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The map label for this gene is hisS

Identifier: 186476177

GI number: 186476177

Start: 1598632

End: 1599972

Strand: Reverse

Name: hisS

Synonym: Bphy_1419

Alternate gene names: 186476177

Gene position: 1599972-1598632 (Counterclockwise)

Preceding gene: 186476178

Following gene: 186476176

Centisome position: 45.99

GC content: 60.03

Gene sequence:

>1341_bases
ATGACTGAACAGAAGAAACGGCTTGAAAAGTTGTCCGGCGTGAAGGGCATGAACGACATCCTTCCGCAGGACGCAGGCTT
GTGGGAGTTTTTCGAAACGACGGTCAAATCGATGCTGCGTTCGTACGGATACCAGAATATCCGCACGCCGATCGTCGAGC
ATACGCAGCTCTTCACGCGCGGTATCGGCGAAGTGACCGACATCGTCGAAAAAGAGATGTACAGTTTCACCGACGCGCTG
AACGGCGAGAACCTGACGATGCGACCGGAAAACACGGCTGCCGTCGTGCGCGCGTCGATCGAGCACAACATGCTGTACGA
CGGCCCGAAGCGTCTGTGGTACATCGGCCCGATGTTCCGCCACGAGCGTCCGCAGCGTGGCCGTTATCGCCAGTTCCATC
AGGTGGGCGTCGAGGCACTCGGCTTCGCCGGTCCGGACACTGACGCCGAAATCATCCTGATGTGTCAACGTCTGTGGGAC
GACCTCGGGCTGACGGGCATCAAGCTCGAAATCAACTCGCTGGGTCTCGCTGAAGAGCGGGCGAAGCATCGCGTCGAACT
GATCGCGTATCTCGAGAAGCACATGGATGTGCTCGACGAAGACGCGAAGCGCCGTCTCTACACGAACCCGCTGCGCGTGC
TGGACACGAAAAATCCGGCCCTTCAGGCCGTCGCGCAGAACGCGCCCAAGCTGATCGATTTCCTCGGCGACGAATCGCGT
GCGCACTTTGAAGGCCTGCAGCGCATCCTCAAGGCGAACAACATTCCGTTCACGATCAATCCGCGTCTCGTGCGCGGTCT
GGATTACTACAACCTGACCGTCTTTGAATGGGTGACCGACAAGCTCGGCGCGCAAGGCACGGTGGCGGCAGGCGGCCGTT
ACGATCCGTTGATCGAGCAACTCGGCGGCAAGCCGACGGCGGCATGCGGTTGGGCGATGGGCATCGAGCGCATTCTCGAA
CTGCTCAAGGAAGAGAACCTCGTGCCCGAAAACGAAGGCTGCGACGTGTATGTCGCGCATCAGGGCGAAGCGGCGCGCGA
CCAGGCGTTCATCGTCGCAGAGCGTTTGCGCGACACGGGCCTCGACGTGATTCTGCATTGCAGTCCTGATGGTCAGGCGT
CCAGCTTCAAGTCGCAGATGAAACGCGCTGACGCAAGCGGCGCGGCGTTCGCCGTGATCCTGGGCGAAGACGAAATCGCG
AACGGCACGGCGGGTGTCAAGGCGCTGCGCGATTCGTCGCAAAGCAATGGAAAGAGCGAGCAACAAACGGTGCCGCTCGA
AGACTTGACCGAATATCTAATCAATGCGATGGTTGCGTCCACCGAAGACGGCGACGATTGA

Upstream 100 bases:

>100_bases
GATCGTGAGCGACTACGTCGAGCGCAGCTATGGGCCCAACGCGGTCCGCGCCGAAGCGACGAACTGATTCGCCCCATCTC
CAATCGTCAATCAAAGACAG

Downstream 100 bases:

>100_bases
GCGCGGCCATGCGTATCGACGTTCTGCGGGCCGCAACGCTTGCGGTCCCAATCAGATAAGGCACCACGAAAGGAAAACGC
GTCGCGATGAGTTACCACGA

Product: histidyl-tRNA synthetase

Products: NA

Alternate protein names: Histidine--tRNA ligase; HisRS

Number of amino acids: Translated: 446; Mature: 445

Protein sequence:

>446_residues
MTEQKKRLEKLSGVKGMNDILPQDAGLWEFFETTVKSMLRSYGYQNIRTPIVEHTQLFTRGIGEVTDIVEKEMYSFTDAL
NGENLTMRPENTAAVVRASIEHNMLYDGPKRLWYIGPMFRHERPQRGRYRQFHQVGVEALGFAGPDTDAEIILMCQRLWD
DLGLTGIKLEINSLGLAEERAKHRVELIAYLEKHMDVLDEDAKRRLYTNPLRVLDTKNPALQAVAQNAPKLIDFLGDESR
AHFEGLQRILKANNIPFTINPRLVRGLDYYNLTVFEWVTDKLGAQGTVAAGGRYDPLIEQLGGKPTAACGWAMGIERILE
LLKEENLVPENEGCDVYVAHQGEAARDQAFIVAERLRDTGLDVILHCSPDGQASSFKSQMKRADASGAAFAVILGEDEIA
NGTAGVKALRDSSQSNGKSEQQTVPLEDLTEYLINAMVASTEDGDD

Sequences:

>Translated_446_residues
MTEQKKRLEKLSGVKGMNDILPQDAGLWEFFETTVKSMLRSYGYQNIRTPIVEHTQLFTRGIGEVTDIVEKEMYSFTDAL
NGENLTMRPENTAAVVRASIEHNMLYDGPKRLWYIGPMFRHERPQRGRYRQFHQVGVEALGFAGPDTDAEIILMCQRLWD
DLGLTGIKLEINSLGLAEERAKHRVELIAYLEKHMDVLDEDAKRRLYTNPLRVLDTKNPALQAVAQNAPKLIDFLGDESR
AHFEGLQRILKANNIPFTINPRLVRGLDYYNLTVFEWVTDKLGAQGTVAAGGRYDPLIEQLGGKPTAACGWAMGIERILE
LLKEENLVPENEGCDVYVAHQGEAARDQAFIVAERLRDTGLDVILHCSPDGQASSFKSQMKRADASGAAFAVILGEDEIA
NGTAGVKALRDSSQSNGKSEQQTVPLEDLTEYLINAMVASTEDGDD
>Mature_445_residues
TEQKKRLEKLSGVKGMNDILPQDAGLWEFFETTVKSMLRSYGYQNIRTPIVEHTQLFTRGIGEVTDIVEKEMYSFTDALN
GENLTMRPENTAAVVRASIEHNMLYDGPKRLWYIGPMFRHERPQRGRYRQFHQVGVEALGFAGPDTDAEIILMCQRLWDD
LGLTGIKLEINSLGLAEERAKHRVELIAYLEKHMDVLDEDAKRRLYTNPLRVLDTKNPALQAVAQNAPKLIDFLGDESRA
HFEGLQRILKANNIPFTINPRLVRGLDYYNLTVFEWVTDKLGAQGTVAAGGRYDPLIEQLGGKPTAACGWAMGIERILEL
LKEENLVPENEGCDVYVAHQGEAARDQAFIVAERLRDTGLDVILHCSPDGQASSFKSQMKRADASGAAFAVILGEDEIAN
GTAGVKALRDSSQSNGKSEQQTVPLEDLTEYLINAMVASTEDGDD

Specific function: Unknown

COG id: COG0124

COG function: function code J; Histidyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family

Homologues:

Organism=Escherichia coli, GI1788861, Length=411, Percent_Identity=55.4744525547445, Blast_Score=459, Evalue=1e-130,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYH_BURP8 (B2JIV0)

Other databases:

- EMBL:   CP001043
- RefSeq:   YP_001857647.1
- ProteinModelPortal:   B2JIV0
- SMR:   B2JIV0
- GeneID:   6242910
- GenomeReviews:   CP001043_GR
- KEGG:   bph:Bphy_1419
- HOGENOM:   HBG616575
- OMA:   VFEWVTT
- ProtClustDB:   PRK00037
- GO:   GO:0005737
- HAMAP:   MF_00127
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR015807
- InterPro:   IPR004516
- Gene3D:   G3DSA:3.40.50.800
- PANTHER:   PTHR11476
- PIRSF:   PIRSF001549
- TIGRFAMs:   TIGR00442

Pfam domain/function: PF03129 HGTP_anticodon; PF00587 tRNA-synt_2b; SSF52954 Anticodon_bd

EC number: =6.1.1.21

Molecular weight: Translated: 49787; Mature: 49656

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEQKKRLEKLSGVKGMNDILPQDAGLWEFFETTVKSMLRSYGYQNIRTPIVEHTQLFTR
CCCHHHHHHHHHCCCCCHHHCCCCCCHHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHH
GIGEVTDIVEKEMYSFTDALNGENLTMRPENTAAVVRASIEHNMLYDGPKRLWYIGPMFR
HHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHCCCEECCCCCEEEECHHHH
HERPQRGRYRQFHQVGVEALGFAGPDTDAEIILMCQRLWDDLGLTGIKLEINSLGLAEER
CCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHH
AKHRVELIAYLEKHMDVLDEDAKRRLYTNPLRVLDTKNPALQAVAQNAPKLIDFLGDESR
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEECCCHHHHHHHHCCHHHHHHHCCCCH
AHFEGLQRILKANNIPFTINPRLVRGLDYYNLTVFEWVTDKLGAQGTVAAGGRYDPLIEQ
HHHHHHHHHHHCCCCCEEECHHHHHCCCCCCCHHHHHHHHHHCCCCEECCCCCCCHHHHH
LGGKPTAACGWAMGIERILELLKEENLVPENEGCDVYVAHQGEAARDQAFIVAERLRDTG
HCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHCCC
LDVILHCSPDGQASSFKSQMKRADASGAAFAVILGEDEIANGTAGVKALRDSSQSNGKSE
CCEEEEECCCCCHHHHHHHHHHCCCCCCEEEEEECCCHHCCCHHHHHHHHCCCCCCCCCH
QQTVPLEDLTEYLINAMVASTEDGDD
HCCCCHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
TEQKKRLEKLSGVKGMNDILPQDAGLWEFFETTVKSMLRSYGYQNIRTPIVEHTQLFTR
CCHHHHHHHHHCCCCCHHHCCCCCCHHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHH
GIGEVTDIVEKEMYSFTDALNGENLTMRPENTAAVVRASIEHNMLYDGPKRLWYIGPMFR
HHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHCCCEECCCCCEEEECHHHH
HERPQRGRYRQFHQVGVEALGFAGPDTDAEIILMCQRLWDDLGLTGIKLEINSLGLAEER
CCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHH
AKHRVELIAYLEKHMDVLDEDAKRRLYTNPLRVLDTKNPALQAVAQNAPKLIDFLGDESR
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEECCCHHHHHHHHCCHHHHHHHCCCCH
AHFEGLQRILKANNIPFTINPRLVRGLDYYNLTVFEWVTDKLGAQGTVAAGGRYDPLIEQ
HHHHHHHHHHHCCCCCEEECHHHHHCCCCCCCHHHHHHHHHHCCCCEECCCCCCCHHHHH
LGGKPTAACGWAMGIERILELLKEENLVPENEGCDVYVAHQGEAARDQAFIVAERLRDTG
HCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHCCC
LDVILHCSPDGQASSFKSQMKRADASGAAFAVILGEDEIANGTAGVKALRDSSQSNGKSE
CCEEEEECCCCCHHHHHHHHHHCCCCCCEEEEEECCCHHCCCHHHHHHHHCCCCCCCCCH
QQTVPLEDLTEYLINAMVASTEDGDD
HCCCCHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA