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The map label for this gene is ykgC [H]

Identifier: 186476254

GI number: 186476254

Start: 1691126

End: 1692529

Strand: Reverse

Name: ykgC [H]

Synonym: Bphy_1496

Alternate gene names: 186476254

Gene position: 1692529-1691126 (Counterclockwise)

Preceding gene: 186476255

Following gene: 186476253

Centisome position: 48.65

GC content: 65.03

Gene sequence:

>1404_bases
ATGCCACAGCATTTCGACGCCATCGTGATCGGCACCGGACAGGGCGGTTCGCCGCTCGCCGTGCGTCTTGCGGAGCAAGG
CCGCAAGACGGCGGTGATCGAACGCGACAAGTTCGGCGGAACCTGCGTGAACGTCGGTTGCACGCCCACCAAGGCGTATG
TGGCGAGCGCGCGCACCGCGCATGTCGCGCGCCGAGCGCTCGACTATGGTGTGCATGTGGCGGGCGGTGTGAGCGTAGAC
CTCGCGAAAGTGAAGGCGCGCAAGGATCAGATCATCGGCCAGTCGCGCGACGGCGTAGAAAAATGGCTGCGCAACACGGA
TAACGTCACCGTTTTCAACGGCCATGCGCGCTTTACTGGCGCGCATACGCTGAGCGTGACGGAGCCCGACAGCGCTAATG
TGCTGGCCGAACTGCAAGCCGACGACATCTTCATCAACACGGGCACGCGGGCCGTCATTCCACAACTCGAAGGCATCGAG
CGCATCCGCTATCACACCAATTCGACACTGCTCGAACTGACCGACTTGCCCGCGCATCTGGCGATCGTCGGCGGCAGCTA
TATTGCGCTCGAATTCGCGCAGGTGTTCCGCCGTTTCGGCAGCCGCGTGACGGTGATCGTGCGCGGCGAGCGGGTGCTCG
CGCGCGAGGACGAAGACTTCGCCCGCAACGTGCAGACCGTGCTCGCGCGTGAAGGCGTCGAATTCCGCTTTGGCGGCGAG
CCGTCGCGCGTCGAGCCGTTGCAGCACGACGGCGACGGCGTGCGGATTTTCTTCGGCAGCGAGGGCGCGCCGCTCGACGC
GTCGCATTTGCTGTTCGCCACGGGCCGCAGCCCGAACACGGACGATCTCGGCCTCGACGCAGCCGGCATCGAGGTCGAGC
GCCACGGCACGATTCCCGTCGACGGGCAGCTGCGCACGAACGTGCCCGGTGTGTGGGCGATCGGCGACGTCAACGGACGC
GGTGCCTTTACGCACACGTCCTACGACGATTTCCAGATCGTCGCGACGAATCTGTTCGACGGCGGCAAGCGCAGCGTCGA
TGACCGGATCATCGCGTATGCGGTGTTCGTCGATCCGCCGCTGGCGCGCGTCGGCCTGTCCGAGCAGGACGTGCGCAAGA
GCGGGCGCGACGCGTTGATCGCGACGATGCCGATGACGCGCGTGGGCCGCGCACGTGAGAAAGGCGAAACGGACGGCTTC
ATGAAAGTGCTCGTCGACCCGTCGTCGAAGCAGATACTCGGCGCGACGATTTACGGCGTCGATGGCGACGAAGCAATCCA
CACTTTCGTCGACATCATGACGGCGCGAGCGCCGTACACGACGCTGCAATACGCGATGCATATCCATCCGACGATCAGCG
AACTGGTGCCGACGTTGCTCGCCGGTCTCGCCCCGATGCAGTGA

Upstream 100 bases:

>100_bases
GTTCAAAAGATCCACGACTCACCGCTGAGGCTCATCACTTCGGGAAACATCGGGCTGGCGTAAGATGACCGACTCGCACA
CGCGCTTCGGGAGATTGGCC

Downstream 100 bases:

>100_bases
GCGATGAGCAGAGGTGACGACATGCAACTGCAAACGGGCAACCTGTTCAGCGGCGAAGCGAAGCGCGACGATGAAGAGCG
GATCGACATGCTCGTCGCGG

Product: mercuric reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 467; Mature: 466

Protein sequence:

>467_residues
MPQHFDAIVIGTGQGGSPLAVRLAEQGRKTAVIERDKFGGTCVNVGCTPTKAYVASARTAHVARRALDYGVHVAGGVSVD
LAKVKARKDQIIGQSRDGVEKWLRNTDNVTVFNGHARFTGAHTLSVTEPDSANVLAELQADDIFINTGTRAVIPQLEGIE
RIRYHTNSTLLELTDLPAHLAIVGGSYIALEFAQVFRRFGSRVTVIVRGERVLAREDEDFARNVQTVLAREGVEFRFGGE
PSRVEPLQHDGDGVRIFFGSEGAPLDASHLLFATGRSPNTDDLGLDAAGIEVERHGTIPVDGQLRTNVPGVWAIGDVNGR
GAFTHTSYDDFQIVATNLFDGGKRSVDDRIIAYAVFVDPPLARVGLSEQDVRKSGRDALIATMPMTRVGRAREKGETDGF
MKVLVDPSSKQILGATIYGVDGDEAIHTFVDIMTARAPYTTLQYAMHIHPTISELVPTLLAGLAPMQ

Sequences:

>Translated_467_residues
MPQHFDAIVIGTGQGGSPLAVRLAEQGRKTAVIERDKFGGTCVNVGCTPTKAYVASARTAHVARRALDYGVHVAGGVSVD
LAKVKARKDQIIGQSRDGVEKWLRNTDNVTVFNGHARFTGAHTLSVTEPDSANVLAELQADDIFINTGTRAVIPQLEGIE
RIRYHTNSTLLELTDLPAHLAIVGGSYIALEFAQVFRRFGSRVTVIVRGERVLAREDEDFARNVQTVLAREGVEFRFGGE
PSRVEPLQHDGDGVRIFFGSEGAPLDASHLLFATGRSPNTDDLGLDAAGIEVERHGTIPVDGQLRTNVPGVWAIGDVNGR
GAFTHTSYDDFQIVATNLFDGGKRSVDDRIIAYAVFVDPPLARVGLSEQDVRKSGRDALIATMPMTRVGRAREKGETDGF
MKVLVDPSSKQILGATIYGVDGDEAIHTFVDIMTARAPYTTLQYAMHIHPTISELVPTLLAGLAPMQ
>Mature_466_residues
PQHFDAIVIGTGQGGSPLAVRLAEQGRKTAVIERDKFGGTCVNVGCTPTKAYVASARTAHVARRALDYGVHVAGGVSVDL
AKVKARKDQIIGQSRDGVEKWLRNTDNVTVFNGHARFTGAHTLSVTEPDSANVLAELQADDIFINTGTRAVIPQLEGIER
IRYHTNSTLLELTDLPAHLAIVGGSYIALEFAQVFRRFGSRVTVIVRGERVLAREDEDFARNVQTVLAREGVEFRFGGEP
SRVEPLQHDGDGVRIFFGSEGAPLDASHLLFATGRSPNTDDLGLDAAGIEVERHGTIPVDGQLRTNVPGVWAIGDVNGRG
AFTHTSYDDFQIVATNLFDGGKRSVDDRIIAYAVFVDPPLARVGLSEQDVRKSGRDALIATMPMTRVGRAREKGETDGFM
KVLVDPSSKQILGATIYGVDGDEAIHTFVDIMTARAPYTTLQYAMHIHPTISELVPTLLAGLAPMQ

Specific function: Unknown

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=467, Percent_Identity=27.1948608137045, Blast_Score=187, Evalue=2e-47,
Organism=Homo sapiens, GI50301238, Length=468, Percent_Identity=30.1282051282051, Blast_Score=162, Evalue=9e-40,
Organism=Homo sapiens, GI22035672, Length=462, Percent_Identity=29.6536796536797, Blast_Score=125, Evalue=6e-29,
Organism=Homo sapiens, GI148277065, Length=461, Percent_Identity=26.0303687635575, Blast_Score=122, Evalue=6e-28,
Organism=Homo sapiens, GI33519430, Length=461, Percent_Identity=26.0303687635575, Blast_Score=122, Evalue=7e-28,
Organism=Homo sapiens, GI33519428, Length=461, Percent_Identity=26.0303687635575, Blast_Score=122, Evalue=7e-28,
Organism=Homo sapiens, GI33519426, Length=461, Percent_Identity=26.0303687635575, Blast_Score=122, Evalue=7e-28,
Organism=Homo sapiens, GI148277071, Length=461, Percent_Identity=26.0303687635575, Blast_Score=122, Evalue=8e-28,
Organism=Homo sapiens, GI291045266, Length=438, Percent_Identity=26.7123287671233, Blast_Score=113, Evalue=3e-25,
Organism=Homo sapiens, GI291045268, Length=433, Percent_Identity=25.4041570438799, Blast_Score=97, Evalue=2e-20,
Organism=Escherichia coli, GI87081717, Length=461, Percent_Identity=37.527114967462, Blast_Score=283, Evalue=2e-77,
Organism=Escherichia coli, GI1786307, Length=455, Percent_Identity=31.2087912087912, Blast_Score=206, Evalue=2e-54,
Organism=Escherichia coli, GI87082354, Length=455, Percent_Identity=29.2307692307692, Blast_Score=174, Evalue=1e-44,
Organism=Escherichia coli, GI1789915, Length=465, Percent_Identity=30.1075268817204, Blast_Score=146, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI32565766, Length=466, Percent_Identity=28.3261802575107, Blast_Score=179, Evalue=4e-45,
Organism=Caenorhabditis elegans, GI17557007, Length=472, Percent_Identity=29.4491525423729, Blast_Score=153, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI71983429, Length=473, Percent_Identity=28.3298097251586, Blast_Score=139, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI71983419, Length=473, Percent_Identity=28.3298097251586, Blast_Score=139, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI71982272, Length=484, Percent_Identity=27.4793388429752, Blast_Score=133, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6321091, Length=460, Percent_Identity=29.3478260869565, Blast_Score=184, Evalue=3e-47,
Organism=Saccharomyces cerevisiae, GI6325166, Length=469, Percent_Identity=26.0127931769723, Blast_Score=142, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6325240, Length=441, Percent_Identity=23.8095238095238, Blast_Score=87, Evalue=6e-18,
Organism=Drosophila melanogaster, GI21358499, Length=457, Percent_Identity=30.1969365426696, Blast_Score=203, Evalue=2e-52,
Organism=Drosophila melanogaster, GI24640553, Length=485, Percent_Identity=28.4536082474227, Blast_Score=121, Evalue=8e-28,
Organism=Drosophila melanogaster, GI24640549, Length=485, Percent_Identity=28.4536082474227, Blast_Score=121, Evalue=8e-28,
Organism=Drosophila melanogaster, GI24640551, Length=485, Percent_Identity=28.4536082474227, Blast_Score=121, Evalue=9e-28,
Organism=Drosophila melanogaster, GI17737741, Length=475, Percent_Identity=25.2631578947368, Blast_Score=104, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: NA

Molecular weight: Translated: 50474; Mature: 50342

Theoretical pI: Translated: 6.28; Mature: 6.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPQHFDAIVIGTGQGGSPLAVRLAEQGRKTAVIERDKFGGTCVNVGCTPTKAYVASARTA
CCCCEEEEEEECCCCCCCEEEEEECCCCEEEEEEECCCCCEEEECCCCCCHHHHHHHHHH
HVARRALDYGVHVAGGVSVDLAKVKARKDQIIGQSRDGVEKWLRNTDNVTVFNGHARFTG
HHHHHHHHCCCEEECCCEEEHHHHHHHHHHHCCCCCHHHHHHHCCCCCEEEEECCEEEEC
AHTLSVTEPDSANVLAELQADDIFINTGTRAVIPQLEGIERIRYHTNSTLLELTDLPAHL
EEEEEECCCCCCCEEEEEECCEEEEECCCCEECCCHHCHHHHEEECCCEEEEEECCCEEE
AIVGGSYIALEFAQVFRRFGSRVTVIVRGERVLAREDEDFARNVQTVLAREGVEFRFGGE
EEECCCHHHHHHHHHHHHHCCEEEEEEECCEEEECCCHHHHHHHHHHHHHCCCEEEECCC
PSRVEPLQHDGDGVRIFFGSEGAPLDASHLLFATGRSPNTDDLGLDAAGIEVERHGTIPV
CCCCCCCCCCCCEEEEEECCCCCCCCCCEEEEEECCCCCCCCCCCCCCCEEEEECCCCCC
DGQLRTNVPGVWAIGDVNGRGAFTHTSYDDFQIVATNLFDGGKRSVDDRIIAYAVFVDPP
CCEEECCCCCEEEEECCCCCCCEEECCCCCEEEEEEECCCCCCCCCCCEEEEEEEEECCC
LARVGLSEQDVRKSGRDALIATMPMTRVGRAREKGETDGFMKVLVDPSSKQILGATIYGV
HHHCCCCHHHHHHCCCCEEEEECCHHHHCCHHHCCCCCCEEEEEECCCCCEEEEEEEEEC
DGDEAIHTFVDIMTARAPYTTLQYAMHIHPTISELVPTLLAGLAPMQ
CCHHHHHHHHHHHHCCCCCCEEEEEEEECCCHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
PQHFDAIVIGTGQGGSPLAVRLAEQGRKTAVIERDKFGGTCVNVGCTPTKAYVASARTA
CCCEEEEEEECCCCCCCEEEEEECCCCEEEEEEECCCCCEEEECCCCCCHHHHHHHHHH
HVARRALDYGVHVAGGVSVDLAKVKARKDQIIGQSRDGVEKWLRNTDNVTVFNGHARFTG
HHHHHHHHCCCEEECCCEEEHHHHHHHHHHHCCCCCHHHHHHHCCCCCEEEEECCEEEEC
AHTLSVTEPDSANVLAELQADDIFINTGTRAVIPQLEGIERIRYHTNSTLLELTDLPAHL
EEEEEECCCCCCCEEEEEECCEEEEECCCCEECCCHHCHHHHEEECCCEEEEEECCCEEE
AIVGGSYIALEFAQVFRRFGSRVTVIVRGERVLAREDEDFARNVQTVLAREGVEFRFGGE
EEECCCHHHHHHHHHHHHHCCEEEEEEECCEEEECCCHHHHHHHHHHHHHCCCEEEECCC
PSRVEPLQHDGDGVRIFFGSEGAPLDASHLLFATGRSPNTDDLGLDAAGIEVERHGTIPV
CCCCCCCCCCCCEEEEEECCCCCCCCCCEEEEEECCCCCCCCCCCCCCCEEEEECCCCCC
DGQLRTNVPGVWAIGDVNGRGAFTHTSYDDFQIVATNLFDGGKRSVDDRIIAYAVFVDPP
CCEEECCCCCEEEEECCCCCCCEEECCCCCEEEEEEECCCCCCCCCCCEEEEEEEEECCC
LARVGLSEQDVRKSGRDALIATMPMTRVGRAREKGETDGFMKVLVDPSSKQILGATIYGV
HHHCCCCHHHHHHCCCCEEEEECCHHHHCCHHHCCCCCCEEEEEECCCCCEEEEEEEEEC
DGDEAIHTFVDIMTARAPYTTLQYAMHIHPTISELVPTLLAGLAPMQ
CCHHHHHHHHHHHHCCCCCCEEEEEEEECCCHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: FAD. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9278503 [H]