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The map label for this gene is tkt1 [H]

Identifier: 186477347

GI number: 186477347

Start: 2936824

End: 2938842

Strand: Reverse

Name: tkt1 [H]

Synonym: Bphy_2599

Alternate gene names: 186477347

Gene position: 2938842-2936824 (Counterclockwise)

Preceding gene: 186477350

Following gene: 186477346

Centisome position: 84.47

GC content: 64.04

Gene sequence:

>2019_bases
ATGACGACCCCGTCTCCCGCCCCTACCTCCCTGATGGCCAACGCGATTCGCGCGCTGTCCATGGATGCTGTTCAAGCAGC
GAACTCCGGTCACCCCGGCATGCCGATGGGCATGGCCGAGATCGGCGTGGCGCTCTGGTCGCGGCACCTGCGTCACAACC
CTAGGAACCCGCGTTGGGCCGATCGCGACCGCTTCGTGCTGTCAAACGGTCACGGCTCGATGCTGCTGTATTCGCTGCTC
CATCTGACGGGCTACGACCTGCCGATGGAGGAGCTGAAGAACTTCCGCCAGCTGCACTCGAAAACGCCGGGCCATCCGGA
ATACGGCATCACCCCGGGCGTCGAGACGACCACGGGCCCGCTCGGCCAGGGTCTCGCGAACGCAGTCGGCATGGCGCTCG
CGGAATCGCTGCTTGCGAACGAATTCAACAAGGCCGACGCGAAGATCGTCGATCACCACACGTACGTGTTCGTCGGCGAC
GGCTGCCTGATGGAAGGCATTTCGCACGAAGCCTGCTCGCTGGCTGGCGTGCTGAAGCTGAACAAGCTGATCGCGTTCTA
CGACGACAACGGTATCTCCATCGACGGCGACGTCGTTCACTGGTTCCACGACGACACGCCGAAGCGCTTTGAAGCGTATG
GCTGGAACGTGATTCCGGGCGTGATCGGCCATGACGTCGAAGCCGTCGACGCAGCCATCAAGAAGGCGAAGCAGTCTGAC
AAGCCGACGCTGATCTGCTGTAAGACCGTGATCGGCGAAGGTTCGCCGAACAAGGCCGGCTCGCACGACGTGCACGGCGC
TGCGCTGGGCGACAAGGAAGTCGCGGCCACGCGCGAGAAGCTCGGCTGGAACTACCCGCCGTTCGTGATCCCGCAGGAAG
TCTACGCAGCGTGGGACGCGAAGGAGAAGGGCGCGAAGATCGAAGGCGAATGGAACGACGCGTTCGCGGCTTATCGTGCG
AAGTATTCGCAGGAAGCCGCCGACTTCGAGCGCCGCATGGCGAACAAGCTTCCCGCCGACTGGGCGGAAAAGGCGCAGGC
GATTATCGCCGGCGCGAACGAGCGCGCTGAAACCATCGCGACCCGCAAGGCGTCGCAGCAGGCCATCGAAGGCCTCTCCG
CCGTGCTGCCGGAACTGGTCGGCGGTTCGGCCGACCTGACGGGCTCGAACCTCACGAACTGGAAGGCGGCAAAGTACGTG
CGCGTCGGCGAAAACGGCGCGGCGGGCAATTACGTCAACTACGGCGTGCGCGAATTCGGCATGAGCGCGGCCATTAACGG
CCTCGCGGTGCATGGCGGCCATAAGGCGTTCGGCGGCACGTTCCTGACGTTCTCGGACTACAGCCGCAATGCGCTGCGCG
TCGCCGCGCTGATGAAGTCGCCGTCCATTTTCGTGTTCACGCACGACTCGATCGGCCTCGGCGAAGACGGTCCGACGCAC
CAGTCGATCGAACATGTCGCGAGCCTGCGCCTGATTCCGCACATGCAGGTGTGGCGTCCGGCGGATACCGTCGAAACGGC
TGTCGCGTGGACGCAGGCTGTCGAACATCAGGGCCCGTCGTGCCTGATCTTCAGCCGTCAGAACCTCGCGTTCAACCCGC
GCACCGACGCGCAGATCGCCAACATCGCGAAGGGCGGCTACGTGCTGAAGGACTGGAACGACGACATTCCTGCGCGCAAG
ATCATCCTGATTGCGACGGGGTCGGAAGTGGAACTGGCGATGAAGTCGGTCGAAGCGCTCGCACGCGAAGGCATTGCGGC
GCGCGTCGTATCGATGCCGTCCACGACTACCTTCGACAAGCAGGATGCCGAGTACCGTGAGCGTGTGCTGCCGCATGGCG
TGCGCCGCGTCGCGATCGAAGCGGGCGTCACGGATTTCTGGCGCAAGTACGTGGGCCTGGAAGGCGGCGTCGTCGGTATC
GACGTGTTCGGCGAATCGGCTCCCGCAGGCGCGCTCTTCAAGTATTTCGGTTTCACCGTCGAGAAGGTTGTCGAGACGGC
CAAGGCCGCACTCGGCTAA

Upstream 100 bases:

>100_bases
TCGCGTCTCCCGGCGCCGCACCGTGCGCCGAAGCAGATTGGCCGCAGGCTTCCGGACCACCATCGGCGCCCCGCTTTTTG
GACCATTCTCCGGAATCGAC

Downstream 100 bases:

>100_bases
GGCGCGCAGCGCGTCGTGCGCGCCGCGTTTCGGGCGGCGCGCATGAATGCTACGAGGCGCACTAGCCGCGCATCACGGAA
GAATTTTTTCAGCCATCAGG

Product: transketolase

Products: NA

Alternate protein names: TK 1 [H]

Number of amino acids: Translated: 672; Mature: 671

Protein sequence:

>672_residues
MTTPSPAPTSLMANAIRALSMDAVQAANSGHPGMPMGMAEIGVALWSRHLRHNPRNPRWADRDRFVLSNGHGSMLLYSLL
HLTGYDLPMEELKNFRQLHSKTPGHPEYGITPGVETTTGPLGQGLANAVGMALAESLLANEFNKADAKIVDHHTYVFVGD
GCLMEGISHEACSLAGVLKLNKLIAFYDDNGISIDGDVVHWFHDDTPKRFEAYGWNVIPGVIGHDVEAVDAAIKKAKQSD
KPTLICCKTVIGEGSPNKAGSHDVHGAALGDKEVAATREKLGWNYPPFVIPQEVYAAWDAKEKGAKIEGEWNDAFAAYRA
KYSQEAADFERRMANKLPADWAEKAQAIIAGANERAETIATRKASQQAIEGLSAVLPELVGGSADLTGSNLTNWKAAKYV
RVGENGAAGNYVNYGVREFGMSAAINGLAVHGGHKAFGGTFLTFSDYSRNALRVAALMKSPSIFVFTHDSIGLGEDGPTH
QSIEHVASLRLIPHMQVWRPADTVETAVAWTQAVEHQGPSCLIFSRQNLAFNPRTDAQIANIAKGGYVLKDWNDDIPARK
IILIATGSEVELAMKSVEALAREGIAARVVSMPSTTTFDKQDAEYRERVLPHGVRRVAIEAGVTDFWRKYVGLEGGVVGI
DVFGESAPAGALFKYFGFTVEKVVETAKAALG

Sequences:

>Translated_672_residues
MTTPSPAPTSLMANAIRALSMDAVQAANSGHPGMPMGMAEIGVALWSRHLRHNPRNPRWADRDRFVLSNGHGSMLLYSLL
HLTGYDLPMEELKNFRQLHSKTPGHPEYGITPGVETTTGPLGQGLANAVGMALAESLLANEFNKADAKIVDHHTYVFVGD
GCLMEGISHEACSLAGVLKLNKLIAFYDDNGISIDGDVVHWFHDDTPKRFEAYGWNVIPGVIGHDVEAVDAAIKKAKQSD
KPTLICCKTVIGEGSPNKAGSHDVHGAALGDKEVAATREKLGWNYPPFVIPQEVYAAWDAKEKGAKIEGEWNDAFAAYRA
KYSQEAADFERRMANKLPADWAEKAQAIIAGANERAETIATRKASQQAIEGLSAVLPELVGGSADLTGSNLTNWKAAKYV
RVGENGAAGNYVNYGVREFGMSAAINGLAVHGGHKAFGGTFLTFSDYSRNALRVAALMKSPSIFVFTHDSIGLGEDGPTH
QSIEHVASLRLIPHMQVWRPADTVETAVAWTQAVEHQGPSCLIFSRQNLAFNPRTDAQIANIAKGGYVLKDWNDDIPARK
IILIATGSEVELAMKSVEALAREGIAARVVSMPSTTTFDKQDAEYRERVLPHGVRRVAIEAGVTDFWRKYVGLEGGVVGI
DVFGESAPAGALFKYFGFTVEKVVETAKAALG
>Mature_671_residues
TTPSPAPTSLMANAIRALSMDAVQAANSGHPGMPMGMAEIGVALWSRHLRHNPRNPRWADRDRFVLSNGHGSMLLYSLLH
LTGYDLPMEELKNFRQLHSKTPGHPEYGITPGVETTTGPLGQGLANAVGMALAESLLANEFNKADAKIVDHHTYVFVGDG
CLMEGISHEACSLAGVLKLNKLIAFYDDNGISIDGDVVHWFHDDTPKRFEAYGWNVIPGVIGHDVEAVDAAIKKAKQSDK
PTLICCKTVIGEGSPNKAGSHDVHGAALGDKEVAATREKLGWNYPPFVIPQEVYAAWDAKEKGAKIEGEWNDAFAAYRAK
YSQEAADFERRMANKLPADWAEKAQAIIAGANERAETIATRKASQQAIEGLSAVLPELVGGSADLTGSNLTNWKAAKYVR
VGENGAAGNYVNYGVREFGMSAAINGLAVHGGHKAFGGTFLTFSDYSRNALRVAALMKSPSIFVFTHDSIGLGEDGPTHQ
SIEHVASLRLIPHMQVWRPADTVETAVAWTQAVEHQGPSCLIFSRQNLAFNPRTDAQIANIAKGGYVLKDWNDDIPARKI
ILIATGSEVELAMKSVEALAREGIAARVVSMPSTTTFDKQDAEYRERVLPHGVRRVAIEAGVTDFWRKYVGLEGGVVGID
VFGESAPAGALFKYFGFTVEKVVETAKAALG

Specific function: Unknown

COG id: COG0021

COG function: function code G; Transketolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=601, Percent_Identity=28.2861896838602, Blast_Score=177, Evalue=4e-44,
Organism=Homo sapiens, GI4507521, Length=601, Percent_Identity=28.2861896838602, Blast_Score=177, Evalue=4e-44,
Organism=Homo sapiens, GI133778974, Length=256, Percent_Identity=35.15625, Blast_Score=117, Evalue=3e-26,
Organism=Escherichia coli, GI48994911, Length=663, Percent_Identity=64.5550527903469, Blast_Score=876, Evalue=0.0,
Organism=Escherichia coli, GI1788808, Length=664, Percent_Identity=62.8012048192771, Blast_Score=837, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539652, Length=675, Percent_Identity=25.9259259259259, Blast_Score=159, Evalue=4e-39,
Organism=Saccharomyces cerevisiae, GI6325331, Length=672, Percent_Identity=49.2559523809524, Blast_Score=597, Evalue=1e-171,
Organism=Saccharomyces cerevisiae, GI6319593, Length=677, Percent_Identity=45.1994091580502, Blast_Score=548, Evalue=1e-156,
Organism=Drosophila melanogaster, GI45551847, Length=610, Percent_Identity=28.8524590163934, Blast_Score=179, Evalue=5e-45,
Organism=Drosophila melanogaster, GI45550715, Length=610, Percent_Identity=28.8524590163934, Blast_Score=179, Evalue=5e-45,
Organism=Drosophila melanogaster, GI24645119, Length=577, Percent_Identity=28.2495667244367, Blast_Score=157, Evalue=2e-38,
Organism=Drosophila melanogaster, GI24666278, Length=270, Percent_Identity=34.0740740740741, Blast_Score=128, Evalue=1e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005478
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 72510; Mature: 72379

Theoretical pI: Translated: 6.55; Mature: 6.55

Prosite motif: PS00801 TRANSKETOLASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTPSPAPTSLMANAIRALSMDAVQAANSGHPGMPMGMAEIGVALWSRHLRHNPRNPRWA
CCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCC
DRDRFVLSNGHGSMLLYSLLHLTGYDLPMEELKNFRQLHSKTPGHPEYGITPGVETTTGP
CCCCEEEECCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
LGQGLANAVGMALAESLLANEFNKADAKIVDHHTYVFVGDGCLMEGISHEACSLAGVLKL
HHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECEEEEEECCCHHHHCCCHHHHHHHHHHHH
NKLIAFYDDNGISIDGDVVHWFHDDTPKRFEAYGWNVIPGVIGHDVEAVDAAIKKAKQSD
CCEEEEECCCCEEECCCEEEEECCCCCHHHHHCCCCCCCCHHCCCHHHHHHHHHHHHCCC
KPTLICCKTVIGEGSPNKAGSHDVHGAALGDKEVAATREKLGWNYPPFVIPQEVYAAWDA
CCEEEEEEHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHCC
KEKGAKIEGEWNDAFAAYRAKYSQEAADFERRMANKLPADWAEKAQAIIAGANERAETIA
HHCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHEEHCCCCHHHHHHH
TRKASQQAIEGLSAVLPELVGGSADLTGSNLTNWKAAKYVRVGENGAAGNYVNYGVREFG
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCCCCCHHHCCHHHHH
MSAAINGLAVHGGHKAFGGTFLTFSDYSRNALRVAALMKSPSIFVFTHDSIGLGEDGPTH
HHHHCCCEEEECCCCCCCCEEEEECCCCCCHHHHHHHHCCCCEEEEECCCCCCCCCCCCH
QSIEHVASLRLIPHMQVWRPADTVETAVAWTQAVEHQGPSCLIFSRQNLAFNPRTDAQIA
HHHHHHHHHHHCCCHHHCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCHHHH
NIAKGGYVLKDWNDDIPARKIILIATGSEVELAMKSVEALAREGIAARVVSMPSTTTFDK
HHCCCCEEEECCCCCCCCEEEEEEEECCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCC
QDAEYRERVLPHGVRRVAIEAGVTDFWRKYVGLEGGVVGIDVFGESAPAGALFKYFGFTV
CCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHH
EKVVETAKAALG
HHHHHHHHHHCC
>Mature Secondary Structure 
TTPSPAPTSLMANAIRALSMDAVQAANSGHPGMPMGMAEIGVALWSRHLRHNPRNPRWA
CCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCC
DRDRFVLSNGHGSMLLYSLLHLTGYDLPMEELKNFRQLHSKTPGHPEYGITPGVETTTGP
CCCCEEEECCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
LGQGLANAVGMALAESLLANEFNKADAKIVDHHTYVFVGDGCLMEGISHEACSLAGVLKL
HHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECEEEEEECCCHHHHCCCHHHHHHHHHHHH
NKLIAFYDDNGISIDGDVVHWFHDDTPKRFEAYGWNVIPGVIGHDVEAVDAAIKKAKQSD
CCEEEEECCCCEEECCCEEEEECCCCCHHHHHCCCCCCCCHHCCCHHHHHHHHHHHHCCC
KPTLICCKTVIGEGSPNKAGSHDVHGAALGDKEVAATREKLGWNYPPFVIPQEVYAAWDA
CCEEEEEEHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHCC
KEKGAKIEGEWNDAFAAYRAKYSQEAADFERRMANKLPADWAEKAQAIIAGANERAETIA
HHCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHEEHCCCCHHHHHHH
TRKASQQAIEGLSAVLPELVGGSADLTGSNLTNWKAAKYVRVGENGAAGNYVNYGVREFG
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCCCCCHHHCCHHHHH
MSAAINGLAVHGGHKAFGGTFLTFSDYSRNALRVAALMKSPSIFVFTHDSIGLGEDGPTH
HHHHCCCEEEECCCCCCCCEEEEECCCCCCHHHHHHHHCCCCEEEEECCCCCCCCCCCCH
QSIEHVASLRLIPHMQVWRPADTVETAVAWTQAVEHQGPSCLIFSRQNLAFNPRTDAQIA
HHHHHHHHHHHCCCHHHCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCHHHH
NIAKGGYVLKDWNDDIPARKIILIATGSEVELAMKSVEALAREGIAARVVSMPSTTTFDK
HHCCCCEEEECCCCCCCCEEEEEEEECCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCC
QDAEYRERVLPHGVRRVAIEAGVTDFWRKYVGLEGGVVGIDVFGESAPAGALFKYFGFTV
CCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHH
EKVVETAKAALG
HHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]