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The map label for this gene is dhaT [H]

Identifier: 186476367

GI number: 186476367

Start: 1827012

End: 1828160

Strand: Reverse

Name: dhaT [H]

Synonym: Bphy_1609

Alternate gene names: 186476367

Gene position: 1828160-1827012 (Counterclockwise)

Preceding gene: 186476368

Following gene: 186476366

Centisome position: 52.55

GC content: 66.84

Gene sequence:

>1149_bases
ATGGCCTACATCTACTATCTGACGCACATTCATCTCGGTTACGATGCGCTCGCGCAATTGCCCGCCGAATGCGAGCGGGC
GGGCATCAAGCGGCCGCTCGTCGTAACGGATAAGGGCGTGATGGCGGCGGGCGTCGCGCGACAGGCGATCGACGCGTTGC
CCATGCGCGACGTGCCCATCTTCGACGACACGCCGTCGAACCCGACGGAAGCGATGGTGATGGCGGCCGTGCAGCGCTAC
CGCGACGAGCGCTGCGACGGGCTGGTCGCGATTGGCGGCGGCTCGTCGATCGATCTGGCCAAAGGCGTTGCGATCATGGC
GACGCATCCGGGCGCGATGACGGACTACGCGACGATCGAAGGCGGCAGCGCGAAGATCACCGACAAGGCCGCGCCGCTGA
TCGCGATTCCGACGACGGCGGGCACGGGCAGCGAAGTGGCGCGCGGCGCGATCGTGATCCTGAACGATGGCCGCAAGCTG
GGCTTCCACTCGTGGCATCTACTGCCGAAGGCGGCGATCTGCGACCCCGGGCTCACGCTCGGCCTGCCGCCGATGCTCAC
GGCCGCCACCGGCATGGACGCGATCGCGCATTGCATCGAAACGTTTCTCGCGCCGTCGTTCAATCCGCCAGCCGACGGCA
TCGCGCTCGACGGCCTGGAGCGTGCATGGGCCAACATCGAACTCGCGACGCACGACGGCGGGCACCGCGACGCGCGCCTG
AACATGATGAGCGCGTCGATGCAGGGCGCGATGGCCTTCCAGAAAGGGCTCGGCTGCGTGCATTCGCTGTCGCATCCGCT
CGGCGGCGTGCCCGTCAATGGTCGCACGTCGCTGCATCACGGCACGCTGAACGCCGTCGTGCTGCCCGCCGTGCTGCGCT
TCAACGAAAGCGCGGAGACGGTTGTCGCGAATCGCCGTTATGCGCGCATGCGCCGCGTGATGAATCTGCCCGAGCATGCC
GATCTCGCGCTGGCGCTGCACGACATGACGGCGCGGCTTGGGTTGCCGACGGGTCTGCGGAAAATGGGCGTCGACGAAAG
CGCGTTCGACAAGGTGATCAAGGGCGCGCTCGCCGATCATTGCCACAAGACGAATCCGCGCGAAGCGACGGCCGACGATT
ACCGGCGCATGCTACAGGAGTCCATGTAG

Upstream 100 bases:

>100_bases
CGACGTGCGCGCACTGTGCGCAGCTTGAGGCAGACGCACCTGTGCGCTTCGCCGTCCAGGTGATCCGCGACCGGTAGCCA
AAGAAAGGAGACGCATCGGC

Downstream 100 bases:

>100_bases
GCGCCGCACCTTCTTCAACCGAACGAGACATGAACAAACCTGCTCCCGCGCCGCGCACGGCTTACCCGCACTTTCTTTGC
ATCGGTACGCGCTGGATGGA

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: 1,3-propanediol oxidoreductase; 3-hydroxypropionaldehyde reductase [H]

Number of amino acids: Translated: 382; Mature: 381

Protein sequence:

>382_residues
MAYIYYLTHIHLGYDALAQLPAECERAGIKRPLVVTDKGVMAAGVARQAIDALPMRDVPIFDDTPSNPTEAMVMAAVQRY
RDERCDGLVAIGGGSSIDLAKGVAIMATHPGAMTDYATIEGGSAKITDKAAPLIAIPTTAGTGSEVARGAIVILNDGRKL
GFHSWHLLPKAAICDPGLTLGLPPMLTAATGMDAIAHCIETFLAPSFNPPADGIALDGLERAWANIELATHDGGHRDARL
NMMSASMQGAMAFQKGLGCVHSLSHPLGGVPVNGRTSLHHGTLNAVVLPAVLRFNESAETVVANRRYARMRRVMNLPEHA
DLALALHDMTARLGLPTGLRKMGVDESAFDKVIKGALADHCHKTNPREATADDYRRMLQESM

Sequences:

>Translated_382_residues
MAYIYYLTHIHLGYDALAQLPAECERAGIKRPLVVTDKGVMAAGVARQAIDALPMRDVPIFDDTPSNPTEAMVMAAVQRY
RDERCDGLVAIGGGSSIDLAKGVAIMATHPGAMTDYATIEGGSAKITDKAAPLIAIPTTAGTGSEVARGAIVILNDGRKL
GFHSWHLLPKAAICDPGLTLGLPPMLTAATGMDAIAHCIETFLAPSFNPPADGIALDGLERAWANIELATHDGGHRDARL
NMMSASMQGAMAFQKGLGCVHSLSHPLGGVPVNGRTSLHHGTLNAVVLPAVLRFNESAETVVANRRYARMRRVMNLPEHA
DLALALHDMTARLGLPTGLRKMGVDESAFDKVIKGALADHCHKTNPREATADDYRRMLQESM
>Mature_381_residues
AYIYYLTHIHLGYDALAQLPAECERAGIKRPLVVTDKGVMAAGVARQAIDALPMRDVPIFDDTPSNPTEAMVMAAVQRYR
DERCDGLVAIGGGSSIDLAKGVAIMATHPGAMTDYATIEGGSAKITDKAAPLIAIPTTAGTGSEVARGAIVILNDGRKLG
FHSWHLLPKAAICDPGLTLGLPPMLTAATGMDAIAHCIETFLAPSFNPPADGIALDGLERAWANIELATHDGGHRDARLN
MMSASMQGAMAFQKGLGCVHSLSHPLGGVPVNGRTSLHHGTLNAVVLPAVLRFNESAETVVANRRYARMRRVMNLPEHAD
LALALHDMTARLGLPTGLRKMGVDESAFDKVIKGALADHCHKTNPREATADDYRRMLQESM

Specific function: Most active with substrates containing two primary alcohol groups separated by one or two carbon atoms. In the physiological direction, 3-hydroxypropionaldehyde is the preferred substrate [H]

COG id: COG1454

COG function: function code C; Alcohol dehydrogenase, class IV

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI133922590, Length=421, Percent_Identity=25.41567695962, Blast_Score=92, Evalue=1e-18,
Organism=Escherichia coli, GI48994951, Length=398, Percent_Identity=33.6683417085427, Blast_Score=185, Evalue=4e-48,
Organism=Escherichia coli, GI1789163, Length=375, Percent_Identity=31.7333333333333, Blast_Score=158, Evalue=7e-40,
Organism=Escherichia coli, GI87082107, Length=359, Percent_Identity=31.4763231197772, Blast_Score=154, Evalue=1e-38,
Organism=Escherichia coli, GI1787493, Length=389, Percent_Identity=29.305912596401, Blast_Score=135, Evalue=3e-33,
Organism=Escherichia coli, GI1789386, Length=388, Percent_Identity=29.8969072164948, Blast_Score=113, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI17537053, Length=388, Percent_Identity=26.2886597938144, Blast_Score=106, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6321181, Length=376, Percent_Identity=33.7765957446808, Blast_Score=194, Evalue=2e-50,
Organism=Drosophila melanogaster, GI24657991, Length=425, Percent_Identity=29.4117647058824, Blast_Score=117, Evalue=2e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001670
- InterPro:   IPR018211 [H]

Pfam domain/function: PF00465 Fe-ADH [H]

EC number: =1.1.1.202 [H]

Molecular weight: Translated: 40646; Mature: 40515

Theoretical pI: Translated: 6.96; Mature: 6.96

Prosite motif: PS00913 ADH_IRON_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
6.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAYIYYLTHIHLGYDALAQLPAECERAGIKRPLVVTDKGVMAAGVARQAIDALPMRDVPI
CEEEEEEEEECCCHHHHHHCHHHHHHCCCCCCEEEECCCHHHHHHHHHHHHHCCCCCCCC
FDDTPSNPTEAMVMAAVQRYRDERCDGLVAIGGGSSIDLAKGVAIMATHPGAMTDYATIE
CCCCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHCCEEEEEECCCCCCCEEEEC
GGSAKITDKAAPLIAIPTTAGTGSEVARGAIVILNDGRKLGFHSWHLLPKAAICDPGLTL
CCCEEEECCCCCEEEEECCCCCCHHHHCCEEEEEECCCEECCCHHCCCCCHHHCCCCCCC
GLPPMLTAATGMDAIAHCIETFLAPSFNPPADGIALDGLERAWANIELATHDGGHRDARL
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEHHHHHHHHHEEEEEECCCCCCCCEE
NMMSASMQGAMAFQKGLGCVHSLSHPLGGVPVNGRTSLHHGTLNAVVLPAVLRFNESAET
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHH
VVANRRYARMRRVMNLPEHADLALALHDMTARLGLPTGLRKMGVDESAFDKVIKGALADH
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCHHHHCCCHHHHHHHHHHHHHHH
CHKTNPREATADDYRRMLQESM
HCCCCCCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
AYIYYLTHIHLGYDALAQLPAECERAGIKRPLVVTDKGVMAAGVARQAIDALPMRDVPI
EEEEEEEEECCCHHHHHHCHHHHHHCCCCCCEEEECCCHHHHHHHHHHHHHCCCCCCCC
FDDTPSNPTEAMVMAAVQRYRDERCDGLVAIGGGSSIDLAKGVAIMATHPGAMTDYATIE
CCCCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHCCEEEEEECCCCCCCEEEEC
GGSAKITDKAAPLIAIPTTAGTGSEVARGAIVILNDGRKLGFHSWHLLPKAAICDPGLTL
CCCEEEECCCCCEEEEECCCCCCHHHHCCEEEEEECCCEECCCHHCCCCCHHHCCCCCCC
GLPPMLTAATGMDAIAHCIETFLAPSFNPPADGIALDGLERAWANIELATHDGGHRDARL
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEHHHHHHHHHEEEEEECCCCCCCCEE
NMMSASMQGAMAFQKGLGCVHSLSHPLGGVPVNGRTSLHHGTLNAVVLPAVLRFNESAET
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHH
VVANRRYARMRRVMNLPEHADLALALHDMTARLGLPTGLRKMGVDESAFDKVIKGALADH
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCHHHHCCCHHHHHHHHHHHHHHH
CHKTNPREATADDYRRMLQESM
HCCCCCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7721705 [H]