BacMap

Definition	Burkholderia phymatum STM815 chromosome chromosome 1, complete sequence.
Accession	NC_010622
Length	3,479,187

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The map label for this gene is fhuC [H]

Identifier: 186476962

GI number: 186476962

Start: 2484706

End: 2485515

Strand: Reverse

Name: fhuC [H]

Synonym: Bphy_2211

Alternate gene names: 186476962

Gene position: 2485515-2484706 (Counterclockwise)

Preceding gene: 186476963

Following gene: 186476961

Centisome position: 71.44

GC content: 67.41

Gene sequence:

>810_bases
ATGAACACCCGCGGTCCCGCCGACATCACATTGCGCGCCGATCAACTCACGCTGCGCGCCGGCGCGCGCACGCTGCTCGC
CAACTTCACGCACACGTTCTATCCGGGCGAAGTCTGGTGCATCGCGGGACCGAACGGCGCGGGCAAAACCACGCTCATCT
CGACACTGGCGGGACTGTTGCGCCCAGCCAAAGGCCACATCGAACTCGACGGACGGCGCGTGAACGAATGGCCGCTCGCG
CGTCTCGCGCGACGCCGCGCATTGATGCCGCAAGCGTCGCACGATGCCTTCGGCGCGAGCGTGCTCGACATCGTGCTGCT
GAACCGCTTTCCGCATCTGACAGGCTGGGGCTGGGAGCGCGCCGAAGATCGCATCGCTGCGCAGACGGCGCTCGACACGC
TCGGTCTTGCAGACTTCGCATCGCGCGACGTGCTGTCGCTGTCGGGCGGCGAGCGGCAGCGGGTCGCGCTTGCGGCGACG
CTGTGCCAGGACGCACCGCTGCTGTTGCTCGACGAGCCGCTCGCGCATCTGGATCTGCACCATCAGATCGATTGCCTCGA
GGTATTGGATAGATGGACGCGCGGCGCCGGGCGTACAGTGATGTTCTCGTGCCACGATCTGAATCTCGCGCGGCGTTTCG
CGACGCATGCGCTGCTGCTGGAAGGCAACGGCGTCGCGCATGCGGGACCCGCGCGCGACGTGCTGACGCCCGAACTGGCC
AGTCGCGCATTCGGCTATCCGCTCGTGCTGATACGCGACGGCGACGACGAAGCGCTGATTCCCGCATTGCGCACACCGGC
GCGCCCCTGA

Upstream 100 bases:

>100_bases
CGCGCACCGTGATCGCGCCCGCGCAATTGCCCGTCGGCGTGATCACCGCGCTGATCGGCGTGCCCTTGTTCCTGTGGATG
TTGCTGCGACGGAGGCACGC

Downstream 100 bases:

>100_bases
ACACACATGAACCGAACCATTCAAGCAGATACCCACATGACCACTTCGCATTCCCTGCCTCACGTCGCGCCGCTCGAACC
GTCGCTGCGCGCCGATTTGC

Product: ABC transporter-like protein

Products: NA

Alternate protein names: Ferric hydroxamate uptake protein C; Ferrichrome transport ATP-binding protein FhuC; Iron(III)-hydroxamate import ATP-binding protein FhuC [H]

Number of amino acids: Translated: 269; Mature: 269

Protein sequence:

>269_residues
MNTRGPADITLRADQLTLRAGARTLLANFTHTFYPGEVWCIAGPNGAGKTTLISTLAGLLRPAKGHIELDGRRVNEWPLA
RLARRRALMPQASHDAFGASVLDIVLLNRFPHLTGWGWERAEDRIAAQTALDTLGLADFASRDVLSLSGGERQRVALAAT
LCQDAPLLLLDEPLAHLDLHHQIDCLEVLDRWTRGAGRTVMFSCHDLNLARRFATHALLLEGNGVAHAGPARDVLTPELA
SRAFGYPLVLIRDGDDEALIPALRTPARP

Sequences:

>Translated_269_residues
MNTRGPADITLRADQLTLRAGARTLLANFTHTFYPGEVWCIAGPNGAGKTTLISTLAGLLRPAKGHIELDGRRVNEWPLA
RLARRRALMPQASHDAFGASVLDIVLLNRFPHLTGWGWERAEDRIAAQTALDTLGLADFASRDVLSLSGGERQRVALAAT
LCQDAPLLLLDEPLAHLDLHHQIDCLEVLDRWTRGAGRTVMFSCHDLNLARRFATHALLLEGNGVAHAGPARDVLTPELA
SRAFGYPLVLIRDGDDEALIPALRTPARP
>Mature_269_residues
MNTRGPADITLRADQLTLRAGARTLLANFTHTFYPGEVWCIAGPNGAGKTTLISTLAGLLRPAKGHIELDGRRVNEWPLA
RLARRRALMPQASHDAFGASVLDIVLLNRFPHLTGWGWERAEDRIAAQTALDTLGLADFASRDVLSLSGGERQRVALAAT
LCQDAPLLLLDEPLAHLDLHHQIDCLEVLDRWTRGAGRTVMFSCHDLNLARRFATHALLLEGNGVAHAGPARDVLTPELA
SRAFGYPLVLIRDGDDEALIPALRTPARP

Specific function: Part of the ABC transporter complex FhuBGCD involved in iron(3+)-hydroxamate import. Responsible for energy coupling to the transport system [H]

COG id: COG1120

COG function: function code PH; ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain [H]

Homologues:

Organism=Homo sapiens, GI9665248, Length=213, Percent_Identity=29.1079812206573, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI31657092, Length=210, Percent_Identity=25.7142857142857, Blast_Score=78, Evalue=8e-15,
Organism=Homo sapiens, GI105990541, Length=179, Percent_Identity=29.0502793296089, Blast_Score=75, Evalue=8e-14,
Organism=Homo sapiens, GI27881501, Length=257, Percent_Identity=26.0700389105058, Blast_Score=72, Evalue=7e-13,
Organism=Homo sapiens, GI30795238, Length=257, Percent_Identity=26.0700389105058, Blast_Score=72, Evalue=7e-13,
Organism=Homo sapiens, GI156105685, Length=216, Percent_Identity=29.1666666666667, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI116734710, Length=192, Percent_Identity=27.0833333333333, Blast_Score=69, Evalue=6e-12,
Organism=Escherichia coli, GI1786803, Length=244, Percent_Identity=39.344262295082, Blast_Score=165, Evalue=3e-42,
Organism=Escherichia coli, GI1790739, Length=256, Percent_Identity=33.59375, Blast_Score=146, Evalue=1e-36,
Organism=Escherichia coli, GI1786345, Length=242, Percent_Identity=35.1239669421488, Blast_Score=144, Evalue=7e-36,
Organism=Escherichia coli, GI1788002, Length=219, Percent_Identity=35.1598173515982, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1790544, Length=214, Percent_Identity=32.2429906542056, Blast_Score=92, Evalue=2e-20,
Organism=Escherichia coli, GI87081709, Length=229, Percent_Identity=28.3842794759825, Blast_Score=92, Evalue=3e-20,
Organism=Escherichia coli, GI1789873, Length=216, Percent_Identity=31.9444444444444, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1788450, Length=249, Percent_Identity=28.1124497991968, Blast_Score=88, Evalue=8e-19,
Organism=Escherichia coli, GI1786253, Length=216, Percent_Identity=29.6296296296296, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1789032, Length=240, Percent_Identity=27.9166666666667, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1786563, Length=228, Percent_Identity=30.2631578947368, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI87081791, Length=245, Percent_Identity=28.1632653061224, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1786872, Length=190, Percent_Identity=31.5789473684211, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1790467, Length=205, Percent_Identity=30.2439024390244, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1787029, Length=221, Percent_Identity=29.4117647058824, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1789672, Length=254, Percent_Identity=26.7716535433071, Blast_Score=81, Evalue=7e-17,
Organism=Escherichia coli, GI1789891, Length=225, Percent_Identity=29.7777777777778, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1788165, Length=235, Percent_Identity=29.3617021276596, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1787712, Length=204, Percent_Identity=29.4117647058824, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI87081834, Length=222, Percent_Identity=30.6306306306306, Blast_Score=78, Evalue=5e-16,
Organism=Escherichia coli, GI87082267, Length=222, Percent_Identity=28.8288288288288, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1788225, Length=235, Percent_Identity=28.0851063829787, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI1786698, Length=191, Percent_Identity=28.7958115183246, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI1790525, Length=232, Percent_Identity=27.1551724137931, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1787112, Length=218, Percent_Identity=30.7339449541284, Blast_Score=74, Evalue=7e-15,
Organism=Escherichia coli, GI1786398, Length=237, Percent_Identity=27.0042194092827, Blast_Score=74, Evalue=8e-15,
Organism=Escherichia coli, GI1787143, Length=237, Percent_Identity=26.5822784810127, Blast_Score=74, Evalue=9e-15,
Organism=Escherichia coli, GI1789864, Length=248, Percent_Identity=25, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1787370, Length=214, Percent_Identity=29.9065420560748, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1789593, Length=237, Percent_Identity=29.1139240506329, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI87082268, Length=241, Percent_Identity=26.5560165975104, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1786703, Length=195, Percent_Identity=32.3076923076923, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1787089, Length=241, Percent_Identity=25.3112033195021, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1787105, Length=199, Percent_Identity=29.6482412060301, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1787500, Length=210, Percent_Identity=25.2380952380952, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1788506, Length=230, Percent_Identity=28.2608695652174, Blast_Score=68, Evalue=5e-13,
Organism=Escherichia coli, GI48994997, Length=216, Percent_Identity=27.7777777777778, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1786653, Length=246, Percent_Identity=28.0487804878049, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1788210, Length=198, Percent_Identity=27.7777777777778, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1786981, Length=201, Percent_Identity=34.3283582089552, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1786319, Length=145, Percent_Identity=31.0344827586207, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1787164, Length=201, Percent_Identity=33.8308457711443, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1789751, Length=215, Percent_Identity=29.7674418604651, Blast_Score=65, Evalue=6e-12,
Organism=Escherichia coli, GI87081782, Length=216, Percent_Identity=30.0925925925926, Blast_Score=64, Evalue=8e-12,
Organism=Escherichia coli, GI1788897, Length=208, Percent_Identity=29.8076923076923, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1787182, Length=224, Percent_Identity=24.5535714285714, Blast_Score=62, Evalue=3e-11,
Organism=Escherichia coli, GI1787759, Length=228, Percent_Identity=24.5614035087719, Blast_Score=62, Evalue=3e-11,
Organism=Escherichia coli, GI1788644, Length=243, Percent_Identity=27.1604938271605, Blast_Score=61, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI115533608, Length=187, Percent_Identity=27.2727272727273, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI115533592, Length=195, Percent_Identity=29.7435897435897, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17511077, Length=195, Percent_Identity=26.6666666666667, Blast_Score=68, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17539902, Length=225, Percent_Identity=30.6666666666667, Blast_Score=67, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17565938, Length=200, Percent_Identity=27.5, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71983523, Length=223, Percent_Identity=25.5605381165919, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI71983516, Length=223, Percent_Identity=25.5605381165919, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI71983510, Length=223, Percent_Identity=25.5605381165919, Blast_Score=65, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6324498, Length=231, Percent_Identity=26.4069264069264, Blast_Score=74, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24648314, Length=212, Percent_Identity=28.3018867924528, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24659289, Length=228, Percent_Identity=28.9473684210526, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24666092, Length=195, Percent_Identity=30.2564102564103, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI45552199, Length=213, Percent_Identity=30.5164319248826, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24581407, Length=213, Percent_Identity=30.5164319248826, Blast_Score=69, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24650855, Length=220, Percent_Identity=28.1818181818182, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24650853, Length=220, Percent_Identity=28.1818181818182, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI281362751, Length=213, Percent_Identity=27.6995305164319, Blast_Score=66, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR003593 [H]

Pfam domain/function: PF00005 ABC_tran [H]

EC number: =3.6.3.34 [H]

Molecular weight: Translated: 29296; Mature: 29296

Theoretical pI: Translated: 7.33; Mature: 7.33

Prosite motif: PS00211 ABC_TRANSPORTER_1 ; PS50893 ABC_TRANSPORTER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTRGPADITLRADQLTLRAGARTLLANFTHTFYPGEVWCIAGPNGAGKTTLISTLAGLL
CCCCCCCEEEEEECCEEEHHHHHHHHHHHHCEECCCEEEEEECCCCCCHHHHHHHHHHHH
RPAKGHIELDGRRVNEWPLARLARRRALMPQASHDAFGASVLDIVLLNRFPHLTGWGWER
CCCCCCEEECCEECCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHH
AEDRIAAQTALDTLGLADFASRDVLSLSGGERQRVALAATLCQDAPLLLLDEPLAHLDLH
HHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHCCCCEEEECCCHHHHCHH
HQIDCLEVLDRWTRGAGRTVMFSCHDLNLARRFATHALLLEGNGVAHAGPARDVLTPELA
CCCHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHEEEEEECCCCCCCCCCCCCCCHHHH
SRAFGYPLVLIRDGDDEALIPALRTPARP
HHHCCCCEEEEECCCCCEECHHCCCCCCC
>Mature Secondary Structure
MNTRGPADITLRADQLTLRAGARTLLANFTHTFYPGEVWCIAGPNGAGKTTLISTLAGLL
CCCCCCCEEEEEECCEEEHHHHHHHHHHHHCEECCCEEEEEECCCCCCHHHHHHHHHHHH
RPAKGHIELDGRRVNEWPLARLARRRALMPQASHDAFGASVLDIVLLNRFPHLTGWGWER
CCCCCCEEECCEECCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHH
AEDRIAAQTALDTLGLADFASRDVLSLSGGERQRVALAATLCQDAPLLLLDEPLAHLDLH
HHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHCCCCEEEECCCHHHHCHH
HQIDCLEVLDRWTRGAGRTVMFSCHDLNLARRFATHALLLEGNGVAHAGPARDVLTPELA
CCCHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHEEEEEECCCCCCCCCCCCCCCHHHH
SRAFGYPLVLIRDGDDEALIPALRTPARP
HHHCCCCEEEEECCCCCEECHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9639930; 9384377 [H]