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The map label for this gene is aqpZ [H]

Identifier: 186477728

GI number: 186477728

Start: 3340296

End: 3341045

Strand: Direct

Name: aqpZ [H]

Synonym: Bphy_2982

Alternate gene names: 186477728

Gene position: 3340296-3341045 (Clockwise)

Preceding gene: 186477726

Following gene: 186477731

Centisome position: 96.01

GC content: 64.27

Gene sequence:

>750_bases
ATGAACCTCTTCAAGCGCCTCGCGGCGGAGCTGTTCGGCACTTTTTGGCTCGTTCTCGGAGGTTGCGGCAGCGCCGTGCT
CGCGGCAAATTTCGCCGGCCCGGTTCATGGGCTCGGCATCGGATTCGTGGGCGTGTCGCTCGCGTTCGGCCTGACTGTCC
TGACCATGGCTTATGCAATCGGACATATTTCTGGTTGTCATCTGAATCCGGCCGTCAGCGTCGGGTTGACCGTCGCGGGC
CGCTTCCCGGCGCGTGACCTAACGCCGTACGTCGTCGCGCAGGTGCTGGGCGCCGTGCTTGGCGCGTATGTGCTGTCCGT
GATTGCTTCGGGCAATCCGGATTTCCATCTGGTTGCAAGCGGCTTCGCGAGCAACGGCTACGGCGACCGCTCGCCGGGCC
ACTATGCGTTGCCTGCCGCGTTTGTGTGCGAAACGGTGATGACGGCTTTCTTCCTGTTCGTCATTCTCGGTGCCACCGAC
AAGCGCGCGCCTGTCGGCTTCGCGCCCATCGCGATCGGCCTGTGCCTTACCTTGATCCACCTGATCTCGATTCCCGTCAC
CAATACGTCGGTGAATCCGGCGCGCTCGACGGGTCCGGCGCTGTTCGTCGGCGGTGCGGCTGTCGATCAGTTGTGGCTAT
TCTGGGTCGCACCTATTCTCGGCGCCGTGATCGCCGGCGTGGTGTATCCGCTGCTTGCCGGCGGCGCGCAGCACGCCGTG
GAAGCCGAGCGCGAGCGTGTGACGGCGTAA

Upstream 100 bases:

>100_bases
GTGCATTTGTGCAACGTTGCTTAAAATTTTTGCTCGCAAGTGCCGGGCAGCGGCGCATGCGCTCTCGTCCTTGAATCCCT
GCACTTATTAGGATTACACA

Downstream 100 bases:

>100_bases
TTAGCCGCTATCCAGTCTGCGTGAAAACGGGGCGCTTCGGCGCCCCGTTTGCTTGTATGTCCAAATGTAAGGCTGGTTCA
GGATGGCGTTCGCCGTCTTT

Product: aquaporin Z

Products: H2O [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 249; Mature: 249

Protein sequence:

>249_residues
MNLFKRLAAELFGTFWLVLGGCGSAVLAANFAGPVHGLGIGFVGVSLAFGLTVLTMAYAIGHISGCHLNPAVSVGLTVAG
RFPARDLTPYVVAQVLGAVLGAYVLSVIASGNPDFHLVASGFASNGYGDRSPGHYALPAAFVCETVMTAFFLFVILGATD
KRAPVGFAPIAIGLCLTLIHLISIPVTNTSVNPARSTGPALFVGGAAVDQLWLFWVAPILGAVIAGVVYPLLAGGAQHAV
EAERERVTA

Sequences:

>Translated_249_residues
MNLFKRLAAELFGTFWLVLGGCGSAVLAANFAGPVHGLGIGFVGVSLAFGLTVLTMAYAIGHISGCHLNPAVSVGLTVAG
RFPARDLTPYVVAQVLGAVLGAYVLSVIASGNPDFHLVASGFASNGYGDRSPGHYALPAAFVCETVMTAFFLFVILGATD
KRAPVGFAPIAIGLCLTLIHLISIPVTNTSVNPARSTGPALFVGGAAVDQLWLFWVAPILGAVIAGVVYPLLAGGAQHAV
EAERERVTA
>Mature_249_residues
MNLFKRLAAELFGTFWLVLGGCGSAVLAANFAGPVHGLGIGFVGVSLAFGLTVLTMAYAIGHISGCHLNPAVSVGLTVAG
RFPARDLTPYVVAQVLGAVLGAYVLSVIASGNPDFHLVASGFASNGYGDRSPGHYALPAAFVCETVMTAFFLFVILGATD
KRAPVGFAPIAIGLCLTLIHLISIPVTNTSVNPARSTGPALFVGGAAVDQLWLFWVAPILGAVIAGVVYPLLAGGAQHAV
EAERERVTA

Specific function: Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response

COG id: COG0580

COG function: function code G; Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MIP/aquaporin (TC 1.A.8) family [H]

Homologues:

Organism=Homo sapiens, GI4755125, Length=231, Percent_Identity=34.6320346320346, Blast_Score=112, Evalue=3e-25,
Organism=Homo sapiens, GI4502181, Length=230, Percent_Identity=34.3478260869565, Blast_Score=112, Evalue=4e-25,
Organism=Homo sapiens, GI37694062, Length=192, Percent_Identity=35.9375, Blast_Score=106, Evalue=2e-23,
Organism=Homo sapiens, GI4502183, Length=228, Percent_Identity=35.5263157894737, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI4502179, Length=223, Percent_Identity=32.7354260089686, Blast_Score=98, Evalue=8e-21,
Organism=Homo sapiens, GI6912506, Length=235, Percent_Identity=32.7659574468085, Blast_Score=95, Evalue=6e-20,
Organism=Homo sapiens, GI157266307, Length=249, Percent_Identity=30.5220883534137, Blast_Score=88, Evalue=6e-18,
Organism=Homo sapiens, GI4826645, Length=270, Percent_Identity=32.2222222222222, Blast_Score=82, Evalue=3e-16,
Organism=Homo sapiens, GI86792455, Length=188, Percent_Identity=31.3829787234043, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI45446752, Length=207, Percent_Identity=29.4685990338164, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI4502187, Length=254, Percent_Identity=26.7716535433071, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI22538420, Length=248, Percent_Identity=28.6290322580645, Blast_Score=69, Evalue=4e-12,
Organism=Escherichia coli, GI1787101, Length=213, Percent_Identity=67.1361502347418, Blast_Score=274, Evalue=3e-75,
Organism=Escherichia coli, GI1790362, Length=268, Percent_Identity=29.1044776119403, Blast_Score=77, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71993722, Length=253, Percent_Identity=31.6205533596838, Blast_Score=98, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI71992966, Length=241, Percent_Identity=29.8755186721992, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17558372, Length=223, Percent_Identity=29.1479820627803, Blast_Score=77, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI17531431, Length=261, Percent_Identity=31.0344827586207, Blast_Score=71, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17531429, Length=261, Percent_Identity=31.0344827586207, Blast_Score=71, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI71994009, Length=259, Percent_Identity=25.4826254826255, Blast_Score=69, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6321054, Length=214, Percent_Identity=29.9065420560748, Blast_Score=63, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24652747, Length=233, Percent_Identity=33.9055793991416, Blast_Score=117, Evalue=9e-27,
Organism=Drosophila melanogaster, GI45551084, Length=233, Percent_Identity=33.9055793991416, Blast_Score=117, Evalue=9e-27,
Organism=Drosophila melanogaster, GI24652751, Length=191, Percent_Identity=36.1256544502618, Blast_Score=85, Evalue=5e-17,
Organism=Drosophila melanogaster, GI19922038, Length=191, Percent_Identity=36.1256544502618, Blast_Score=84, Evalue=7e-17,
Organism=Drosophila melanogaster, GI45550503, Length=241, Percent_Identity=28.2157676348548, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24762344, Length=236, Percent_Identity=30.9322033898305, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24762346, Length=236, Percent_Identity=30.9322033898305, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24762348, Length=236, Percent_Identity=30.9322033898305, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI20130305, Length=236, Percent_Identity=30.9322033898305, Blast_Score=66, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012269
- InterPro:   IPR000425
- InterPro:   IPR022357 [H]

Pfam domain/function: PF00230 MIP [H]

EC number: NA

Molecular weight: Translated: 25502; Mature: 25502

Theoretical pI: Translated: 7.58; Mature: 7.58

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00221 MIP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLFKRLAAELFGTFWLVLGGCGSAVLAANFAGPVHGLGIGFVGVSLAFGLTVLTMAYAI
CCHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
GHISGCHLNPAVSVGLTVAGRFPARDLTPYVVAQVLGAVLGAYVLSVIASGNPDFHLVAS
HHCCCCCCCCHHHEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEC
GFASNGYGDRSPGHYALPAAFVCETVMTAFFLFVILGATDKRAPVGFAPIAIGLCLTLIH
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHH
LISIPVTNTSVNPARSTGPALFVGGAAVDQLWLFWVAPILGAVIAGVVYPLLAGGAQHAV
HHHCCCCCCCCCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
EAERERVTA
HHHHHHCCC
>Mature Secondary Structure
MNLFKRLAAELFGTFWLVLGGCGSAVLAANFAGPVHGLGIGFVGVSLAFGLTVLTMAYAI
CCHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
GHISGCHLNPAVSVGLTVAGRFPARDLTPYVVAQVLGAVLGAYVLSVIASGNPDFHLVAS
HHCCCCCCCCHHHEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEC
GFASNGYGDRSPGHYALPAAFVCETVMTAFFLFVILGATDKRAPVGFAPIAIGLCLTLIH
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHH
LISIPVTNTSVNPARSTGPALFVGGAAVDQLWLFWVAPILGAVIAGVVYPLLAGGAQHAV
HHHCCCCCCCCCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
EAERERVTA
HHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: H2O [Periplasm] [C]

Specific reaction: H2O [Periplasm] = H2O [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 14500782 [H]