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The map label for this gene is pepA [H]

Identifier: 186476976

GI number: 186476976

Start: 2497245

End: 2498756

Strand: Reverse

Name: pepA [H]

Synonym: Bphy_2225

Alternate gene names: 186476976

Gene position: 2498756-2497245 (Counterclockwise)

Preceding gene: 186476980

Following gene: 186476975

Centisome position: 71.82

GC content: 63.82

Gene sequence:

>1512_bases
ATGGACTTTAGCATAAAAGCCTGTGATTGGAGCAAAGGCTCGACCAACGGGTTCCTTACCGGCAAATCGGATTGCATCGT
GATCGGCGTCTTCGAGTCGCAGACGCTGTCGGGCGCGGCGCTGGAAATCGACGCTGCCACCAAGGGACTGCTCACGCGCA
TCATCAAGGCGGGCGACATGGACGGGAAGACGGGGAGCACGGTGTTCCTGCATGAAGTGCAAGGCATCGGCGCATCGCGC
GTGCTGCTCGTCGGTCTTGGCAAGCAGGATGCGTTCACACAGAAGGTCTACGGCGACGCCGTGCGCGCCGCGTGGCGCGC
CATTCTCGGGACCAAGGTCGCACAGGTCACCTTCACGCTGGTGCAAGCGCCCGTCAAGGAGCGTTCGTCGGACTGGGCCG
TGCGCGCTGCGATCCTCGCGCTGCGCGAGCTGACCTACAAGTTTACACAGATGAAGAGCAAGCCCGACACCAGCACGCGT
GCGCTCAAGCGCATCGTGTTCAGTGTCGACGCCGCGGACGAAAAACTCGCGAAGGTCGCCGTCAAGCAGGGCGTCGCGCT
CGCGAACGGAATGGATCTCACGAAAGATCTGGGCAATCTGCCGGGCAACGTCTGCACGCCCACCTATCTGGGCAACACCG
CGAAGAAGCTCGCGAAGGACTGGAAGCTGAAGGTCGAGGTGCTTGGCCAGAAGCAGATCGAAGCGCTGAAGATGGGCTCG
TTCCTGGCGGTCACGCAGGGTTCCGTCGAGCCGCCGCAGTTCATCGTCCTCCAGTATCAGGGCGGTGCCGCGAAGGCTGC
GCCCGTCGTGCTGGTCGGCAAAGGCATCACGTTCGACACGGGCGGCATTTCGCTGAAACCCGGCGACAGCATGGACGAGA
TGAAGTACGACATGTGCGGCGCGGGCTCGGTGCTCGGCACGCTGCGCGCGGTCGCCGAAATGGGCCTGAAGCTTAACGTG
GTCGGCATTATTCCGACCTGCGAAAACATGCCGGCCGGCAACGCGACCAAACCGGGCGACATCGTCACCAGCATGAAAGG
CCTGACGATCGAAGTGTTGAACACGGACGCGGAAGGGCGCCTGATCCTATGCGATGCGCTCACCTACGCGGAGCGCTTCA
AGCCGGCCGCCGTGATCGACATCGCCACGCTGACGGGCGCCTGTATCATCGCGCTCGGCCACCACAACAGTGGCCTGTTC
TCGAAGGACGACGCGCTCGCGGGCGAACTGCTCGACGCTTCGAAGGAAGCGTCCGACCCTGCATGGCGTCTGCCCCTCGA
CGACGAATATCAGGATCAGCTCAAGTCGAATTTCGCGGACATCGCGAACATCGGCGGCCGTCCGGCGGGTAGCGTGACGG
CGGCGTGCTTCCTGTCGCGCTTCACAGAAGCGTATCCGTGGGCCCACCTCGACATCGCGGGTACCGCGTGGAAGAGCGGC
GCGGCAAAGGGCGCGACGGGCCGTCCCGTGCCGCTGCTCGCGCAGTTCCTGATCGACCGCGCCGCACAATGA

Upstream 100 bases:

>100_bases
GGTTGGGGCCCCTCACGCCTTTCGTGCAGCCGCCGCGGGAAAAATAGCGGATAATTGCGGCTTTCATCCTAAGCCCAGAT
TTCATCCGAGGACAAGCGCG

Downstream 100 bases:

>100_bases
CGCGTCGCAGTTCGATCGTACGCCAGGCAGTAAACCGGGATCGCCGATGACCCGAATCGACTTTCATTCGAACGTCGGCG
ATTCGTTGCTGTATGCATGC

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase [H]

Number of amino acids: Translated: 503; Mature: 503

Protein sequence:

>503_residues
MDFSIKACDWSKGSTNGFLTGKSDCIVIGVFESQTLSGAALEIDAATKGLLTRIIKAGDMDGKTGSTVFLHEVQGIGASR
VLLVGLGKQDAFTQKVYGDAVRAAWRAILGTKVAQVTFTLVQAPVKERSSDWAVRAAILALRELTYKFTQMKSKPDTSTR
ALKRIVFSVDAADEKLAKVAVKQGVALANGMDLTKDLGNLPGNVCTPTYLGNTAKKLAKDWKLKVEVLGQKQIEALKMGS
FLAVTQGSVEPPQFIVLQYQGGAAKAAPVVLVGKGITFDTGGISLKPGDSMDEMKYDMCGAGSVLGTLRAVAEMGLKLNV
VGIIPTCENMPAGNATKPGDIVTSMKGLTIEVLNTDAEGRLILCDALTYAERFKPAAVIDIATLTGACIIALGHHNSGLF
SKDDALAGELLDASKEASDPAWRLPLDDEYQDQLKSNFADIANIGGRPAGSVTAACFLSRFTEAYPWAHLDIAGTAWKSG
AAKGATGRPVPLLAQFLIDRAAQ

Sequences:

>Translated_503_residues
MDFSIKACDWSKGSTNGFLTGKSDCIVIGVFESQTLSGAALEIDAATKGLLTRIIKAGDMDGKTGSTVFLHEVQGIGASR
VLLVGLGKQDAFTQKVYGDAVRAAWRAILGTKVAQVTFTLVQAPVKERSSDWAVRAAILALRELTYKFTQMKSKPDTSTR
ALKRIVFSVDAADEKLAKVAVKQGVALANGMDLTKDLGNLPGNVCTPTYLGNTAKKLAKDWKLKVEVLGQKQIEALKMGS
FLAVTQGSVEPPQFIVLQYQGGAAKAAPVVLVGKGITFDTGGISLKPGDSMDEMKYDMCGAGSVLGTLRAVAEMGLKLNV
VGIIPTCENMPAGNATKPGDIVTSMKGLTIEVLNTDAEGRLILCDALTYAERFKPAAVIDIATLTGACIIALGHHNSGLF
SKDDALAGELLDASKEASDPAWRLPLDDEYQDQLKSNFADIANIGGRPAGSVTAACFLSRFTEAYPWAHLDIAGTAWKSG
AAKGATGRPVPLLAQFLIDRAAQ
>Mature_503_residues
MDFSIKACDWSKGSTNGFLTGKSDCIVIGVFESQTLSGAALEIDAATKGLLTRIIKAGDMDGKTGSTVFLHEVQGIGASR
VLLVGLGKQDAFTQKVYGDAVRAAWRAILGTKVAQVTFTLVQAPVKERSSDWAVRAAILALRELTYKFTQMKSKPDTSTR
ALKRIVFSVDAADEKLAKVAVKQGVALANGMDLTKDLGNLPGNVCTPTYLGNTAKKLAKDWKLKVEVLGQKQIEALKMGS
FLAVTQGSVEPPQFIVLQYQGGAAKAAPVVLVGKGITFDTGGISLKPGDSMDEMKYDMCGAGSVLGTLRAVAEMGLKLNV
VGIIPTCENMPAGNATKPGDIVTSMKGLTIEVLNTDAEGRLILCDALTYAERFKPAAVIDIATLTGACIIALGHHNSGLF
SKDDALAGELLDASKEASDPAWRLPLDDEYQDQLKSNFADIANIGGRPAGSVTAACFLSRFTEAYPWAHLDIAGTAWKSG
AAKGATGRPVPLLAQFLIDRAAQ

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=455, Percent_Identity=39.1208791208791, Blast_Score=268, Evalue=1e-71,
Organism=Homo sapiens, GI47155554, Length=372, Percent_Identity=31.7204301075269, Blast_Score=127, Evalue=3e-29,
Organism=Escherichia coli, GI1790710, Length=505, Percent_Identity=49.9009900990099, Blast_Score=518, Evalue=1e-148,
Organism=Escherichia coli, GI87082123, Length=320, Percent_Identity=42.8125, Blast_Score=204, Evalue=1e-53,
Organism=Caenorhabditis elegans, GI17556903, Length=330, Percent_Identity=31.5151515151515, Blast_Score=136, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17565172, Length=249, Percent_Identity=29.3172690763052, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI21355725, Length=321, Percent_Identity=37.6947040498442, Blast_Score=211, Evalue=1e-54,
Organism=Drosophila melanogaster, GI24661038, Length=321, Percent_Identity=37.3831775700935, Blast_Score=210, Evalue=2e-54,
Organism=Drosophila melanogaster, GI20129969, Length=498, Percent_Identity=30.5220883534137, Blast_Score=202, Evalue=3e-52,
Organism=Drosophila melanogaster, GI24662227, Length=329, Percent_Identity=35.5623100303951, Blast_Score=196, Evalue=3e-50,
Organism=Drosophila melanogaster, GI161077148, Length=492, Percent_Identity=30.4878048780488, Blast_Score=196, Evalue=4e-50,
Organism=Drosophila melanogaster, GI20130057, Length=492, Percent_Identity=30.4878048780488, Blast_Score=196, Evalue=4e-50,
Organism=Drosophila melanogaster, GI21355645, Length=496, Percent_Identity=29.6370967741936, Blast_Score=188, Evalue=8e-48,
Organism=Drosophila melanogaster, GI24662223, Length=496, Percent_Identity=29.6370967741936, Blast_Score=188, Evalue=8e-48,
Organism=Drosophila melanogaster, GI20129963, Length=496, Percent_Identity=28.4274193548387, Blast_Score=177, Evalue=1e-44,
Organism=Drosophila melanogaster, GI19922386, Length=520, Percent_Identity=28.0769230769231, Blast_Score=169, Evalue=5e-42,
Organism=Drosophila melanogaster, GI21357381, Length=310, Percent_Identity=31.2903225806452, Blast_Score=131, Evalue=1e-30,
Organism=Drosophila melanogaster, GI221379063, Length=310, Percent_Identity=31.2903225806452, Blast_Score=131, Evalue=1e-30,
Organism=Drosophila melanogaster, GI221379062, Length=310, Percent_Identity=31.2903225806452, Blast_Score=131, Evalue=1e-30,
Organism=Drosophila melanogaster, GI24646701, Length=236, Percent_Identity=29.6610169491525, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24646703, Length=236, Percent_Identity=29.6610169491525, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI21358201, Length=236, Percent_Identity=29.6610169491525, Blast_Score=87, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283 [H]

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N [H]

EC number: =3.4.11.1; =3.4.11.10 [H]

Molecular weight: Translated: 53089; Mature: 53089

Theoretical pI: Translated: 8.19; Mature: 8.19

Prosite motif: PS00631 CYTOSOL_AP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFSIKACDWSKGSTNGFLTGKSDCIVIGVFESQTLSGAALEIDAATKGLLTRIIKAGDM
CCCEEEECCCCCCCCCCEEECCCCEEEEEEECCCCCCCCEEEECHHHHHHHHHHHHHCCC
DGKTGSTVFLHEVQGIGASRVLLVGLGKQDAFTQKVYGDAVRAAWRAILGTKVAQVTFTL
CCCCCCEEEEEECCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VQAPVKERSSDWAVRAAILALRELTYKFTQMKSKPDTSTRALKRIVFSVDAADEKLAKVA
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHH
VKQGVALANGMDLTKDLGNLPGNVCTPTYLGNTAKKLAKDWKLKVEVLGQKQIEALKMGS
HHHCCHHCCCCHHHHHHHCCCCCCCCCHHCCHHHHHHHHHHEEEEEECCHHHHHHHHCCC
FLAVTQGSVEPPQFIVLQYQGGAAKAAPVVLVGKGITFDTGGISLKPGDSMDEMKYDMCG
EEEEECCCCCCCEEEEEEECCCCCCCCCEEEEECCEEECCCCEEECCCCCHHHHHHHHCC
AGSVLGTLRAVAEMGLKLNVVGIIPTCENMPAGNATKPGDIVTSMKGLTIEVLNTDAEGR
CHHHHHHHHHHHHCCCEEEEEEEEECCCCCCCCCCCCCCHHHHHCCCCEEEEEECCCCCC
LILCDALTYAERFKPAAVIDIATLTGACIIALGHHNSGLFSKDDALAGELLDASKEASDP
EEEEEHHHHHHHCCCCEEEEHHHHCCEEEEEEECCCCCCCCCCHHHHHHHHHCCCCCCCC
AWRLPLDDEYQDQLKSNFADIANIGGRPAGSVTAACFLSRFTEAYPWAHLDIAGTAWKSG
EEECCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCC
AAKGATGRPVPLLAQFLIDRAAQ
CCCCCCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MDFSIKACDWSKGSTNGFLTGKSDCIVIGVFESQTLSGAALEIDAATKGLLTRIIKAGDM
CCCEEEECCCCCCCCCCEEECCCCEEEEEEECCCCCCCCEEEECHHHHHHHHHHHHHCCC
DGKTGSTVFLHEVQGIGASRVLLVGLGKQDAFTQKVYGDAVRAAWRAILGTKVAQVTFTL
CCCCCCEEEEEECCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VQAPVKERSSDWAVRAAILALRELTYKFTQMKSKPDTSTRALKRIVFSVDAADEKLAKVA
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHH
VKQGVALANGMDLTKDLGNLPGNVCTPTYLGNTAKKLAKDWKLKVEVLGQKQIEALKMGS
HHHCCHHCCCCHHHHHHHCCCCCCCCCHHCCHHHHHHHHHHEEEEEECCHHHHHHHHCCC
FLAVTQGSVEPPQFIVLQYQGGAAKAAPVVLVGKGITFDTGGISLKPGDSMDEMKYDMCG
EEEEECCCCCCCEEEEEEECCCCCCCCCEEEEECCEEECCCCEEECCCCCHHHHHHHHCC
AGSVLGTLRAVAEMGLKLNVVGIIPTCENMPAGNATKPGDIVTSMKGLTIEVLNTDAEGR
CHHHHHHHHHHHHCCCEEEEEEEEECCCCCCCCCCCCCCHHHHHCCCCEEEEEECCCCCC
LILCDALTYAERFKPAAVIDIATLTGACIIALGHHNSGLFSKDDALAGELLDASKEASDP
EEEEEHHHHHHHCCCCEEEEHHHHCCEEEEEEECCCCCCCCCCHHHHHHHHHCCCCCCCC
AWRLPLDDEYQDQLKSNFADIANIGGRPAGSVTAACFLSRFTEAYPWAHLDIAGTAWKSG
EEECCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCC
AAKGATGRPVPLLAQFLIDRAAQ
CCCCCCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA