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The map label for this gene is glcD [H]

Identifier: 186477262

GI number: 186477262

Start: 2831749

End: 2833254

Strand: Direct

Name: glcD [H]

Synonym: Bphy_2514

Alternate gene names: 186477262

Gene position: 2831749-2833254 (Clockwise)

Preceding gene: 186477261

Following gene: 186477263

Centisome position: 81.39

GC content: 64.21

Gene sequence:

>1506_bases
ATGAACGCACCCGGCGAGCTGTCCCCAGAGCTGTCGCCCGAGATGCTCGCGCAGCGTCAGCGTGAAGTCGTGCAGGCGTT
GATGGCCGTACTGCCGACGCATTGCCTGTTGTATCGCGAAGAAGATACCGTCGCTTACGAATGCGATGGTCTCGCCGCCT
ATCGCCGCCTGCCGCTGGCCGTCGCGTTGCCCGAAACCGAATCGCAGGTGCAGCGCATCGTGCAGATCTGCCATCGGCTG
AATGTGCCCATCGTGCCGCGCGGCGCGGGCACCAGCCTGTCCGGCGGCGCGATGCCGATCCGTCATGGCGTGGTCGTGTC
GCTCGCGCGCTTTCGCAAGATCGTCGAAGTCGATCCGTATGCGCGCACGGCAACTGTCCAGCCGGGCGTACGCAATCTGT
CGATCTCCGAAGCAGCCGCGCCTTACGGCCTTTACTATGCGCCCGATCCTTCGTCGCAGATCGCCTGCACGATCGGCGGG
AACGTCGCGGAAAACTCGGGCGGCGTGCACTGCCTCAAATACGGCCTCACCGTTCATAACGTGCTGCGCGTGCGCGCGAT
CACAATGGAAGGCGAGATCGTCGAGTTTGGCTCGCTCAGCCCGGATGCGCCGGGTCTCGATCTGCTCGCCGTCGTGATCG
GCAGCGAGGGGATGTTCGCGATCGTCACGGAAGTCACGGTCAAGCTGATTCCGAAGCCGCAGGCCTCGCAGGTCATCATG
GCGAGTTTCGACGACGTCGTGAAGGGCGGCGATGCCGTCGCAGGCATCATTGCCGCGGGCATCATTCCGGCCGGTCTCGA
GATGATGGACAAGCCGGCCACGCGTGCCGTCGAGGAATTTGTGAACGCGGGCTACGACCTTGACGCGGCCGCCATCCTGC
TGTGCGAATCCGACGGCACCCCCGAGGAAGTCAGCGAGGAAATCGTCCGCATGACGGCCGTATTGCGCGAGCATGGCGCG
ACGCGCATCCAGATCTCACGAACGGAAGCCGAGCGCCTGCGTTTCTGGTCGGGCCGCAAGAACGCGTTTCCGGCCGCCGG
CCGCATCTCGCCCGACTACTACTGCATGGACGGCACGGTGCCGCGCCGCAGCATCGGCCCGCTGCTCGCTCGCATCGAAG
AGATGGAGAAGAAGTACAACCTGCGCTGCATCAACGTGTTCCACGCGGGCGACGGCAACATGCACCCGCTGATCCTGTTC
AATGGCAACGACCTCGATGAATGGCATCGCGCCGAGGCATTCGGATGCGACATTCTCGAAACGTGCGTCGAACTGGGCGG
CACGGTGACGGGCGAACATGGCGTAGGCATCGAGAAGATCAATTCGATGTGCGTGCAGTTTTCGCCGGAAGAGCGCGACG
CGTTCCACGCGGTCAAGCGCGCTTTCGATCCTGCCTGCCTGCTCAACCCCGACAAAGGCATTCCGACGCGAGCCCGCTGC
GCCGAGTACGGAAAGATGCATGTGCGCGGCGGGCTGCTGCCGCACCCGGACCTGCCTCGTTTCTGA

Upstream 100 bases:

>100_bases
ATGAATCCAGGCAAGATCTTTACGTGGGCAGCATAGCGTAACCGTATGTCCGGCCGCGCTGCGCAACGACGCGTGCGGTC
GTCCAACGAGGAGACATTCC

Downstream 100 bases:

>100_bases
GCACCGCACCGCGCCATGCCGCTGTTGGCTGCATGGCGCTTGCGTCGTCTTGCGTCGCATAACGCATAAAAGCAGCAATA
CCTTCGATACGGGTCTGAAC

Product: D-lactate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 501; Mature: 501

Protein sequence:

>501_residues
MNAPGELSPELSPEMLAQRQREVVQALMAVLPTHCLLYREEDTVAYECDGLAAYRRLPLAVALPETESQVQRIVQICHRL
NVPIVPRGAGTSLSGGAMPIRHGVVVSLARFRKIVEVDPYARTATVQPGVRNLSISEAAAPYGLYYAPDPSSQIACTIGG
NVAENSGGVHCLKYGLTVHNVLRVRAITMEGEIVEFGSLSPDAPGLDLLAVVIGSEGMFAIVTEVTVKLIPKPQASQVIM
ASFDDVVKGGDAVAGIIAAGIIPAGLEMMDKPATRAVEEFVNAGYDLDAAAILLCESDGTPEEVSEEIVRMTAVLREHGA
TRIQISRTEAERLRFWSGRKNAFPAAGRISPDYYCMDGTVPRRSIGPLLARIEEMEKKYNLRCINVFHAGDGNMHPLILF
NGNDLDEWHRAEAFGCDILETCVELGGTVTGEHGVGIEKINSMCVQFSPEERDAFHAVKRAFDPACLLNPDKGIPTRARC
AEYGKMHVRGGLLPHPDLPRF

Sequences:

>Translated_501_residues
MNAPGELSPELSPEMLAQRQREVVQALMAVLPTHCLLYREEDTVAYECDGLAAYRRLPLAVALPETESQVQRIVQICHRL
NVPIVPRGAGTSLSGGAMPIRHGVVVSLARFRKIVEVDPYARTATVQPGVRNLSISEAAAPYGLYYAPDPSSQIACTIGG
NVAENSGGVHCLKYGLTVHNVLRVRAITMEGEIVEFGSLSPDAPGLDLLAVVIGSEGMFAIVTEVTVKLIPKPQASQVIM
ASFDDVVKGGDAVAGIIAAGIIPAGLEMMDKPATRAVEEFVNAGYDLDAAAILLCESDGTPEEVSEEIVRMTAVLREHGA
TRIQISRTEAERLRFWSGRKNAFPAAGRISPDYYCMDGTVPRRSIGPLLARIEEMEKKYNLRCINVFHAGDGNMHPLILF
NGNDLDEWHRAEAFGCDILETCVELGGTVTGEHGVGIEKINSMCVQFSPEERDAFHAVKRAFDPACLLNPDKGIPTRARC
AEYGKMHVRGGLLPHPDLPRF
>Mature_501_residues
MNAPGELSPELSPEMLAQRQREVVQALMAVLPTHCLLYREEDTVAYECDGLAAYRRLPLAVALPETESQVQRIVQICHRL
NVPIVPRGAGTSLSGGAMPIRHGVVVSLARFRKIVEVDPYARTATVQPGVRNLSISEAAAPYGLYYAPDPSSQIACTIGG
NVAENSGGVHCLKYGLTVHNVLRVRAITMEGEIVEFGSLSPDAPGLDLLAVVIGSEGMFAIVTEVTVKLIPKPQASQVIM
ASFDDVVKGGDAVAGIIAAGIIPAGLEMMDKPATRAVEEFVNAGYDLDAAAILLCESDGTPEEVSEEIVRMTAVLREHGA
TRIQISRTEAERLRFWSGRKNAFPAAGRISPDYYCMDGTVPRRSIGPLLARIEEMEKKYNLRCINVFHAGDGNMHPLILF
NGNDLDEWHRAEAFGCDILETCVELGGTVTGEHGVGIEKINSMCVQFSPEERDAFHAVKRAFDPACLLNPDKGIPTRARC
AEYGKMHVRGGLLPHPDLPRF

Specific function: Unknown

COG id: COG0277

COG function: function code C; FAD/FMN-containing dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain [H]

Homologues:

Organism=Homo sapiens, GI37595756, Length=465, Percent_Identity=27.741935483871, Blast_Score=192, Evalue=9e-49,
Organism=Homo sapiens, GI37595754, Length=488, Percent_Identity=27.2540983606557, Blast_Score=184, Evalue=2e-46,
Organism=Homo sapiens, GI119964728, Length=455, Percent_Identity=24.8351648351648, Blast_Score=129, Evalue=7e-30,
Organism=Homo sapiens, GI4501993, Length=222, Percent_Identity=27.027027027027, Blast_Score=85, Evalue=2e-16,
Organism=Escherichia coli, GI1789351, Length=479, Percent_Identity=59.4989561586639, Blast_Score=600, Evalue=1e-173,
Organism=Escherichia coli, GI1787977, Length=497, Percent_Identity=22.9376257545272, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI48994907, Length=445, Percent_Identity=23.1460674157303, Blast_Score=77, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71992373, Length=429, Percent_Identity=25.8741258741259, Blast_Score=164, Evalue=8e-41,
Organism=Caenorhabditis elegans, GI71992381, Length=429, Percent_Identity=24.4755244755245, Blast_Score=145, Evalue=6e-35,
Organism=Caenorhabditis elegans, GI71992392, Length=369, Percent_Identity=24.6612466124661, Blast_Score=134, Evalue=9e-32,
Organism=Caenorhabditis elegans, GI17534361, Length=448, Percent_Identity=25, Blast_Score=133, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17556096, Length=455, Percent_Identity=22.1978021978022, Blast_Score=89, Evalue=5e-18,
Organism=Saccharomyces cerevisiae, GI6320027, Length=432, Percent_Identity=27.3148148148148, Blast_Score=164, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6320023, Length=460, Percent_Identity=29.1304347826087, Blast_Score=157, Evalue=3e-39,
Organism=Saccharomyces cerevisiae, GI6320764, Length=461, Percent_Identity=25.1626898047722, Blast_Score=139, Evalue=7e-34,
Organism=Drosophila melanogaster, GI18921117, Length=444, Percent_Identity=27.2522522522523, Blast_Score=132, Evalue=8e-31,
Organism=Drosophila melanogaster, GI24639277, Length=444, Percent_Identity=27.2522522522523, Blast_Score=132, Evalue=8e-31,
Organism=Drosophila melanogaster, GI24639275, Length=444, Percent_Identity=27.2522522522523, Blast_Score=132, Evalue=8e-31,
Organism=Drosophila melanogaster, GI24653753, Length=271, Percent_Identity=26.1992619926199, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR016164
- InterPro:   IPR016168
- InterPro:   IPR004113
- InterPro:   IPR004490
- InterPro:   IPR006094
- InterPro:   IPR016171 [H]

Pfam domain/function: PF02913 FAD-oxidase_C; PF01565 FAD_binding_4 [H]

EC number: NA

Molecular weight: Translated: 54289; Mature: 54289

Theoretical pI: Translated: 5.36; Mature: 5.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNAPGELSPELSPEMLAQRQREVVQALMAVLPTHCLLYREEDTVAYECDGLAAYRRLPLA
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCEEEECCCHHHHHHCCEE
VALPETESQVQRIVQICHRLNVPIVPRGAGTSLSGGAMPIRHGVVVSLARFRKIVEVDPY
EECCCCHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCC
ARTATVQPGVRNLSISEAAAPYGLYYAPDPSSQIACTIGGNVAENSGGVHCLKYGLTVHN
CCEEECCCCCCCCCHHHHCCCCCEEECCCCCCCEEEEECCCEECCCCCEEEEEECCHHHH
VLRVRAITMEGEIVEFGSLSPDAPGLDLLAVVIGSEGMFAIVTEVTVKLIPKPQASQVIM
EEEEEEEEECCCEEECCCCCCCCCCHHEEEEEECCCCCEEEEEEHHHEECCCCCCCHHHH
ASFDDVVKGGDAVAGIIAAGIIPAGLEMMDKPATRAVEEFVNAGYDLDAAAILLCESDGT
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCEEEEEECCCCC
PEEVSEEIVRMTAVLREHGATRIQISRTEAERLRFWSGRKNAFPAAGRISPDYYCMDGTV
HHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCC
PRRSIGPLLARIEEMEKKYNLRCINVFHAGDGNMHPLILFNGNDLDEWHRAEAFGCDILE
CHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCEEEEECCCCHHHHHHHHHCCCHHHH
TCVELGGTVTGEHGVGIEKINSMCVQFSPEERDAFHAVKRAFDPACLLNPDKGIPTRARC
HHHHHCCEEECCCCCCHHHHHHHHEECCCCHHHHHHHHHHHCCCCEEECCCCCCCCHHHH
AEYGKMHVRGGLLPHPDLPRF
HHHCCEEECCCCCCCCCCCCC
>Mature Secondary Structure
MNAPGELSPELSPEMLAQRQREVVQALMAVLPTHCLLYREEDTVAYECDGLAAYRRLPLA
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCEEEECCCHHHHHHCCEE
VALPETESQVQRIVQICHRLNVPIVPRGAGTSLSGGAMPIRHGVVVSLARFRKIVEVDPY
EECCCCHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCC
ARTATVQPGVRNLSISEAAAPYGLYYAPDPSSQIACTIGGNVAENSGGVHCLKYGLTVHN
CCEEECCCCCCCCCHHHHCCCCCEEECCCCCCCEEEEECCCEECCCCCEEEEEECCHHHH
VLRVRAITMEGEIVEFGSLSPDAPGLDLLAVVIGSEGMFAIVTEVTVKLIPKPQASQVIM
EEEEEEEEECCCEEECCCCCCCCCCHHEEEEEECCCCCEEEEEEHHHEECCCCCCCHHHH
ASFDDVVKGGDAVAGIIAAGIIPAGLEMMDKPATRAVEEFVNAGYDLDAAAILLCESDGT
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCEEEEEECCCCC
PEEVSEEIVRMTAVLREHGATRIQISRTEAERLRFWSGRKNAFPAAGRISPDYYCMDGTV
HHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCC
PRRSIGPLLARIEEMEKKYNLRCINVFHAGDGNMHPLILFNGNDLDEWHRAEAFGCDILE
CHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCEEEEECCCCHHHHHHHHHCCCHHHH
TCVELGGTVTGEHGVGIEKINSMCVQFSPEERDAFHAVKRAFDPACLLNPDKGIPTRARC
HHHHHCCEEECCCCCCHHHHHHHHEECCCCHHHHHHHHHHHCCCCEEECCCCCCCCHHHH
AEYGKMHVRGGLLPHPDLPRF
HHHCCEEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]