Click here to switch to the map view.

The map label for this gene is fabG [C]

Identifier: 186477024

GI number: 186477024

Start: 2548260

End: 2549000

Strand: Direct

Name: fabG [C]

Synonym: Bphy_2273

Alternate gene names: 186477024

Gene position: 2548260-2549000 (Clockwise)

Preceding gene: 186477023

Following gene: 186477025

Centisome position: 73.24

GC content: 63.7

Gene sequence:

>741_bases
ATGAAGAACATCCTTGTCATTGGCGGCTCGTCAGCCATCGCCGCCGCTTGCGCACGGCACTGGGCCGCAGACGGCGACCG
CCTGTTCCTCGCTGGCCGTCATGCCGCGCGGCTGGAAACCATTGCTCAGGATTTGCGCGTGCGCGGCAGTCAGGACGTGC
TTACGCACGTACTCGACCTGAATGACTACACGCAGCATGCCGCCATGCTCGATGCCTGCCGCACGTCCCTTGGTTCCGTC
GATATCGTACTCATCGCACACGGCACCCTGGCTGACCAGGCGCTGTGCGAACGCAATGTGGACGCGGCTCTACATGAATT
CTCGACCAACGCACTCTCCACGATTGCGCTACTTACGCGGCTCGCCAGCCTGCTCGAGGCGCAGCGTAGCGGCACCATCG
CGGTGATATCGTCCGTCGCAGGCGACCGCGGGCGCGCCTCGAACTATGTCTACGGGGCGGCGAAGGCTGCCGTCACGACC
TTCTGCGAGGGCCTGCGCGCACGGCTCTTCAAATCGGGCGTGCACGTGCTCACGATCAAGCCCGGCTTCGTCGATACGCC
AATGACTGCAGGCCTTGCCCTGCCCAAGCCGCTTGTCGCAACGCCAGAACAGGTCAGTAAAGACATCGTGCGCGCCATCG
CGCAGGGCAAGGACCTGGTCTATACCCCGTGGTTCTGGAGCGCGATCATGCTCGTTATCCGCGCCCTGCCGCGCTTCGTG
TTCAAGCGGGTTTCGCTGTGA

Upstream 100 bases:

>100_bases
GCGGGGAGCACTTCCGCGCGGCTTACCCCGCGTGGCAGGAACTCGAGCGGCATCGCGATCCCGCGCTGATGTCGCGTTTC
TGGAAACGGACGACTCAATC

Downstream 100 bases:

>100_bases
ACACCATCGTCGCAAGCCGCACCGCTCTCGTGACGTGGTACGCGCTCTTCGCACTCGTCTCAATGGCGGCGAATCTCGGT
AGTCAGAAGATCGCGTGGCA

Product: short chain dehydrogenase

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: NA

Number of amino acids: Translated: 246; Mature: 246

Protein sequence:

>246_residues
MKNILVIGGSSAIAAACARHWAADGDRLFLAGRHAARLETIAQDLRVRGSQDVLTHVLDLNDYTQHAAMLDACRTSLGSV
DIVLIAHGTLADQALCERNVDAALHEFSTNALSTIALLTRLASLLEAQRSGTIAVISSVAGDRGRASNYVYGAAKAAVTT
FCEGLRARLFKSGVHVLTIKPGFVDTPMTAGLALPKPLVATPEQVSKDIVRAIAQGKDLVYTPWFWSAIMLVIRALPRFV
FKRVSL

Sequences:

>Translated_246_residues
MKNILVIGGSSAIAAACARHWAADGDRLFLAGRHAARLETIAQDLRVRGSQDVLTHVLDLNDYTQHAAMLDACRTSLGSV
DIVLIAHGTLADQALCERNVDAALHEFSTNALSTIALLTRLASLLEAQRSGTIAVISSVAGDRGRASNYVYGAAKAAVTT
FCEGLRARLFKSGVHVLTIKPGFVDTPMTAGLALPKPLVATPEQVSKDIVRAIAQGKDLVYTPWFWSAIMLVIRALPRFV
FKRVSL
>Mature_246_residues
MKNILVIGGSSAIAAACARHWAADGDRLFLAGRHAARLETIAQDLRVRGSQDVLTHVLDLNDYTQHAAMLDACRTSLGSV
DIVLIAHGTLADQALCERNVDAALHEFSTNALSTIALLTRLASLLEAQRSGTIAVISSVAGDRGRASNYVYGAAKAAVTT
FCEGLRARLFKSGVHVLTIKPGFVDTPMTAGLALPKPLVATPEQVSKDIVRAIAQGKDLVYTPWFWSAIMLVIRALPRFV
FKRVSL

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI20149619, Length=254, Percent_Identity=24.0157480314961, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI4503817, Length=229, Percent_Identity=26.2008733624454, Blast_Score=68, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17563726, Length=220, Percent_Identity=24.5454545454545, Blast_Score=64, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6323882, Length=194, Percent_Identity=25.7731958762887, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI116007236, Length=219, Percent_Identity=27.3972602739726, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI23397609, Length=188, Percent_Identity=31.9148936170213, Blast_Score=68, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 26360; Mature: 26360

Theoretical pI: Translated: 9.58; Mature: 9.58

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNILVIGGSSAIAAACARHWAADGDRLFLAGRHAARLETIAQDLRVRGSQDVLTHVLDL
CCCEEEECCCHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHCCCCHHHHHHHHCC
NDYTQHAAMLDACRTSLGSVDIVLIAHGTLADQALCERNVDAALHEFSTNALSTIALLTR
CHHHHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
LASLLEAQRSGTIAVISSVAGDRGRASNYVYGAAKAAVTTFCEGLRARLFKSGVHVLTIK
HHHHHHHHHCCCEEEHHHHCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHCCCEEEEEC
PGFVDTPMTAGLALPKPLVATPEQVSKDIVRAIAQGKDLVYTPWFWSAIMLVIRALPRFV
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHHHHH
FKRVSL
HHHCCC
>Mature Secondary Structure
MKNILVIGGSSAIAAACARHWAADGDRLFLAGRHAARLETIAQDLRVRGSQDVLTHVLDL
CCCEEEECCCHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHCCCCHHHHHHHHCC
NDYTQHAAMLDACRTSLGSVDIVLIAHGTLADQALCERNVDAALHEFSTNALSTIALLTR
CHHHHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
LASLLEAQRSGTIAVISSVAGDRGRASNYVYGAAKAAVTTFCEGLRARLFKSGVHVLTIK
HHHHHHHHHCCCEEEHHHHCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHCCCEEEEEC
PGFVDTPMTAGLALPKPLVATPEQVSKDIVRAIAQGKDLVYTPWFWSAIMLVIRALPRFV
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHHHHH
FKRVSL
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]