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The map label for this gene is dapA [H]

Identifier: 187734770

GI number: 187734770

Start: 314850

End: 315731

Strand: Reverse

Name: dapA [H]

Synonym: Amuc_0258

Alternate gene names: 187734770

Gene position: 315731-314850 (Counterclockwise)

Preceding gene: 187734771

Following gene: 187734769

Centisome position: 11.85

GC content: 51.47

Gene sequence:

>882_bases
ATGAAGTTTCAAGGTCTTTATACAGCAATTGTGACTCCGTTTGCCGGCAACCGGGTCGATGAAGAGGCTTTTAGAATGCT
TGTGGAAGCGCAGATAGCTGCCGGCGTGGCCGGCATTGTGGCTGTCGGTACCACGGGAGAATCCCCCACCTTGACTGTAA
AAGAACACTTGAGGGTAATAGAATTGGCCGTGGAGATCGCGGCTGGCCGTATTCAGGTTATTGCGGGAACGGGCGCTAAT
TCCACCGCAGAAGCTATCCATATGACCCAGGAAGCGGAAAAGATGGGAGTAGACGGAACGCTCCAGGTGTGCCCCTATTA
CAATAAACCTTCTCAGGATGGAGTTTATGCCCATTTCAAGGCTATTGCGGACGCTACCCGTCTGCCGATTATGCTGTACA
GCATTCCGGGGCGTTGCGGTATTGAAATCAGTGTGGAAACAATCAGCCGTCTGGCGAAGGATTGCCCGCATATTGTTTGT
GTGAAAGAGGCCGGCGGCAATGTGGACCGCGTGAACCAGCTGATGCAGGTGGTTCCGGAAAATTTCACTGTTCTGTGTGG
CGATGACGGTCTGACGGTGCCTTTTATGGCCTGTGGCGCCAGCGGATTGGTTTCCGTAACATCCAATCTGGTTCCGGGCA
TCATGAATTCCATTGTCAAAGCTGGCCTGAATCAGGATATGGGGGAAATGCTTTCCCTCCAGAAGAAATTTTATCCGTTG
ATGAAAGGGCTAATGACTCTGGATTCCAATCCTGTTCCGATCAAGGCGGCTTTGGCGATGAGGGGAGATATACAGCCCGG
CATACGTCTTCCGCTGGTTCCATTGGCGGAAGAGAAGGAAGCTCAGCTTTCCGCTCTTCTTCAGCGTTTCAATATTCTTT
AA

Upstream 100 bases:

>100_bases
TCACGAATGGTATTTCAGGATGCCTGACAGGCGTGCCATATTTCTGTATTCTGTCGTGACAAAAAGTGTCTGTTAAGATA
GTATATTTCCAAGTAAGGTT

Downstream 100 bases:

>100_bases
CATTTTAGTGATATGATTTCCATTCTTGTTACAGGCATTTCGGGCCGCATGGGCCAAGCTATTCAAGAGGCGGTGACGCA
GAATCCGGATACTTGCGTGG

Product: dihydrodipicolinate synthase

Products: NA

Alternate protein names: DHDPS [H]

Number of amino acids: Translated: 293; Mature: 293

Protein sequence:

>293_residues
MKFQGLYTAIVTPFAGNRVDEEAFRMLVEAQIAAGVAGIVAVGTTGESPTLTVKEHLRVIELAVEIAAGRIQVIAGTGAN
STAEAIHMTQEAEKMGVDGTLQVCPYYNKPSQDGVYAHFKAIADATRLPIMLYSIPGRCGIEISVETISRLAKDCPHIVC
VKEAGGNVDRVNQLMQVVPENFTVLCGDDGLTVPFMACGASGLVSVTSNLVPGIMNSIVKAGLNQDMGEMLSLQKKFYPL
MKGLMTLDSNPVPIKAALAMRGDIQPGIRLPLVPLAEEKEAQLSALLQRFNIL

Sequences:

>Translated_293_residues
MKFQGLYTAIVTPFAGNRVDEEAFRMLVEAQIAAGVAGIVAVGTTGESPTLTVKEHLRVIELAVEIAAGRIQVIAGTGAN
STAEAIHMTQEAEKMGVDGTLQVCPYYNKPSQDGVYAHFKAIADATRLPIMLYSIPGRCGIEISVETISRLAKDCPHIVC
VKEAGGNVDRVNQLMQVVPENFTVLCGDDGLTVPFMACGASGLVSVTSNLVPGIMNSIVKAGLNQDMGEMLSLQKKFYPL
MKGLMTLDSNPVPIKAALAMRGDIQPGIRLPLVPLAEEKEAQLSALLQRFNIL
>Mature_293_residues
MKFQGLYTAIVTPFAGNRVDEEAFRMLVEAQIAAGVAGIVAVGTTGESPTLTVKEHLRVIELAVEIAAGRIQVIAGTGAN
STAEAIHMTQEAEKMGVDGTLQVCPYYNKPSQDGVYAHFKAIADATRLPIMLYSIPGRCGIEISVETISRLAKDCPHIVC
VKEAGGNVDRVNQLMQVVPENFTVLCGDDGLTVPFMACGASGLVSVTSNLVPGIMNSIVKAGLNQDMGEMLSLQKKFYPL
MKGLMTLDSNPVPIKAALAMRGDIQPGIRLPLVPLAEEKEAQLSALLQRFNIL

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; first step. [C]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family [H]

Homologues:

Organism=Homo sapiens, GI31543060, Length=211, Percent_Identity=29.3838862559242, Blast_Score=95, Evalue=8e-20,
Organism=Homo sapiens, GI13540533, Length=303, Percent_Identity=27.7227722772277, Blast_Score=81, Evalue=1e-15,
Organism=Escherichia coli, GI1788823, Length=294, Percent_Identity=41.4965986394558, Blast_Score=223, Evalue=1e-59,
Organism=Escherichia coli, GI87082415, Length=243, Percent_Identity=29.6296296296296, Blast_Score=124, Evalue=5e-30,
Organism=Escherichia coli, GI1786463, Length=291, Percent_Identity=27.1477663230241, Blast_Score=118, Evalue=4e-28,
Organism=Escherichia coli, GI1789620, Length=303, Percent_Identity=27.3927392739274, Blast_Score=107, Evalue=1e-24,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005263
- InterPro:   IPR002220
- InterPro:   IPR020625
- InterPro:   IPR020624 [H]

Pfam domain/function: PF00701 DHDPS [H]

EC number: =4.2.1.52 [H]

Molecular weight: Translated: 31254; Mature: 31254

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: PS00665 DHDPS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
6.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFQGLYTAIVTPFAGNRVDEEAFRMLVEAQIAAGVAGIVAVGTTGESPTLTVKEHLRVI
CCCCCEEHHHCCCCCCCCCCHHHHHHHHHHHHHHCCEEEEEECCCCCCCEEEHHHHHHHH
ELAVEIAAGRIQVIAGTGANSTAEAIHMTQEAEKMGVDGTLQVCPYYNKPSQDGVYAHFK
HHHHHHHCCEEEEEEECCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHH
AIADATRLPIMLYSIPGRCGIEISVETISRLAKDCPHIVCVKEAGGNVDRVNQLMQVVPE
HHHHHHCCCEEEEECCCCCCEEEEHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHCCC
NFTVLCGDDGLTVPFMACGASGLVSVTSNLVPGIMNSIVKAGLNQDMGEMLSLQKKFYPL
CCEEEECCCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
MKGLMTLDSNPVPIKAALAMRGDIQPGIRLPLVPLAEEKEAQLSALLQRFNIL
HHHHHHCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKFQGLYTAIVTPFAGNRVDEEAFRMLVEAQIAAGVAGIVAVGTTGESPTLTVKEHLRVI
CCCCCEEHHHCCCCCCCCCCHHHHHHHHHHHHHHCCEEEEEECCCCCCCEEEHHHHHHHH
ELAVEIAAGRIQVIAGTGANSTAEAIHMTQEAEKMGVDGTLQVCPYYNKPSQDGVYAHFK
HHHHHHHCCEEEEEEECCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHH
AIADATRLPIMLYSIPGRCGIEISVETISRLAKDCPHIVCVKEAGGNVDRVNQLMQVVPE
HHHHHHCCCEEEEECCCCCCEEEEHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHCCC
NFTVLCGDDGLTVPFMACGASGLVSVTSNLVPGIMNSIVKAGLNQDMGEMLSLQKKFYPL
CCEEEECCCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
MKGLMTLDSNPVPIKAALAMRGDIQPGIRLPLVPLAEEKEAQLSALLQRFNIL
HHHHHHCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]