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The map label for this gene is groEL [H]

Identifier: 186477084

GI number: 186477084

Start: 2615893

End: 2617533

Strand: Reverse

Name: groEL [H]

Synonym: Bphy_2333

Alternate gene names: 186477084

Gene position: 2617533-2615893 (Counterclockwise)

Preceding gene: 186477085

Following gene: 186477081

Centisome position: 75.23

GC content: 61.55

Gene sequence:

>1641_bases
ATGGCAGCTAAAGACGTCGTGTTCGGCGATTCCGCCCGTGCCAAGATGGTTGAAGGCGTGAACATTCTCGCCAACGCAGT
GAAGGTTACGCTCGGTCCGAAGGGCCGTAACGTTGTGCTCGAGCGCAGCTTCGGCGGCCCGACGGTCACCAAGGACGGTG
TGTCGGTCGCGAAGGAAATCGAGCTGAAGGACAAGCTCCAGAACATGGGCGCGCAAATGGTCAAGGAAGTCGCTTCCAAG
ACCAGCGACAACGCCGGCGACGGCACGACGACGGCAACGGTTCTGGCCCAGTCGATCGTTCGCGAAGGCATGAAGTACGT
CGCATCGGGCATGAACCCGATGGACCTGAAGCGCGGCATCGACAAGGCCGTCGCAGCAGCAATCGAAGAGCTGCGCAAGA
TCAGCAAGCCCTGCACGACCAACAAGGAAATCGCTCAGGTCGGCGCGATCTCGGCGAACAGCGACACGTCGATCGGCGAT
CGCATCGCTGAAGCGATGGACAAGGTCGGCAAGGAAGGCGTCATCACCGTCGAAGACGGCAAGTCGCTGCAAGACGAGCT
GGACGTCGTCGAAGGTATGCAATTCGACCGCGGCTACCTGTCGCCGTACTTCATCAACAACCCGGATAAGCAAGTCGCCG
TTCTGGACAACCCGTTCGTGCTGCTGCACGACAAGAAGGTGTCGAACATCCGTGATCTGCTGCCGGTTCTCGAGCAGGTC
GCCAAGGCTGGCCGTCCGCTGCTGATCATCGCTGAAGACGTCGAAGGCGAAGCGCTGGCTACGCTGGTCGTCAACAACAT
CCGCGGCATCCTGAAGACGGTTGCTGTGAAGGCTCCGGGCTTCGGCGACCGCCGCAAGGCAATGCTGGAAGACATCGCGA
TCCTGACGGGTGGCCAGGTCATCGCCGAAGAAACCGGCCTGACGCTGGAAAAGGCGACGCTGCAGGAACTGGGTCAAGCC
AAGCGTATCGAAGTGGGCAAGGAAAACACGACGATCATCGACGGCGCTGGCGAAGCAGCAAACATCGAAGCGCGCGTCAA
GCAAGTGCGCACGCAGATCGAAGAAGCAACGTCGGACTACGACCGTGAAAAGCTGCAAGAGCGCGTGGCCAAGCTGGCGG
GCGGCGTTGCAGTGATCAAGGTCGGTGCTGCGACCGAAGTCGAAATGAAGGAAAAGAAGGCACGTGTCGAAGACGCACTG
CACGCAACGCGCGCAGCTGTGGAAGAAGGCATCGTGGCTGGCGGCGGCGTCGCGCTGATCCGTGCACGCAGCGCAATCAG
CGGCGTGAAGGGCGACAACGCTGACCAGGACGCAGGTATCAAGATCGTTCTGCGCGCAATGGAAGAGCCGCTGCGCCAGA
TCGTCACGAACGGCGGCGAAGAAGCCAGCGTCGTGGTGGCAGCAGTTGCTGGCGGCACGGGCAACTACGGCTACAACGCA
GCAACGGGCGAGTACGGTGACCTGGTGGAAGCCGGTGTCGTCGACCCGACCAAGGTGACGCGTACGGCACTGCAGAACGC
AGCTTCGGTTGCTGGCCTGCTGCTGACGACGGACGCTGCTGTCTGCGAACTGCCGAAGGAAGATGCACCGATGCCTGGCG
GCATGCCCGGCGGCATGGGTGGCATGGGCATGGACATGTAA

Upstream 100 bases:

>100_bases
GCAACGAACTGCTGGTGATGCGCGAAGAAGACATCATGGCCGTTGTCAACAAGTAAGCACTTGTTACCGGTTCATTCTCA
CGAATTCAAGGAGTTAGAAG

Downstream 100 bases:

>100_bases
TTTCCGGGTAACCGGATTGCATGGGGGAGGCGCGCTGCGAAGCGTGCTTCCCGTGCCAAAAAAAGAAAAACCCGCAGCGA
TGCGGGTTTTTCTTTTGGTG

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein; Protein Cpn60 [H]

Number of amino acids: Translated: 546; Mature: 545

Protein sequence:

>546_residues
MAAKDVVFGDSARAKMVEGVNILANAVKVTLGPKGRNVVLERSFGGPTVTKDGVSVAKEIELKDKLQNMGAQMVKEVASK
TSDNAGDGTTTATVLAQSIVREGMKYVASGMNPMDLKRGIDKAVAAAIEELRKISKPCTTNKEIAQVGAISANSDTSIGD
RIAEAMDKVGKEGVITVEDGKSLQDELDVVEGMQFDRGYLSPYFINNPDKQVAVLDNPFVLLHDKKVSNIRDLLPVLEQV
AKAGRPLLIIAEDVEGEALATLVVNNIRGILKTVAVKAPGFGDRRKAMLEDIAILTGGQVIAEETGLTLEKATLQELGQA
KRIEVGKENTTIIDGAGEAANIEARVKQVRTQIEEATSDYDREKLQERVAKLAGGVAVIKVGAATEVEMKEKKARVEDAL
HATRAAVEEGIVAGGGVALIRARSAISGVKGDNADQDAGIKIVLRAMEEPLRQIVTNGGEEASVVVAAVAGGTGNYGYNA
ATGEYGDLVEAGVVDPTKVTRTALQNAASVAGLLLTTDAAVCELPKEDAPMPGGMPGGMGGMGMDM

Sequences:

>Translated_546_residues
MAAKDVVFGDSARAKMVEGVNILANAVKVTLGPKGRNVVLERSFGGPTVTKDGVSVAKEIELKDKLQNMGAQMVKEVASK
TSDNAGDGTTTATVLAQSIVREGMKYVASGMNPMDLKRGIDKAVAAAIEELRKISKPCTTNKEIAQVGAISANSDTSIGD
RIAEAMDKVGKEGVITVEDGKSLQDELDVVEGMQFDRGYLSPYFINNPDKQVAVLDNPFVLLHDKKVSNIRDLLPVLEQV
AKAGRPLLIIAEDVEGEALATLVVNNIRGILKTVAVKAPGFGDRRKAMLEDIAILTGGQVIAEETGLTLEKATLQELGQA
KRIEVGKENTTIIDGAGEAANIEARVKQVRTQIEEATSDYDREKLQERVAKLAGGVAVIKVGAATEVEMKEKKARVEDAL
HATRAAVEEGIVAGGGVALIRARSAISGVKGDNADQDAGIKIVLRAMEEPLRQIVTNGGEEASVVVAAVAGGTGNYGYNA
ATGEYGDLVEAGVVDPTKVTRTALQNAASVAGLLLTTDAAVCELPKEDAPMPGGMPGGMGGMGMDM
>Mature_545_residues
AAKDVVFGDSARAKMVEGVNILANAVKVTLGPKGRNVVLERSFGGPTVTKDGVSVAKEIELKDKLQNMGAQMVKEVASKT
SDNAGDGTTTATVLAQSIVREGMKYVASGMNPMDLKRGIDKAVAAAIEELRKISKPCTTNKEIAQVGAISANSDTSIGDR
IAEAMDKVGKEGVITVEDGKSLQDELDVVEGMQFDRGYLSPYFINNPDKQVAVLDNPFVLLHDKKVSNIRDLLPVLEQVA
KAGRPLLIIAEDVEGEALATLVVNNIRGILKTVAVKAPGFGDRRKAMLEDIAILTGGQVIAEETGLTLEKATLQELGQAK
RIEVGKENTTIIDGAGEAANIEARVKQVRTQIEEATSDYDREKLQERVAKLAGGVAVIKVGAATEVEMKEKKARVEDALH
ATRAAVEEGIVAGGGVALIRARSAISGVKGDNADQDAGIKIVLRAMEEPLRQIVTNGGEEASVVVAAVAGGTGNYGYNAA
TGEYGDLVEAGVVDPTKVTRTALQNAASVAGLLLTTDAAVCELPKEDAPMPGGMPGGMGGMGMDM

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions [H]

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family [H]

Homologues:

Organism=Homo sapiens, GI41399285, Length=528, Percent_Identity=53.030303030303, Blast_Score=541, Evalue=1e-154,
Organism=Homo sapiens, GI31542947, Length=528, Percent_Identity=53.030303030303, Blast_Score=541, Evalue=1e-154,
Organism=Homo sapiens, GI24307939, Length=350, Percent_Identity=24, Blast_Score=76, Evalue=7e-14,
Organism=Homo sapiens, GI5453607, Length=552, Percent_Identity=22.1014492753623, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI1790586, Length=529, Percent_Identity=75.6143667296786, Blast_Score=803, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17555558, Length=529, Percent_Identity=51.9848771266541, Blast_Score=546, Evalue=1e-155,
Organism=Caenorhabditis elegans, GI193210679, Length=211, Percent_Identity=50.7109004739336, Blast_Score=213, Evalue=2e-55,
Organism=Caenorhabditis elegans, GI17564182, Length=563, Percent_Identity=23.2682060390764, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI25144674, Length=293, Percent_Identity=23.8907849829352, Blast_Score=67, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6323288, Length=526, Percent_Identity=52.0912547528517, Blast_Score=536, Evalue=1e-153,
Organism=Saccharomyces cerevisiae, GI6322524, Length=389, Percent_Identity=24.4215938303342, Blast_Score=74, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6322350, Length=562, Percent_Identity=23.4875444839858, Blast_Score=69, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6322446, Length=570, Percent_Identity=22.4561403508772, Blast_Score=67, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24641193, Length=527, Percent_Identity=52.3719165085389, Blast_Score=555, Evalue=1e-158,
Organism=Drosophila melanogaster, GI24641191, Length=527, Percent_Identity=52.3719165085389, Blast_Score=555, Evalue=1e-158,
Organism=Drosophila melanogaster, GI45550936, Length=527, Percent_Identity=50.6641366223909, Blast_Score=533, Evalue=1e-151,
Organism=Drosophila melanogaster, GI45550132, Length=527, Percent_Identity=50.6641366223909, Blast_Score=533, Evalue=1e-151,
Organism=Drosophila melanogaster, GI45550935, Length=527, Percent_Identity=50.6641366223909, Blast_Score=533, Evalue=1e-151,
Organism=Drosophila melanogaster, GI17864606, Length=550, Percent_Identity=43.8181818181818, Blast_Score=460, Evalue=1e-129,
Organism=Drosophila melanogaster, GI24584129, Length=526, Percent_Identity=36.8821292775665, Blast_Score=331, Evalue=6e-91,
Organism=Drosophila melanogaster, GI19921262, Length=526, Percent_Identity=36.8821292775665, Blast_Score=331, Evalue=6e-91,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423 [H]

Pfam domain/function: PF00118 Cpn60_TCP1 [H]

EC number: NA

Molecular weight: Translated: 57167; Mature: 57036

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAKDVVFGDSARAKMVEGVNILANAVKVTLGPKGRNVVLERSFGGPTVTKDGVSVAKEI
CCCCCCEECCCHHHHHHHHHHHHHHHHEEEECCCCCEEEEEECCCCCCCCCCHHHHHHHH
ELKDKLQNMGAQMVKEVASKTSDNAGDGTTTATVLAQSIVREGMKYVASGMNPMDLKRGI
HHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
DKAVAAAIEELRKISKPCTTNKEIAQVGAISANSDTSIGDRIAEAMDKVGKEGVITVEDG
HHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCC
KSLQDELDVVEGMQFDRGYLSPYFINNPDKQVAVLDNPFVLLHDKKVSNIRDLLPVLEQV
CCHHHHHHHHHCCCCCCCCCCCEEECCCCCEEEEECCCEEEEECCHHHHHHHHHHHHHHH
AKAGRPLLIIAEDVEGEALATLVVNNIRGILKTVAVKAPGFGDRRKAMLEDIAILTGGQV
HHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCEE
IAEETGLTLEKATLQELGQAKRIEVGKENTTIIDGAGEAANIEARVKQVRTQIEEATSDY
EECCCCCCHHHHHHHHHCCCCEEECCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHH
DREKLQERVAKLAGGVAVIKVGAATEVEMKEKKARVEDALHATRAAVEEGIVAGGGVALI
HHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
RARSAISGVKGDNADQDAGIKIVLRAMEEPLRQIVTNGGEEASVVVAAVAGGTGNYGYNA
HHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCCC
ATGEYGDLVEAGVVDPTKVTRTALQNAASVAGLLLTTDAAVCELPKEDAPMPGGMPGGMG
CCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCCCCCCCC
GMGMDM
CCCCCC
>Mature Secondary Structure 
AAKDVVFGDSARAKMVEGVNILANAVKVTLGPKGRNVVLERSFGGPTVTKDGVSVAKEI
CCCCCEECCCHHHHHHHHHHHHHHHHEEEECCCCCEEEEEECCCCCCCCCCHHHHHHHH
ELKDKLQNMGAQMVKEVASKTSDNAGDGTTTATVLAQSIVREGMKYVASGMNPMDLKRGI
HHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
DKAVAAAIEELRKISKPCTTNKEIAQVGAISANSDTSIGDRIAEAMDKVGKEGVITVEDG
HHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCC
KSLQDELDVVEGMQFDRGYLSPYFINNPDKQVAVLDNPFVLLHDKKVSNIRDLLPVLEQV
CCHHHHHHHHHCCCCCCCCCCCEEECCCCCEEEEECCCEEEEECCHHHHHHHHHHHHHHH
AKAGRPLLIIAEDVEGEALATLVVNNIRGILKTVAVKAPGFGDRRKAMLEDIAILTGGQV
HHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCEE
IAEETGLTLEKATLQELGQAKRIEVGKENTTIIDGAGEAANIEARVKQVRTQIEEATSDY
EECCCCCCHHHHHHHHHCCCCEEECCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHH
DREKLQERVAKLAGGVAVIKVGAATEVEMKEKKARVEDALHATRAAVEEGIVAGGGVALI
HHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
RARSAISGVKGDNADQDAGIKIVLRAMEEPLRQIVTNGGEEASVVVAAVAGGTGNYGYNA
HHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCCC
ATGEYGDLVEAGVVDPTKVTRTALQNAASVAGLLLTTDAAVCELPKEDAPMPGGMPGGMG
CCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCCCCCCCC
GMGMDM
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA