Click here to switch to the map view.

The map label for this gene is glyA [H]

Identifier: 186477198

GI number: 186477198

Start: 2748292

End: 2749539

Strand: Reverse

Name: glyA [H]

Synonym: Bphy_2449

Alternate gene names: 186477198

Gene position: 2749539-2748292 (Counterclockwise)

Preceding gene: 186477207

Following gene: 186477197

Centisome position: 79.03

GC content: 63.54

Gene sequence:

>1248_bases
ATGTTTGACAGAGCCCAAAGCACCATCGCCAACGTCGATCCCGAGATCTGGAACGCCATCCAGGACGAAAACCGCCGTCA
GGAAGAGCACATCGAACTGATCGCGTCGGAAAACTACACGAGCCCGGCCGTGATGGCCGCGCAGGGCTCGCAGCTCACCA
ACAAGTACGCCGAAGGCTACCCGGGCAAGCGCTACTACGGCGGCTGCGAATACGTCGACGTCGTCGAGCAGCTCGCGATC
GACCGCGTGAAGCAGCTGTTTGGCGCTGAAGCCGCGAACGTTCAGCCGAACTCGGGCTCGCAGGCCAACCAGGGCGTGTT
TTTCGCGATGCTGAAGCCGGGCGACACGATCATGGGCATGAGCCTCGCGCACGGCGGCCACCTGACGCACGGCTCGCCTG
TCAACATGTCGGGCAAGTGGTTTAACGTGGTGAGCTACGGCCTGAACGAAGCCGAAGACATCGACTACGACGCGGCCGAG
AAGCTCGCACAGGAACACAAGCCGAAGATCATCGTCGCGGGCGCATCGGCGTTCGCGCTGCGCATCGACTTCGAGCGTCT
GTCGAAGATCGCGAAGTCGGTCGGCGCGTATCTGATGGTCGACATGGCGCACTACGCCGGCCTGATTGCTGCCGGCGTCT
ATCCGAACCCGGTACCGTTCGCCGACTTCGTCACCACGACCACGCACAAGAGCCTGCGCGGCCCGCGCGGCGGCGTGATC
CTGATGAAGGCCGAATTCGAAAAGCAGATCAATTCGGCCATCTTCCCGGGCATCCAGGGCGGTCCGCTGATGCACGTAAT
CGCGGGCAAGGCCGTCGCGTTCAAGGAAGCGCTGGCGCCGGAATTCAAGGAATACCAGCAGCGCGTGGTCGACAATGCTC
GCGTGCTGGCTGAAACGCTTGTCAAGCGCGGTCTGCGCATCGTCTCGGGACGCACCGAAAGCCACGTGATGCTGGTCGAC
CTGCGCGCGAAGAAGATCACGGGCAAGGCAGCGGAAGCGGCGCTCGGCGCGGCGCACATCACGGTCAACAAGAACGCGAT
TCCGAATGACCCGGAAAAGCCGTTCGTGACGAGCGGCATCCGTCTCGGTTCGCCCGCGATGACGACGCGCGGCTTCGGTA
CGAAGGAAGCCGAGCAGGTCGGCAACCTGATTGCCGACGTGCTGGACAACCCCGAAGACACGGCGACGATCGAGCGCGTG
CGCGCGCAGGTCGCCGAGCTGACGCAGCGTTTCCCGGTCTACCGCTAA

Upstream 100 bases:

>100_bases
CCATCATCAGCAGTGGCCAGCAGTGCTGCGTACCTGCTACGGCCCCGGCACTCGACCTGCGCACGATCCGGTCAACCTGA
ACACACTTAACGGAACCAGC

Downstream 100 bases:

>100_bases
GCCGCCATGCGCTGCCCCTTCTGCCGGCACGACGACACGCAGGTCGTCGACTCGCGGGTGTCCGAAGACGGCGCCGCGAT
CCGGCGCCGCCGGCGTTGCC

Product: serine hydroxymethyltransferase

Products: NA

Alternate protein names: SHMT 1; Serine methylase 1 [H]

Number of amino acids: Translated: 415; Mature: 415

Protein sequence:

>415_residues
MFDRAQSTIANVDPEIWNAIQDENRRQEEHIELIASENYTSPAVMAAQGSQLTNKYAEGYPGKRYYGGCEYVDVVEQLAI
DRVKQLFGAEAANVQPNSGSQANQGVFFAMLKPGDTIMGMSLAHGGHLTHGSPVNMSGKWFNVVSYGLNEAEDIDYDAAE
KLAQEHKPKIIVAGASAFALRIDFERLSKIAKSVGAYLMVDMAHYAGLIAAGVYPNPVPFADFVTTTTHKSLRGPRGGVI
LMKAEFEKQINSAIFPGIQGGPLMHVIAGKAVAFKEALAPEFKEYQQRVVDNARVLAETLVKRGLRIVSGRTESHVMLVD
LRAKKITGKAAEAALGAAHITVNKNAIPNDPEKPFVTSGIRLGSPAMTTRGFGTKEAEQVGNLIADVLDNPEDTATIERV
RAQVAELTQRFPVYR

Sequences:

>Translated_415_residues
MFDRAQSTIANVDPEIWNAIQDENRRQEEHIELIASENYTSPAVMAAQGSQLTNKYAEGYPGKRYYGGCEYVDVVEQLAI
DRVKQLFGAEAANVQPNSGSQANQGVFFAMLKPGDTIMGMSLAHGGHLTHGSPVNMSGKWFNVVSYGLNEAEDIDYDAAE
KLAQEHKPKIIVAGASAFALRIDFERLSKIAKSVGAYLMVDMAHYAGLIAAGVYPNPVPFADFVTTTTHKSLRGPRGGVI
LMKAEFEKQINSAIFPGIQGGPLMHVIAGKAVAFKEALAPEFKEYQQRVVDNARVLAETLVKRGLRIVSGRTESHVMLVD
LRAKKITGKAAEAALGAAHITVNKNAIPNDPEKPFVTSGIRLGSPAMTTRGFGTKEAEQVGNLIADVLDNPEDTATIERV
RAQVAELTQRFPVYR
>Mature_415_residues
MFDRAQSTIANVDPEIWNAIQDENRRQEEHIELIASENYTSPAVMAAQGSQLTNKYAEGYPGKRYYGGCEYVDVVEQLAI
DRVKQLFGAEAANVQPNSGSQANQGVFFAMLKPGDTIMGMSLAHGGHLTHGSPVNMSGKWFNVVSYGLNEAEDIDYDAAE
KLAQEHKPKIIVAGASAFALRIDFERLSKIAKSVGAYLMVDMAHYAGLIAAGVYPNPVPFADFVTTTTHKSLRGPRGGVI
LMKAEFEKQINSAIFPGIQGGPLMHVIAGKAVAFKEALAPEFKEYQQRVVDNARVLAETLVKRGLRIVSGRTESHVMLVD
LRAKKITGKAAEAALGAAHITVNKNAIPNDPEKPFVTSGIRLGSPAMTTRGFGTKEAEQVGNLIADVLDNPEDTATIERV
RAQVAELTQRFPVYR

Specific function: Interconversion of serine and glycine [H]

COG id: COG0112

COG function: function code E; Glycine/serine hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SHMT family [H]

Homologues:

Organism=Homo sapiens, GI19923315, Length=454, Percent_Identity=40.9691629955947, Blast_Score=338, Evalue=5e-93,
Organism=Homo sapiens, GI261862352, Length=454, Percent_Identity=40.9691629955947, Blast_Score=338, Evalue=5e-93,
Organism=Homo sapiens, GI261862350, Length=454, Percent_Identity=40.9691629955947, Blast_Score=338, Evalue=5e-93,
Organism=Homo sapiens, GI261862348, Length=454, Percent_Identity=40.9691629955947, Blast_Score=338, Evalue=5e-93,
Organism=Homo sapiens, GI261862346, Length=453, Percent_Identity=40.6181015452539, Blast_Score=332, Evalue=5e-91,
Organism=Homo sapiens, GI22547186, Length=428, Percent_Identity=43.2242990654206, Blast_Score=321, Evalue=8e-88,
Organism=Homo sapiens, GI22547189, Length=413, Percent_Identity=41.1622276029056, Blast_Score=286, Evalue=2e-77,
Organism=Escherichia coli, GI1788902, Length=414, Percent_Identity=63.768115942029, Blast_Score=545, Evalue=1e-156,
Organism=Caenorhabditis elegans, GI25144732, Length=441, Percent_Identity=43.7641723356009, Blast_Score=355, Evalue=2e-98,
Organism=Caenorhabditis elegans, GI25144729, Length=441, Percent_Identity=43.7641723356009, Blast_Score=355, Evalue=2e-98,
Organism=Saccharomyces cerevisiae, GI6319739, Length=415, Percent_Identity=45.5421686746988, Blast_Score=368, Evalue=1e-103,
Organism=Saccharomyces cerevisiae, GI6323087, Length=433, Percent_Identity=43.4180138568129, Blast_Score=340, Evalue=2e-94,
Organism=Drosophila melanogaster, GI24640005, Length=455, Percent_Identity=42.6373626373626, Blast_Score=363, Evalue=1e-100,
Organism=Drosophila melanogaster, GI221329721, Length=455, Percent_Identity=42.6373626373626, Blast_Score=363, Evalue=1e-100,

Paralogues:

None

Copy number: 3180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 12,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR001085
- InterPro:   IPR019798 [H]

Pfam domain/function: PF00464 SHMT [H]

EC number: =2.1.2.1 [H]

Molecular weight: Translated: 45072; Mature: 45072

Theoretical pI: Translated: 6.87; Mature: 6.87

Prosite motif: PS00096 SHMT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFDRAQSTIANVDPEIWNAIQDENRRQEEHIELIASENYTSPAVMAAQGSQLTNKYAEGY
CCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCHHHHHHHCCC
PGKRYYGGCEYVDVVEQLAIDRVKQLFGAEAANVQPNSGSQANQGVFFAMLKPGDTIMGM
CCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEECCCCCEEEE
SLAHGGHLTHGSPVNMSGKWFNVVSYGLNEAEDIDYDAAEKLAQEHKPKIIVAGASAFAL
EECCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHCCCEEEEECCCEEEE
RIDFERLSKIAKSVGAYLMVDMAHYAGLIAAGVYPNPVPFADFVTTTTHKSLRGPRGGVI
EECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCEE
LMKAEFEKQINSAIFPGIQGGPLMHVIAGKAVAFKEALAPEFKEYQQRVVDNARVLAETL
EEEHHHHHHHHHHHCCCCCCCCEEEEHHCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHH
VKRGLRIVSGRTESHVMLVDLRAKKITGKAAEAALGAAHITVNKNAIPNDPEKPFVTSGI
HHCCCEEECCCCCCEEEEEEECHHHHCCHHHHHHHCEEEEEECCCCCCCCCCCCCEECCE
RLGSPAMTTRGFGTKEAEQVGNLIADVLDNPEDTATIERVRAQVAELTQRFPVYR
ECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MFDRAQSTIANVDPEIWNAIQDENRRQEEHIELIASENYTSPAVMAAQGSQLTNKYAEGY
CCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCHHHHHHHCCC
PGKRYYGGCEYVDVVEQLAIDRVKQLFGAEAANVQPNSGSQANQGVFFAMLKPGDTIMGM
CCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEECCCCCEEEE
SLAHGGHLTHGSPVNMSGKWFNVVSYGLNEAEDIDYDAAEKLAQEHKPKIIVAGASAFAL
EECCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHCCCEEEEECCCEEEE
RIDFERLSKIAKSVGAYLMVDMAHYAGLIAAGVYPNPVPFADFVTTTTHKSLRGPRGGVI
EECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCEE
LMKAEFEKQINSAIFPGIQGGPLMHVIAGKAVAFKEALAPEFKEYQQRVVDNARVLAETL
EEEHHHHHHHHHHHCCCCCCCCEEEEHHCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHH
VKRGLRIVSGRTESHVMLVDLRAKKITGKAAEAALGAAHITVNKNAIPNDPEKPFVTSGI
HHCCCEEECCCCCCEEEEEEECHHHHCCHHHHHHHCEEEEEECCCCCCCCCCCCCEECCE
RLGSPAMTTRGFGTKEAEQVGNLIADVLDNPEDTATIERVRAQVAELTQRFPVYR
ECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA