASIRSHADLMEIPESELPRLAEEIRNTLIHSLSLTGGHLGPNLGVVELSIALHRVFETPRDKIIFDVS
HQAYVHKMLTGRAPLIHTIRQHGGLSGFAKMSESPHDSYGAGHAGTALSAALGMCAARDLKGEDYHVVAVAGDAAFTCGT
TLEALNNISQTTKRYITILNDNEWAIDKNVGALAKYFNSLQTSETFSWLRDKTASFIEKLGGTQARDFAFKLEGTTKNLI
FPSLLFNKFGLRYFGPLDGHDIPTLIRTLAYIKDLNEPVILHVVTQKGKGYQPALDNPTKFHGLGSYCVRDGETQAAPTP
TFSHIFGSTLVEMAREDESITAITAAMASGTKLDLFKEAFPKRYFDVGIAEEHGALFACGLAAEGMKPYIAIYSTFMQRC
IDMIQHDAALQKLPVRFCMDRAGLSPDDGPTHHGLFDIAMIRSIPNIVFMQPKDEAEFVHMLRTMNHYQNGPTVIRYPRG
CGAGTPVPAKAEILPIGKAEVLQAGQDVTLVSLGTMIGIARETASLLEVRGYTVTLINARFIKPLDDECIRRHAARSRVV
CTFEDHSISGGFNSAVLESLETGDVKTPVEAIAWPDQFIEHGSESILRKKYGLTAEAALQKIIPHLNS

Sequences:

>Translated_628_residues
MNSPSPELPELLASIRSHADLMEIPESELPRLAEEIRNTLIHSLSLTGGHLGPNLGVVELSIALHRVFETPRDKIIFDVS
HQAYVHKMLTGRAPLIHTIRQHGGLSGFAKMSESPHDSYGAGHAGTALSAALGMCAARDLKGEDYHVVAVAGDAAFTCGT
TLEALNNISQTTKRYITILNDNEWAIDKNVGALAKYFNSLQTSETFSWLRDKTASFIEKLGGTQARDFAFKLEGTTKNLI
FPSLLFNKFGLRYFGPLDGHDIPTLIRTLAYIKDLNEPVILHVVTQKGKGYQPALDNPTKFHGLGSYCVRDGETQAAPTP
TFSHIFGSTLVEMAREDESITAITAAMASGTKLDLFKEAFPKRYFDVGIAEEHGALFACGLAAEGMKPYIAIYSTFMQRC
IDMIQHDAALQKLPVRFCMDRAGLSPDDGPTHHGLFDIAMIRSIPNIVFMQPKDEAEFVHMLRTMNHYQNGPTVIRYPRG
CGAGTPVPAKAEILPIGKAEVLQAGQDVTLVSLGTMIGIARETASLLEVRGYTVTLINARFIKPLDDECIRRHAARSRVV
CTFEDHSISGGFNSAVLESLETGDVKTPVEAIAWPDQFIEHGSESILRKKYGLTAEAALQKIIPHLNS
>Mature_628_residues
MNSPSPELPELLASIRSHADLMEIPESELPRLAEEIRNTLIHSLSLTGGHLGPNLGVVELSIALHRVFETPRDKIIFDVS
HQAYVHKMLTGRAPLIHTIRQHGGLSGFAKMSESPHDSYGAGHAGTALSAALGMCAARDLKGEDYHVVAVAGDAAFTCGT
TLEALNNISQTTKRYITILNDNEWAIDKNVGALAKYFNSLQTSETFSWLRDKTASFIEKLGGTQARDFAFKLEGTTKNLI
FPSLLFNKFGLRYFGPLDGHDIPTLIRTLAYIKDLNEPVILHVVTQKGKGYQPALDNPTKFHGLGSYCVRDGETQAAPTP
TFSHIFGSTLVEMAREDESITAITAAMASGTKLDLFKEAFPKRYFDVGIAEEHGALFACGLAAEGMKPYIAIYSTFMQRC
IDMIQHDAALQKLPVRFCMDRAGLSPDDGPTHHGLFDIAMIRSIPNIVFMQPKDEAEFVHMLRTMNHYQNGPTVIRYPRG
CGAGTPVPAKAEILPIGKAEVLQAGQDVTLVSLGTMIGIARETASLLEVRGYTVTLINARFIKPLDDECIRRHAARSRVV
CTFEDHSISGGFNSAVLESLETGDVKTPVEAIAWPDQFIEHGSESILRKKYGLTAEAALQKIIPHLNS

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) [H]

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=303, Percent_Identity=26.4026402640264, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI4507521, Length=303, Percent_Identity=26.4026402640264, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI133778974, Length=368, Percent_Identity=24.4565217391304, Blast_Score=78, Evalue=3e-14,
Organism=Homo sapiens, GI225637463, Length=296, Percent_Identity=25.3378378378378, Blast_Score=70, Evalue=6e-12,
Organism=Homo sapiens, GI225637459, Length=296, Percent_Identity=25.3378378378378, Blast_Score=70, Evalue=7e-12,
Organism=Homo sapiens, GI225637461, Length=296, Percent_Identity=25.3378378378378, Blast_Score=70, Evalue=7e-12,
Organism=Escherichia coli, GI1786622, Length=613, Percent_Identity=41.2724306688418, Blast_Score=471, Evalue=1e-134,
Organism=Caenorhabditis elegans, GI17539652, Length=304, Percent_Identity=27.3026315789474, Blast_Score=79, Evalue=8e-15,
Organism=Drosophila melanogaster, GI24645119, Length=307, Percent_Identity=28.3387622149837, Blast_Score=91, Evalue=3e-18,
Organism=Drosophila melanogaster, GI45551847, Length=307, Percent_Identity=28.3387622149837, Blast_Score=91, Evalue=4e-18,
Organism=Drosophila melanogaster, GI45550715, Length=307, Percent_Identity=28.3387622149837, Blast_Score=91, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24666278, Length=482, Percent_Identity=25.5186721991701, Blast_Score=87, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005477
- InterPro:   IPR011766
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =2.2.1.7 [H]

Molecular weight: Translated: 68739; Mature: 68739

Theoretical pI: Translated: 6.61; Mature: 6.61

Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSPSPELPELLASIRSHADLMEIPESELPRLAEEIRNTLIHSLSLTGGHLGPNLGVVEL
CCCCCCHHHHHHHHHHHCCHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHH
SIALHRVFETPRDKIIFDVSHQAYVHKMLTGRAPLIHTIRQHGGLSGFAKMSESPHDSYG
HHHHHHHHHCCCCCEEEECCHHHHHHHHHHCCCHHHHHHHHCCCCCHHHHCCCCCCCCCC
AGHAGTALSAALGMCAARDLKGEDYHVVAVAGDAAFTCGTTLEALNNISQTTKRYITILN
CCCCHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCEECCHHHHHHHHHHHHHHHEEEEEC
DNEWAIDKNVGALAKYFNSLQTSETFSWLRDKTASFIEKLGGTQARDFAFKLEGTTKNLI
CCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCHHH
FPSLLFNKFGLRYFGPLDGHDIPTLIRTLAYIKDLNEPVILHVVTQKGKGYQPALDNPTK
HHHHHHHHCCCCEECCCCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCH
FHGLGSYCVRDGETQAAPTPTFSHIFGSTLVEMAREDESITAITAAMASGTKLDLFKEAF
HCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHC
PKRYFDVGIAEEHGALFACGLAAEGMKPYIAIYSTFMQRCIDMIQHDAALQKLPVRFCMD
CHHHHCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RAGLSPDDGPTHHGLFDIAMIRSIPNIVFMQPKDEAEFVHMLRTMNHYQNGPTVIRYPRG
HCCCCCCCCCCCCCHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHCCCCEEEECCCC
CGAGTPVPAKAEILPIGKAEVLQAGQDVTLVSLGTMIGIARETASLLEVRGYTVTLINAR
CCCCCCCCCCCEEEECCHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHCCCEEEEEECC
FIKPLDDECIRRHAARSRVVCTFEDHSISGGFNSAVLESLETGDVKTPVEAIAWPDQFIE
CCCCCCHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHCCCCCCCHHHHCCCHHHHH
HGSESILRKKYGLTAEAALQKIIPHLNS
CCHHHHHHHHHCCCHHHHHHHHHHCCCC
>Mature Secondary Structure
MNSPSPELPELLASIRSHADLMEIPESELPRLAEEIRNTLIHSLSLTGGHLGPNLGVVEL
CCCCCCHHHHHHHHHHHCCHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHH
SIALHRVFETPRDKIIFDVSHQAYVHKMLTGRAPLIHTIRQHGGLSGFAKMSESPHDSYG
HHHHHHHHHCCCCCEEEECCHHHHHHHHHHCCCHHHHHHHHCCCCCHHHHCCCCCCCCCC
AGHAGTALSAALGMCAARDLKGEDYHVVAVAGDAAFTCGTTLEALNNISQTTKRYITILN
CCCCHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCEECCHHHHHHHHHHHHHHHEEEEEC
DNEWAIDKNVGALAKYFNSLQTSETFSWLRDKTASFIEKLGGTQARDFAFKLEGTTKNLI
CCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCHHH
FPSLLFNKFGLRYFGPLDGHDIPTLIRTLAYIKDLNEPVILHVVTQKGKGYQPALDNPTK
HHHHHHHHCCCCEECCCCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCH
FHGLGSYCVRDGETQAAPTPTFSHIFGSTLVEMAREDESITAITAAMASGTKLDLFKEAF
HCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHC
PKRYFDVGIAEEHGALFACGLAAEGMKPYIAIYSTFMQRCIDMIQHDAALQKLPVRFCMD
CHHHHCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RAGLSPDDGPTHHGLFDIAMIRSIPNIVFMQPKDEAEFVHMLRTMNHYQNGPTVIRYPRG
HCCCCCCCCCCCCCHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHCCCCEEEECCCC
CGAGTPVPAKAEILPIGKAEVLQAGQDVTLVSLGTMIGIARETASLLEVRGYTVTLINAR
CCCCCCCCCCCEEEECCHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHCCCEEEEEECC
FIKPLDDECIRRHAARSRVVCTFEDHSISGGFNSAVLESLETGDVKTPVEAIAWPDQFIE
CCCCCCHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHCCCCCCCHHHHCCCHHHHH
HGSESILRKKYGLTAEAALQKIIPHLNS
CCHHHHHHHHHCCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA