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The map label for this gene is serA [H]

Identifier: 187733261

GI number: 187733261

Start: 2854678

End: 2855523

Strand: Direct

Name: serA [H]

Synonym: SbBS512_E3053

Alternate gene names: 187733261

Gene position: 2854678-2855523 (Clockwise)

Preceding gene: 187733808

Following gene: 187730960

Centisome position: 61.84

GC content: 44.21

Gene sequence:

>846_bases
GTGGAGCATCTGCTTAAATCAGAATCCACTGCATTACGAGAATCTATTTGCGCGGTCATCGCCGGAAAAGATTGTTATCA
GGCGGACACGCTATCATTGCTGCCTGGTGTGAAAATAATATCGAGATTCAGGACGGGGATAGATAATATTGATCTTCGTG
CAGCACAACAATCCGGTATTGTAGTCAATAATGCGGTTGGGATTAATTCAAATGCTGTCGCGGAATTTATCATTGGACTT
ATCTTCGCGAGCATGAGAAATATTCCCGGCAGCTATCATGCGATGCAAAATGGCTACTGGGGTGAGTCGCATGGCTATGA
ATTACAAGGCAAACGGATTGGCATGGTTGGCTACGGCAATATAGGTAAAACCCTGGCAAAAAGGTTATCCGGTTTTGATG
TTGAGCTTTTAGCTTATGACAAACAACCCGATTATCAGGTTGCTGACAAAGTTGGAGTTCAGTTTGTATCAATTGAAGAT
ATCTTTATGCAGTCGCATGTCATCATTGTTCTTTTGCCTTTTTCTCCTGAGCTGGAGAACTTCATTAGTCATAAATATTT
GTCGATGATGCGCAATGGTGCTCTAATCATCAATGCCGCAAGGGGAAAGTTGCTGGATGAGGGCGCTTTACTACAGGTGA
TTGAAGAACGAAATGTGTTTGCGGCGCTGGATGTGTTTAGCTCTGAACCGTTGGCGCAATTTAGCCCACTGCTACATGCC
AAAAATATCATTACAACGCCGCATATTGCGGCCGCCACCGTTGAGTCATACCAGCAAACCGGTACACACGTTGCCCAGTC
GATAATTGATTACTTCGCAGGAAGGGAGATAAAAAACGTGTTGTGA

Upstream 100 bases:

>100_bases
GAAAAATGTTCTGGTCACCGTCCCCAGCTTTTCAGCACGCTGTGTTTCCGCCAGCAAGTTGCTAAGAGAGAATAATTTTA
ATCTTATTATTAAGAATAAT

Downstream 100 bases:

>100_bases
GTTCAGCGAACGAAGTTTTTAAATACAAAAAAACCGCAATTTGTGGAACACATTGCGGTTTATCAGCATTCTAAGTATTG
GTTGCGGGGGCCGGATTTGA

Product: D-isomer specific 2-hydroxyacid dehydrogenase family protein

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 281; Mature: 281

Protein sequence:

>281_residues
MEHLLKSESTALRESICAVIAGKDCYQADTLSLLPGVKIISRFRTGIDNIDLRAAQQSGIVVNNAVGINSNAVAEFIIGL
IFASMRNIPGSYHAMQNGYWGESHGYELQGKRIGMVGYGNIGKTLAKRLSGFDVELLAYDKQPDYQVADKVGVQFVSIED
IFMQSHVIIVLLPFSPELENFISHKYLSMMRNGALIINAARGKLLDEGALLQVIEERNVFAALDVFSSEPLAQFSPLLHA
KNIITTPHIAAATVESYQQTGTHVAQSIIDYFAGREIKNVL

Sequences:

>Translated_281_residues
MEHLLKSESTALRESICAVIAGKDCYQADTLSLLPGVKIISRFRTGIDNIDLRAAQQSGIVVNNAVGINSNAVAEFIIGL
IFASMRNIPGSYHAMQNGYWGESHGYELQGKRIGMVGYGNIGKTLAKRLSGFDVELLAYDKQPDYQVADKVGVQFVSIED
IFMQSHVIIVLLPFSPELENFISHKYLSMMRNGALIINAARGKLLDEGALLQVIEERNVFAALDVFSSEPLAQFSPLLHA
KNIITTPHIAAATVESYQQTGTHVAQSIIDYFAGREIKNVL
>Mature_281_residues
MEHLLKSESTALRESICAVIAGKDCYQADTLSLLPGVKIISRFRTGIDNIDLRAAQQSGIVVNNAVGINSNAVAEFIIGL
IFASMRNIPGSYHAMQNGYWGESHGYELQGKRIGMVGYGNIGKTLAKRLSGFDVELLAYDKQPDYQVADKVGVQFVSIED
IFMQSHVIIVLLPFSPELENFISHKYLSMMRNGALIINAARGKLLDEGALLQVIEERNVFAALDVFSSEPLAQFSPLLHA
KNIITTPHIAAATVESYQQTGTHVAQSIIDYFAGREIKNVL

Specific function: Serine biosynthesis; first step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=257, Percent_Identity=32.6848249027237, Blast_Score=160, Evalue=9e-40,
Organism=Homo sapiens, GI6912396, Length=252, Percent_Identity=29.3650793650794, Blast_Score=126, Evalue=3e-29,
Organism=Homo sapiens, GI145580575, Length=274, Percent_Identity=29.5620437956204, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI145580578, Length=273, Percent_Identity=28.9377289377289, Blast_Score=108, Evalue=5e-24,
Organism=Homo sapiens, GI4557499, Length=273, Percent_Identity=28.9377289377289, Blast_Score=108, Evalue=5e-24,
Organism=Homo sapiens, GI4557497, Length=277, Percent_Identity=28.8808664259928, Blast_Score=106, Evalue=3e-23,
Organism=Homo sapiens, GI61743967, Length=277, Percent_Identity=28.8808664259928, Blast_Score=106, Evalue=3e-23,
Organism=Escherichia coli, GI1789279, Length=239, Percent_Identity=32.6359832635983, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI87082289, Length=258, Percent_Identity=27.1317829457364, Blast_Score=125, Evalue=3e-30,
Organism=Escherichia coli, GI1787645, Length=262, Percent_Identity=28.2442748091603, Blast_Score=107, Evalue=6e-25,
Organism=Escherichia coli, GI87081824, Length=185, Percent_Identity=30.8108108108108, Blast_Score=75, Evalue=3e-15,
Organism=Escherichia coli, GI1788660, Length=243, Percent_Identity=27.9835390946502, Blast_Score=61, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI17532191, Length=241, Percent_Identity=31.5352697095436, Blast_Score=137, Evalue=4e-33,
Organism=Caenorhabditis elegans, GI25147481, Length=282, Percent_Identity=26.241134751773, Blast_Score=77, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6322116, Length=248, Percent_Identity=30.241935483871, Blast_Score=117, Evalue=3e-27,
Organism=Saccharomyces cerevisiae, GI6320925, Length=248, Percent_Identity=29.8387096774194, Blast_Score=112, Evalue=5e-26,
Organism=Saccharomyces cerevisiae, GI6324055, Length=237, Percent_Identity=27.0042194092827, Blast_Score=103, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6324964, Length=267, Percent_Identity=26.9662921348315, Blast_Score=86, Evalue=8e-18,
Organism=Saccharomyces cerevisiae, GI6321253, Length=160, Percent_Identity=28.75, Blast_Score=72, Evalue=1e-13,
Organism=Drosophila melanogaster, GI19921140, Length=238, Percent_Identity=31.5126050420168, Blast_Score=126, Evalue=2e-29,
Organism=Drosophila melanogaster, GI28574286, Length=272, Percent_Identity=25.3676470588235, Blast_Score=124, Evalue=5e-29,
Organism=Drosophila melanogaster, GI45552429, Length=248, Percent_Identity=26.2096774193548, Blast_Score=119, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24585514, Length=251, Percent_Identity=25.8964143426295, Blast_Score=119, Evalue=2e-27,
Organism=Drosophila melanogaster, GI28574282, Length=251, Percent_Identity=25.8964143426295, Blast_Score=119, Evalue=2e-27,
Organism=Drosophila melanogaster, GI45551003, Length=251, Percent_Identity=25.8964143426295, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI28574284, Length=251, Percent_Identity=25.8964143426295, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24585516, Length=247, Percent_Identity=27.5303643724696, Blast_Score=116, Evalue=1e-26,
Organism=Drosophila melanogaster, GI28571528, Length=278, Percent_Identity=27.6978417266187, Blast_Score=112, Evalue=4e-25,
Organism=Drosophila melanogaster, GI24646446, Length=274, Percent_Identity=28.8321167883212, Blast_Score=98, Evalue=6e-21,
Organism=Drosophila melanogaster, GI24646448, Length=274, Percent_Identity=28.8321167883212, Blast_Score=98, Evalue=6e-21,
Organism=Drosophila melanogaster, GI24646452, Length=274, Percent_Identity=28.8321167883212, Blast_Score=98, Evalue=6e-21,
Organism=Drosophila melanogaster, GI24646450, Length=274, Percent_Identity=28.8321167883212, Blast_Score=98, Evalue=6e-21,
Organism=Drosophila melanogaster, GI62472511, Length=274, Percent_Identity=28.8321167883212, Blast_Score=97, Evalue=1e-20,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 30815; Mature: 30815

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEHLLKSESTALRESICAVIAGKDCYQADTLSLLPGVKIISRFRTGIDNIDLRAAQQSGI
CCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCHHHHHHHHHCCCCCCEEEEHHCCCE
VVNNAVGINSNAVAEFIIGLIFASMRNIPGSYHAMQNGYWGESHGYELQGKRIGMVGYGN
EEEEECCCCCHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCEEECCCEEEEEECCC
IGKTLAKRLSGFDVELLAYDKQPDYQVADKVGVQFVSIEDIFMQSHVIIVLLPFSPELEN
HHHHHHHHHCCCCEEEEEECCCCCHHHHHHHCEEEEEHHHHHHCCCEEEEEECCCCCHHH
FISHKYLSMMRNGALIINAARGKLLDEGALLQVIEERNVFAALDVFSSEPLAQFSPLLHA
HHHHHHHHHHHCCCEEEECCCCCCCCCCHHHHHHHHCCCEEEEHHHCCCCHHHHHHHHHH
KNIITTPHIAAATVESYQQTGTHVAQSIIDYFAGREIKNVL
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCC
>Mature Secondary Structure
MEHLLKSESTALRESICAVIAGKDCYQADTLSLLPGVKIISRFRTGIDNIDLRAAQQSGI
CCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCHHHHHHHHHCCCCCCEEEEHHCCCE
VVNNAVGINSNAVAEFIIGLIFASMRNIPGSYHAMQNGYWGESHGYELQGKRIGMVGYGN
EEEEECCCCCHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCEEECCCEEEEEECCC
IGKTLAKRLSGFDVELLAYDKQPDYQVADKVGVQFVSIEDIFMQSHVIIVLLPFSPELEN
HHHHHHHHHCCCCEEEEEECCCCCHHHHHHHCEEEEEHHHHHHCCCEEEEEECCCCCHHH
FISHKYLSMMRNGALIINAARGKLLDEGALLQVIEERNVFAALDVFSSEPLAQFSPLLHA
HHHHHHHHHHHCCCEEEECCCCCCCCCCHHHHHHHHCCCEEEEHHHCCCCHHHHHHHHHH
KNIITTPHIAAATVESYQQTGTHVAQSIIDYFAGREIKNVL
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9389475 [H]