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The map label for this gene is rmlC [H]

Identifier: 186477068

GI number: 186477068

Start: 2601735

End: 2602286

Strand: Reverse

Name: rmlC [H]

Synonym: Bphy_2317

Alternate gene names: 186477068

Gene position: 2602286-2601735 (Counterclockwise)

Preceding gene: 186477069

Following gene: 186477067

Centisome position: 74.8

GC content: 59.06

Gene sequence:

>552_bases
ATGGCCATCAGTGTAACTGCAACGGCGCTTCCCGAAGTCAAGATCATCGAGCCGAAGGTGTTCGGTGATGCGCGGGGGTT
TTTCTACGAGAGCTTCAACGCGCGTGAATTTGCAGAAAAGGTCGAAGCGGGCGTCGAGTTCGTGCAGGACAACCATTCGC
GGTCGGCCAAGGGCGTGCTGCGCGGGCTGCATTATCAGATTGAGCATGCGCAAGGAAAACTCGTGCGCGTGGTCGAAGGT
GAAGTGTTCGACGTAGCGGTCGACGTTCGCAAGAGTTCGCCGACTTTCGGCAAGTGGGAAGGCGTGCTGCTGTCGGGCGA
CAACCATCGGCAGCTTTGGATTCCACCCGGGTTCGCGCATGGTTTCGTGGTGTTGTCGGAGGCGGCGCAGTTCCTCTACA
AGACAACCGACTACTGGTTTCCTGAACACGAGCGCAGCATCGTCTGGAACGATCCGGAGATCGGCATCGAATGGCCGATC
GATTTCGAGCCGGTGCTGGCCGCCAAGGACGCGGCCGGAAAGCGCCTGAGCGAAGCCGAATGCTTTGCATGA

Upstream 100 bases:

>100_bases
GCAAGTGGATCAATGCCGAGCAATTGCTTGCGCTCGCCAGGCCGCTGTCGAAGAACGCTTACGGGCAGTATCTGCAAAAC
CTTCTTACGGACCAAGTCGC

Downstream 100 bases:

>100_bases
GGGTGATATGAAGGCGTCTGCGCAACGGACCATCCTGCTGACGGGTGTGAACGGCCAGGTCGGATTCGAACTGGCTCGCA
GCCTTCAGGGGCTCGGCACG

Product: dTDP-4-dehydrorhamnose 3,5-epimerase

Products: NA

Alternate protein names: Thymidine diphospho-4-keto-rhamnose 3,5-epimerase; dTDP-4-keto-6-deoxyglucose 3,5-epimerase; dTDP-6-deoxy-D-xylo-4-hexulose 3,5-epimerase; dTDP-L-rhamnose synthase [H]

Number of amino acids: Translated: 183; Mature: 182

Protein sequence:

>183_residues
MAISVTATALPEVKIIEPKVFGDARGFFYESFNAREFAEKVEAGVEFVQDNHSRSAKGVLRGLHYQIEHAQGKLVRVVEG
EVFDVAVDVRKSSPTFGKWEGVLLSGDNHRQLWIPPGFAHGFVVLSEAAQFLYKTTDYWFPEHERSIVWNDPEIGIEWPI
DFEPVLAAKDAAGKRLSEAECFA

Sequences:

>Translated_183_residues
MAISVTATALPEVKIIEPKVFGDARGFFYESFNAREFAEKVEAGVEFVQDNHSRSAKGVLRGLHYQIEHAQGKLVRVVEG
EVFDVAVDVRKSSPTFGKWEGVLLSGDNHRQLWIPPGFAHGFVVLSEAAQFLYKTTDYWFPEHERSIVWNDPEIGIEWPI
DFEPVLAAKDAAGKRLSEAECFA
>Mature_182_residues
AISVTATALPEVKIIEPKVFGDARGFFYESFNAREFAEKVEAGVEFVQDNHSRSAKGVLRGLHYQIEHAQGKLVRVVEGE
VFDVAVDVRKSSPTFGKWEGVLLSGDNHRQLWIPPGFAHGFVVLSEAAQFLYKTTDYWFPEHERSIVWNDPEIGIEWPID
FEPVLAAKDAAGKRLSEAECFA

Specific function: Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose [H]

COG id: COG1898

COG function: function code M; dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family [H]

Homologues:

Organism=Escherichia coli, GI1788350, Length=169, Percent_Identity=59.1715976331361, Blast_Score=204, Evalue=4e-54,
Organism=Caenorhabditis elegans, GI17550412, Length=153, Percent_Identity=54.9019607843137, Blast_Score=161, Evalue=2e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR000888
- InterPro:   IPR014710
- ProDom:   PD001462 [H]

Pfam domain/function: PF00908 dTDP_sugar_isom [H]

EC number: =5.1.3.13 [H]

Molecular weight: Translated: 20539; Mature: 20408

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
0.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAISVTATALPEVKIIEPKVFGDARGFFYESFNAREFAEKVEAGVEFVQDNHSRSAKGVL
CEEEEEECCCCCEEEECCEECCCCCCEEEECCCHHHHHHHHHHHHHHHHCCCCCHHHHHH
RGLHYQIEHAQGKLVRVVEGEVFDVAVDVRKSSPTFGKWEGVLLSGDNHRQLWIPPGFAH
HHHHEEEECCCCEEEEEECCCEEEEEEEEECCCCCCCCCCEEEEECCCCCEEEECCCCCH
GFVVLSEAAQFLYKTTDYWFPEHERSIVWNDPEIGIEWPIDFEPVLAAKDAAGKRLSEAE
HHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCEECCCCCCCCEECCCCCCCCCCCCC
CFA
CCC
>Mature Secondary Structure 
AISVTATALPEVKIIEPKVFGDARGFFYESFNAREFAEKVEAGVEFVQDNHSRSAKGVL
EEEEEECCCCCEEEECCEECCCCCCEEEECCCHHHHHHHHHHHHHHHHCCCCCHHHHHH
RGLHYQIEHAQGKLVRVVEGEVFDVAVDVRKSSPTFGKWEGVLLSGDNHRQLWIPPGFAH
HHHHEEEECCCCEEEEEECCCEEEEEEEEECCCCCCCCCCEEEEECCCCCEEEECCCCCH
GFVVLSEAAQFLYKTTDYWFPEHERSIVWNDPEIGIEWPIDFEPVLAAKDAAGKRLSEAE
HHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCEECCCCCCCCEECCCCCCCCCCCCC
CFA
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]