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The map label for this gene is nuoH

Identifier: 186476757

GI number: 186476757

Start: 2252067

End: 2253131

Strand: Reverse

Name: nuoH

Synonym: Bphy_2002

Alternate gene names: 186476757

Gene position: 2253131-2252067 (Counterclockwise)

Preceding gene: 186476758

Following gene: 186476756

Centisome position: 64.76

GC content: 61.03

Gene sequence:

>1065_bases
ATGACCTTGTTCGAATCGATCAACGCGGGCGGCACCCAGATTCTCGGCGTCGCATGGCCCACCGTGTGGGCCCTCGTGCG
CATTCTCGTAGTGGCCGTCGTCATCCTGCTGTGTGTCGCGTACCTGATCCTGTGGGAGCGTAAGCTGATCGGCTGGATGC
ACGTTCGTCTTGGCCCGAATCGGGTCGGCCCCGCCGGTCTGCTGCAGCCGATCGCCGACGTGCTCAAGCTGCTGCTGAAA
GAAGTGATCCAGCCGACTCAGGCAAGCCGCTGGGTCTATCTGGTTGCCCCCGTCATGGTGGTGGTTCCCGCATTCGCGGT
CTGGGCGGTGATTCCGTTCCAGGCGGGCGCGGTGCTGGGCGACATCAATGCGGGTCTGCTGTACGCGATTTCGATCTCGT
CGGTCGGCGTGTACGGCGTGATTCTGGCGGGCTGGGCGTCGAACTCGAAGTACGCGTTCCTCGGCGCGATGCGCGCAGCG
GCACAGATGGTGTCGTACGAAGTGTCGATGGGCTTTGCGCTGGTCGTCGTGATGATGACGGCGGGCACGATGAACCTGTC
GGACATCGTCGGTTCGCAGATGCGCGGCATCTTCGCGAGTCACGGCGTAACGTTCCTGTCGTGGAACTGGCTGCCGTTGC
TGCCGGCCTTCGTCGTCTACTTCGTGTCGGGTATCGCCGAAACGAACCGTCACCCGTTCGACGTGGTGGAAGGCGAGTCG
GAAATCGTCGCGGGTCACATGATCGATTACTCGGGTATGGCGTTCGCGCTGTTCTTCCTCGCCGAGTACATCAACATGAT
CGTCATTTCGGCACTGGCATCGATCCTGTTCCTGGGCGGCTGGAGCGCACCGTTCGAATTCCTGTCGTTCATCCCGGGCA
TTGTCTGGCTGGTCCTGAAAGTCTTCCTCCTGCTGTCGGTATTCATCTGGGTGCGTGCGACGTTCCCGCGCTACCGCTAT
GACCAGATCATGCGTCTGGGCTGGAAGGTGTTTCTGCCTGTCACCGTGATCTGGGTCGTGGTGGTCGGCTTCTGGATCAT
GTCGCCGTTGAATATCTGGAACTAA

Upstream 100 bases:

>100_bases
TGCGAATCTTGCGGAGACGGTCGTCCGCGTGTCGGCGGCTACGCCTGCCGGTGCAGCGCTGGGCAGCCTGTTCGGTGAAC
TGGTGGTGGAGAAGGCGTAA

Downstream 100 bases:

>100_bases
AGGGCGGACGAACCATGACCGCAATCCAAAATTTCTTCAAGACCTTCTTTCTGACCGAGCTGCTCAAGGGCCTCGCGCTG
ACGGGACGCTACACGTTCCA

Product: NADH dehydrogenase subunit H

Products: NA

Alternate protein names: NADH dehydrogenase I subunit H; NDH-1 subunit H

Number of amino acids: Translated: 354; Mature: 353

Protein sequence:

>354_residues
MTLFESINAGGTQILGVAWPTVWALVRILVVAVVILLCVAYLILWERKLIGWMHVRLGPNRVGPAGLLQPIADVLKLLLK
EVIQPTQASRWVYLVAPVMVVVPAFAVWAVIPFQAGAVLGDINAGLLYAISISSVGVYGVILAGWASNSKYAFLGAMRAA
AQMVSYEVSMGFALVVVMMTAGTMNLSDIVGSQMRGIFASHGVTFLSWNWLPLLPAFVVYFVSGIAETNRHPFDVVEGES
EIVAGHMIDYSGMAFALFFLAEYINMIVISALASILFLGGWSAPFEFLSFIPGIVWLVLKVFLLLSVFIWVRATFPRYRY
DQIMRLGWKVFLPVTVIWVVVVGFWIMSPLNIWN

Sequences:

>Translated_354_residues
MTLFESINAGGTQILGVAWPTVWALVRILVVAVVILLCVAYLILWERKLIGWMHVRLGPNRVGPAGLLQPIADVLKLLLK
EVIQPTQASRWVYLVAPVMVVVPAFAVWAVIPFQAGAVLGDINAGLLYAISISSVGVYGVILAGWASNSKYAFLGAMRAA
AQMVSYEVSMGFALVVVMMTAGTMNLSDIVGSQMRGIFASHGVTFLSWNWLPLLPAFVVYFVSGIAETNRHPFDVVEGES
EIVAGHMIDYSGMAFALFFLAEYINMIVISALASILFLGGWSAPFEFLSFIPGIVWLVLKVFLLLSVFIWVRATFPRYRY
DQIMRLGWKVFLPVTVIWVVVVGFWIMSPLNIWN
>Mature_353_residues
TLFESINAGGTQILGVAWPTVWALVRILVVAVVILLCVAYLILWERKLIGWMHVRLGPNRVGPAGLLQPIADVLKLLLKE
VIQPTQASRWVYLVAPVMVVVPAFAVWAVIPFQAGAVLGDINAGLLYAISISSVGVYGVILAGWASNSKYAFLGAMRAAA
QMVSYEVSMGFALVVVMMTAGTMNLSDIVGSQMRGIFASHGVTFLSWNWLPLLPAFVVYFVSGIAETNRHPFDVVEGESE
IVAGHMIDYSGMAFALFFLAEYINMIVISALASILFLGGWSAPFEFLSFIPGIVWLVLKVFLLLSVFIWVRATFPRYRYD
QIMRLGWKVFLPVTVIWVVVVGFWIMSPLNIWN

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1005

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 1 (chain H)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 1 family

Homologues:

Organism=Homo sapiens, GI251831107, Length=299, Percent_Identity=41.1371237458194, Blast_Score=246, Evalue=3e-65,
Organism=Escherichia coli, GI1788618, Length=319, Percent_Identity=40.1253918495298, Blast_Score=258, Evalue=4e-70,
Organism=Escherichia coli, GI1789077, Length=289, Percent_Identity=26.643598615917, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NUOH_BURP8 (B2JDM1)

Other databases:

- EMBL:   CP001043
- RefSeq:   YP_001858227.1
- GeneID:   6243491
- GenomeReviews:   CP001043_GR
- KEGG:   bph:Bphy_2002
- HOGENOM:   HBG727670
- OMA:   FMVEYGS
- ProtClustDB:   PRK06076
- HAMAP:   MF_01350
- InterPro:   IPR023020
- InterPro:   IPR001694
- InterPro:   IPR018086
- PANTHER:   PTHR11432

Pfam domain/function: PF00146 NADHdh

EC number: =1.6.99.5

Molecular weight: Translated: 39069; Mature: 38938

Theoretical pI: Translated: 8.86; Mature: 8.86

Prosite motif: PS00667 COMPLEX1_ND1_1; PS00668 COMPLEX1_ND1_2

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1f3537f4)-; HASH(0x1eea8e50)-; HASH(0x1f01dec0)-; HASH(0x1f423b80)-; HASH(0x1f41e93c)-; HASH(0x1ee34928)-; HASH(0x1e7a16f8)-; HASH(0x1f41c200)-;

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLFESINAGGTQILGVAWPTVWALVRILVVAVVILLCVAYLILWERKLIGWMHVRLGPN
CCCHHCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCC
RVGPAGLLQPIADVLKLLLKEVIQPTQASRWVYLVAPVMVVVPAFAVWAVIPFQAGAVLG
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEE
DINAGLLYAISISSVGVYGVILAGWASNSKYAFLGAMRAAAQMVSYEVSMGFALVVVMMT
CCCCCEEEEEEHHCCCHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AGTMNLSDIVGSQMRGIFASHGVTFLSWNWLPLLPAFVVYFVSGIAETNRHPFDVVEGES
CCCCCHHHHHHHHHHHHHHHCCEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCEECCCC
EIVAGHMIDYSGMAFALFFLAEYINMIVISALASILFLGGWSAPFEFLSFIPGIVWLVLK
CEEEHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
VFLLLSVFIWVRATFPRYRYDQIMRLGWKVFLPVTVIWVVVVGFWIMSPLNIWN
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCH
>Mature Secondary Structure 
TLFESINAGGTQILGVAWPTVWALVRILVVAVVILLCVAYLILWERKLIGWMHVRLGPN
CCHHCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCC
RVGPAGLLQPIADVLKLLLKEVIQPTQASRWVYLVAPVMVVVPAFAVWAVIPFQAGAVLG
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEE
DINAGLLYAISISSVGVYGVILAGWASNSKYAFLGAMRAAAQMVSYEVSMGFALVVVMMT
CCCCCEEEEEEHHCCCHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AGTMNLSDIVGSQMRGIFASHGVTFLSWNWLPLLPAFVVYFVSGIAETNRHPFDVVEGES
CCCCCHHHHHHHHHHHHHHHCCEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCEECCCC
EIVAGHMIDYSGMAFALFFLAEYINMIVISALASILFLGGWSAPFEFLSFIPGIVWLVLK
CEEEHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
VFLLLSVFIWVRATFPRYRYDQIMRLGWKVFLPVTVIWVVVVGFWIMSPLNIWN
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA