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The map label for this gene is dht [H]

Identifier: 186476290

GI number: 186476290

Start: 1729204

End: 1730655

Strand: Reverse

Name: dht [H]

Synonym: Bphy_1532

Alternate gene names: 186476290

Gene position: 1730655-1729204 (Counterclockwise)

Preceding gene: 186476291

Following gene: 186476289

Centisome position: 49.74

GC content: 61.29

Gene sequence:

>1452_bases
ATGACAACTCTTATTCGCGGCGGCACGGTGATCGATGCCGACCGCACGCATAGAGCCGACGTATTGATTGCGGACCCGCA
GGACGGCGGCACGATCCTGCAGGTCGATCGCACGATCGAGCCGCCCGCGGGTGCGCGCATCGTTGACGCTCACGATCAGT
ATGTGATGCCGGGCGGCATCGATCCGCACACGCACATGGAACTGCCTTTCATGGGCACGACGGCGAGCGACGACTTCTAC
ACGGGCACGGCGGCGGGGCTGTCGGGCGGCACGACGAGCATCATCGACTTCGTGATTCCGAGCCCGAAGCAGCCGCTGAT
GGACGCATTTAATGAATGGCGCGGCTGGGCGGAAAAGGCATCGGCCGATTATGGCTTTCATGTGGCTGTGACGTGGTGGG
ACGACTCCGTGTATCGCGACATGGGCACGCTCGTCAACGAGCATGGCGTGTCGAGCTTCAAGCACTTCATGGCCTACAAG
AACGCGATCATGGCTGACGACGAAGTGCTCGTGAACAGCTTCTCGCGTTCGCTAGAACTCGGTGCGCTGCCGACTGTGCA
TGCGGAAAACGGCGAGCTCGTATTCCAGTTGCAGAAGCAGCTATTGGCGAAGGGTTTCAGGGGGCCGGAGGCGCATCCGC
TGTCGCGTCCGCCCGAAGTGGAGGGCGAGGCCGCGAATCGCGCGATCCGCATTGCGCAAGTGCTCGGCGTGCCCGTGTAC
ATCGTGCATGTGTCATCGAGAGAAGCGGTCGAAGCGATTTCACGCGCGCGCAACGAAGGCCAGCGCGTATTTGGGGAGGT
GCTGCCGGGGCATCTTGTGATCGACGAAAGCGTATATCGCGATCCCGACTGGACGCGTGCCGCCGCGCACGTGATGAGTC
CGCCGTTTCGCACGCGCGAGCATCGCGAGGCGCTATGGCGCGGCTTGCAAGCGGGCCAGTTGCATACGACGGCCACCGAT
CATTGTGTGTTCTGCGCGTCCCAGAAGGCGATGGGGCGCGAGGATTTCACGAAGATTCCGAACGGGTGCGGTGGGATTGA
AGACCGGATGTCGGTGTTGTGGCATGAGGGCGTGAATCAAGGGCGCGTTACACCGAATGAGTTCGTTCGTATTACGTCTG
CGAATGCTGCCCAGATTTTCAATCTTTATCCCCGCAAGGGCGCTGTGCAGGCCGGTGCGGACGCGGATCTTGTTATCTGG
GATCCGGCTGCGACGAAGACCATTTCTGTGAAGACGCATCATCAGAAGGTCGACTTCAATGTGTTCGAAGGGATGACGGT
GCAAGGCGCGGCCATGCATACCTTTGCGCGTGGGGCGCACGTGTGGGCCGATGGCGATCTTCGCGCACAGCGCGGCGCTG
GGCAGTATTTGAGGCGTCCGCCCAATGCAGCTTATTACGACGCCGTGCGTGTCGTTAATCGGCTTAGGGAGCCGCATCCC
GTAGAGCGGTAA

Upstream 100 bases:

>100_bases
CATCCATTGTGTATGGCACGTGGATGAAGCTGCGCCGCAATCCCGGCGCGAGCATGGCGAGTGCGTGATGTGATTCGATG
TTTGACCGAGGAGGCAAGCG

Downstream 100 bases:

>100_bases
CGTTTGTGCTTGACGGCGGCTGCTTGATGCTTTTTTGTCTGCGACGTAGTGGCCGCGCCTGGTTTTTTGTTGGCATCCGC
GATTTGCCTTCGTTGTTCAG

Product: phenylhydantoinase

Products: NA

Alternate protein names: DHPase [H]

Number of amino acids: Translated: 483; Mature: 482

Protein sequence:

>483_residues
MTTLIRGGTVIDADRTHRADVLIADPQDGGTILQVDRTIEPPAGARIVDAHDQYVMPGGIDPHTHMELPFMGTTASDDFY
TGTAAGLSGGTTSIIDFVIPSPKQPLMDAFNEWRGWAEKASADYGFHVAVTWWDDSVYRDMGTLVNEHGVSSFKHFMAYK
NAIMADDEVLVNSFSRSLELGALPTVHAENGELVFQLQKQLLAKGFRGPEAHPLSRPPEVEGEAANRAIRIAQVLGVPVY
IVHVSSREAVEAISRARNEGQRVFGEVLPGHLVIDESVYRDPDWTRAAAHVMSPPFRTREHREALWRGLQAGQLHTTATD
HCVFCASQKAMGREDFTKIPNGCGGIEDRMSVLWHEGVNQGRVTPNEFVRITSANAAQIFNLYPRKGAVQAGADADLVIW
DPAATKTISVKTHHQKVDFNVFEGMTVQGAAMHTFARGAHVWADGDLRAQRGAGQYLRRPPNAAYYDAVRVVNRLREPHP
VER

Sequences:

>Translated_483_residues
MTTLIRGGTVIDADRTHRADVLIADPQDGGTILQVDRTIEPPAGARIVDAHDQYVMPGGIDPHTHMELPFMGTTASDDFY
TGTAAGLSGGTTSIIDFVIPSPKQPLMDAFNEWRGWAEKASADYGFHVAVTWWDDSVYRDMGTLVNEHGVSSFKHFMAYK
NAIMADDEVLVNSFSRSLELGALPTVHAENGELVFQLQKQLLAKGFRGPEAHPLSRPPEVEGEAANRAIRIAQVLGVPVY
IVHVSSREAVEAISRARNEGQRVFGEVLPGHLVIDESVYRDPDWTRAAAHVMSPPFRTREHREALWRGLQAGQLHTTATD
HCVFCASQKAMGREDFTKIPNGCGGIEDRMSVLWHEGVNQGRVTPNEFVRITSANAAQIFNLYPRKGAVQAGADADLVIW
DPAATKTISVKTHHQKVDFNVFEGMTVQGAAMHTFARGAHVWADGDLRAQRGAGQYLRRPPNAAYYDAVRVVNRLREPHP
VER
>Mature_482_residues
TTLIRGGTVIDADRTHRADVLIADPQDGGTILQVDRTIEPPAGARIVDAHDQYVMPGGIDPHTHMELPFMGTTASDDFYT
GTAAGLSGGTTSIIDFVIPSPKQPLMDAFNEWRGWAEKASADYGFHVAVTWWDDSVYRDMGTLVNEHGVSSFKHFMAYKN
AIMADDEVLVNSFSRSLELGALPTVHAENGELVFQLQKQLLAKGFRGPEAHPLSRPPEVEGEAANRAIRIAQVLGVPVYI
VHVSSREAVEAISRARNEGQRVFGEVLPGHLVIDESVYRDPDWTRAAAHVMSPPFRTREHREALWRGLQAGQLHTTATDH
CVFCASQKAMGREDFTKIPNGCGGIEDRMSVLWHEGVNQGRVTPNEFVRITSANAAQIFNLYPRKGAVQAGADADLVIWD
PAATKTISVKTHHQKVDFNVFEGMTVQGAAMHTFARGAHVWADGDLRAQRGAGQYLRRPPNAAYYDAVRVVNRLREPHPV
ER

Specific function: Catalyzes the hydrolysis of dihydropyrimidines and of the structurally related DL-5-mono-substituted hydantoins, to produce N-carbamoyl-D-amino acids [H]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily [H]

Homologues:

Organism=Homo sapiens, GI4503375, Length=487, Percent_Identity=49.2813141683778, Blast_Score=472, Evalue=1e-133,
Organism=Homo sapiens, GI4503379, Length=486, Percent_Identity=41.9753086419753, Blast_Score=417, Evalue=1e-116,
Organism=Homo sapiens, GI4503377, Length=486, Percent_Identity=42.3868312757202, Blast_Score=412, Evalue=1e-115,
Organism=Homo sapiens, GI190194363, Length=486, Percent_Identity=43.6213991769547, Blast_Score=401, Evalue=1e-112,
Organism=Homo sapiens, GI19923821, Length=477, Percent_Identity=44.4444444444444, Blast_Score=397, Evalue=1e-110,
Organism=Homo sapiens, GI4503051, Length=478, Percent_Identity=42.2594142259414, Blast_Score=395, Evalue=1e-110,
Organism=Homo sapiens, GI62422571, Length=481, Percent_Identity=42.2037422037422, Blast_Score=394, Evalue=1e-109,
Organism=Homo sapiens, GI18105007, Length=409, Percent_Identity=25.6723716381418, Blast_Score=84, Evalue=2e-16,
Organism=Escherichia coli, GI87082175, Length=465, Percent_Identity=38.0645161290323, Blast_Score=315, Evalue=6e-87,
Organism=Escherichia coli, GI1786722, Length=460, Percent_Identity=26.7391304347826, Blast_Score=137, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI17539558, Length=487, Percent_Identity=45.9958932238193, Blast_Score=447, Evalue=1e-126,
Organism=Caenorhabditis elegans, GI71989490, Length=467, Percent_Identity=45.610278372591, Blast_Score=422, Evalue=1e-118,
Organism=Caenorhabditis elegans, GI86575075, Length=472, Percent_Identity=30.2966101694915, Blast_Score=227, Evalue=9e-60,
Organism=Caenorhabditis elegans, GI193204318, Length=448, Percent_Identity=25.4464285714286, Blast_Score=88, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6322218, Length=422, Percent_Identity=26.0663507109005, Blast_Score=117, Evalue=4e-27,
Organism=Drosophila melanogaster, GI221377917, Length=484, Percent_Identity=44.4214876033058, Blast_Score=420, Evalue=1e-117,
Organism=Drosophila melanogaster, GI17137462, Length=482, Percent_Identity=43.9834024896266, Blast_Score=413, Evalue=1e-115,
Organism=Drosophila melanogaster, GI24644287, Length=298, Percent_Identity=44.6308724832215, Blast_Score=261, Evalue=1e-69,
Organism=Drosophila melanogaster, GI24644289, Length=239, Percent_Identity=46.8619246861925, Blast_Score=223, Evalue=3e-58,
Organism=Drosophila melanogaster, GI24642586, Length=404, Percent_Identity=26.980198019802, Blast_Score=95, Evalue=1e-19,
Organism=Drosophila melanogaster, GI18859883, Length=475, Percent_Identity=24.8421052631579, Blast_Score=94, Evalue=3e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR011778
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.2 [H]

Molecular weight: Translated: 53208; Mature: 53077

Theoretical pI: Translated: 6.47; Mature: 6.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTLIRGGTVIDADRTHRADVLIADPQDGGTILQVDRTIEPPAGARIVDAHDQYVMPGGI
CCEEEECCEEEECCCCCCCCEEEECCCCCCEEEEECCCCCCCCCCEEEECCCCEECCCCC
DPHTHMELPFMGTTASDDFYTGTAAGLSGGTTSIIDFVIPSPKQPLMDAFNEWRGWAEKA
CCCCEEECCEECCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHC
SADYGFHVAVTWWDDSVYRDMGTLVNEHGVSSFKHFMAYKNAIMADDEVLVNSFSRSLEL
CCCCCEEEEEEEECCHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCHHHHHHHHHHCEEC
GALPTVHAENGELVFQLQKQLLAKGFRGPEAHPLSRPPEVEGEAANRAIRIAQVLGVPVY
CCCCEEECCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEE
IVHVSSREAVEAISRARNEGQRVFGEVLPGHLVIDESVYRDPDWTRAAAHVMSPPFRTRE
EEEECCHHHHHHHHHHHHHHHHHHHHHCCCCEEECCHHCCCCCHHHHHHHHCCCCCCCHH
HREALWRGLQAGQLHTTATDHCVFCASQKAMGREDFTKIPNGCGGIEDRMSVLWHEGVNQ
HHHHHHCCCCCCEEECCCCCCEEEECCCHHCCCHHHHHCCCCCCCHHHHHHHHHHCCCCC
GRVTPNEFVRITSANAAQIFNLYPRKGAVQAGADADLVIWDPAATKTISVKTHHQKVDFN
CCCCHHHEEEEECCCHHHHEEECCCCCCCCCCCCCCEEEECCCCCEEEEEEECCCEECEE
VFEGMTVQGAAMHTFARGAHVWADGDLRAQRGAGQYLRRPPNAAYYDAVRVVNRLREPHP
HHCCCEECCHHHHHHHCCCEEEECCCCCCCCCCCHHHHCCCCCHHHHHHHHHHHHCCCCC
VER
CCC
>Mature Secondary Structure 
TTLIRGGTVIDADRTHRADVLIADPQDGGTILQVDRTIEPPAGARIVDAHDQYVMPGGI
CEEEECCEEEECCCCCCCCEEEECCCCCCEEEEECCCCCCCCCCEEEECCCCEECCCCC
DPHTHMELPFMGTTASDDFYTGTAAGLSGGTTSIIDFVIPSPKQPLMDAFNEWRGWAEKA
CCCCEEECCEECCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHC
SADYGFHVAVTWWDDSVYRDMGTLVNEHGVSSFKHFMAYKNAIMADDEVLVNSFSRSLEL
CCCCCEEEEEEEECCHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCHHHHHHHHHHCEEC
GALPTVHAENGELVFQLQKQLLAKGFRGPEAHPLSRPPEVEGEAANRAIRIAQVLGVPVY
CCCCEEECCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEE
IVHVSSREAVEAISRARNEGQRVFGEVLPGHLVIDESVYRDPDWTRAAAHVMSPPFRTRE
EEEECCHHHHHHHHHHHHHHHHHHHHHCCCCEEECCHHCCCCCHHHHHHHHCCCCCCCHH
HREALWRGLQAGQLHTTATDHCVFCASQKAMGREDFTKIPNGCGGIEDRMSVLWHEGVNQ
HHHHHHCCCCCCEEECCCCCCEEEECCCHHCCCHHHHHCCCCCCCHHHHHHHHHHCCCCC
GRVTPNEFVRITSANAAQIFNLYPRKGAVQAGADADLVIWDPAATKTISVKTHHQKVDFN
CCCCHHHEEEEECCCHHHHEEECCCCCCCCCCCCCCEEEECCCCCEEEEEEECCCEECEE
VFEGMTVQGAAMHTFARGAHVWADGDLRAQRGAGQYLRRPPNAAYYDAVRVVNRLREPHP
HHCCCEECCHHHHHHHCCCEEEECCCCCCCCCCCHHHHCCCCCHHHHHHHHHHHHCCCCC
VER
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]