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The map label for this gene is pdxY

Identifier: 186476557

GI number: 186476557

Start: 2056898

End: 2057761

Strand: Direct

Name: pdxY

Synonym: Bphy_1799

Alternate gene names: 186476557

Gene position: 2056898-2057761 (Clockwise)

Preceding gene: 186476556

Following gene: 186476558

Centisome position: 59.12

GC content: 66.2

Gene sequence:

>864_bases
ATGAAAAACGTTCTGAGCATCCAGTCGCACGTCGTGTTCGGGCACGCAGGCAACGGCGCCTCGGAGTTTCCGATGCGGCG
CCTCGGCGTCAACGTGTGGCCGCTCAACACGGTGCAGTTCTCGAATCATACGCAGTACGGCCATTGGGAAGGCAGCGCGA
TCGACGCGTCGCAGATGCTGGCGCTCGTCGAGGGCATCGGCGCGATCGGCATGCTGCCGCGTTGCGATGCCGTGCTGTCG
GGTTATCTCGGCACGCCCGAGCAGGCGCAGGCCGTGATCGAAATCGTGCGCGCCGTGAAGGCCGCGAATCCGCACGCGCT
CTATTTCTGCGACCCGGTGATGGGCACGGCGACGGGCTACCGCGTCGAGCCGGGCATCCAGGAGTTTCTCGTCAGGACGA
TGCCCGAAGTGTCCGACGTGATGTGCCCGAATCACAGCGAACTGCAACGGCTGGTCGGGCGCGAGATCGAGACGGTCGAA
GAAGCCGTCGCCGCGTGCCGCGAGCTGATGAAGCGCGGCCCGAAGATGGTGCTCGTCAAGCACCTGCTCGATCGCAACAG
TCTCGCGGACCGCTTCAACATGCTGGTGGTGACGGGACGCGAAGCGTGGATGGGCCAGCGTCCGCTGTACCCGTTCGCGC
GTCAGCCGGTGGGTGTCGGCGACATGACGAGCGCCGTGTTCGTCGCGCGCACGCTGCTAGGCGACTCCGTACGCAGCGCG
TTCGAGCACACGCTCGCCGCGGTGAACGCCGTGGTGCGCGCGACGTGGGACGCGGGGCGTTATGAACTCGAGATCGTCGC
TGCACAGGACGACATTGCGCGGCCGCGCGACTGGTTCGATGCGTGGGTGGTGGATCCCGCGTAA

Upstream 100 bases:

>100_bases
CGGCAGACACAACGATCGCAATGATCGGCAACGCGCATCTGATCGCCCATCCGTTCAGCCTTTTTTGTTCTGGCGCCCTA
CTCGCGCCGTATCGGTCGAC

Downstream 100 bases:

>100_bases
CGCGCAAGGCTTGATACCGCTCTCGTATTGATCTCCGACTACTTCCGTCCACAGTAGGCTCGTTAGACGCGCGTCTCGCC
CTGTACGACAGAGATGTGGT

Product: pyridoxal kinase

Products: NA

Alternate protein names: PM kinase

Number of amino acids: Translated: 287; Mature: 287

Protein sequence:

>287_residues
MKNVLSIQSHVVFGHAGNGASEFPMRRLGVNVWPLNTVQFSNHTQYGHWEGSAIDASQMLALVEGIGAIGMLPRCDAVLS
GYLGTPEQAQAVIEIVRAVKAANPHALYFCDPVMGTATGYRVEPGIQEFLVRTMPEVSDVMCPNHSELQRLVGREIETVE
EAVAACRELMKRGPKMVLVKHLLDRNSLADRFNMLVVTGREAWMGQRPLYPFARQPVGVGDMTSAVFVARTLLGDSVRSA
FEHTLAAVNAVVRATWDAGRYELEIVAAQDDIARPRDWFDAWVVDPA

Sequences:

>Translated_287_residues
MKNVLSIQSHVVFGHAGNGASEFPMRRLGVNVWPLNTVQFSNHTQYGHWEGSAIDASQMLALVEGIGAIGMLPRCDAVLS
GYLGTPEQAQAVIEIVRAVKAANPHALYFCDPVMGTATGYRVEPGIQEFLVRTMPEVSDVMCPNHSELQRLVGREIETVE
EAVAACRELMKRGPKMVLVKHLLDRNSLADRFNMLVVTGREAWMGQRPLYPFARQPVGVGDMTSAVFVARTLLGDSVRSA
FEHTLAAVNAVVRATWDAGRYELEIVAAQDDIARPRDWFDAWVVDPA
>Mature_287_residues
MKNVLSIQSHVVFGHAGNGASEFPMRRLGVNVWPLNTVQFSNHTQYGHWEGSAIDASQMLALVEGIGAIGMLPRCDAVLS
GYLGTPEQAQAVIEIVRAVKAANPHALYFCDPVMGTATGYRVEPGIQEFLVRTMPEVSDVMCPNHSELQRLVGREIETVE
EAVAACRELMKRGPKMVLVKHLLDRNSLADRFNMLVVTGREAWMGQRPLYPFARQPVGVGDMTSAVFVARTLLGDSVRSA
FEHTLAAVNAVVRATWDAGRYELEIVAAQDDIARPRDWFDAWVVDPA

Specific function: Phosphorylates B6 vitamers; functions in a salvage pathway. Uses pyridoxamine

COG id: COG2240

COG function: function code H; Pyridoxal/pyridoxine/pyridoxamine kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyridoxine kinase family

Homologues:

Organism=Homo sapiens, GI4505701, Length=310, Percent_Identity=30, Blast_Score=124, Evalue=7e-29,
Organism=Escherichia coli, GI1787924, Length=283, Percent_Identity=55.8303886925795, Blast_Score=311, Evalue=4e-86,
Organism=Escherichia coli, GI1788758, Length=178, Percent_Identity=28.6516853932584, Blast_Score=83, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17507759, Length=287, Percent_Identity=31.0104529616725, Blast_Score=122, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17507757, Length=297, Percent_Identity=30.3030303030303, Blast_Score=118, Evalue=3e-27,
Organism=Saccharomyces cerevisiae, GI6324354, Length=270, Percent_Identity=31.1111111111111, Blast_Score=109, Evalue=6e-25,
Organism=Saccharomyces cerevisiae, GI6320806, Length=272, Percent_Identity=30.8823529411765, Blast_Score=100, Evalue=4e-22,
Organism=Drosophila melanogaster, GI45553007, Length=298, Percent_Identity=28.5234899328859, Blast_Score=132, Evalue=2e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PDXY_BURP8 (B2JCI0)

Other databases:

- EMBL:   CP001043
- RefSeq:   YP_001858027.1
- ProteinModelPortal:   B2JCI0
- SMR:   B2JCI0
- GeneID:   6243290
- GenomeReviews:   CP001043_GR
- KEGG:   bph:Bphy_1799
- HOGENOM:   HBG661459
- OMA:   CPNQLEL
- ProtClustDB:   CLSK930954
- HAMAP:   MF_01639
- InterPro:   IPR013749
- InterPro:   IPR004625
- TIGRFAMs:   TIGR00687

Pfam domain/function: PF08543 Phos_pyr_kin

EC number: =2.7.1.35

Molecular weight: Translated: 31585; Mature: 31585

Theoretical pI: Translated: 6.09; Mature: 6.09

Prosite motif: NA

Important sites: BINDING 9-9 BINDING 44-44 BINDING 221-221

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNVLSIQSHVVFGHAGNGASEFPMRRLGVNVWPLNTVQFSNHTQYGHWEGSAIDASQML
CCCCCEEHHEEEEEECCCCCCCCCHHHHCCEEECCCEEEECCCCCCCCCCCCCCCHHHHH
ALVEGIGAIGMLPRCDAVLSGYLGTPEQAQAVIEIVRAVKAANPHALYFCDPVMGTATGY
HHHHHHHHHCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCC
RVEPGIQEFLVRTMPEVSDVMCPNHSELQRLVGREIETVEEAVAACRELMKRGPKMVLVK
EECCCHHHHHHHHCCHHHHHCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHHH
HLLDRNSLADRFNMLVVTGREAWMGQRPLYPFARQPVGVGDMTSAVFVARTLLGDSVRSA
HHHCCHHHHHHHCEEEEECCHHHCCCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHH
FEHTLAAVNAVVRATWDAGRYELEIVAAQDDIARPRDWFDAWVVDPA
HHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCHHHHHEEECCCC
>Mature Secondary Structure
MKNVLSIQSHVVFGHAGNGASEFPMRRLGVNVWPLNTVQFSNHTQYGHWEGSAIDASQML
CCCCCEEHHEEEEEECCCCCCCCCHHHHCCEEECCCEEEECCCCCCCCCCCCCCCHHHHH
ALVEGIGAIGMLPRCDAVLSGYLGTPEQAQAVIEIVRAVKAANPHALYFCDPVMGTATGY
HHHHHHHHHCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCC
RVEPGIQEFLVRTMPEVSDVMCPNHSELQRLVGREIETVEEAVAACRELMKRGPKMVLVK
EECCCHHHHHHHHCCHHHHHCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHHH
HLLDRNSLADRFNMLVVTGREAWMGQRPLYPFARQPVGVGDMTSAVFVARTLLGDSVRSA
HHHCCHHHHHHHCEEEEECCHHHCCCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHH
FEHTLAAVNAVVRATWDAGRYELEIVAAQDDIARPRDWFDAWVVDPA
HHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCHHHHHEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA