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The map label for this gene is uvrD [H]

Identifier: 186476348

GI number: 186476348

Start: 1802445

End: 1804817

Strand: Reverse

Name: uvrD [H]

Synonym: Bphy_1590

Alternate gene names: 186476348

Gene position: 1804817-1802445 (Counterclockwise)

Preceding gene: 186476351

Following gene: 186476347

Centisome position: 51.87

GC content: 64.01

Gene sequence:

>2373_bases
ATGCCCGAACTGCTCGCGAATCTGAACCCCGAACAACACGCCGCCGTCACGCTGCCGAACGAACCGGCGCTCATTCTGGC
GGGCGCAGGCAGCGGCAAGACGCGCGTGCTGATCACACGGATCGCGTGGCTGATCCAGCAAGGTTTCGCTTCTCCGCCCA
CCATTCTCGGCGTCACGTTCACCAACAAGGCCGCGCGCGAAATGATGTCGCGCCTGTCGGCGCTCTTGCCCATCGACACG
CGCGGGATGTGGATCGGCACGTTCCACGGCCTGTGCAACCGGATGCTGCGCGCACATTACCGTGACGCGGGTCTGCCGCA
GACCTTCCAGATTCTCGACACGTCGGATCAACTCTCGGCGATCAAGCGCCTGATGAAGGGCCTGAACATCGACGACGAGA
AATATCCGCCGAAGAACCTGCAGTACTTCATCAACAACGCGAAGGAGCAGGGGCTGCGTCCGAAGGACGTCGACGCGTCG
GACAACTTCAACCGCAAGTTCATCGAACTGTACGAGGCGTACGACCAGCAATGCCAGCGCGAAGGGGTGGTCGATTTCCC
CGAGCTGCTGCTGCGCTGCTACGAACTGCTCTCGTACAACCCGCCGCTGCGCGCGCATTACCAGGCGCGCTTCCGGCACA
TTCTCGTCGACGAGTTTCAGGACACCAACAAGCTGCAGTACGCGTGGCTCAAGATGCTGGCGGGCGAGCACAACGCGATC
TTCGCGGTGGGCGACGACGACCAATCCATCTATGCGTTCCGCGGCGCGAACGTCGGCAACATGCGCGACTTCGAGAGCGA
GTTCAAGGTTCGCAACCTGATCAAGCTCGAGCAGAACTACCGCTCGCACGGCCACATTCTCGATGCCGCGAATCATCTGA
TCGCCAACAACTCGCGGCGTCTCGGCAAGAACCTGCGCACGGATGCCGGGCACGGCGAACCGGTGCGCGTCTATGAAGCC
GCGACAGATTCCCAGGAAGCGGGCTGGATCGTCGAAGAGATTCGCGCACTGATCAACACGGGCCTGTCGCGCAGCGAAAT
CGCCGTGCTGTACCGGAGCAACGCGCAGTCGCGGACCATCGAACATACGCTCGTGAACGTCGGCATTCCGTATCGCGTGT
ATGGCGGCCTGCGCTTCTTCGAGCGTCAGGAAGTCAAGCATGCGCTCGCGTATCTGCGTCTGATCGACAACCCGAACGAC
GACACCGCGTTTGCGCGCGTCGTCAATTTCCCGACGCGCGGCATCGGCGCGCGCTCGATCGAACAGCTGGCTGACGCGGC
GCGTCTCTACAACTGCTCGATGGCGGCGGCGATTGCGTACGTGACGGGCAAGGCGGGCACGAGTCTCGGCACCTTCGCGA
ACCTGATCGCGAAGATGCGCGCGGAAACGGCGCAGATGAGCCTGCCCGAAACGGTCGAATACGTCGTGCGCGCAAGTGGC
CTGTCCGAGTTCTATCAGAACGAACGCGAAGGGCAGGAGCGGCTGGAGAACTTGCAGGAACTCGTCAACGCGGCCACGGC
GTTCGTCAGCGAAGAAGGCTACGGTCTCGACACGCCCGCGCGTTCGATTCCGCTGCGCCCCGGCGCAACGTCCGCACCAG
AACTCGTCGTCTCGACCGACGATCCCGGCATCGACGTGCTCGACGCCGCGAACCCGGCGGACCCTGCACAGAACCCCGAC
ACGATGACGCCGCTCGCCGGCTTCCTGTCGCACGCGTCGCTCGAAGCGGGCGACAACCAGGCGCAGGCGGGCCAGGAGGC
CGTGCAGCTGATGACGGTGCACGCGGCGAAGGGCCTCGAATTCACGGCCGTGTTCATCACGGGTCTCGAAGAAGGTCTAT
TCCCGCATGAAAACAGTGCGATGGAATCGGACGGGCTGGAAGAAGAGCGCCGTCTGATGTACGTCGCGATCACGCGCGCG
AAGGAGCGGCTGTATCTGTCGTTCGCGCAGAGCCGGATGCTGCATGGCCAGACGCGCTACAACATCCGCTCGCGCTTCTT
CGACGAATTGCCGCAGGAAACGCTCAAGTGGCTCACGCCGAAGGTGGAAGCGGGCGCGCGCTGGGGCGGCCGTTCGGACA
ACGCCGGCTGGGGCCGCGACTGGTTTTCGCGCCCCGATCGTCAGCAGAAGGGCTATCAGGGCAGCGCGAGCTACGCGACG
ACCAGCGCGCCGCTGCCCGCATTCGCCAACGAGCAGCGTGCGGCAGACACGGGCTTCCGCGTCGGCCAGCAGGTGTTCCA
TACGAAGTTCGGCGAAGGCACGATCACCGCGCTCGAAGGCGGTGGCGCGGATGCGAAGGCACAGGTCAAGTTCAAGCGGC
ACGGCGAGAAATGGCTCGCGCTGGCCGTCGCCAAACTGCAGGCGGTCGAATGA

Upstream 100 bases:

>100_bases
CGGCGGCAGACGGCGCGCGGCAAGCGGCGATTGCTCACGGTCTTATAATGACGGACTACCCGCCGCAATCGTCGTCAATC
GTCGTTTCTCTTCCTGACTC

Downstream 100 bases:

>100_bases
GCGCGCTACCTTCGGAAGCGACGATTCCGCGCCGTCCGCTTGGCGTGATGGCGGCGCTGCAGCAGGAACTCGGTGATCTG
CTGATCGCGATGCGCGCCGA

Product: UvrD/REP helicase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 790; Mature: 789

Protein sequence:

>790_residues
MPELLANLNPEQHAAVTLPNEPALILAGAGSGKTRVLITRIAWLIQQGFASPPTILGVTFTNKAAREMMSRLSALLPIDT
RGMWIGTFHGLCNRMLRAHYRDAGLPQTFQILDTSDQLSAIKRLMKGLNIDDEKYPPKNLQYFINNAKEQGLRPKDVDAS
DNFNRKFIELYEAYDQQCQREGVVDFPELLLRCYELLSYNPPLRAHYQARFRHILVDEFQDTNKLQYAWLKMLAGEHNAI
FAVGDDDQSIYAFRGANVGNMRDFESEFKVRNLIKLEQNYRSHGHILDAANHLIANNSRRLGKNLRTDAGHGEPVRVYEA
ATDSQEAGWIVEEIRALINTGLSRSEIAVLYRSNAQSRTIEHTLVNVGIPYRVYGGLRFFERQEVKHALAYLRLIDNPND
DTAFARVVNFPTRGIGARSIEQLADAARLYNCSMAAAIAYVTGKAGTSLGTFANLIAKMRAETAQMSLPETVEYVVRASG
LSEFYQNEREGQERLENLQELVNAATAFVSEEGYGLDTPARSIPLRPGATSAPELVVSTDDPGIDVLDAANPADPAQNPD
TMTPLAGFLSHASLEAGDNQAQAGQEAVQLMTVHAAKGLEFTAVFITGLEEGLFPHENSAMESDGLEEERRLMYVAITRA
KERLYLSFAQSRMLHGQTRYNIRSRFFDELPQETLKWLTPKVEAGARWGGRSDNAGWGRDWFSRPDRQQKGYQGSASYAT
TSAPLPAFANEQRAADTGFRVGQQVFHTKFGEGTITALEGGGADAKAQVKFKRHGEKWLALAVAKLQAVE

Sequences:

>Translated_790_residues
MPELLANLNPEQHAAVTLPNEPALILAGAGSGKTRVLITRIAWLIQQGFASPPTILGVTFTNKAAREMMSRLSALLPIDT
RGMWIGTFHGLCNRMLRAHYRDAGLPQTFQILDTSDQLSAIKRLMKGLNIDDEKYPPKNLQYFINNAKEQGLRPKDVDAS
DNFNRKFIELYEAYDQQCQREGVVDFPELLLRCYELLSYNPPLRAHYQARFRHILVDEFQDTNKLQYAWLKMLAGEHNAI
FAVGDDDQSIYAFRGANVGNMRDFESEFKVRNLIKLEQNYRSHGHILDAANHLIANNSRRLGKNLRTDAGHGEPVRVYEA
ATDSQEAGWIVEEIRALINTGLSRSEIAVLYRSNAQSRTIEHTLVNVGIPYRVYGGLRFFERQEVKHALAYLRLIDNPND
DTAFARVVNFPTRGIGARSIEQLADAARLYNCSMAAAIAYVTGKAGTSLGTFANLIAKMRAETAQMSLPETVEYVVRASG
LSEFYQNEREGQERLENLQELVNAATAFVSEEGYGLDTPARSIPLRPGATSAPELVVSTDDPGIDVLDAANPADPAQNPD
TMTPLAGFLSHASLEAGDNQAQAGQEAVQLMTVHAAKGLEFTAVFITGLEEGLFPHENSAMESDGLEEERRLMYVAITRA
KERLYLSFAQSRMLHGQTRYNIRSRFFDELPQETLKWLTPKVEAGARWGGRSDNAGWGRDWFSRPDRQQKGYQGSASYAT
TSAPLPAFANEQRAADTGFRVGQQVFHTKFGEGTITALEGGGADAKAQVKFKRHGEKWLALAVAKLQAVE
>Mature_789_residues
PELLANLNPEQHAAVTLPNEPALILAGAGSGKTRVLITRIAWLIQQGFASPPTILGVTFTNKAAREMMSRLSALLPIDTR
GMWIGTFHGLCNRMLRAHYRDAGLPQTFQILDTSDQLSAIKRLMKGLNIDDEKYPPKNLQYFINNAKEQGLRPKDVDASD
NFNRKFIELYEAYDQQCQREGVVDFPELLLRCYELLSYNPPLRAHYQARFRHILVDEFQDTNKLQYAWLKMLAGEHNAIF
AVGDDDQSIYAFRGANVGNMRDFESEFKVRNLIKLEQNYRSHGHILDAANHLIANNSRRLGKNLRTDAGHGEPVRVYEAA
TDSQEAGWIVEEIRALINTGLSRSEIAVLYRSNAQSRTIEHTLVNVGIPYRVYGGLRFFERQEVKHALAYLRLIDNPNDD
TAFARVVNFPTRGIGARSIEQLADAARLYNCSMAAAIAYVTGKAGTSLGTFANLIAKMRAETAQMSLPETVEYVVRASGL
SEFYQNEREGQERLENLQELVNAATAFVSEEGYGLDTPARSIPLRPGATSAPELVVSTDDPGIDVLDAANPADPAQNPDT
MTPLAGFLSHASLEAGDNQAQAGQEAVQLMTVHAAKGLEFTAVFITGLEEGLFPHENSAMESDGLEEERRLMYVAITRAK
ERLYLSFAQSRMLHGQTRYNIRSRFFDELPQETLKWLTPKVEAGARWGGRSDNAGWGRDWFSRPDRQQKGYQGSASYATT
SAPLPAFANEQRAADTGFRVGQQVFHTKFGEGTITALEGGGADAKAQVKFKRHGEKWLALAVAKLQAVE

Specific function: Has both ATPase and helicase activities. Unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present. Involved in the post-incision events of nucleotide exc

COG id: COG0210

COG function: function code L; Superfamily I DNA and RNA helicases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 uvrD-like helicase C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI2367296, Length=795, Percent_Identity=44.4025157232704, Blast_Score=652, Evalue=0.0,
Organism=Escherichia coli, GI48994965, Length=685, Percent_Identity=36.6423357664234, Blast_Score=370, Evalue=1e-103,
Organism=Escherichia coli, GI1787196, Length=340, Percent_Identity=29.7058823529412, Blast_Score=110, Evalue=5e-25,
Organism=Saccharomyces cerevisiae, GI6322369, Length=768, Percent_Identity=28.2552083333333, Blast_Score=216, Evalue=1e-56,
Organism=Saccharomyces cerevisiae, GI6324477, Length=729, Percent_Identity=23.8683127572016, Blast_Score=105, Evalue=4e-23,

Paralogues:

None

Copy number: 3000 [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005753
- InterPro:   IPR013986
- InterPro:   IPR014017
- InterPro:   IPR000212
- InterPro:   IPR014016 [H]

Pfam domain/function: PF00580 UvrD-helicase [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 87865; Mature: 87734

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPELLANLNPEQHAAVTLPNEPALILAGAGSGKTRVLITRIAWLIQQGFASPPTILGVTF
CCCHHHCCCCCCCEEEECCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEE
TNKAAREMMSRLSALLPIDTRGMWIGTFHGLCNRMLRAHYRDAGLPQTFQILDTSDQLSA
CCHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHH
IKRLMKGLNIDDEKYPPKNLQYFINNAKEQGLRPKDVDASDNFNRKFIELYEAYDQQCQR
HHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
EGVVDFPELLLRCYELLSYNPPLRAHYQARFRHILVDEFQDTNKLQYAWLKMLAGEHNAI
CCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEE
FAVGDDDQSIYAFRGANVGNMRDFESEFKVRNLIKLEQNYRSHGHILDAANHLIANNSRR
EEECCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHH
LGKNLRTDAGHGEPVRVYEAATDSQEAGWIVEEIRALINTGLSRSEIAVLYRSNAQSRTI
HHCCCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHCCCCHHHEEEEEECCCCHHHH
EHTLVNVGIPYRVYGGLRFFERQEVKHALAYLRLIDNPNDDTAFARVVNFPTRGIGARSI
HHHHEECCCCEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCHHHH
EQLADAARLYNCSMAAAIAYVTGKAGTSLGTFANLIAKMRAETAQMSLPETVEYVVRASG
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
LSEFYQNEREGQERLENLQELVNAATAFVSEEGYGLDTPARSIPLRPGATSAPELVVSTD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEECC
DPGIDVLDAANPADPAQNPDTMTPLAGFLSHASLEAGDNQAQAGQEAVQLMTVHAAKGLE
CCCCEEECCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCE
FTAVFITGLEEGLFPHENSAMESDGLEEERRLMYVAITRAKERLYLSFAQSRMLHGQTRY
EEEEEEEHHHHCCCCCCCCCCCCCCCCHHHHEEEEEEHHHHHHHHHHHHHHHHHCCCHHH
NIRSRFFDELPQETLKWLTPKVEAGARWGGRSDNAGWGRDWFSRPDRQQKGYQGSASYAT
HHHHHHHHHHHHHHHHHHCCCHHCCCCCCCCCCCCCCCCHHHCCCCHHHCCCCCCCCCCC
TSAPLPAFANEQRAADTGFRVGQQVFHTKFGEGTITALEGGGADAKAQVKFKRHGEKWLA
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCEEEEEHHHCCHHHHH
LAVAKLQAVE
HHHHHHHHCC
>Mature Secondary Structure 
PELLANLNPEQHAAVTLPNEPALILAGAGSGKTRVLITRIAWLIQQGFASPPTILGVTF
CCHHHCCCCCCCEEEECCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEE
TNKAAREMMSRLSALLPIDTRGMWIGTFHGLCNRMLRAHYRDAGLPQTFQILDTSDQLSA
CCHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHH
IKRLMKGLNIDDEKYPPKNLQYFINNAKEQGLRPKDVDASDNFNRKFIELYEAYDQQCQR
HHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
EGVVDFPELLLRCYELLSYNPPLRAHYQARFRHILVDEFQDTNKLQYAWLKMLAGEHNAI
CCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEE
FAVGDDDQSIYAFRGANVGNMRDFESEFKVRNLIKLEQNYRSHGHILDAANHLIANNSRR
EEECCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHH
LGKNLRTDAGHGEPVRVYEAATDSQEAGWIVEEIRALINTGLSRSEIAVLYRSNAQSRTI
HHCCCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHCCCCHHHEEEEEECCCCHHHH
EHTLVNVGIPYRVYGGLRFFERQEVKHALAYLRLIDNPNDDTAFARVVNFPTRGIGARSI
HHHHEECCCCEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCHHHH
EQLADAARLYNCSMAAAIAYVTGKAGTSLGTFANLIAKMRAETAQMSLPETVEYVVRASG
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
LSEFYQNEREGQERLENLQELVNAATAFVSEEGYGLDTPARSIPLRPGATSAPELVVSTD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEECC
DPGIDVLDAANPADPAQNPDTMTPLAGFLSHASLEAGDNQAQAGQEAVQLMTVHAAKGLE
CCCCEEECCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCE
FTAVFITGLEEGLFPHENSAMESDGLEEERRLMYVAITRAKERLYLSFAQSRMLHGQTRY
EEEEEEEHHHHCCCCCCCCCCCCCCCCHHHHEEEEEEHHHHHHHHHHHHHHHHHCCCHHH
NIRSRFFDELPQETLKWLTPKVEAGARWGGRSDNAGWGRDWFSRPDRQQKGYQGSASYAT
HHHHHHHHHHHHHHHHHHCCCHHCCCCCCCCCCCCCCCCHHHCCCCHHHCCCCCCCCCCC
TSAPLPAFANEQRAADTGFRVGQQVFHTKFGEGTITALEGGGADAKAQVKFKRHGEKWLA
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCEEEEEHHHCCHHHHH
LAVAKLQAVE
HHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 6379604; 2943729; 1379743; 9278503; 6324092; 2254268; 8419285 [H]