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The map label for this gene is hisQ

Identifier: 187732192

GI number: 187732192

Start: 2486559

End: 2487245

Strand: Reverse

Name: hisQ

Synonym: SbBS512_E2686

Alternate gene names: 187732192

Gene position: 2487245-2486559 (Counterclockwise)

Preceding gene: 187731129

Following gene: 187732602

Centisome position: 53.88

GC content: 52.55

Gene sequence:

>687_bases
ATGTTGTATGGGTTTTCAGGTGTTATTTTACAGGGTGCGCTCGTCACGCTGGAGCTGGCTATCAGCTCTGTAGTGCTCGC
TGTAATCATCGGTTTAATTGGCGCTGGCGGTAAGCTCTCGCAAAATCGGCTTTCGGAGCTGATTTTCGAAGGGTACACCA
CGCTGATTCGTGGCGTGCCGGACTTAGTGTTGATGCTGCTGATTTTCTTCGGTTTGCAGATTGCGCTAAACACGGTGACG
GAGGCGATGGGCGTCGGGCAGATTGATATCGATCCGATGGTCGCTGGTATTATCACTCTCGGTTTTATCTACGGTGCTTA
TTTTACCGAAACGTTCCGTGGTGCTTTTATGGCAGTGCCGAAAGGACATATAGAGGCGGCGACGGCGTTCGGTTTTACTC
GTGGGCAAGTGTTTCGGCGGATCATGTTTCCGGCGATGATGCGTTACGCCCTGCCAGGCATTGGCAACAACTGGCAGGTG
ATCCTCAAATCTACCGCACTGGTTTCGTTACTCGGCCTGGAAGATGTGGTCAAAGCCACCCAACTGGCAGGCAAAAGTAC
CTGGGAACCGTTCTATTTCGCCATCGTCTGTGGCGTGATTTACCTGGTTTTCACCACTGTTTCCAATGGTGTGCTGCTGT
TCCTTGAGCGCCGCTACTCCGTGGGTGTGAAGAGGGCTGACCTGTGA

Upstream 100 bases:

>100_bases
ATGGTGGCTAATCGCCATCGGTGAAAGAAAGCCCGCTCCCTTCGGGTAACCGGAGGGAGACAAGAGGCGGTAATTCACCA
CACACGACAGGACAGGCAGC

Downstream 100 bases:

>100_bases
TCGAAATCTTACATGAATACTGGAAACCGCTGCTGTGGACCGACGGTTATCGCTTTACTGGTGTGGCGATCACTCTGTGG
CTGCTTATTTTGTCGGTAGT

Product: histidine ABC transporter permease HisQ

Products: ADP; phosphate; L-histidine [Cytoplasm]; ADP; L-ornithine [Cytoplasm]; L-arginine [Cytoplasm]; L-lysine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 228; Mature: 228

Protein sequence:

>228_residues
MLYGFSGVILQGALVTLELAISSVVLAVIIGLIGAGGKLSQNRLSELIFEGYTTLIRGVPDLVLMLLIFFGLQIALNTVT
EAMGVGQIDIDPMVAGIITLGFIYGAYFTETFRGAFMAVPKGHIEAATAFGFTRGQVFRRIMFPAMMRYALPGIGNNWQV
ILKSTALVSLLGLEDVVKATQLAGKSTWEPFYFAIVCGVIYLVFTTVSNGVLLFLERRYSVGVKRADL

Sequences:

>Translated_228_residues
MLYGFSGVILQGALVTLELAISSVVLAVIIGLIGAGGKLSQNRLSELIFEGYTTLIRGVPDLVLMLLIFFGLQIALNTVT
EAMGVGQIDIDPMVAGIITLGFIYGAYFTETFRGAFMAVPKGHIEAATAFGFTRGQVFRRIMFPAMMRYALPGIGNNWQV
ILKSTALVSLLGLEDVVKATQLAGKSTWEPFYFAIVCGVIYLVFTTVSNGVLLFLERRYSVGVKRADL
>Mature_228_residues
MLYGFSGVILQGALVTLELAISSVVLAVIIGLIGAGGKLSQNRLSELIFEGYTTLIRGVPDLVLMLLIFFGLQIALNTVT
EAMGVGQIDIDPMVAGIITLGFIYGAYFTETFRGAFMAVPKGHIEAATAFGFTRGQVFRRIMFPAMMRYALPGIGNNWQV
ILKSTALVSLLGLEDVVKATQLAGKSTWEPFYFAIVCGVIYLVFTTVSNGVLLFLERRYSVGVKRADL

Specific function: Part of the binding-protein-dependent transport system for histidine; probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG4215

COG function: function code E; ABC-type arginine transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1788646, Length=228, Percent_Identity=98.6842105263158, Blast_Score=446, Evalue=1e-127,
Organism=Escherichia coli, GI1787087, Length=226, Percent_Identity=32.3008849557522, Blast_Score=134, Evalue=5e-33,
Organism=Escherichia coli, GI1788645, Length=222, Percent_Identity=30.6306306306306, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI1787030, Length=214, Percent_Identity=27.5700934579439, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI1788226, Length=199, Percent_Identity=29.6482412060301, Blast_Score=91, Evalue=7e-20,
Organism=Escherichia coli, GI1787086, Length=222, Percent_Identity=27.027027027027, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1786873, Length=210, Percent_Identity=23.3333333333333, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1786874, Length=220, Percent_Identity=26.8181818181818, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI87082239, Length=219, Percent_Identity=27.3972602739726, Blast_Score=61, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010065
- InterPro:   IPR000515 [H]

Pfam domain/function: PF00528 BPD_transp_1 [H]

EC number: NA

Molecular weight: Translated: 24690; Mature: 24690

Theoretical pI: Translated: 8.93; Mature: 8.93

Prosite motif: PS50928 ABC_TM1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLYGFSGVILQGALVTLELAISSVVLAVIIGLIGAGGKLSQNRLSELIFEGYTTLIRGVP
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCH
DLVLMLLIFFGLQIALNTVTEAMGVGQIDIDPMVAGIITLGFIYGAYFTETFRGAFMAVP
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHEECC
KGHIEAATAFGFTRGQVFRRIMFPAMMRYALPGIGNNWQVILKSTALVSLLGLEDVVKAT
CCHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
QLAGKSTWEPFYFAIVCGVIYLVFTTVSNGVLLFLERRYSVGVKRADL
HHCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEEHHHHCCCCCCCC
>Mature Secondary Structure
MLYGFSGVILQGALVTLELAISSVVLAVIIGLIGAGGKLSQNRLSELIFEGYTTLIRGVP
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCH
DLVLMLLIFFGLQIALNTVTEAMGVGQIDIDPMVAGIITLGFIYGAYFTETFRGAFMAVP
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHEECC
KGHIEAATAFGFTRGQVFRRIMFPAMMRYALPGIGNNWQVILKSTALVSLLGLEDVVKAT
CCHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
QLAGKSTWEPFYFAIVCGVIYLVFTTVSNGVLLFLERRYSVGVKRADL
HHCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEEHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-histidine [Periplasm]; H2O; ATP; L-ornithine [Periplasm]; L-arginine [Periplasm]; L-lysine [Periplasm] [C]

Specific reaction: ATP + L-histidine [Periplasm] + H2O = ADP + phosphate + L-histidine [Cytoplasm] ATP + L-ornithine [Periplasm] + H2O = ADP + phosphate + L-ornithine [Cytoplasm] ATP + L-arginine [Periplasm] + H2O = ADP + phosphate + L-arginine [Cytoplasm] ATP + L-lysine [P

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503 [H]