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The map label for this gene is ltaE [H]

Identifier: 186476368

GI number: 186476368

Start: 1828233

End: 1829264

Strand: Reverse

Name: ltaE [H]

Synonym: Bphy_1610

Alternate gene names: 186476368

Gene position: 1829264-1828233 (Counterclockwise)

Preceding gene: 186476369

Following gene: 186476367

Centisome position: 52.58

GC content: 65.02

Gene sequence:

>1032_bases
ATGCAACATTTCGCGTCGGACAACTACGCCGGCATCTGCCCCGAGGCGCTCGAAGCGCTGATCGCCGCCAACCACAGCGG
TCACGAACCGGCCTATGGCGACGACTCATGGACACAGCAGGTCTGCGACCGCCTGCGCAATCTGTTCCAGACCGACTGCG
AAGTATTCTTCGTCTTCAACGGCACCGCGGCCAACTCGCTCGCGCTCGCGTCGCTGTGCCAGTCGTATCACTCGGTGATC
TGCCACGAACTCGCGCATATCGAAACGGACGAATGCGGCGGCCCGGAGTTTTTCTCGAATGGCTCGAAGCTGCTGACGGC
GCCGGGCATCGGCGGCAAGCTCACGCCGGACGCGATCGAAGCCGTCGTCACGCGCCGCGCGGACATTCACTACCCGAAGC
CCAAAGTCGTTACGCTCACGCAATCGACGGAAGTGGGCACCGTCTACAGCGTCGAGGACATTCGCGCGATTGCGGCTATC
GCCAAGCGCCGTCATCTGACAGTGCACATGGACGGCGCGCGCTTTGCGAACGCGGTCGCCGCGCTCGACGTGCATCCATC
CGAGATCACCTGGCGTGCAGGCGTCGACGTGCTGTGCTTCGGCGGCACGAAGAACGGCTTGCCCGTCGGCGAAGCGGTGG
TGTTCTTCGACCGCACGCTCGCCGACGACTTTGCGTATCGCCTGAAGCAGGCGGGCCAGCTCGCGTCGAAGATGCGCTTC
ATTTCCGCGCCGTGGCTCGGCTTGCTCGACAACGACGTGTGGCTGCGCAACGCGCGTCACGCCAACGCGATGGCGAAGCT
GCTGGAGTCGCGGCTCGCGCAGATTCCGGGCGTGAGCATCATGTTCCCGACGGAGTCGAATGCCGTGTTCGCGCAACTGC
CGCCCCACGTCGCGAAGGCGATGCGCACGCAAGGCTGGAAATTCTACGAGTTCATCGGCGCGGGCGGCTGCCGGCTGATG
TGCGCGTGGGACACGCAGCCCGAAACGGTCGAGCGCTTCGTCGCCGACGTGCGCGCACTGTGCGCAGCTTGA

Upstream 100 bases:

>100_bases
CGCCGCGCCCAGCTTCGAGAAACACATTCACCACCCTCCGCACTAAAATGTCCGCTTTCCAGTCATTCCCGCGGGCCCAT
CGCCGGGCGCGCCGCCTGCC

Downstream 100 bases:

>100_bases
GGCAGACGCACCTGTGCGCTTCGCCGTCCAGGTGATCCGCGACCGGTAGCCAAAGAAAGGAGACGCATCGGCATGGCCTA
CATCTACTATCTGACGCACA

Product: threonine aldolase

Products: NA

Alternate protein names: Low specificity L-TA [H]

Number of amino acids: Translated: 343; Mature: 343

Protein sequence:

>343_residues
MQHFASDNYAGICPEALEALIAANHSGHEPAYGDDSWTQQVCDRLRNLFQTDCEVFFVFNGTAANSLALASLCQSYHSVI
CHELAHIETDECGGPEFFSNGSKLLTAPGIGGKLTPDAIEAVVTRRADIHYPKPKVVTLTQSTEVGTVYSVEDIRAIAAI
AKRRHLTVHMDGARFANAVAALDVHPSEITWRAGVDVLCFGGTKNGLPVGEAVVFFDRTLADDFAYRLKQAGQLASKMRF
ISAPWLGLLDNDVWLRNARHANAMAKLLESRLAQIPGVSIMFPTESNAVFAQLPPHVAKAMRTQGWKFYEFIGAGGCRLM
CAWDTQPETVERFVADVRALCAA

Sequences:

>Translated_343_residues
MQHFASDNYAGICPEALEALIAANHSGHEPAYGDDSWTQQVCDRLRNLFQTDCEVFFVFNGTAANSLALASLCQSYHSVI
CHELAHIETDECGGPEFFSNGSKLLTAPGIGGKLTPDAIEAVVTRRADIHYPKPKVVTLTQSTEVGTVYSVEDIRAIAAI
AKRRHLTVHMDGARFANAVAALDVHPSEITWRAGVDVLCFGGTKNGLPVGEAVVFFDRTLADDFAYRLKQAGQLASKMRF
ISAPWLGLLDNDVWLRNARHANAMAKLLESRLAQIPGVSIMFPTESNAVFAQLPPHVAKAMRTQGWKFYEFIGAGGCRLM
CAWDTQPETVERFVADVRALCAA
>Mature_343_residues
MQHFASDNYAGICPEALEALIAANHSGHEPAYGDDSWTQQVCDRLRNLFQTDCEVFFVFNGTAANSLALASLCQSYHSVI
CHELAHIETDECGGPEFFSNGSKLLTAPGIGGKLTPDAIEAVVTRRADIHYPKPKVVTLTQSTEVGTVYSVEDIRAIAAI
AKRRHLTVHMDGARFANAVAALDVHPSEITWRAGVDVLCFGGTKNGLPVGEAVVFFDRTLADDFAYRLKQAGQLASKMRF
ISAPWLGLLDNDVWLRNARHANAMAKLLESRLAQIPGVSIMFPTESNAVFAQLPPHVAKAMRTQGWKFYEFIGAGGCRLM
CAWDTQPETVERFVADVRALCAA

Specific function: Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde. Can also act on L-erythro- phenylserine, L-threo-phenylserine, L-beta-3,4- methylenedioxyphenylserine and L-beta-3,4-dihydroxyphenylserine [H]

COG id: COG2008

COG function: function code E; Threonine aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine aldolase family [H]

Homologues:

Organism=Escherichia coli, GI1787095, Length=345, Percent_Identity=26.3768115942029, Blast_Score=69, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI193206520, Length=196, Percent_Identity=32.1428571428571, Blast_Score=81, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI193206522, Length=196, Percent_Identity=32.1428571428571, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI193206524, Length=196, Percent_Identity=32.1428571428571, Blast_Score=80, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6320789, Length=334, Percent_Identity=23.9520958083832, Blast_Score=71, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001597
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01212 Beta_elim_lyase [H]

EC number: =4.1.2.5 [H]

Molecular weight: Translated: 37442; Mature: 37442

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQHFASDNYAGICPEALEALIAANHSGHEPAYGDDSWTQQVCDRLRNLFQTDCEVFFVFN
CCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEC
GTAANSLALASLCQSYHSVICHELAHIETDECGGPEFFSNGSKLLTAPGIGGKLTPDAIE
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCEEEECCCCCCCCCHHHHH
AVVTRRADIHYPKPKVVTLTQSTEVGTVYSVEDIRAIAAIAKRRHLTVHMDGARFANAVA
HHHHHHCCCCCCCCCEEEEECCCCCCEEEEHHHHHHHHHHHHHCCEEEEECCHHHHHHHH
ALDVHPSEITWRAGVDVLCFGGTKNGLPVGEAVVFFDRTLADDFAYRLKQAGQLASKMRF
EEECCCCCEEEECCCEEEEECCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHH
ISAPWLGLLDNDVWLRNARHANAMAKLLESRLAQIPGVSIMFPTESNAVFAQLPPHVAKA
HCCCCHHHCCCCHHHHCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCEEEEECCHHHHHH
MRTQGWKFYEFIGAGGCRLMCAWDTQPETVERFVADVRALCAA
HHHCCCEEEEECCCCCEEEEEEECCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MQHFASDNYAGICPEALEALIAANHSGHEPAYGDDSWTQQVCDRLRNLFQTDCEVFFVFN
CCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEC
GTAANSLALASLCQSYHSVICHELAHIETDECGGPEFFSNGSKLLTAPGIGGKLTPDAIE
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCEEEECCCCCCCCCHHHHH
AVVTRRADIHYPKPKVVTLTQSTEVGTVYSVEDIRAIAAIAKRRHLTVHMDGARFANAVA
HHHHHHCCCCCCCCCEEEEECCCCCCEEEEHHHHHHHHHHHHHCCEEEEECCHHHHHHHH
ALDVHPSEITWRAGVDVLCFGGTKNGLPVGEAVVFFDRTLADDFAYRLKQAGQLASKMRF
EEECCCCCEEEECCCEEEEECCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHH
ISAPWLGLLDNDVWLRNARHANAMAKLLESRLAQIPGVSIMFPTESNAVFAQLPPHVAKA
HCCCCHHHCCCCHHHHCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCEEEEECCHHHHHH
MRTQGWKFYEFIGAGGCRLMCAWDTQPETVERFVADVRALCAA
HHHCCCEEEEECCCCCEEEEEEECCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9464392 [H]