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The map label for this gene is mmgC [H]

Identifier: 186477187

GI number: 186477187

Start: 2741157

End: 2742347

Strand: Direct

Name: mmgC [H]

Synonym: Bphy_2438

Alternate gene names: 186477187

Gene position: 2741157-2742347 (Clockwise)

Preceding gene: 186477185

Following gene: 186477189

Centisome position: 78.79

GC content: 61.71

Gene sequence:

>1191_bases
ATGGCAGCCGCCGCGCAATTTCACTGGGAAGACCCGCTGCTTTTGAACCAGCAGCTCACGGAAGAAGAACGCATGGTGCG
CGACGCCGCAGAGGCTTACGCGCAGGACAAGCTCGCGCCGCGTGTGCTCGAAGCGTTCCGCAATGAGAAGACGGACATCG
CGATCTTCCGCGAAATGGGCGAACTCGGTCTGCTCGGCCCGACCATTCCCGAGCAATACGGCGGACCGGGGCTGAATTAT
GTGAGCTACGGGCTGATCGCACGAGAAGTCGAGCGCGTGGATTCGGGCTATCGCTCGATGATGTCGGTGCAGTCGTCACT
GGTGATGGTCCCGATCTTCGAATTCGGCTCCGACGCGCAGAAGGACAAATACCTGCCGAAGCTCGCTTCGGGCGAGTGGA
TCGGCTGCTTCGGTCTGACCGAGCCGAATCACGGCTCCGATCCGGGCAGCATGGTCACGCGCGCGAAAAAGGTCGACGGC
GGCTATTCGCTCTCCGGCGCGAAGATGTGGATCACGAATTCGCCGATCGCGGACGTTTTCGTCGTCTGGGCACAGCTCGA
AACAGACGGCAAGGACGAGATTCGCGGCTTCATTCTTGAGAAGGGCTGGAAGGGTTTGAGCGCACCCGCGATTCACGGCA
AGGTTGGCCTGCGTGCGTCGATCACGGGTGAGATCGTTCTCGATGAAGTCTTCGTGCCCGAGGAAAATCTGATGCCGGGC
GTGAAAGGGCTGCGCGGACCGTTCACCTGTCTGAACTCAGCGCGTTATGGCATCGCGTGGGGCGCGCTCGGCGCGGCGGA
ATCGTGCTGGCACACGGCGCGTCAGTACACGCTGGATCGCAAGCAGTTTGGCCGTCCACTCGCGGCCAACCAGCTGATCC
AGAAGAAGCTCGCCGACATGCAAACGGAAATCACGCTCGGCCTGCAAGGCGTGCTGCGCCTTGGCCGGATGAAGGACGAA
GGCACGGCGGCCGTCGAAATCACGTCGATCATGAAGCGCAATTCATGCGGCAAGGCGCTCGATATCGCGCGCATGGCGCG
TGACATGCTGGGCGGCAACGGCATATCCGACGAGTTCGGCGTCGCGCGGCATCTGGTGAACCTGGAAGTGGTGAACACCT
ACGAGGGTACGCACGATATCCACGCGCTGATCCTCGGACGCGCACAGACGGGCATTCAGGCGTTCTTCTGA

Upstream 100 bases:

>100_bases
CGTCGTTTTGCAAAACATTGTTTCGCAGAGCGGAACTCAAGTCAAGCATTCGGACGAGGATACGCGCGAAGGCGCCCTCT
CGTCGACAAGGAGATACGTC

Downstream 100 bases:

>100_bases
CACCTCAGTGCGCCTCAAACGGCGCCTATTTAAAAGCCCGCGTTCTCAACGAACGCGGGCTTTTCTTTTTGCCTCGTCAG
AGGCCGATGCTTACTTGTTC

Product: acyl-CoA dehydrogenase domain-containing protein

Products: crotonoyl-CoA; CO2; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 396; Mature: 395

Protein sequence:

>396_residues
MAAAAQFHWEDPLLLNQQLTEEERMVRDAAEAYAQDKLAPRVLEAFRNEKTDIAIFREMGELGLLGPTIPEQYGGPGLNY
VSYGLIAREVERVDSGYRSMMSVQSSLVMVPIFEFGSDAQKDKYLPKLASGEWIGCFGLTEPNHGSDPGSMVTRAKKVDG
GYSLSGAKMWITNSPIADVFVVWAQLETDGKDEIRGFILEKGWKGLSAPAIHGKVGLRASITGEIVLDEVFVPEENLMPG
VKGLRGPFTCLNSARYGIAWGALGAAESCWHTARQYTLDRKQFGRPLAANQLIQKKLADMQTEITLGLQGVLRLGRMKDE
GTAAVEITSIMKRNSCGKALDIARMARDMLGGNGISDEFGVARHLVNLEVVNTYEGTHDIHALILGRAQTGIQAFF

Sequences:

>Translated_396_residues
MAAAAQFHWEDPLLLNQQLTEEERMVRDAAEAYAQDKLAPRVLEAFRNEKTDIAIFREMGELGLLGPTIPEQYGGPGLNY
VSYGLIAREVERVDSGYRSMMSVQSSLVMVPIFEFGSDAQKDKYLPKLASGEWIGCFGLTEPNHGSDPGSMVTRAKKVDG
GYSLSGAKMWITNSPIADVFVVWAQLETDGKDEIRGFILEKGWKGLSAPAIHGKVGLRASITGEIVLDEVFVPEENLMPG
VKGLRGPFTCLNSARYGIAWGALGAAESCWHTARQYTLDRKQFGRPLAANQLIQKKLADMQTEITLGLQGVLRLGRMKDE
GTAAVEITSIMKRNSCGKALDIARMARDMLGGNGISDEFGVARHLVNLEVVNTYEGTHDIHALILGRAQTGIQAFF
>Mature_395_residues
AAAAQFHWEDPLLLNQQLTEEERMVRDAAEAYAQDKLAPRVLEAFRNEKTDIAIFREMGELGLLGPTIPEQYGGPGLNYV
SYGLIAREVERVDSGYRSMMSVQSSLVMVPIFEFGSDAQKDKYLPKLASGEWIGCFGLTEPNHGSDPGSMVTRAKKVDGG
YSLSGAKMWITNSPIADVFVVWAQLETDGKDEIRGFILEKGWKGLSAPAIHGKVGLRASITGEIVLDEVFVPEENLMPGV
KGLRGPFTCLNSARYGIAWGALGAAESCWHTARQYTLDRKQFGRPLAANQLIQKKLADMQTEITLGLQGVLRLGRMKDEG
TAAVEITSIMKRNSCGKALDIARMARDMLGGNGISDEFGVARHLVNLEVVNTYEGTHDIHALILGRAQTGIQAFF

Specific function: Catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA. [C]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4503943, Length=392, Percent_Identity=67.0918367346939, Blast_Score=531, Evalue=1e-151,
Organism=Homo sapiens, GI7669494, Length=376, Percent_Identity=64.8936170212766, Blast_Score=492, Evalue=1e-139,
Organism=Homo sapiens, GI226958412, Length=376, Percent_Identity=34.5744680851064, Blast_Score=207, Evalue=2e-53,
Organism=Homo sapiens, GI4557233, Length=372, Percent_Identity=31.7204301075269, Blast_Score=191, Evalue=1e-48,
Organism=Homo sapiens, GI226958414, Length=338, Percent_Identity=34.3195266272189, Blast_Score=189, Evalue=4e-48,
Organism=Homo sapiens, GI4501859, Length=367, Percent_Identity=29.700272479564, Blast_Score=176, Evalue=4e-44,
Organism=Homo sapiens, GI76496475, Length=384, Percent_Identity=31.7708333333333, Blast_Score=169, Evalue=3e-42,
Organism=Homo sapiens, GI4557235, Length=384, Percent_Identity=31.7708333333333, Blast_Score=169, Evalue=4e-42,
Organism=Homo sapiens, GI187960098, Length=399, Percent_Identity=30.3258145363409, Blast_Score=168, Evalue=9e-42,
Organism=Homo sapiens, GI4557231, Length=399, Percent_Identity=30.3258145363409, Blast_Score=168, Evalue=1e-41,
Organism=Homo sapiens, GI21361497, Length=346, Percent_Identity=32.6589595375723, Blast_Score=157, Evalue=1e-38,
Organism=Homo sapiens, GI7656849, Length=377, Percent_Identity=29.1777188328912, Blast_Score=151, Evalue=1e-36,
Organism=Homo sapiens, GI4501857, Length=377, Percent_Identity=27.5862068965517, Blast_Score=130, Evalue=2e-30,
Organism=Escherichia coli, GI1786223, Length=376, Percent_Identity=25.2659574468085, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI87081958, Length=340, Percent_Identity=27.6470588235294, Blast_Score=92, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI17534353, Length=390, Percent_Identity=63.5897435897436, Blast_Score=509, Evalue=1e-144,
Organism=Caenorhabditis elegans, GI17538396, Length=374, Percent_Identity=32.8877005347594, Blast_Score=188, Evalue=5e-48,
Organism=Caenorhabditis elegans, GI17508101, Length=376, Percent_Identity=32.7127659574468, Blast_Score=187, Evalue=7e-48,
Organism=Caenorhabditis elegans, GI17506239, Length=365, Percent_Identity=31.2328767123288, Blast_Score=176, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI71985184, Length=394, Percent_Identity=32.741116751269, Blast_Score=170, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI17569725, Length=375, Percent_Identity=30.1333333333333, Blast_Score=167, Evalue=7e-42,
Organism=Caenorhabditis elegans, GI71990804, Length=288, Percent_Identity=34.0277777777778, Blast_Score=160, Evalue=7e-40,
Organism=Caenorhabditis elegans, GI71985192, Length=321, Percent_Identity=33.9563862928349, Blast_Score=155, Evalue=5e-38,
Organism=Caenorhabditis elegans, GI17534899, Length=376, Percent_Identity=28.7234042553192, Blast_Score=152, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI17570075, Length=379, Percent_Identity=27.9683377308707, Blast_Score=145, Evalue=4e-35,
Organism=Caenorhabditis elegans, GI71982178, Length=273, Percent_Identity=31.5018315018315, Blast_Score=137, Evalue=8e-33,
Organism=Caenorhabditis elegans, GI32563615, Length=231, Percent_Identity=33.7662337662338, Blast_Score=133, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI17533517, Length=372, Percent_Identity=25, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17551932, Length=357, Percent_Identity=24.3697478991597, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17505929, Length=351, Percent_Identity=24.7863247863248, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI19920834, Length=398, Percent_Identity=62.8140703517588, Blast_Score=491, Evalue=1e-139,
Organism=Drosophila melanogaster, GI21356377, Length=370, Percent_Identity=32.4324324324324, Blast_Score=204, Evalue=6e-53,
Organism=Drosophila melanogaster, GI24666513, Length=365, Percent_Identity=32.0547945205479, Blast_Score=190, Evalue=1e-48,
Organism=Drosophila melanogaster, GI24646207, Length=372, Percent_Identity=31.989247311828, Blast_Score=186, Evalue=2e-47,
Organism=Drosophila melanogaster, GI21355753, Length=375, Percent_Identity=31.4666666666667, Blast_Score=176, Evalue=2e-44,
Organism=Drosophila melanogaster, GI281363737, Length=394, Percent_Identity=31.7258883248731, Blast_Score=171, Evalue=1e-42,
Organism=Drosophila melanogaster, GI24660351, Length=378, Percent_Identity=30.952380952381, Blast_Score=165, Evalue=5e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.7

Molecular weight: Translated: 43355; Mature: 43224

Theoretical pI: Translated: 5.72; Mature: 5.72

Prosite motif: PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAAAQFHWEDPLLLNQQLTEEERMVRDAAEAYAQDKLAPRVLEAFRNEKTDIAIFREMG
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCHHHHHHHHC
ELGLLGPTIPEQYGGPGLNYVSYGLIAREVERVDSGYRSMMSVQSSLVMVPIFEFGSDAQ
CCCCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEEHHCCCCCC
KDKYLPKLASGEWIGCFGLTEPNHGSDPGSMVTRAKKVDGGYSLSGAKMWITNSPIADVF
HHHCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHCCCCEEECCCEEEEECCCHHHHH
VVWAQLETDGKDEIRGFILEKGWKGLSAPAIHGKVGLRASITGEIVLDEVFVPEENLMPG
EEEHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCEEECCCEEEEEEEECCCHHCCCC
VKGLRGPFTCLNSARYGIAWGALGAAESCWHTARQYTLDRKQFGRPLAANQLIQKKLADM
HHHCCCHHHHHHCCCCCEEECCCCHHHHHHHHHHHHCCCHHHHCCCHHHHHHHHHHHHHH
QTEITLGLQGVLRLGRMKDEGTAAVEITSIMKRNSCGKALDIARMARDMLGGNGISDEFG
HHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCHHHH
VARHLVNLEVVNTYEGTHDIHALILGRAQTGIQAFF
HHHHHHEEEEEECCCCCHHEEHHEECCHHCCHHHCC
>Mature Secondary Structure 
AAAAQFHWEDPLLLNQQLTEEERMVRDAAEAYAQDKLAPRVLEAFRNEKTDIAIFREMG
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCHHHHHHHHC
ELGLLGPTIPEQYGGPGLNYVSYGLIAREVERVDSGYRSMMSVQSSLVMVPIFEFGSDAQ
CCCCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEEHHCCCCCC
KDKYLPKLASGEWIGCFGLTEPNHGSDPGSMVTRAKKVDGGYSLSGAKMWITNSPIADVF
HHHCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHCCCCEEECCCEEEEECCCHHHHH
VVWAQLETDGKDEIRGFILEKGWKGLSAPAIHGKVGLRASITGEIVLDEVFVPEENLMPG
EEEHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCEEECCCEEEEEEEECCCHHCCCC
VKGLRGPFTCLNSARYGIAWGALGAAESCWHTARQYTLDRKQFGRPLAANQLIQKKLADM
HHHCCCHHHHHHCCCCCEEECCCCHHHHHHHHHHHHCCCHHHHCCCHHHHHHHHHHHHHH
QTEITLGLQGVLRLGRMKDEGTAAVEITSIMKRNSCGKALDIARMARDMLGGNGISDEFG
HHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCHHHH
VARHLVNLEVVNTYEGTHDIHALILGRAQTGIQAFF
HHHHHHEEEEEECCCCCHHEEHHEECCHHCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: glutaryl-CoA; acceptor

Specific reaction: glutaryl-CoA + acceptor = crotonoyl-CoA + CO2 + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8759838; 8969508; 9384377 [H]