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The map label for this gene is ahcY [H]

Identifier: 186477666

GI number: 186477666

Start: 3273656

End: 3275077

Strand: Reverse

Name: ahcY [H]

Synonym: Bphy_2918

Alternate gene names: 186477666

Gene position: 3275077-3273656 (Counterclockwise)

Preceding gene: 186477667

Following gene: 186477665

Centisome position: 94.13

GC content: 61.11

Gene sequence:

>1422_bases
ATGAACGCCGCAGTTATCGATTCCAAACATTCCCAGGATTTCATCGTTGCCGACCTGTCGCTTGCCGATTGGGGCCGCAA
GGAACTCGACATCGCCGAAACGGAAATGCCCGGCCTCGTGCAAATCCGTGAAGAGTACAAGGCGCAGCAGCCGCTGAAGG
GCGCGCGCGTTGCCGGCTCGCTGCACATGACGATCCAGACGGGCGTGCTGATCGAGACGCTGAAGGCGCTGGGCGCCGAC
GTGCGCTGGGCATCGTGCAACATCTTCTCGACGCAGGACCACGCCGCGGCTGCCATCGCGAAGGGCGGCACGCCCGTATT
CGCGTTCAAGGGCGAATCGCTCGACGAATACTGGGAGTTCTCGCACCGCATCTTCGAATGGCCAAACGGCGAATTCGCGA
ACATGATCCTCGACGACGGCGGCGACGCAACGCTGCTGCTGATCCTCGGCTCGAAGGCAGAGAAGGATCGCTCGGTAATC
TCGAAGCCGACCAACGAAGAAGAAGTCGCGCTGTACAAGTCGATCGCCCGTCATCTGGACGCGGATCCCGTGTGGTACTC
CACGCGTCTCGCGCACATCAAGGGCGTCACGGAAGAAACGACGACGGGCGTGCATCGCCTGTATCAGATGGAGAAGGAAG
GCCGTCTGCCGTTCCCGGCAATCAACGTGAACGACTCGGTCACGAAGTCGAAGTTCGACAACCTGTATGGCTGCCGCGAA
TCGCTGGTCGACGGCATCAAGCGCGCGACGGACGTAATGATTGCCGGCAAGATCGCGGTCGTCGCGGGTTATGGCGACGT
GGGCAAGGGATGCGCGCAATCGCTGCGCGGTCTGGGCGCGACCGTGTGGGTCACGGAAATCGACCCGATCTGCGCGCTGC
AAGCCGCGATGGAAGGCTACCGCGTCGTGACGATGGAATACGCTGCCGACAAGGCCGACATCTTCGTGACGGCAACGGGC
AACTACCACGTGATCGGCCACGATCACATGAAGGCGATGCGTCACAACGCGATCGTCTGCAACATCGGTCACTTCGACTC
GGAAATCGACGTTGCTTCGACGCGCCAGTACACGTGGGAAAACATCAAGCCGCAAGTCGACCACATCATCTTCCCGGACG
GCAAGCGCGTGATCCTTCTGGCCGAAGGCCGCCTCGTGAACCTGGGCTGCGCGACGGGCCACCCGTCGTTCGTGATGTCG
AACTCGTTCACGAACCAGACGCTCGCGCAGATCGAGTTGTTCGTCGAAGGCAGCAAGTACGAGAACAAGGTTTATGTTCT
GCCGAAGCAGCTCGACGAGAAAGTCGCGCGCCTGCACCTCGCGCGCATCGGCGCGAACCTGACGGAGTTGACGTCGGAAC
AGGCGGGCTACATCGGCGTCGACAAGAACGGTCCGTTCAAGCCGAACCACTACCGTTACTAA

Upstream 100 bases:

>100_bases
CTTTCAATCGGAAGGATTGGACGCGCGCCGCGCTAACAACCCAACCGCATCGAACGGCGCTCACGTCACATTTCTAGTCT
TTTTTAGAAAGGAGGGCGTG

Downstream 100 bases:

>100_bases
ACCGCAAACAGGCGGCATGAAGGGTGCGGGCGCATGCCACGGCGTGCCCCGCACCGGATGAAGCACGCAGCCGATGCGAC
GCATTGCATCGGGTGACGCT

Product: S-adenosyl-L-homocysteine hydrolase

Products: NA

Alternate protein names: S-adenosyl-L-homocysteine hydrolase; AdoHcyase [H]

Number of amino acids: Translated: 473; Mature: 473

Protein sequence:

>473_residues
MNAAVIDSKHSQDFIVADLSLADWGRKELDIAETEMPGLVQIREEYKAQQPLKGARVAGSLHMTIQTGVLIETLKALGAD
VRWASCNIFSTQDHAAAAIAKGGTPVFAFKGESLDEYWEFSHRIFEWPNGEFANMILDDGGDATLLLILGSKAEKDRSVI
SKPTNEEEVALYKSIARHLDADPVWYSTRLAHIKGVTEETTTGVHRLYQMEKEGRLPFPAINVNDSVTKSKFDNLYGCRE
SLVDGIKRATDVMIAGKIAVVAGYGDVGKGCAQSLRGLGATVWVTEIDPICALQAAMEGYRVVTMEYAADKADIFVTATG
NYHVIGHDHMKAMRHNAIVCNIGHFDSEIDVASTRQYTWENIKPQVDHIIFPDGKRVILLAEGRLVNLGCATGHPSFVMS
NSFTNQTLAQIELFVEGSKYENKVYVLPKQLDEKVARLHLARIGANLTELTSEQAGYIGVDKNGPFKPNHYRY

Sequences:

>Translated_473_residues
MNAAVIDSKHSQDFIVADLSLADWGRKELDIAETEMPGLVQIREEYKAQQPLKGARVAGSLHMTIQTGVLIETLKALGAD
VRWASCNIFSTQDHAAAAIAKGGTPVFAFKGESLDEYWEFSHRIFEWPNGEFANMILDDGGDATLLLILGSKAEKDRSVI
SKPTNEEEVALYKSIARHLDADPVWYSTRLAHIKGVTEETTTGVHRLYQMEKEGRLPFPAINVNDSVTKSKFDNLYGCRE
SLVDGIKRATDVMIAGKIAVVAGYGDVGKGCAQSLRGLGATVWVTEIDPICALQAAMEGYRVVTMEYAADKADIFVTATG
NYHVIGHDHMKAMRHNAIVCNIGHFDSEIDVASTRQYTWENIKPQVDHIIFPDGKRVILLAEGRLVNLGCATGHPSFVMS
NSFTNQTLAQIELFVEGSKYENKVYVLPKQLDEKVARLHLARIGANLTELTSEQAGYIGVDKNGPFKPNHYRY
>Mature_473_residues
MNAAVIDSKHSQDFIVADLSLADWGRKELDIAETEMPGLVQIREEYKAQQPLKGARVAGSLHMTIQTGVLIETLKALGAD
VRWASCNIFSTQDHAAAAIAKGGTPVFAFKGESLDEYWEFSHRIFEWPNGEFANMILDDGGDATLLLILGSKAEKDRSVI
SKPTNEEEVALYKSIARHLDADPVWYSTRLAHIKGVTEETTTGVHRLYQMEKEGRLPFPAINVNDSVTKSKFDNLYGCRE
SLVDGIKRATDVMIAGKIAVVAGYGDVGKGCAQSLRGLGATVWVTEIDPICALQAAMEGYRVVTMEYAADKADIFVTATG
NYHVIGHDHMKAMRHNAIVCNIGHFDSEIDVASTRQYTWENIKPQVDHIIFPDGKRVILLAEGRLVNLGCATGHPSFVMS
NSFTNQTLAQIELFVEGSKYENKVYVLPKQLDEKVARLHLARIGANLTELTSEQAGYIGVDKNGPFKPNHYRY

Specific function: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine [H]

COG id: COG0499

COG function: function code H; S-adenosylhomocysteine hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosylhomocysteinase family [H]

Homologues:

Organism=Homo sapiens, GI9951915, Length=462, Percent_Identity=59.95670995671, Blast_Score=525, Evalue=1e-149,
Organism=Homo sapiens, GI239937451, Length=440, Percent_Identity=59.5454545454545, Blast_Score=494, Evalue=1e-140,
Organism=Homo sapiens, GI24308043, Length=470, Percent_Identity=51.063829787234, Blast_Score=487, Evalue=1e-137,
Organism=Homo sapiens, GI298286489, Length=470, Percent_Identity=51.063829787234, Blast_Score=486, Evalue=1e-137,
Organism=Homo sapiens, GI195539337, Length=470, Percent_Identity=51.063829787234, Blast_Score=486, Evalue=1e-137,
Organism=Homo sapiens, GI195539349, Length=470, Percent_Identity=51.063829787234, Blast_Score=486, Evalue=1e-137,
Organism=Homo sapiens, GI21361647, Length=470, Percent_Identity=50.6382978723404, Blast_Score=469, Evalue=1e-132,
Organism=Caenorhabditis elegans, GI17506425, Length=465, Percent_Identity=58.9247311827957, Blast_Score=522, Evalue=1e-148,
Organism=Saccharomyces cerevisiae, GI6320882, Length=483, Percent_Identity=57.5569358178054, Blast_Score=513, Evalue=1e-146,
Organism=Drosophila melanogaster, GI24642172, Length=462, Percent_Identity=60.3896103896104, Blast_Score=531, Evalue=1e-151,
Organism=Drosophila melanogaster, GI24656245, Length=471, Percent_Identity=50.3184713375796, Blast_Score=472, Evalue=1e-133,
Organism=Drosophila melanogaster, GI45553387, Length=469, Percent_Identity=49.8933901918977, Blast_Score=454, Evalue=1e-128,
Organism=Drosophila melanogaster, GI45553385, Length=468, Percent_Identity=49.7863247863248, Blast_Score=451, Evalue=1e-127,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000043
- InterPro:   IPR015878
- InterPro:   IPR020082 [H]

Pfam domain/function: PF05221 AdoHcyase; PF00670 AdoHcyase_NAD [H]

EC number: =3.3.1.1 [H]

Molecular weight: Translated: 52205; Mature: 52205

Theoretical pI: Translated: 6.09; Mature: 6.09

Prosite motif: PS00738 ADOHCYASE_1 ; PS00739 ADOHCYASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNAAVIDSKHSQDFIVADLSLADWGRKELDIAETEMPGLVQIREEYKAQQPLKGARVAGS
CCCEEECCCCCCCEEEEEEEHHCCCCCCCCCHHCCCCCHHHHHHHHHHCCCCCCCEEECE
LHMTIQTGVLIETLKALGADVRWASCNIFSTQDHAAAAIAKGGTPVFAFKGESLDEYWEF
EEEEEECCHHHHHHHHHCCCCEEEEEEEECCCCHHHHHHHCCCCEEEEEECCCHHHHHHH
SHRIFEWPNGEFANMILDDGGDATLLLILGSKAEKDRSVISKPTNEEEVALYKSIARHLD
HHHEEECCCCCEEEEEEECCCCEEEEEEECCCCCCCHHHHCCCCCHHHHHHHHHHHHHCC
ADPVWYSTRLAHIKGVTEETTTGVHRLYQMEKEGRLPFPAINVNDSVTKSKFDNLYGCRE
CCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCEECCCCCHHHHHHHHHHHHHH
SLVDGIKRATDVMIAGKIAVVAGYGDVGKGCAQSLRGLGATVWVTEIDPICALQAAMEGY
HHHHHHHHHHHEEEECEEEEEECCCCCCHHHHHHHHHCCCEEEEEECCHHHHHHHHHCCE
RVVTMEYAADKADIFVTATGNYHVIGHDHMKAMRHNAIVCNIGHFDSEIDVASTRQYTWE
EEEEEEECCCCCCEEEEECCCEEEEEHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCCCC
NIKPQVDHIIFPDGKRVILLAEGRLVNLGCATGHPSFVMSNSFTNQTLAQIELFVEGSKY
CCCCCCCEEECCCCCEEEEEECCEEEEEEECCCCCCEEEECCCCCCEEEEEEEEEECCCC
ENKVYVLPKQLDEKVARLHLARIGANLTELTSEQAGYIGVDKNGPFKPNHYRY
CCEEEEECHHHHHHHHHHHHHHHCCCHHHHHCCCCCEEEECCCCCCCCCCCCC
>Mature Secondary Structure
MNAAVIDSKHSQDFIVADLSLADWGRKELDIAETEMPGLVQIREEYKAQQPLKGARVAGS
CCCEEECCCCCCCEEEEEEEHHCCCCCCCCCHHCCCCCHHHHHHHHHHCCCCCCCEEECE
LHMTIQTGVLIETLKALGADVRWASCNIFSTQDHAAAAIAKGGTPVFAFKGESLDEYWEF
EEEEEECCHHHHHHHHHCCCCEEEEEEEECCCCHHHHHHHCCCCEEEEEECCCHHHHHHH
SHRIFEWPNGEFANMILDDGGDATLLLILGSKAEKDRSVISKPTNEEEVALYKSIARHLD
HHHEEECCCCCEEEEEEECCCCEEEEEEECCCCCCCHHHHCCCCCHHHHHHHHHHHHHCC
ADPVWYSTRLAHIKGVTEETTTGVHRLYQMEKEGRLPFPAINVNDSVTKSKFDNLYGCRE
CCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCEECCCCCHHHHHHHHHHHHHH
SLVDGIKRATDVMIAGKIAVVAGYGDVGKGCAQSLRGLGATVWVTEIDPICALQAAMEGY
HHHHHHHHHHHEEEECEEEEEECCCCCCHHHHHHHHHCCCEEEEEECCHHHHHHHHHCCE
RVVTMEYAADKADIFVTATGNYHVIGHDHMKAMRHNAIVCNIGHFDSEIDVASTRQYTWE
EEEEEEECCCCCCEEEEECCCEEEEEHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCCCC
NIKPQVDHIIFPDGKRVILLAEGRLVNLGCATGHPSFVMSNSFTNQTLAQIELFVEGSKY
CCCCCCCEEECCCCCEEEEEECCEEEEEEECCCCCCEEEECCCCCCEEEEEEEEEECCCC
ENKVYVLPKQLDEKVARLHLARIGANLTELTSEQAGYIGVDKNGPFKPNHYRY
CCEEEEECHHHHHHHHHHHHHHHCCCHHHHHCCCCCEEEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA