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The map label for this gene is 187734750

Identifier: 187734750

GI number: 187734750

Start: 295927

End: 297333

Strand: Reverse

Name: 187734750

Synonym: Amuc_0238

Alternate gene names: NA

Gene position: 297333-295927 (Counterclockwise)

Preceding gene: 187734751

Following gene: 187734749

Centisome position: 11.16

GC content: 53.73

Gene sequence:

>1407_bases
ATGAAAATTCATTTTTGCGGCGCAGCGGGAACGACGACGGGCTCCCAGCATTTGCTGGAGGTGAACGGGTGCCGGATTCT
TCTGGATTGCGGCATGTATCAGGGGCGGCGTGAGGAGGCATGGCATATCAATAAGGATTTCCCCTATTTTTCCCCGGCGG
GGGTGGATGCGGTAGTTCTGTCCCACGCTCATATTGATCATTCCGGCAATATTCCCAATTTAGTGAAACAGGGGTTTCAG
GGAAATATTTACAGTACATTTGCAACCAGAGATCTTTGCCAGCTCATGCTGGCGGACGCCGCCCGCATTCAGGAGCACGA
CTGCGCATTCATCAATAAGATGAACAAGCGCCGCGGTATTCATCAGCCGGATGTTTATCCTACTTATTCCGAACAGGATG
CGGAGCGGTGCATGCGCCAGTTCGTGAATATCGGGTATGACCGGCCCATTCCCGTTGTTCCGGGGGTGACACTCACGTTT
TATGATGCGGGCCATATTCTGGGCGCTGCGCAAGTGTGCCTGGATATTGAGGACAGGGAAGACGGGCGGAAGAAGCGTTT
CCTGTTTTCCGGGGATGTGGGGCGGGGAGATAACGAATTACTGCGCGATCCCGTCCCTGTTCCGGATGTGGATATTTTGC
TGATGGAGAGCACTTACGGCGGCCGTTTCCATGAGGCCCCCTCCCGTGATGACGAGACGTTCTGCCGGGCTATCAAGGAG
GCTCTGGAATTAGGAGGCCGCGTTTATATTCCGGCTTTTGCGGTGGAACGCACCCAGCAGCTGCTTTATCTGCTGAACAG
GGCCTACCATGAAGGCACTCTGCCCTTGCTGCCCGTATATGTGGACAGTCCCATGGCAGTGGGTGCGACGGAGATTTTCC
GCATTCATCCGGAGTGTTTCAATAAGGAGGTTTATGATTTCCTGTTCCGGGAGAAGGATCCGTTTTGTTTTGAACAGCTG
CGTTTGATCCGTTCCGTGGGCGAGTCCCAGGCTTTGAATAAAATGAACGGGCAGGCTATTATTATTTCCGCCTCAGGAAT
GTGTGAAGCAGGGCGCATTCTTCACCACTTGGCGAATAACATCGGCGATCCGAAAAATACGGTTCTTTTTGTAGGCTATT
GTGCGGAACATACACTTGGCCGCAAGATTATGGATGGGTGGAAAGAGGTTCCCATCCTGGGTAAACAATATCCTGTCCGG
GCCAGAATACGGGAGATGGATTCCTTTTCCGGCCATGCGGACCATGGAGAACTGCTGGAGTATTTTGACAGGACCGGGGG
GCCCAAGAGGAATATCATTCTGGTGCATGGGGAGGAGAAGGCTACCCAGGCTCTGGCGGGGGCACTTCGGGAGCGTCAGG
CCAATCCCGTTTCCATCGCGCAGTTGGGAAGCGCCATGGTGCTTTAA

Upstream 100 bases:

>100_bases
TTGCGGCTGATGTTTCCCGTCTTTCAAAGGGTATATTGAATGAAAGGCTTCAGGTATTGATTTCTTGCGTTGCCCGCTGG
CTTGTTGTACACATGTATTA

Downstream 100 bases:

>100_bases
TGTTCCGGAATATAGAATTTCTGCGGTATCCGCACGCATTCCGGGCTTTCGTTCTCAGGTTTTGTGTTCAACGGCGGGTA
CATCGGCAGCCTTCCAATCA

Product: beta-lactamase domain protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 468; Mature: 468

Protein sequence:

>468_residues
MKIHFCGAAGTTTGSQHLLEVNGCRILLDCGMYQGRREEAWHINKDFPYFSPAGVDAVVLSHAHIDHSGNIPNLVKQGFQ
GNIYSTFATRDLCQLMLADAARIQEHDCAFINKMNKRRGIHQPDVYPTYSEQDAERCMRQFVNIGYDRPIPVVPGVTLTF
YDAGHILGAAQVCLDIEDREDGRKKRFLFSGDVGRGDNELLRDPVPVPDVDILLMESTYGGRFHEAPSRDDETFCRAIKE
ALELGGRVYIPAFAVERTQQLLYLLNRAYHEGTLPLLPVYVDSPMAVGATEIFRIHPECFNKEVYDFLFREKDPFCFEQL
RLIRSVGESQALNKMNGQAIIISASGMCEAGRILHHLANNIGDPKNTVLFVGYCAEHTLGRKIMDGWKEVPILGKQYPVR
ARIREMDSFSGHADHGELLEYFDRTGGPKRNIILVHGEEKATQALAGALRERQANPVSIAQLGSAMVL

Sequences:

>Translated_468_residues
MKIHFCGAAGTTTGSQHLLEVNGCRILLDCGMYQGRREEAWHINKDFPYFSPAGVDAVVLSHAHIDHSGNIPNLVKQGFQ
GNIYSTFATRDLCQLMLADAARIQEHDCAFINKMNKRRGIHQPDVYPTYSEQDAERCMRQFVNIGYDRPIPVVPGVTLTF
YDAGHILGAAQVCLDIEDREDGRKKRFLFSGDVGRGDNELLRDPVPVPDVDILLMESTYGGRFHEAPSRDDETFCRAIKE
ALELGGRVYIPAFAVERTQQLLYLLNRAYHEGTLPLLPVYVDSPMAVGATEIFRIHPECFNKEVYDFLFREKDPFCFEQL
RLIRSVGESQALNKMNGQAIIISASGMCEAGRILHHLANNIGDPKNTVLFVGYCAEHTLGRKIMDGWKEVPILGKQYPVR
ARIREMDSFSGHADHGELLEYFDRTGGPKRNIILVHGEEKATQALAGALRERQANPVSIAQLGSAMVL
>Mature_468_residues
MKIHFCGAAGTTTGSQHLLEVNGCRILLDCGMYQGRREEAWHINKDFPYFSPAGVDAVVLSHAHIDHSGNIPNLVKQGFQ
GNIYSTFATRDLCQLMLADAARIQEHDCAFINKMNKRRGIHQPDVYPTYSEQDAERCMRQFVNIGYDRPIPVVPGVTLTF
YDAGHILGAAQVCLDIEDREDGRKKRFLFSGDVGRGDNELLRDPVPVPDVDILLMESTYGGRFHEAPSRDDETFCRAIKE
ALELGGRVYIPAFAVERTQQLLYLLNRAYHEGTLPLLPVYVDSPMAVGATEIFRIHPECFNKEVYDFLFREKDPFCFEQL
RLIRSVGESQALNKMNGQAIIISASGMCEAGRILHHLANNIGDPKNTVLFVGYCAEHTLGRKIMDGWKEVPILGKQYPVR
ARIREMDSFSGHADHGELLEYFDRTGGPKRNIILVHGEEKATQALAGALRERQANPVSIAQLGSAMVL

Specific function: Has endoribonuclease activity towards 23S and 16S rRNA (in vitro) [H]

COG id: COG1236

COG function: function code J; Predicted exonuclease of the beta-lactamase fold involved in RNA processing

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family [H]

Homologues:

Organism=Homo sapiens, GI7706427, Length=457, Percent_Identity=28.4463894967177, Blast_Score=181, Evalue=1e-45,
Organism=Homo sapiens, GI33300633, Length=453, Percent_Identity=25.3863134657837, Blast_Score=155, Evalue=8e-38,
Organism=Caenorhabditis elegans, GI32564696, Length=479, Percent_Identity=27.348643006263, Blast_Score=177, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI32566029, Length=461, Percent_Identity=27.5488069414317, Blast_Score=167, Evalue=1e-41,
Organism=Saccharomyces cerevisiae, GI6323307, Length=461, Percent_Identity=26.6811279826464, Blast_Score=165, Evalue=1e-41,
Organism=Drosophila melanogaster, GI24648013, Length=463, Percent_Identity=28.0777537796976, Blast_Score=171, Evalue=1e-42,
Organism=Drosophila melanogaster, GI21358523, Length=458, Percent_Identity=25.9825327510917, Blast_Score=149, Evalue=3e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022712
- InterPro:   IPR001279
- InterPro:   IPR011108 [H]

Pfam domain/function: PF10996 Beta-Casp; PF00753 Lactamase_B; PF07521 RMMBL [H]

EC number: NA

Molecular weight: Translated: 52421; Mature: 52421

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIHFCGAAGTTTGSQHLLEVNGCRILLDCGMYQGRREEAWHINKDFPYFSPAGVDAVVL
CEEEEECCCCCCCCCCEEEEECCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCEEEE
SHAHIDHSGNIPNLVKQGFQGNIYSTFATRDLCQLMLADAARIQEHDCAFINKMNKRRGI
EHHCCCCCCCCCHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
HQPDVYPTYSEQDAERCMRQFVNIGYDRPIPVVPGVTLTFYDAGHILGAAQVCLDIEDRE
CCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCHHHHHHHHEEECCCCC
DGRKKRFLFSGDVGRGDNELLRDPVPVPDVDILLMESTYGGRFHEAPSRDDETFCRAIKE
CCCCEEEEEECCCCCCCHHHHCCCCCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHH
ALELGGRVYIPAFAVERTQQLLYLLNRAYHEGTLPLLPVYVDSPMAVGATEIFRIHPECF
HHHHCCEEEEEHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCHHHEEECHHHH
NKEVYDFLFREKDPFCFEQLRLIRSVGESQALNKMNGQAIIISASGMCEAGRILHHLANN
CHHHHHHHHCCCCCHHHHHHHHHHHHCHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHH
IGDPKNTVLFVGYCAEHTLGRKIMDGWKEVPILGKQYPVRARIREMDSFSGHADHGELLE
CCCCCCEEEEEEEHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHH
YFDRTGGPKRNIILVHGEEKATQALAGALRERQANPVSIAQLGSAMVL
HHHHCCCCCCCEEEEECCHHHHHHHHHHHHHHCCCCCHHHHHCCHHCC
>Mature Secondary Structure
MKIHFCGAAGTTTGSQHLLEVNGCRILLDCGMYQGRREEAWHINKDFPYFSPAGVDAVVL
CEEEEECCCCCCCCCCEEEEECCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCEEEE
SHAHIDHSGNIPNLVKQGFQGNIYSTFATRDLCQLMLADAARIQEHDCAFINKMNKRRGI
EHHCCCCCCCCCHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
HQPDVYPTYSEQDAERCMRQFVNIGYDRPIPVVPGVTLTFYDAGHILGAAQVCLDIEDRE
CCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCHHHHHHHHEEECCCCC
DGRKKRFLFSGDVGRGDNELLRDPVPVPDVDILLMESTYGGRFHEAPSRDDETFCRAIKE
CCCCEEEEEECCCCCCCHHHHCCCCCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHH
ALELGGRVYIPAFAVERTQQLLYLLNRAYHEGTLPLLPVYVDSPMAVGATEIFRIHPECF
HHHHCCEEEEEHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCHHHEEECHHHH
NKEVYDFLFREKDPFCFEQLRLIRSVGESQALNKMNGQAIIISASGMCEAGRILHHLANN
CHHHHHHHHCCCCCHHHHHHHHHHHHCHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHH
IGDPKNTVLFVGYCAEHTLGRKIMDGWKEVPILGKQYPVRARIREMDSFSGHADHGELLE
CCCCCCEEEEEEEHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHH
YFDRTGGPKRNIILVHGEEKATQALAGALRERQANPVSIAQLGSAMVL
HHHHCCCCCCCEEEEECCHHHHHHHHHHHHHHCCCCCHHHHHCCHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA