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The map label for this gene is srlD

Identifier: 187731541

GI number: 187731541

Start: 2964313

End: 2965092

Strand: Reverse

Name: srlD

Synonym: SbBS512_E3172

Alternate gene names: 187731541

Gene position: 2965092-2964313 (Counterclockwise)

Preceding gene: 187732253

Following gene: 187732944

Centisome position: 64.24

GC content: 52.82

Gene sequence:

>780_bases
ATGAATCAGGTTGCCGTTGTCATCGGTGGTGGGCAAACCTTAGGCGCGTTCCTGTGCCACGGTCTGGTTGCCGAGGGGTA
TCGCGTCGCGGTTGTCGATATTCAGAGCGACAAAGCCGCAAATGTGGCACAAGAAATTAACGCCGAATATGGTGAAAGTA
TGGCGTACGGTTTTGGTGCTGACGCCACTAGCGAGCAAAGCGTTCTGGCGCTCTCTCGTGGGGTAGATGAAATCTTTGGT
CGCGTGGATTTGCTGGTCTATAGCGCCGGAATAGCAAAAGCAGCCTTTATCAGCGACTTCCAGCTCGGCGATTTTGACCG
TTCGCTACAAGTGAATCTGGTGGGTTATTTCCTGTGTGCCCGTGAATTTTCGCGTTTGATGATCCGCGACGGGATTCAGG
GTCGCATTATTCAGATCAACTCGAAATCCGGCAAAGTGGGCAGCAAACACAACTCTGGCTACAGCGCAGCGAAATTTGGT
GGCGTCGGGCTGACTCAATCACTGGCGCTGGATCTGGCGGAGTACGGCATTACGGTGCATTCACTGATGCTCGGTAACCT
GCTGAAATCGCCGATGTTCCAGTCACTGTTGCCACAATACGCGACCAAGCTGGGTATCAAACCGGATCAAGTCGAGCAGT
ATTACATCGACAAAGTACCGCTCAAACGCGGCTGCGATTATCAAGATGTGCTGAATATGCTGCTGTTCTACGCCAGTCCT
AAGGCGTCGTACTGCACCGGACAGTCGATCAATGTCACCGGCGGTCAGGTGATGTTCTGA

Upstream 100 bases:

>100_bases
CGAAGCGGAATTTCCGGGCACTGTCCATGTGGCAGGCCCTGTACCCGACGATATCGCGCCGGGATCGGTTTTGAAGTTTG
AATCTGTTAAGGAGTAAAAA

Downstream 100 bases:

>100_bases
TCAACAGCGGAGATCCATTAAGGATCTCCGTGAGACTATAGAATGCCTGATGCGCTACGCTCATCAGGCATACAGGACTT
CCGCCACTACATTAAGGGAA

Product: sorbitol-6-phosphate dehydrogenase

Products: NA

Alternate protein names: Glucitol-6-phosphate dehydrogenase; Ketosephosphate reductase [H]

Number of amino acids: Translated: 259; Mature: 259

Protein sequence:

>259_residues
MNQVAVVIGGGQTLGAFLCHGLVAEGYRVAVVDIQSDKAANVAQEINAEYGESMAYGFGADATSEQSVLALSRGVDEIFG
RVDLLVYSAGIAKAAFISDFQLGDFDRSLQVNLVGYFLCAREFSRLMIRDGIQGRIIQINSKSGKVGSKHNSGYSAAKFG
GVGLTQSLALDLAEYGITVHSLMLGNLLKSPMFQSLLPQYATKLGIKPDQVEQYYIDKVPLKRGCDYQDVLNMLLFYASP
KASYCTGQSINVTGGQVMF

Sequences:

>Translated_259_residues
MNQVAVVIGGGQTLGAFLCHGLVAEGYRVAVVDIQSDKAANVAQEINAEYGESMAYGFGADATSEQSVLALSRGVDEIFG
RVDLLVYSAGIAKAAFISDFQLGDFDRSLQVNLVGYFLCAREFSRLMIRDGIQGRIIQINSKSGKVGSKHNSGYSAAKFG
GVGLTQSLALDLAEYGITVHSLMLGNLLKSPMFQSLLPQYATKLGIKPDQVEQYYIDKVPLKRGCDYQDVLNMLLFYASP
KASYCTGQSINVTGGQVMF
>Mature_259_residues
MNQVAVVIGGGQTLGAFLCHGLVAEGYRVAVVDIQSDKAANVAQEINAEYGESMAYGFGADATSEQSVLALSRGVDEIFG
RVDLLVYSAGIAKAAFISDFQLGDFDRSLQVNLVGYFLCAREFSRLMIRDGIQGRIIQINSKSGKVGSKHNSGYSAAKFG
GVGLTQSLALDLAEYGITVHSLMLGNLLKSPMFQSLLPQYATKLGIKPDQVEQYYIDKVPLKRGCDYQDVLNMLLFYASP
KASYCTGQSINVTGGQVMF

Specific function: Sorbitol metabolism. [C]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI15277342, Length=265, Percent_Identity=32.4528301886792, Blast_Score=112, Evalue=4e-25,
Organism=Homo sapiens, GI4758504, Length=233, Percent_Identity=32.618025751073, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI40254992, Length=256, Percent_Identity=26.953125, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI19923817, Length=266, Percent_Identity=26.6917293233083, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI83715985, Length=233, Percent_Identity=31.3304721030043, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI59889578, Length=237, Percent_Identity=27.4261603375527, Blast_Score=66, Evalue=3e-11,
Organism=Escherichia coli, GI1789057, Length=259, Percent_Identity=99.6138996138996, Blast_Score=523, Evalue=1e-150,
Organism=Escherichia coli, GI1787335, Length=256, Percent_Identity=28.515625, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1787905, Length=255, Percent_Identity=28.6274509803922, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI87082160, Length=259, Percent_Identity=28.1853281853282, Blast_Score=91, Evalue=5e-20,
Organism=Escherichia coli, GI1788459, Length=264, Percent_Identity=28.030303030303, Blast_Score=87, Evalue=9e-19,
Organism=Escherichia coli, GI2367175, Length=257, Percent_Identity=29.5719844357977, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI87082100, Length=257, Percent_Identity=27.2373540856031, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1790717, Length=253, Percent_Identity=22.5296442687747, Blast_Score=79, Evalue=2e-16,
Organism=Escherichia coli, GI1789208, Length=188, Percent_Identity=27.1276595744681, Blast_Score=69, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17555706, Length=254, Percent_Identity=28.3464566929134, Blast_Score=102, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI25147288, Length=254, Percent_Identity=29.9212598425197, Blast_Score=100, Evalue=7e-22,
Organism=Caenorhabditis elegans, GI17508895, Length=169, Percent_Identity=30.1775147928994, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17538182, Length=228, Percent_Identity=31.5789473684211, Blast_Score=77, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI17531453, Length=270, Percent_Identity=25.5555555555556, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17568967, Length=219, Percent_Identity=28.7671232876712, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI193203115, Length=243, Percent_Identity=25.9259259259259, Blast_Score=64, Evalue=1e-10,
Organism=Saccharomyces cerevisiae, GI6322861, Length=211, Percent_Identity=31.2796208530806, Blast_Score=75, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24639444, Length=255, Percent_Identity=27.843137254902, Blast_Score=105, Evalue=3e-23,
Organism=Drosophila melanogaster, GI17737361, Length=233, Percent_Identity=30.4721030042918, Blast_Score=88, Evalue=6e-18,
Organism=Drosophila melanogaster, GI21355631, Length=170, Percent_Identity=29.4117647058824, Blast_Score=75, Evalue=6e-14,
Organism=Drosophila melanogaster, GI23397609, Length=259, Percent_Identity=25.4826254826255, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI21357041, Length=255, Percent_Identity=26.6666666666667, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24581726, Length=194, Percent_Identity=23.1958762886598, Blast_Score=65, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.1.1.140 [H]

Molecular weight: Translated: 27886; Mature: 27886

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQVAVVIGGGQTLGAFLCHGLVAEGYRVAVVDIQSDKAANVAQEINAEYGESMAYGFGA
CCEEEEEEECCHHHHHHHHHHHHHCCEEEEEEEECCCCHHHHHHHHHHHHCCCEEECCCC
DATSEQSVLALSRGVDEIFGRVDLLVYSAGIAKAAFISDFQLGDFDRSLQVNLVGYFLCA
CCCCCHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCEEHHHHHHHHHH
REFSRLMIRDGIQGRIIQINSKSGKVGSKHNSGYSAAKFGGVGLTQSLALDLAEYGITVH
HHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCHHHCCCCCHHHHHHHHHHHHCHHHH
SLMLGNLLKSPMFQSLLPQYATKLGIKPDQVEQYYIDKVPLKRGCDYQDVLNMLLFYASP
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHCCCCHHHHHHHHHHHCCC
KASYCTGQSINVTGGQVMF
CCCCCCCCEEECCCCEEEC
>Mature Secondary Structure
MNQVAVVIGGGQTLGAFLCHGLVAEGYRVAVVDIQSDKAANVAQEINAEYGESMAYGFGA
CCEEEEEEECCHHHHHHHHHHHHHCCEEEEEEEECCCCHHHHHHHHHHHHCCCEEECCCC
DATSEQSVLALSRGVDEIFGRVDLLVYSAGIAKAAFISDFQLGDFDRSLQVNLVGYFLCA
CCCCCHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCEEHHHHHHHHHH
REFSRLMIRDGIQGRIIQINSKSGKVGSKHNSGYSAAKFGGVGLTQSLALDLAEYGITVH
HHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCHHHCCCCCHHHHHHHHHHHHCHHHH
SLMLGNLLKSPMFQSLLPQYATKLGIKPDQVEQYYIDKVPLKRGCDYQDVLNMLLFYASP
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHCCCCHHHHHHHHHHHCCC
KASYCTGQSINVTGGQVMF
CCCCCCCCEEECCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3553176; 9205837; 9278503; 6384188 [H]